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Phylogeny of Culex theileri virus flavivirus in Spain, Myanmar, Portugal and Turkey

Asian Pacific Journal of Tropical medicine 2019年第5期12卷 216-223页

作者： Eleonora Cella Domenico Benvenuto Daniele Donati Francesco Garilli Silvia Angeletti Stefano Pascarella Massimo Ciccozzi Unit of Medical Statistics and Molecular Epidemiology,university Campus Bio-Medico of Rome school of nursing,faculty of medicine,department of biomedicine and prevention,tor vergata university faculty of medicine,university Campus Bio-Medico of Rome Unit of Clinical Laboratory Science,university Campus Bio-Medico of Rome department of Biochemical Sciences'A.Rossi Fanelli',university of Rome'La Sapienza' Unit of Medical Statistics and Molecular Epidemiology University Campus Bio-Medico of Rome school of nursing Faculty of Medicine Department of Biomedicine and Prevention Tor Vergata University faculty of medicine University Campus Bio-Medico of Rome Unit of Clinical Laboratory Science University Campus Bio-Medico of Rome department of Biochemical Sciences"A.Rossi Fanelli" University of Rome "La Sapienza"

Objective: To study the genetic diversity of Culex theileri flavivirus and the spread of this virus among Spain, Portugal and ***: A database consisting of 55 sequences of the NS5/3'UTR region of Culex theileri flavivirus group downloaded from GenBank were aligned and manual edited with *** est v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset was investigated by the likelihood mapping ***: The phylogenetic tree showed three *** sequences clusterd together with Turkish sequences, Spain and Portugal strains grouped together and two Turkish sequences grouped *** pressure analysis showed a moderate percentage of sites(22.5%) under pervasive negative selection and only 1% under pervasive positive *** sites subject to selective pressure in CTFV RdRp NS5 fragments have been located onto the predicted three-dimensional ***: Phylogenetic and evolutionary analysis can be an important tool for understanding the evolutionary impact of the probable contemporary existence between nonpathogenic and pathogenic flaviviruses among these vectors.

关键词： Culex virus Flaviviridae Phylogenetic analysis Evolution

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