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2007年全国砌体结构基本理论与工程应用学术会议

作者： Allen J.Clark Rod Larson Tony Y.Yang Bozidar Stojadinovic Jack P.Moehle Robert Tremblay Nilolay Velev Sina Merzouq Martin Leclerc Pierre Leger Bruno Massicotte Caroline Blais Colin Rogers M.Pangiotou Jose I.Restrepo Robert E.Englekirk Nathan Johnson M.Saiid Saiidi David Sanders Richard T.Ranf Marc Eberhard Andrei M.Reinhorn Mettupalayam V.Sivaselvan Zach Liang Mark Pittman scot.Weinreber MTS Systems Corporation Department of Civil and Environmental Engineering University of California at Berkeley Group for Research and Studies in Structural Engineering.Department of Civil Geological and Mining Engineering.Ecole Polytechnique Department of Civil Engineering and Applied Mechanics McGill University Department of Structural Engineering University of California at San Diego Englekirk Partners Consulting Structural Engineers Inc. University of Nevada University of Washington Department of Civil Structural and Environmental Engineering University of Buffalo

＜正＞Earthquake damage of property and loss and injury of human life *** many laboratories worldwide have increased their abilities to mitigate the hazards of these reoccurring natural *** paper presents new experimental techniques and applications from five laboratories,one in Canada,and four in the United *** new techniques and technologies range from combining computational analyses with structural testing with strong wall and strong floor at the University of California at Berkelely, a new technique for increasing the capability of a medium size uniaxial shaking table at Ecole Polytechnique,a description of the world’s highest capacity outdoor shaking table at the University of California at San Diego,testing with multiple biaxial shaking tables at the University of Reno,Nevada,and finally,the combination of strong wall dynamic structural actuators with a shaking table and real time computational sub-structuring computations at the University at Buffalo（SUNY）.These new capabilities allow the researcher to increase the size of the specimens of interest,allowing much better results to study nonlinear behaviors and failure mechanisms.

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使用不散瞳数码相机和标准的眼底彩照观测年龄相关性黄斑变性

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美国医学会眼科杂志（中文版） 2005年第3期17卷 188-188页

作者： Ronald Klein Stacy M. Meuer scot.E. Moss Barbara E. K. Klein Michael W. Neider Jennifer Reinke 韩亮（译）

目的：应用数码和眼底立体照象技术比较与老年黄斑变性相关的病变区的分级。设计：仪器确认研究。研究对象：62名患者（124只眼）伴有不同程度的AMD，其中也包括无AMD者。

关键词：年龄相关性黄斑变性眼底彩照数码相机观测标准散瞳老年黄斑变性不同程度研究对象

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Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Qiuwei Pan scot.D.Henry Herold J.Metselaar Bob Scholte Jaap Kwekkeboom Hugo W.Tilanus Harry L.A.Janssen Luc J.W.van der Laan

The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effective in approximately half of the patients,prompting the need for alternative *** interference(RNAi)represents novel approach to combat HCV by sequence-specific targeting of viral or host factors involved in *** of RNAi,however,may lead to therapeutic resistance by mutational escape of the ***,we proposed that combining lentiviral vector-mediated RNAi and IFN-a could be more effective and avoid therapeutic *** this study,we found that IFN-α treatment did not interfere with RNAi-mediated gene *** and IFN-α act independently on HCV replication showing combined antiviral activity when used simultaneously or *** ofmouse hepatocytes in vivo and in vitro was not effected by IFN-α *** conclusion,RNAi and IFN-a can be effectively combined without crossinterference and may represent a promising combinational strategy for the treatment of hepatitis C.

关键词： RNAi IFN-α Gene therapy Lentiviral vector HCV

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Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Qiuwei Pan scot.D.Henry Herold J.Metselaar Bob Scholte Jaap Kwekkeboom Hugo W.Tilanus Harry L.A.Janssen Auc J.W.van der Laan

The current standard interferon-alpha(IFN-α)-based therapy for chronic hepatitis C virus(HCV) infection is only effective in approximately half of the patients, prompting the need for alternative treatments. RNA interference(RNAi) represents novel approach to combat HCV by sequence-specific targeting of viral or host factors involved in infection. Monotherapy of RNAi, however, may lead to therapeutic resistance by mutational escape of the virus. Here, we proposed that combining lentiviral vector-mediated RNAi and IFN-α could be more effective and avoid therapeutic resistance. In this study, we found that IFN-α treatment did not interfere with RNAi-mediated gene silencing. RNAi and IFN-α act independently on HCV replication showing combined antiviral activity when used simultaneously or sequentially. Transduction ofmouse hepatocytes in vivo and in vitro was not effected by IFN-α treatment. In conclusion, RNAi and IFN-α can be effectively combined without crossinterference and may represent a promising combinational strategy for the treatment of hepatitis c.

关键词： RNAi IFN-α Gene therapy Lentiviral vector HCV

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抗马铃薯晚疫病质粒的分子克隆及其体外PCR扩增

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生物技术 2002年第2期12卷 4-5页

作者：赵晓祥浦瑞斯-王革伏王玉霞王佳龙赵晓宇黑龙江省科学院应用微生物研究所黑龙江哈尔滨150010 加拿大诺娃斯高沙农学院植物学系

从一株假单胞菌中分离其质粒DNA ,并将其转化到大肠杆菌DH5α中。通过晚疫病抑菌实验证明此菌对马铃薯晚疫病有很强的抑制作用 ,对该质粒进行纯化和限制性酶切位点分析后 ,将此质粒重组到含有绿色发光蛋白基因的质粒载体中。

关键词：抗马铃薯晚疫病质粒分子克隆体外PCR扩增

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