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5%咪喹莫特乳膏治疗浅表性基底细胞癌:欧洲Ⅲ期随机、赋形剂对照研究结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 19-20页

作者： schulze h.- j. Cribier B. Requena L. 李政霄 Fach.linik h.rnh.ide Dorbaumstr. 300 48157 M¨ unster Germany

Background: Imiquimod is an immune response modifier th.t acts th.ough.toll- like receptor 7 to induce cytokine production and a subsequent innate and adaptive cell- mediated immune response. Clinical studies h.ve demonstrated clinical and h.stological clearance of superficial basal cell carcinoma (sBCC) after treatment with.imiquimod 5% cream. Obj.ctives: To evaluate th. safety and clinical efficacy of imiquimod (Aldara.; 3M Ph.rmaceuticals, St Paul, MN, U.S.A.) 5% cream for th. treatment of sBCC in a multicentre, randomized, parallel, veh.cle- controlled, double- blind, ph.se III clinical study conducted at 26 centres in Europe. Meth.ds: Subj.cts wh. h.d at least one h.stologically confirmed sBCC tumour were randomized to apply imiquimod or veh.cle cream to th. target tumour once daily, seven times, per week (7 x/week)for 6 weeks. Th. target tumour location was identified with.an indelible ink mark before treatment initiation. Th. treated tumour site was clinically assessed for treatment response at 12 weeks post- treatment and was th.n excised for h.stological evaluation. Efficacy assessments included th. composite response rates (proportion of subj.cts with.clinical and h.stological clearance) and response rates solely based on h.stology (proportion of subj.cts with.h.stological clearance). Safety assessments, wh.ch.included adverse events and scoring of local skin reactions (LSRs), were carried out th.ough.ut th. study. Results: In total, 166 subj.cts were enrolled in th.s study. For th. intent- to- treat dataset, th.re was a statistically significant difference between imiquimod and veh.cle groups for both.composite clearance rates (clinical and h.stological assessments) and h.stological clearance rates. Composite clearance was demonstrated in 77% and 6% of subj.cts treated with.imiquimod and veh.cle cream, respectively. h.stological clearance was demonstrated in 80% and 6% of subj.cts treated with.imiquimod and veh.cle cream, respectively. Th. most frequently

关键词：咪喹莫特组织学检查赋形免疫应答局部活检清除率用药反应细胞调节细胞因子皮肤反应

Two-flavor h.brid stars with.th. Dyson-Sch.inger quark model

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Ch.nese Ph.sics C 2017年第11期41卷 110-116页

作者：魏金标陈欢 h.-j.schulze Sch.ol of Math.matics and Ph.sics China University of Geosciences INFN Sezione di Catania Dipartimento di FisicaUniversitá di Catania

We study th. properties of two-flavor quark matter in th. Dyson-Sch.inger model and investigate th. possible consequences for h.brid neutron stars,with.particular regard to th. two-solar-mass *** find th.t with.some extreme values of th. model parameters,th. mass fraction of two-flavor quark matter in h.avy neutron stars can be as h.gh.as 30 percent and th. possible energy release during th. conversion from nucleonic neutron stars to h.brid stars can reach.1052 erg.

关键词： h.brid stars quark matter equation of state Dyson-Sch.inger equations

^3PF2 neutron superfluidity in neutron stars and th.ee-body force effect

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Ch.nese Ph.sics B 2008年第9期17卷 3289-3293页

作者：崔常喜左维 h.j.schulze Institute of Modern Ph.sics Chinese Academy of Sciences INFN Sezione di Catania

We investigate th. ^3PF2 neutron superfluidity in h.stable neutron star matter and neutron stars by using th. BCS th.ory and th. Brueckner-h.rtree-Fock approach. We adopt th. Argonne V18 potential supplemented with.a microscopic th.ee-body force as th. realistic nucleon-nucleon interaction. We h.ve concentrated on studying th. th.eebody force effect on th. ^3PF2 neutron pairing gap. It is found th.t th. th.ee-body force effect is to enh.nce remarkably th. ^3PF2 neutron superfluidity in neutron star matter and neutron stars.

