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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 505-515页

作者： Mehmet Kadir Erdoğan can Ali Ağca Hakan Aşkın Department of Biology Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of SciencesAtaturk University25000ErzurumTurkey

Objective:To investigate the antiproliferative,anti-angiogenic,and apoptotic effects of extracts of Achillea biebersteinii(ABE)and combined treatments of ABE with 5-fluorouracil(5-FU)on HT-29 ***:The effects of ABE,5-FU,and combined treatments on the viability of HT-29 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** analysis was used to determine synergism between ABE and *** apoptotic and anti-angiogenic effects were determined by cell death detection and human vascular endothelial growth factor ELISA method,*** and translational expressions of p53,Bax,Bcl-2,p38 MAPK,Akt,PTEN,and m TOR were also evaluated by real-time PCR and Western blotting ***:ABE decreased the viability of HT-29 cells in a dosedependent *** treatment of hexane,chloroform,and methanol extracts of Achillea biebersteinii with 5-FU at IC50 doses decreased the cell viability to 26.0%,19.1%,and 14.9%,respectively(Pcantly downregulated m TOR,Akt,Bcl-2 expression,upregulated p53,Bax,PTEN,p38 MAPK expression,and exhibited anti-angiogenetic ***:Our findings indicate that ABE shows synergism with 5-FU and inhibits the proliferation of HT-29 cells by inducing apoptosis and suppressing angiogenesis,which may provide biological evidence for further use of ABE in the treatment of colorectal cancer.

关键词： angiogenesis doses colon

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梅州市石窟河健康评价分析

陕西水利 2024年第9期 75-77,80页

作者：郭晓娟蔡金妤钟伟强广东省水利水电科学研究院广东广州510635 河口水利技术国家地方联合工程实验室广东广州510635 广东省水动力学应用研究重点实验室广东广州510635

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数... 详细信息

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数低等健康问题提出保护对策,以更好地发挥石窟河的生态环境和社会服务功能。

关键词：健康评价石窟河河湖管理

POLES OF ZETA FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese Annals of Mathematics,Series B 2000年第2期21卷 187-200页

作者： WAN DAQING(Department of Mathematics, University of california, Irvine, ca 92697-3875, USA.) Department of Mathematics University of California Irvine CA 92697-3875 USA

A vanishing theorem is proved for e-adic cohomology with compact support on an affine (singular) complete intersection. As an application, it is shown that for an affine complete intersection defined over a finite field of q elements, the reciprocal "poles" of the zeta function are always divisible by q as algebraic integers. A p-adic proof is also given, which leads to further q-divisibiliy of the poles or equivalently an improvement of the polar part of the AxKatz theorem for an affine complete intersection. Similar results hold for a projective complete intersection.

关键词： Pole Zeta function Complete intersection

全容积IVIM直方图分析对乳腺良恶性病变的影响

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中国CT和MRI杂志 2024年第3期22卷 82-85页

作者：李俊蔡小丽吴奇川牟方胜重庆大学附属三峡医院放射科重庆404000

目的探讨全容积测量体素内不相干运动(IVIM)直方图参数对乳腺良恶性病变的诊断价值。方法收集我院2021年2月-2022年10月术前行多模态磁共振检查并获得病理的153例女性共158例肿瘤。利用直方图处理软件得到肿瘤IVIM(D、D*、f)的直方图... 详细信息

