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Long-Term Animal Feeding Trial of the Refined Konjac Meal Ⅰ. Effects of the Refined Konjac Meal on the Calcium and Phosphorus Metabolism and the Bone in Rat

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Biomedical and Environmental sciences 1995年第1期8卷 74-79页

作者： ZHANG MAO-YU PENG SHU-SHENG ZHANG YIN-ZHU AND WU ZI-HUA(school of public health, west china university of medical sciences,Chengdu 610041, china) school of public health West China University of Medical Sciences Chengdu.

Effects of refined konjac meal (RKM) on the calcium and phosphorus metabolism and bone parameters were observed in rats of both sexes fed with food containing 1% of RKM for 18 months. A comparable group of rats fed on basic diet only was used as a *** obtained indicate that all the measured parameters (serum calcium and phosphorus level, femur weight and its calcium and phesphorus content, and the osteometry of the tibia) showed no significant difference between the experimental and the control *** there is no adverse effect either on the calcium and phosphorus metabolism or on the bone after a long-term intake at a moderate dosage.

关键词： Jun Effects of the Refined Konjac Meal on the Calcium and Phosphorus Metabolism and the Bone in Rat Long-Term Animal Feeding Trial of the Refined Konjac Meal

Long-Term Animal Feeding Trial of the Refined Konjac Meal Ⅱ. Effects of the Refined Konjac Meal on the Aging of the Brain, Liver, and Cardiovascular Tissue Cells in Rats

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Biomedical and Environmental sciences 1995年第1期8卷 80-87页

作者： PENG SHU-SHENG ZHANG MAO-YU ZHANG YIN-ZU AND WU ZI-HUA(school of public health, west china university of medical sciences,Chengdu 610041, china) school of public health West China University of Medical Sciences Chengdu.

Rats of both sexes were fed on a basal feed containing 1% refined konjac meal (RKM) for 18 months and the effects of RKM on the cell aging were observed. A comparable group fed on the basic feed was used as the control. Results obtained demonstrate that the long-term feeding of RKM to rats can delay the course of cell aging of the gliocyte, cadiomyocyte, and the endothelial cell of the large and medium arteriases, hence it is likely to delay the occurrence of arteriosclerosis and improve the functions of the brain, heart and vascular system.

关键词： and Cardiovascular Tissue Cells in Rats Liver Effects of the Refined Konjac Meal on the Aging of the Brain Long-Term Animal Feeding Trial of the Refined Konjac Meal

An Investigation of Crocidolite Contamination and Mesothelioma in a Rural Area of china^1

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Biomedical and Environmental sciences 1990年第2期3卷 156-165页

作者： LIU XUEZE, LUO SUQIONG, WANG ZHIMING, WANG MIANZHEN, AND ZHAN CHENGLIE Department of Occupational health, school of public health, west china university of medical sciences, Chengdu. Sichuan. china Department of Occupational health School of Public Health West China University of Medical Sciences Chengdu Sichuan.

Crocidolite was found to be ubiquitous in a county in southwestern china. It had been widely used in the making of road pavement, stoves, wall paint, etc. The environmental levels of the asbestos fibers were determined. Of the 2175 local residents examined. 16 had asbestosis and 232 had pleural plaques. These clinical manifestations were noted mainly in patients over 50 years of age. (c)1990 Academic Press. Inc.

关键词： An Investigation of Crocidolite Contamination and Mesothelioma in a Rural Area of china~1

Influences of Refined Konjac Meal on the Levels of Tissue Lipids and the Absorption of Four Minerals in Rats

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Biomedical and Environmental sciences 1990年第3期3卷 306-314页

作者： HOU YUN-HUA, ZHANG LI-SHI, ZHOU HONG-MING, WANG RUI-SHU, AND ZHANG YIN-ZHU school of public health, west china university of medical sciences, Chengdu,china school of public health West China University of Medical Sciences Chengdu.

This paper reports a study on the hypocholesterolemic effect of the refined konjac meal (RKM) containing about 80% glucomannan prepared from the tubers of Amorphophallus konjac *** and female Sprague-Dawley rats, 5 weeks old, were divided into five groups and fed a normal basal diet, a hypercholesterolemic diet (control diet), and three test diets (RKM added to the control diet at levels of 2.5.5, and 10%, respectively) for 12 *** results obtained indicate that RKM could markedly lower the cholesterol levels in the serum and the liver of rats eating hypercholesterolemic *** the end of the 4th week of the feeding experiment, the serum cholesterol levels in the 5 and the 10% RKM groups and the liver cholesterol level in the 10% RKM group were significantly lower than those in the control *** the end of the 12th week, the serum cholesterol levels of all the three RKM groups were lowered to a normal level as was the liver cholesterol level of the 10% RKM *** lipolropic effect of RKM was also confirmed by histopathologic examination of the *** addition to the hypocholesterolemic effects, RKM diets also increased stool *** effects on the absorption and utilization of Ca, Fe, Zn, and Cu were found. 1990 Academic ***.

关键词： RK Four

Carotenoid Analysis of Several Dark-Green Leafy Vegetables Associated With a Lower Risk of Cancers

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Biomedical and Environmental sciences 1996年第4期9卷 386-392页

作者： YANG YI HUANG CHENG-YU PENG SHU-SHENG AND LI JIAN (Department of Clinical Oncology, medical Institute of Biorngulation,Kyushu university 69, Beppu 874, Japan school of public health, west china university of medical sciences (WCUMS),Chengdu, china) Department of Clinical Oncology Kyushu University Beppu Japan.

