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Epidemiological, Clinical and Biological Aspects of Kidney Disease in People Living with HIV Naive Antiretroviral Therapy at CHU Sylvanus Olympio of Lome (TOGO)

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Open Journal of Nephrology 2019年第1期9卷 26-34页

作者： Kossi Akomola Sabi Badomta Dolaama Eyram Yoan Makafui Amekoudi Awereou Kotosso Befa Noto-Kadou-Kaza Claude Mawufemo Tsevi Komlan George Tona Eugene Ametepe Attisso schyldia bonou-selegbe Hamat Ibrahim Guillaume Abderhamman Mahamat Jaques Vigan Majeste Ihou Wateba Service de Néphrologie et Hémodialyse CHU Sylvanus Olympio Lomé Togo Service des Maladies Infectieuses et Tropicales du CHU Sylvanus Olympio de Lomé Lomé Togo Service de Néphrologie et d’Hémodialyse H&ocirc pital Universitaire de N’djaména N’djamena Tchad Clinique de Néphrologie CNHU Cotonou Bénin

Introduction: Human immunodeficiency virus (HIV) infection is a common cause of kidney disease worldwide. HIV-related renal diseases are associated with high morbidity and mortality in Sub-Saharan African countries. The aim is to describe the epidemiological, clinical and biological aspects of kidney disease in people living with HIV naive antiretroviral therapy in Lomé in Togo. Methods: This was a cross-sectional study done in the department of Infectious and Tropical Diseases in Lomé from ESOPE database. Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. Kidney disease was defined as GFR less than 90 mL/min/1.73 m2. Results: In total, 3118 HIV-infected ART-naive patients were included in this study. Among them, the prevalence of renal disease at the beginning of their care, was 41.8% or 1303 patients [95% CI: 40.0% - 43.5%]. The median estimated GFR was 94.7 ml/min/1.73 m2: 2.9% had eGFR 2. The median age was 40 years [IQR = 34 - 48 years] with a sex ratio at 0.45. BMI median was 20.6 Kg/m2. Most of patients (30.8%) were at clinic OMS stage 1. Median CD4 was 165/uL [IQR = 72 - 274/uL];median hemoglobin was 10.4 g/dl [IQR = 8.8 - 11.9 g/dl];median glycemia was 0.84 g/l [IQR = 0.75 - 0.95 g/l]. Most of patients (99.9%) had HIV-1. 8.5% had hyperleukocytosis, and all patients had thrombopenia. Conclusion: The incidence of kidney disease is high in Togolese HIV-infected ART naive patients.

关键词： HIV Kidney Disease Prevalence Togo

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Determinants and Risks Factors of Renal Failure in Patients with Heart Failure in Cardiology Department of CHU Sylvanus Olympio of Lomé(Togo)

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Open Journal of Nephrology 2019年第3期9卷 65-76页

作者： Kossi Akomola Sabi Eyram Yoan Makafui Amekoudi Soudougoua Baragou Komlan Georges Tona Yaovi Afassinou Machioude Pio Béfa Noto-Kadou-Kaza Badomta Dolaama Eugene Ametepe Attisso Anani Amen Tevi Mawusse Koffi Mensah Mindessou Murielle schyldia bonou-selegbe Jaques Vigan Department of Nephrology and Hemodialysis CHU Sylvanus Olympio Lomé Togo Department of cardiology CHU Sylvanus Olympio Lomé Togo Clinique de Néphrologie CNHU Cotonou Bénin

Introduction: The morbidity and mortality of patients with heart failure are known to increase rapidly in the presence of renal insufficiency, which is usually the cause but may be a consequence. To organize better prevention of renal failure, we undertook this study to identify the determinants of renal failure in the population of patients with heart failure. Methodology: This was a retrospective descriptive and analytical study of heart failure (HF) cases hospitalized from January 1st to December 31st, 2016, over a period for twelve (12) months at CHU Sylvanus Olympio. Patients who performed cardiac Doppler ultrasound were included in our study. Renal failure was defined as eGFR (estimated glomerular filtration rate) less than 60 ml/min/1.73m2. Multivariate logistic regression was performed to investigate associated factors. The dependent variable was DFG status: coded 1 if the GFR is less than 60 ml/min and 0 if not. Results: A total of 216 patients were included. The majority were female (54.17%). The median age of patients was 53 years [IQI = 32 - 61 years] with extremes of 15 and 96 years. 16.49% of patients had a GFR of less than 60 ml/min. In multivariate analysis the average standard of living (OR = 2.40, p = 0.0456), diabetes (OR = 2.67, p = 0.0300), hypertension (OR = 5.66, p = 0.0399), alcoholism (OR = 4.00, p = 0.0063) were the main factors in the development of an RF/HF. Conclusion: The average standard of living, diabetes, hypertension, and chronic alcoholism are the determinants of renal failure in HF.

关键词： Heart Failure Renal Failure Determinants Togo

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