目的探讨全容积测量体素内不相干运动(IVIM)直方图参数对乳腺良恶性病变的诊断价值。方法收集我院2021年2月-2022年10月术前行多模态磁共振检查并获得病理的153例女性共158例肿瘤。利用直方图处理软件得到肿瘤IVIM(D、D*、f)的直方图参数。采用两独立样本t检验(正态分布)或Mann-WhitneyU检验(偏态分布)比较乳腺良、恶性病灶的IVIM直方图参数的差异。绘制ROC评价IVIM直方图参数独立和联合鉴别诊断乳腺良、恶性病变的效能,Z检验评价联合诊断ROC下面积(AUC)差异性。单变量及多变量二元logisti回归分析独立影响因素。结果乳腺恶性病变116个,良性病变42个。良、恶性病变D(90th、熵、峰度、均值、中位数、最小值、偏度)、f峰度、D*(90th、熵、峰度、均值、中位数、最大值、偏度)单因素分析有统计学意义。AUC最大为D偏度(0.818);敏感度最高为D熵(0.957);特异度最高为D偏度(0.857);准确度最高为D偏度(0.797)。D直方图联合诊断AUC、敏感度、特异度、准确度分别为0.903、0.948、0.786、0.88;f直方图联合诊断分别为0.604、0.672、0.548、0.73;D*直方图联合诊断为0.833、0.897、0.619、0.823;IVIM直方图联合诊断为0.953、0.982、0.833、0.924;IVIM直方图联合诊断AUC面积最大,与D值、f值、D*直方图分别联合诊断AUC差异有统计学意义。D熵(OR=2.943;P=0.037)及D中位数(OR=0.984;P=0.029)为乳腺恶性病变独立影响因素。结论乳腺磁共振IVIM直方图参数联合能显著提高判断乳腺良恶性病变诊断效能,D熵及D中位数为乳腺恶性病变独立影响因素。

关键词：乳腺病变体素内不相干运动成像联合诊断影响因素

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Design of Sliding Mode Control with Disturbance Observers for Inertial Platform 25th

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Optimization of phenol degradation by candida tropicalis Z-04 using Plackett-Burman design and response surface methodology

第25届中国控制与决策会议

作者： Yue Hu Yuan ca Shifeng Zhang College of Aerospace Science and Engineering National University of Defense and Technology

ISBN: (纸本)9781467355339

In the flight process, the disturbances such as vibrations and frictions affect the stability accuracy of the servo loop of the inertial platform. Besides, the model uncertainties exist due to the couplings of the three subsystem of the inertial platform. This paper presents a sliding mode controller based on a proportional integral （PI） disturbance observer. The state variables and disturbing torque are estimated accurately by the PI observer. Additionally, an integral sliding mode controller is designed. The vibration and stability error are reduced by employing the integral items of the states in designing the sliding mode surface. The simulation results show that the proposed methods can improve the control precision of the servo loop of the platform.

关键词： integral sliding mode control disturbance observer stabilized control of platform

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Journal of Environmental Sciences 2011年第1期23卷 22-30页

作者： Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin ca School of Environmental Science and Engineering Shanghai Jiaotong University Dongchuan Road 800 Shanghai 200240 China.

Statistical experimental designs were used to optimize the process of phenol degradation by candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degradation （p 〈 0.05）, as identified by a two-level Plackett-Burman design with 11 variables, were yeast extract, phenol, inoculum size, and temperature. Steepest ascent method was undertaken to determine the optimal regions of these four significant factors. Central composite design （CCD） and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation. The analysis results indicated that interactions between yeast extract and temperature, phenol and temperature, inocuhim size and temperature affected the response variable （phenol degradation） significantly. The predicted results showed that the maximum removal efficiency of phenol （99.10%） could be obtained under the optimum conditions of yeast extract 0.41 g/L, phenol 1.03 g/L, inoculum size 1.43% （V/V） and temperature 30.04℃. These predicted values were further verified by validation experiments. The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy. This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents.

关键词： phenol degradation candida tropicalis Z-04 optimization Plackett-Burman design response surface methodology

Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children

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World Journal of Gastroenterology 2006年第39期12卷 6366-6370页

作者： Roberto caete Angel A Escobedo María E González Pedro Almirall Hygiene Epidemiology and Microbiology Centre Matanzas City Cuba Academic Paediatric Hospital "Pedro Borrás" Havana City Cuba Institute of Gastro-enterology Havana City Cuba "Pedro Kourí" Institute Havana City Cuba

AIM： To compare the efficacy and safety of five days apostrophe therapy of mebendazole （MBZ） versus quinacrine （QC） on human giardiasis in children.METHODS： A clinical trial was carried out in paediatric patients （aged 5-15 years） with confirmed symptomatic G. duodenalis mono-infection. Patients were randomly assigned to receive either MBZ [200 mg taken three times per day GRID）（n = 61）] or QC [2 mg/kg bodyweight tid （n = 61）], both for five days. Follow-up faecal samples were obtained at 3, 5 and 7 d after the end of the treatment.RESULTS： Although the frequency of cure was higher for QC （83.6%） than for MBZ （78.7%）, the difference was not statistically significant （P 〉 0.05）. Adverse events were reported more in the QC group （P 〈 0.05）, all of them transient and self-limiting.CONCLUSION： Despite final cure rates ocurring lower than expected, the overall results of this study reconfirmed the efficacy of MBZ in giardiasis and also indicate that, although comparable to QC, at least in this setting the 5 d course of MBZ did not appear to improve the cure rates in this intestinal parasitic infection.