关键词： ^3PF2 superfluidity neutron star th.ee-body force Brueckner-h.rtree-Fock approach

Nuclear liquid-gas ph.se transition with.n a Brueckner-h.rtree-Fock approach

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Ch.nese Ph.sics C 2022年第11期46卷 231-237页

作者： j.ng Zh.ng h.ng-Ming Liu Zeng-h.a Li G.F.Burgio h.-j.schulze Institute of Modern Ph.sics Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)Fudan UniversityShanghai 200433China INFN Sezione di Catania Dipartimento di Fisica e AstronomiaUniversitàdi CataniaVia S.Sofia 64I-95123 CataniaItaly

Th. critical parameters of th. liquid-gas ph.se transition of symmetric nuclear matter are computed using th. Brueckner-h.rtree-Fock meth.d at finite temperature by employing different realistic nucleon-nucleon *** effects on single-particle potentials,defect functions,and th.ee-body forces are discussed in *** obtained from th. full procedure and frozen-correlations approximation are *** find critical temperatures of approximately 14 to 19 MeV and critical densities in th. range of 0.05 to 0.08fm^(-3),depending on th. interactions employed.

关键词： nuclear liquid-gas ph.se transition Brueckner-h.rtree-Fock approach symmetric nuclear matter

Effects of Λ h.perons on th. deformations of even–even nuclei

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Ch.nese Ph.sics C 2022年第6期46卷 212-218页

作者： C.F.Ch.n Q.B.Ch.n Xian-Rong Zh.u Y.Y.Ch.ng j.-Wei Cui h.-j.schulze Department of Ph.sics East China Normal UniversityShanghai 200241China Sch.ol of Ph.sics and Optoelectronic Engineering Xidian UniversityXi'an 710071China INFN Sezione di Catania Dipartimento di FisicaUniversitádi CataniaVia Santa Sofia 6495123 CataniaItaly

Th. deformations of multi-Λ h.pernuclei corresponding to even-even core nuclei ranging from^(8)Be to^(40)Ca with.2,4,6,and 8 h.perons are studied using th. deformed Skyrme-h.rtree-Fock *** is found th.t th. deformations are reduced wh.n adding 2 or 8 Λ h.perons,but enh.nced wh.n adding 4 or 6 Λ *** differences are attributed to th. fact th.t Λ h.perons are filled gradually into th. th.ee deformed p orbits,of wh.ch.th. [110] 1/2^(-)orbit is prolately deformed and th. degenerate [101]1/2^(-)and [101]3/2^(-)orbits are oblately deformed.

关键词： deformation even-even nuclei effects of h.peron(s)

Effects of a kaonic meson on th. ground-state properties of nuclei

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Ch.nese Ph.sics C 2022年第6期46卷 183-191页

作者： j.ng Guo D.h.Ch.n Xian-Rong Zh.u Q.B.Ch.n h.j.schulze Department of Ph.sics East China Normal UniversityShanghai 200241China INFN Sezione di Catania Dipartirnento di FisicaUniversita di CataniaVia Santa Sofia 6495123 CataniaItaly

Th. effects of an additional K-meson on th. ground-state properties of nuclei are investigated with.n an axially-deformed Skyrme-h.rtree-Fock approach.combined with.a Skyrme-type kaon-nucleon *** K-meson increases th. binding energies of all nuclei,wh.reas it affects deformations only for ligh. nuclei with.ut sh.ll *** nucleon drip lines are modified due to th. strongly attractive K-N *** is attributed to th. beh.vior of th. h.gh.st-occupied nucleon single-particle levels near th. drip lines,wh.ch.is analyzed in detail.

关键词： kaonic nuclei drip line Skyrme-h.rtree-Fock approach

Measurement and analysis tech.ologies for magnetic pulse welding： establish.d meth.ds and new strategies

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Advances in Manufacturing 2016年第4期4卷 322-339页

作者： j. Bellmann j. Lueg-Alth.ff S. schulze S. Gies E. Beyer A. E. Tekkaya Institute of Manufacturing Science and Engineering TUDresden 01062 Dresden Germany Fraunh.fer Institute for Material and Beam Tech.ology Winterbergstrasse 28 01277 Dresden Germany Institute of Forming Tech.ology and Ligh.weigh.Construction TU Dortmund Baroper Strasse 30344227 Dortmund Germany

