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A REVIEW OF THE PALEO-HYDROLOGICAL AND GEOMORPHOLOGICAL CHARACTER OF LAKE NAM CO, SOUTH-CENTRAL TIBET

丛书名： The Pine Forge Press series in research methods and statistics

1996年

作者： schutt Russell K.

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第四纪研究 2009年第4期29卷 655-664页

作者： J. Berking A. Keil B. schutt Department of Earth Sciences Freie Universitait Berlin MalteserstraBe 74 - 100 12249 Berlin Germany

The endorheic Lake Nam Co, south Eastern Tibetan Plateau, was selected to investigate the interrelationbetween drainage basin processes, especially post-glacial glacier decay, and lake level fluctuations. Landforms of thedrainage basin are highly influenced by tectonics, superimposed by fluvial and periglacial processes, and locally by glacialand eolian processes. Thus,geomorphological features and hydrological characteristics were compiled for the lake-basin toprovide an overview of the landscape character. Data show that during the Last Glacial Maximum melt water from themountains accumulated fluvial deposits in the foreland. Concurrently, an increase of the lake level occurred which ispresently shown by a cliff line all around Nam Co with its base approximately 29m above the present lake level. TheHolocene decrease of the lake level is traced by beach ridges. As Nam Co is an endorheic lake post-glacial water loss has tobe primarily explained by evaporation and moisture conditions. However, more detailed conclusions on quantitative andchronological patterns of both factors, melt-water input and evaporation output, still remain to be drawn.

关键词：湖泊水位蒸发量内陆湖

Investigating the social world : the process and practice of research

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PHGDH as a mechanism for resistance in metabolically-driven cancers

2004年

作者： schutt Russell K.

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Cancer Drug Resistance 2020年第4期3卷 762-774页

作者： Richa Rathore Charles R.schutt Brian A.Van Tine Division of Medical Oncology Washington University in St.LouisSt.LouisMO 63110USA Siteman Cancer Center St.LouisMO 63110USA

At the forefront of cancer research is the rapidly evolving understanding of metabolic reprogramming within cancer *** expeditious adaptation to metabolic inhibition allows cells to evolve and acquire resistance to targeted treatments,which makes therapeutic exploitation complex but achievable.3-phosphoglycerate dehydrogenase(PHGDH)is the rate-limiting enzyme of de novo serine biosynthesis and is highly expressed in a variety of cancers,including breast cancer,melanoma,and Ewing’s *** review will investigate the role of PHGDH in normal biological processes,leading to the role of PHGDH in the progression of *** an understanding of the molecular mechanisms by which PHGDH expression advances cancer growth,we will highlight the known mechanisms of resistance to cancer therapeutics facilitated by PHGDH biology and identify avenues for combatting PHGDH-driven resistance with inhibitors of PHGDH to allow for the development of effective metabolic therapies.

关键词： PHGDH cancer metabolism serine one-carbon metabolism folate cycle drug resistance

HIV-1蛋白酶抑制剂Nelfinavir降低大鼠胰岛素瘤INS-1细胞胰岛素释放

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中华内分泌代谢杂志 2004年第5期20卷 463-464页

作者：周嘉强 Morten schutt 浙江大学医学院附属第一医院内分泌科杭州310003 德国Schleswig-Holstein大学Luebeck校区内科Ⅰ

HIV 1蛋白酶抑制剂Nelfinavir处理 48h ,显著降低大鼠INS 1细胞基础胰岛素分泌和葡萄糖刺激的胰岛素释放 ,Nelfinavir对后者的抑制作用更强 ,提示Nelfinavir长期治疗可能导致胰岛 β细胞功能损害。

关键词： HIV-1蛋白酶 INS-1细胞酶抑制剂大鼠胰岛素瘤长期治疗胰岛β细胞功能释放葡萄糖刺激

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一次性产品生产商面临的机遇和挑战

产业用纺织品 1998年第11期16卷 43-43,46页

作者： Ellen Noonan schutt 吴英

卫生用品是非织造布工业的最大市场之一,已被证明它最具有竞争力.提高主要生产企业的技术水平,不断竞争以及发展由小型企业生产的精致产品,可持续推进市场走向繁荣.非织造布卫生用品包括婴儿尿布和训练裤、成年人失禁用品和卫生防护用品... 详细信息

卫生用品是非织造布工业的最大市场之一,已被证明它最具有竞争力.提高主要生产企业的技术水平,不断竞争以及发展由小型企业生产的精致产品,可持续推进市场走向繁荣.非织造布卫生用品包括婴儿尿布和训练裤、成年人失禁用品和卫生防护用品,其中婴儿尿布用量最大.目前卫生用品市场在发达国家如美国、西欧和日本已趋于成熟,而在发展中国家和地区,

关键词：卫生用品非织造布一次性产品

Nelfinavir损害鼠胰岛素瘤INS-1细胞内IRS-2信号传导

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浙江大学学报（医学版） 2004年第4期33卷 311-314页

作者：周嘉强项尊 Morten schutt 浙江大学医学院附属第一医院浙江杭州310003 德国石荷州大学吕贝克校区

目的 :探讨 HIV- 1蛋白酶抑制剂 nelfinavir对胰岛 β细胞内胰岛素信号传导蛋白磷酸化的影响。方法 :体外观察鼠胰岛素瘤 INS- 1细胞经 nelfinavir治疗 4 8h后 ,用 10 0 nmol/ L胰岛素刺激 2 min,细胞裂解产物中的胰岛素信号传导蛋白磷... 详细信息