关键词： Giardia infection/drug therapy Children Me- bendazole/therapeutic use Quinacrine/therapeutic use Benzimidazoles/therapeutic use Giardiasis/drug therapy Cuba

A New Perspective of the Physical Processes Associated with the Clear-Sky Greenhouse Effect over High Latitudes

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Advances in Atmospheric Sciences 2004年第2期21卷 171-180页

作者： Zuohao ca0 Ronald E．STEWART M．K．YAU MeteorologicalServiceofcanada，Ontario，canada DepartmentofAtmosphericandOceanicSciences，McGillUniversityMontreal，Quebec，canada

The physical processes associated with the clear-sky greenhouse effect in the presence of water vapor are examined by including surface emissivity in the greenhouse effect formulation, and by introducing a new way to partition physical processes of the greenhouse effect. In this new framework, it is found that the clear-sky greenhouse effect is governed by three physical processes associated with (1) the temperature contrast between the surface and the atmosphere, (2) the interaction between the surface emissivity and the temperature contrast, and (3) the surface emissivity. The importance of the three physical processes is assessed by computing their vertical and spectral variations far the subarctic winter and summer standard atmosphere using the radiation model MODTRAN3 (Moderate Resolution Transmittance code Version 3). The results show that the process associated with the temperature contrast between the surface and the atmosphere dominates over the other two processes in magnitude. The magnitude of this process has substantial variations in the spectral region of 1250 to 1880 cm-1 and in the far infrared region. Due to the low-level temperature inversion over the subarctic winter, there exists a negative contribution to the greenhouse trapping. The seasonal variations are, however, dominated by the processes associated with the interaction between the surface emissivity and the temperature contrast as well as the surface emissivity itself. The magnitudes of these two physical processes contributing to the greenhouse trapping over the subarctic winter are about 7 to 10 times of those over the subarctic summer, whereas the magnitude of the processes associated with the temperature contrast in the subarctic summer is only about 2 times of that in the subarctic winter.

关键词： greenhouse effect surface ernissivity physical processe high latitude seasonal variation

Representations of Knot Groups and Twisted Alexander Polynomials

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Acta Mathematica Sinica,English Series 2001年第3期17卷 5+362-380页

作者： Xiao Song LIN Department of Mathematics,University of california,Riversides,ca 92521.USA Department of Mathematics University of California Riverside USA

We present a twisted version of the Alexander polynomial associated with a matrix rep- resentation of the knot *** of two knots with the same Alexander module but different twisted Alexander polynomials are given.

关键词： Twisted Alexander polynomial Representation space Knot group

ON THE KINEMATIC GEOMETRY OF MANY BODY SYSTEMS

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Chinese Annals of Mathematics,Series B 1999年第1期20卷 11-28页

作者： WU-YI HSIANG(Department of Mathematics,University of caLIFORNIA,berkeley,ca 94720-3840,USA) Department of Mathematics University of California Berkeley CA 94720-3840 USA

In mechanics, both classical and quantum, one studies the profound interaction betweentwo types of energy, namely, the kinetic energy and the potential energy. The former can beorganized as the kinematic metric on the configuration space while the latter can be representedby a suitable potential function, such as the Newtonian potential in celestial mechanics andthe Coulomb potential in quantum mechanics of atomic and molecular physics. In this paper,the author studies the kinematic geometry of n-body systems. The main results are (i) theintroduction of a canonical coordinate svstem which reveals the total amount of kinematicsymmetry by an SO(3) x O(n-1) action in such a canonical coordinate representationt (ii) anin depth analysis of the above kinematic system both in the setting of classical invariant theoryand by the technique of equivariant Riemannian geometry; (iii) a remarkably simple formulafor the potential function in such a canonical coordinate system which reveals the well-fittingbetween the kinematic symmetry and the Potential energy.

关键词： Kinematic geometry Many body system Configuration space