Magnetic pulse welding （MPW） is a fast and clean j.ining tech.ique th.t offers th. possibility to weld dissimilar metals, e.g., aluminum and steel. Th. h.gh.speed collision of th. j.ining partners is used to generate strong atomic bonded areas. Critical brittle intermetallic ph.ses can be avoided due to th. absence of external h.at. Th.se features attract th. notice of industries performing large scale productions of dissimilar metal j.ints, like automo- tive and plant engineering. Th. most important issue is to guarantee a proper weld quality. Numerical simulations are often used to predict th. welding result a priori. Neverth.less, experiments and th. measurement of process parameters are needed for th. validation of th.se data. Sensors nearby th. j.ining zone are exposed to h.gh.pressures and intense magnetic fields wh.ch.h.nder th. evaluation of th. electrical output signals. In th.s paper, existing analysis tools for process development and quality assurance in MPW are reviewed. New meth.ds for th. process monitoring and weld ch.racterization during and after MPW are introduced, wh.ch.h.lp to overcome th. mentioned drawbacks of establish.d tech.ologies. Th.se meth.ds are based on optical and mech.nical measuring tech.ologies taking advantage of th. h.pervelocity impact flash. th. impact pressure and th. deformation necessary for th. weld formation.

关键词： Magnetic pulse welding (MPW) Processmonitoring Collision conditions Dissimilar metalj.ining Materials testing

Targeting cell death.signaling in colorectal cancer:Current strategies and future perspectives

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World j.urnal of Gastroenterology 2014年第8期20卷 1923-1934页

作者： Bruno Ch.istian Koeh.er Dirk j.ger h.nning schulze-Bergkamen National Center for Tumor Diseases University Hospitals Heidelberg69120 HeidelbergGermany

Th. evasion from controlled cell death.induction h.s been considered as one of th. h.llmarks of cancer cells. Defects in cell death.signaling are a fundamental ph.nomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. h.wever, apoptosis resistance is th. maj.r cause for insufficient th.rapeutic success and disease relapse in gastrointestinal oncology. Various compounds h.ve been developed and evaluated with.th. aim to meet with.th.s obstacle by triggering cell death.in cancer cells. Th. aim of th.s review is to illustrate current approach.s and future directions in targeting cell death.signaling in colorectal cancer. Th. complex signaling network of apoptosis will be demonstrated and th. “druggability” of targets will be identified. In detail, proteins regulating mitoch.ndrial cell death.in colorectal cancer, such.as Bcl-2 and survivin, will be discussed with.respect to potential th.rapeutic exploitation. Death.receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death.based targeted th.rapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death.in cancer is rapidly emerging and new types of controlled cellular death.h.ve been identified. To meet th.s progress in cell death.research. th. implication of autoph.gy and necroptosis for colorectal carcinogenesis and th.rapeutic approach.s will also be depicted. Th. main focus of th.s topic h.gh.igh. will be on th. revelation of th. complex cell death.concepts in colorectal cancer and th. bridging from basic research.to clinical use.

关键词： Colorectal cancer Apoptosis Necroptosis Autoph.gy Clinical trial Bcl-2 proteins Bh.3 mimetics Inflammatory bowel disease

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility

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Particuology 2010年第3期8卷 279-285页

作者： Ratna Tantra Ph.lipp schulze Paul Quincey National Ph.sical Laboratory Hampton Road Teddington Middlesex TW11 0LW UK Department of Ph.sics University of Bath Bath BA2 7AY UK. National Ph.sical Laboratory Hampton Road Teddington Middlesex TW11 0LW

Th. effect of nanoparticle concentration on zeta-potential measurement results at dilute concentrations was evaluated. Th. values of th. zeta-potential for four different types of nanoparticles, Ludox （silica）, multi-walled carbon nanotubes （bamboo-sh.ped and h.llow nanotubes） and gold, at various concentrations, were obtained using a laser Doppler electroph.resis instrument. Th. size of th. nanoparticles on dilution was measured using dynamic ligh. scattering （DLS）. Th. results sh.w th.t th.re is a concentration range with.n wh.ch.th. zeta-potential, and particle size, are not affected by nanoparticle concentration. Th. lower concentration limit for th. system to produce consistent results was dependent on th. nature of th. sample under study and ranged between 10-2 and 10-4 wt%. Below th.s concentration, th.re was an apparent sh.ft in zeta-potential values to less negative values, wh.ch.was accompanied by an increase in th. particle size. Th. sh.ft in zeta-potential was attributed to an increase in contribution of th. signal from extraneous particulate matter. Th. increase in particle size was attributed to th. nature of th. h.modyne optical configuration of th. instrument. Th. aim of th.s study was to elucidate th. range in nanoparticle concentration th.t allows for accurate and reliable measurement of th. zeta-potential and DLS data.

关键词： Nanoparticles Zeta-potential Dynamic ligh. scattering Reproducibility