目的 :探讨 HIV- 1蛋白酶抑制剂 nelfinavir对胰岛 β细胞内胰岛素信号传导蛋白磷酸化的影响。方法 :体外观察鼠胰岛素瘤 INS- 1细胞经 nelfinavir治疗 4 8h后 ,用 10 0 nmol/ L胰岛素刺激 2 min,细胞裂解产物中的胰岛素信号传导蛋白磷酸化采用免疫沉淀和 Western印迹方法测定。用台盼蓝染色细胞计数和 MTT衰减试验 ,评估nelfinavir对 INS- 1细胞活力的影响。结果 :nelfinavir降低胰岛素刺激的胰岛素受体底物 IRS- 2和 Akt- Thr3 0 8磷酸化 ,并呈剂量依赖关系。nelfinavir浓度为 10 μmol/ L时 ,分别降低 IRS- 2和 Akt- Thr3 0 8磷酸化达 5 2 %和 5 5 % ,在这个浓度下 nelfinavir没有细胞毒性作用。结论 :nelfinavir治疗可以损害胰岛 β细胞内 IRS-

关键词：蛋白酶抑制药/投药和剂量受体胰岛素 Nelfinavir INS-1细胞胰岛素受体底物-2 信号传导

不同HIV蛋白酶抑制剂对鼠胰岛素瘤细胞功能的影响

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浙江大学学报（医学版） 2006年第3期35卷 251-254页

作者：周嘉强李闻鹏项尊 schutt Morten 浙江大学医学院附属第一医院浙江杭州310003 德国石荷州大学吕贝克校区

目的:探讨不同H IV蛋白酶抑制剂对胰岛beta-细胞功能的影响。方法:体外观察不同浓度ritonav ir或am prenav ir干预48 h对鼠胰岛素瘤IN S-1细胞葡萄糖刺激的胰岛素释放速率的影响,胰岛素测定采用EL ISA法,并用细胞内DNA含量标准化。用苔... 详细信息

目的:探讨不同H IV蛋白酶抑制剂对胰岛beta-细胞功能的影响。方法:体外观察不同浓度ritonav ir或am prenav ir干预48 h对鼠胰岛素瘤IN S-1细胞葡萄糖刺激的胰岛素释放速率的影响,胰岛素测定采用EL ISA法,并用细胞内DNA含量标准化。用苔盘蓝染色细胞计数、MTT试验评估ritonav ir或am prenav ir对IN S-1细胞活力的影响。结果:R itonav ir治疗可以显著降低基础胰岛素分泌速率及葡萄糖刺激的胰岛素释放速率,并呈剂量依赖关系(r分别为-0.861,-0.839,均P<0.01)。10μm o l/L ritonav ir分别降低基础胰岛素分泌和葡萄糖刺激的胰岛素释放达46%和47%。Am prenav ir对胰岛素释放功能没有影响。结论:不同H IV蛋白酶抑制剂对胰岛beta-细胞功能的影响不同。

关键词：胰岛素瘤/病理学磺胺类/药理学利托纳韦/药理学抗HIV药 HIV蛋白酶抑制药/药理学葡萄糖/药理学胰岛素/代谢

Study guide and activities to accompany Investigating the social world, the process and practice of research, second edition

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Study guide and activities to accompany Investigating the so...

STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function

1999年

作者： schutt Russell K.

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Cellular & Molecular Immunology 2021年第3期18卷 632-643页

作者： Hee-Jin ChoiTaylor Ticer Yongxia Wu Chih-Hang Anthony Tang Corey Mealer David Bastian M.Hanief Sofi Linlu Tian Steven schutt Hee-Jin Choi Taylor Ticer Mengmeng Zhang Xiaohui Sui Lei Huang Andrew L.Mellor Chih-Chi Andrew Hu Xue-Zhong Yu Microbiology&Immunology Medical University of South CarolinaCharlestonSCUSA Immunology Microenvironment&Metastasis ProgramThe Wistar InstitutePhiladelphiaPAUSA Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle upon TyneUK Department of Medicine Medical University of South CarolinaCharlestonSCUSA Hollings Cancer Center Medical University of South CarolinaCharlestonSCUSA

Stimulator of interferon genes(STING)-mediated innate immune activation plays a key role in tumor-and self-DNA-elicited antitumor immunity and ***,STING can also suppress tumor immunity and *** signaling In host nonhematopoietic cells was reported to either protect against or promote graft-versus-host disease(GVHD),a major complication of allogeneic hematopoietic cell transplantation(allo-HCT).Host hematopoietic antigen-presenting cells(APCs)play key roles in donor T-cell priming during GVHD ***,how STING regulates host hematopoietic APCs after allo-HCT remains *** utilized murine models of allo-HCT to assess the role of STING in hematopoietic ***-deficient recipients developed more severe GVHD after major histocompatibility complex-mismatched *** bone marrow chimeras,we found that STING deficiency in host hematopoietic cells was primarily responsible for exacerbating the ***,STING on host CD11c+cells played a dominant role in suppressing allogeneic T-cell ***,STING deficiency resulted in increased survival,activation,and function of APCs,including macrophages and dendritic ***,constitutive activation of STING attenuated the survival,activation,and function of APCs isolated from STING V154M knock-in ***-deficient APCs augmented donor T-cell expansion,chemokine receptor expression,and migration into intestinal tissues,resulting in accelerated/exacerbated *** pharmacologic approaches,we demonstrated that systemic administration of a STING agonist(bis-(3'-5')-cyclic dimeric guanosine monophosphate)to recipient mice before transplantation significantly reduced GVHD *** conclusion,we revealed a novel role of STING in APC activity that dictates T-cell allogeneic responses and validated STING as a potential therapeutic target for controlling GVHD after allo-HCT.

关键词： Stimulator of interferon genes antigen-presenting cells allogeneic hematopoietic cell transplantation graft-versushost diseases hematopoietic stem-cell transplantation T cells