We have examined the carotenoid contents of several dark green vegetables found to be associated with a lower risk of various epithelial cancers in our epidemiological study and animal study. Samples of these vegetables were quantitatively examined by highperformance liquid chromatography (HPLC) on a C-18 reversed-phase column for individual carotenoid content. Pure reference compounds (alpha-carotene, beta-carotent, lycopene, canthaxanthin, and lutein) and internal standard (beta-Apo-8'-carotenal) were employed to quantify xanthophylls and carotenes in these vegetables. The results indicated that fresh, dark-green, leafy vegetables were high in beta-carotene (0.94-9.36 mg/100 g) and oxygenated carotenoids or xanthophylls, primarily lutein (0.94-7.39 mg/100 g),whereas lycopene and alpha-carotene were not prominent and canthaxanthin was non existent in these vegetables. These analyses suggest that consumption of carotenoids such as lutein in addition to beta-carotene may be associated with a lower risk of cancers

关键词： Res Am Carotenoid Analysis of Several Dark-Green Leafy Vegetables Associated With a Lower Risk of Cancers

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学龄前儿童灵敏素质检测指标的初步探讨

四川体育科学 1998年第1期17卷 61-62页

作者：沈丽琴魏嗣琼张建新龚雪桦杨晓英曾勇唐风莲华西医科大学公共卫生学院少儿卫生教研室万县市鸡公岭幼儿园

为研究学龄前幼儿体质测定指标体系，本文以３～６岁７１６名健康幼儿为对象，进行了１０ｍ×２和１０ｍ×４交换木块折返跑灵敏素质测定。结果表明，小班（３～４岁）１０ｍ×２。

关键词：学前儿童灵敏素质体质指标

传染病多点触发智慧化监测预警系统关键技术专家共识

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中华医学杂志 2024年第32期104卷 2995-3009页

作者：中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算... 详细信息

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算机科学等多学科专家的研究成果与实践经验, 经过反复多轮专家研讨, 形成了传染病多点触发智慧化监测预警系统关键技术专家共识。本共识内容主要包括传染病多点触发智慧化监测预警系统的相关概念和定义, 关键技术框架, 多渠道监测预警数据来源、获取与治理, 预警方法分类, 多点触发智慧化监测预警关键流程及路径, 多点触发预警及综合研判, 预警信号响应以及预警效果评价等方面, 以期为传染病多点触发智慧化监测预警系统建设及应用提供技术参考。

关键词：传染病监测预警多点触发智慧化

The Synthesis of an Optically Active Intermediate of A-Ring for 1α,25-Dihydroxy Vitamin D_3 Analogs

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Chinese Chemical Letters 1998年第5期9卷 431-432页

作者： Yong WU and (school of Pharmacy, west china university of medical sciences, Chengdu 610041)Mei GUAN (The First Hospital, west china university of medical sciences, Chengdu 610041) W china Univ Med Sci Sch Pharm Chengdu 610041 Peoples R China W china Univ Med Sci Hosp 1 Chengdu 610041 Peoples R China

Synthesis of an optically active intermediate 4b for the A-ring of 1a,25-dihydroxyvitamin D3 analogs has been achieved in eight steps, starting from readily available, inexpensive D-(+)-xylose.

关键词： 1α 25-dihydroxyvitamin D_3 D(+)-xylose synthesis

Apoptosis Induced by Zinc Deficiency in Rat Osteoblast:Possible Involvement of Protein Kinase C

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Biomedical and Environmental sciences 1999年第3期12卷 101-109页

作者： CEN XIAO-BO WANG RUI-SHU AND WANG HANG(medical Experimeatel Center, the First Hospital of west china university of medical sciences (WCUMS), Chengdu 610041, china Derpartment of public of health (WCUMS) Department of Stomatology (WCUMS)) medical Experimental Center First Hospital of West China University of Medical Sciences Chengdu China

Ra ostcobasts were isolated from the 21-day fetal rat calvchas. The cells were grown in DMEM Plus 10% FBS, and were treated for 24 h. with 10 μmol/L TPEN or 10 μmol/L TPEN supplemented with 10 μmol/L Zn2+. Apoptosis of osteoblasts were measured by fiow cytometry, electron microscopy and DNA fragmentation analyzed by gel elecmphoresis. In addition, IP3 production and PKC activity were measmed in ordr to show whether they are involved in apoptosis in osteoblast induced by alnc deficiency. The results showed that 10 μmol/L TPEN could induce apoptosis in osteoblast in 24 h. But cells ed with 10μmol/L TPEN supplemented with 10 μmol/L Zn2+ showed no apoptotic changs in 24 h. TPEN significantly reduced the formation of IP3 and PKC activity after 24 h incubation. No differences were observed between the cells treated with TPEN supPlemented with Zn2+ simulaneosly and the untreated cells. It can be inferred that apoptosis induced by ainc deficiency may be due to the decreased activity of PKC which is impaired by reduced formation of IP3.

关键词： Apoptosis Induced by Zinc Deficiency in Rat Osteoblast Cell cell