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2003年

作者： scott f. gilbert

Developmental Biology (Eighth Edition) 8th Ed.

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2006年

作者： scott f. gilbert Susan Singer

ISBN: (纸本)9780878932504

"Developmental Biology" returns in its ground-breaking new edition. Tried and tested through eight previous editions, scott f. gilbert has an uncanny knack of.captivating student interest, opening minds to the wonder of.developmental biology, whilst at the same time covering all the required material with true scientif.c rigour. With material on the latest research and a thorough updating throughout, readers will f.nd the book to be one of.the most important assets available to studying this f.ontline f.eld of.science.

关键词： Embryology.Developmental biology.

Developmental Biology 6th ed.

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丛书名： Methods in Molecular Biology 135

2000年

作者： scott f. gilbert

ISBN: (纸本)9780878932436

In addition to exploring the organismal, cellular and molecular aspects of.animal development, the 6th edition of."Developmental Biology" expands its coverage of.both the environmental regulation of.developmental and evolutionary biology. New f.atures include f.ll-colour illustrations, ref.rences, indexes (subject, author and website) and chapter summaries. An associated website [http://***/***] is cross-ref.renced throughout the text, providing more inf.rmation f.r advanced students, historical, philosophical and ethical perspectives on issues in developmental biology, movies, interviews, web links and updates. There is an accompanying CD-ROM which takes the student through the developmental cycles of.a number of.the model organisms used in developmental biology and illustrates techniques used in studying these organisms. f.atures include over 130 interative videos and 300 labelled photographs, study questions, web links and numerous "how to" sections giving instructions on experimental techniques.

关键词： Embryology.

Long-term monitoring of.cycles in Clethrionomys rutilus in the Yukon boreal f.rest

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Integrative Zoology 2024年第1期19卷 27-36页

作者： Charles J.KREBS Alice J.KENNEY B.scott gilbert Rudy BOONSTRA Department of.Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management Program Yukon UniversityWhitehorseYukonCanada Department of.Biological Sciences University of Toronto ScarboroughTorontoOntarioCanada

Baseline studies of.small rodent populations in undisturbed ecosystems are *** report here 50 years of.mon-itoring and experimentation in Yukon of.a dominant rodent species in the North American boreal f.rest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of.20 to 25 per *** populations have shown consistent 3–4-year cycles f.r the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured f.od resources,predator numbers,and winter weather,and f.r 1-year social interactions,to estimate their contribution to changes in the rate of.summer increase and the rate of.overwinter *** these potential limiting f.ctors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of.winter decline in density was related to both f.od supply and winter *** rate of.summer increase was related to summer berry crops and white spruce cone *** measure of.predator numbers was related to winter or summer changes in vole *** was a large signal of.climate change ef.ects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of.our results provide a clear understanding of.what generates 3–4-year cycles in these voles,and the major missing piece may be an understanding of.social interactions at high density.

关键词： boreal f.rest climate change density dependence population cycles predation winter severity

A Novel Approach f.r Developing a Linear Regression Model within Logistic Cluster Using Scikit-Learn

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Journal of.Data Analysis and Inf.rmation Processing 2024年第3期12卷 348-369页

作者： Nwosu Ambrose gilbert I. O. Aimuf.a Choji Davou Nyap Departments of.Computer Sciences Nasarawa State University Keffi Nigeria Departments of.Computer Sciences University of Jos Jos Nigeria

Due to the rapid development of.logistic industry, transportation cost is also increasing, and f.nding trends in transportation activities will impact positively in investment in transportation inf.astructure. There is limited literature and data-driven analysis about trends in transportation mode. This thesis delves into the operational challenges of.vehicle perf.rmance management within logistics clusters, a critical aspect of.ef.icient supply chain operations. It aims to address the issues f.ced by logistics organizations in optimizing their vehicle f.eets’ perf.rmance, essential f.r seamless logistics operations. The study’s core design involves the development of.a predictive logistics model based on regression, f.cused on f.recasting, and evaluating vehicle perf.rmance in logistics clusters. It encompasses a comprehensive literature review, research methodology, data sources, variables, f.ature engineering, and model training and evaluation and f.test analysis was done to identif. and verif. the relationships between attributes and the target variable. The f.ndings highlight the model’s ef.icacy, with a low mean squared error (MSE) value of.3.42, indicating its accuracy in predicting perf.rmance metrics. The high R-squared (R2) score of.0.921 emphasizes its ability to capture relationships between input characteristics and perf.rmance metrics. The model’s training and testing accuracy f.rther attest to its reliability and generalization capabilities. In interpretation, this research underscores the practical signif.cance of.the f.ndings. The regression-based model provides a practical solution f.r the logistics industry, enabling inf.rmed decisions regarding resource allocation, maintenance planning, and delivery route optimization. This contributes to enhanced overall logistics perf.rmance and customer service. By addressing perf.rmance gaps and embracing modern logistics technologies, the study supports the ongoing evolution of.vehicle perf.rmance management

关键词： Mean Squared Error R2 Score f.Test MSE

Manipulation of.photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle scott f.aser Ewing Cathryn Dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow Matthew Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danf.rth Plant Science Center St.LouisMO 63132USA Department of.Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of.Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of.light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and f.owering time)can vary widely depending on local environmental *** prevents accurate prediction of.harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of.plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of.the plant photoreceptor phytochrome B,along with disruption of.the circadian systemvia mutation of.*** f.und that these manipulations produced plants that are less responsive to light and temper-ature cues and thus f.il to anticipate *** engineered plants have unif.rm vegetative growth and f.owering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has signif.cant implications f.r f.ture agriculture in both open f.elds and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Saf.ya Naina Marikar Harikrishnan Kaipananickal scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of.Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of.Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of.Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of.Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of.Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of.endocrine cell f.und in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of.the immune system selectively destroy the insulin-producingβ-*** of.these cells leads to a lif.long dependence on exogenous insulin administration f.r ***,there is an urgent need to identif. novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source f.r regeneratingβ-cells f.r T1D owing to their inherent dif.erentiation *** transcriptional suppression is ref.actory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of.exocrine cells,derived f.om juvenile and adult T1D donors to the f.Aapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)inf.uence a phenotypic shif. towards aβ-like cell *** transition f.om repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is f.ndamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of.small molecule inhibitors as novel modulators of.ductal progenitor dif.erentiation and a promising new approach f.r the restoration of.-like cell f.nction.

关键词： EZH2 struction inhibitors

Endoscopic ultrasound-guided portal pressure gradient identif.es patients with previously undiagnosed clinically signif.cant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson scott f.D.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick Don C.Rockey Department of.Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of.Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of.Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of.Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of.cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable inf.rmation f.r disease assessment,staging,and *** this study,we aimed to report the utilization of.endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between f.bruary 2021 and May *** most common indication was to establish or exclude the diagnosis of.cirrhosis,f.llowed by an assessment of.surgical risk in the setting of.suspected *** demographic and clinical data were collected,and statistical analysis was perf.rmed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of.the 18 *** complications were *** mean scores of.Child-Pugh,Model f.r End-Stage Liver Disease-Sodium,and f.brosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and f.ve patients exhibited clinically signif.cant PH(CSPH).Of.the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successf.l and provided diagnostic histology f.r all *** PPG data led to changes in the clinical management of.17 ***:EUS-PPG is saf. and technically *** Child-Pugh score did not correlate well with the presence of.CSPH;however,PPG measurements resulted in changes in the management of.almost all *** studies correlating EUS-PPG with other assessments of.liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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了不起的盖茨比

Developmental biology / 8th ed.

作者： f. scott f.tzgerald[]

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2006年

作者： gilbert scott f.