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Extending the Relational Model to Deal withProbabilistic Data

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journal of Computer Science & Technology 2000年第3期15卷 230-240页

作者：马宗民 ZHANG w.j MA w.Y CityUniversityofHongKong KowloonHongKongP.R.China

According to the soundness and completeness of information in databases, the expressive form and the semantics of incomplete information are discussed in this paper. On the basis of the discussion, the current studies on incomplete data in relational databases are reviewed. In order to represent stochastic uncertainty in most general sense in the real world, probabilistic data are introduced into relational databases. An extended relational data model is presented to express and manipulate probabilistic data and the operations in relational algebra based on the extended model are defined in this paper.

关键词： incomplete information uncertain information extended relational model probabilistic data relational algebra

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Towards high-performance,efficient and sustainable material processing technologies for aerospace applications

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Chinese journal of Aeronautics 2025年第1期38卷 1-2页

作者： jun MA M.w.FU Stefania BRUSCHI Heng LI State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyTrondheim 7491Norway Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Industrial Engineering University of PadovaPadova 35131Italy

The aerospace and aviation industry has long been at the forefront of materials and processing technologies,driven by its ongoing demand for lightweight,highly reliable,and durable *** manufacturing is a critical discipline that directly affects the performance,functionality,and safety of aircraft and aerospace *** meet the above-mentioned stringent requirements,advanced materials and cutting-edge processing technologies have evolved alongside aerospace innovations.

关键词： performance aviation mentioned

Two-plasmon-decay instability stimulated by dual laser beams in inertial confinement fusion

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Matter and Radiation at Extremes 2025年第1期10卷 48-56页

作者： C.-w.Lian Y.ji R.Yan j.Li L.-F.wang Y.-K.Ding j.Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefeiAnhui 230026China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Two-plasmon-decay instability(TPD)poses a critical target preheating risk in direct-drive inertial confinement *** this paper,TPD collectively driven by dual laser beams consisting of a normal-incidence laser beam(Beam-N)and a large-angle-incidence laser beam(Beam-L)is investigated via particle-in-cell *** is found that significant TPD growth can develop in this regime at previously unexpected low laser intensities if the intensity of Beam-L exceeds the large-angle-incidence *** beams contribute to the growth of TPD in a“seed-amplification”manner in which the absolute instability driven by Beam-L provides the seeds that are convectively amplified by Beam-N,making TPD energetically important and causing significant pump depletion and hot-electron generation.

关键词： laser pump decay

Searching Radio Signals from Two Magnetars and a High-magnetic Field Pulsar and the Serendipitous Discovery of a New Radio Pulsar PSR j1935+2200

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Research in Astronomy and Astrophysics 2025年第1期25卷 110-115页

作者： Lang Xie j.L.Han Z.L.Yang w.C.jing D.j.Zhou w.Q.Su Yi Yan Tao wang Nan-Nan Cai P.F.wang Chen wang National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences National Key Laboratory for Radio Astronomy Chinese Academy of Sciences

Magnetars are slowly rotating, highly magnetized young neutron stars that can show transient radio phenomena for radio pulses and fast radio bursts. we conducted radio observations from two magnetars SGR j1935+2154 and3XMM j185246.6+003317 and a high-magnetic field pulsar PSR j1846–0258 using the Five-hundred-meter Aperture Spherical radio Telescope（FAST）. we performed single pulse and periodicity searches and did not detect radio signals from them. From the piggyback data recorded by other FAST telescope beams when we observed the magnetar SGR 1935+2154, we serendipitously discovered a new radio pulsar, PSR j1935+2200. we carried out the follow-up observations and obtained the timing solution based on these new observations and the archive FAST data. PSR j1935+2200 is an isolated old pulsar, with a spin period of 0.91 s, a spin-period derivative of9.19 × 10-15s s-1, and a characteristic age of 1.57 Myr. It is a weak pulsar with a flux density of 9.8 μjy at1.25 GHz. Discovery of a new pulsar from the long FAST observations of 30 minutes implies that there may be more weak older pulsars in the Galactic disk to be discovered.

关键词： (stars:) pulsars: individual (PSR j1935+2200) stars: neutron

Deep view of composite SNR CTA1 with LHAASO in γ-rays up to 300 TeV

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.w.Bao D.Bastieri X.j.Bi Y.j.Bi w.Bian A.V.Bukevich Q.Cao w.Y.Cao Zhe Cao j.Chang j.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.C.Chu M.Y.Cui S.w.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.H.Fan Y.Z.Fan j.Fang j.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao w.Gao w.K.Gao M.M.Ge T.T.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo j.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He j.Y.He Y.He Y.K.Hor B.w.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu C.Huang D.H.Huang T.Q.Huang w.j.Huang X.T.Huang X.Y.Huang Y.Huang Y.Y.Huang X.L.ji H.Y.jia K.jia H.B.jiang K.jiang X.w.jiang Z.j.jiang M.jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li jian Li jie Li K.Li S.D.Li w.L.Li w.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.w.Liang Y.F.Liang S.j.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu j.Liu j.L.Liu M.Y.Liu R.Y.Liu S.M.Liu w.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma j.R.Mao Z.Min w.Mitthumsiri H.j.Mu Y.C.Nan A.Neronov K.C.Y.Ng L.j.Ou P.Pattarakijwanich Z.Y.Pei j.C.Qi M.Y.Qi B.Q.Qiao j.j.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.w.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun j.Takata P.H.T.Tam Q.w.Tang R.Tang Z.B.Tang w.w.Tian L.H.wan C.wang C.B.wang G.w.wang H.G.wang H.H.wang j.C.wang Kai wang Kai wang L.P.wang L.Y.wang P.H.wang R.wang w.wang X.G.wang X.Y.wang Y.wang Y.D.wang Y.j.wang Z.H.wang Z.X.wang Zhen wang Zheng wang D.M.wei j.j.wei Y.j.wei T.wen C.Y.wu H.R.wu Q.w.wu S.wu X.F.wu Y.S.wu S.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu w.L.Xu L.Xue D.H.Yan j.Z.Yan T.Yan C.w.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang R.Z.Yang w.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H Southwest jiaotong University School of Astronomy and Space Science Nanjing University Center for Astrophysics Guangzhou University Tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai jiao Tong University Institute for Nuclear Research of Russian Academy of Sciences Hebei Normal University University of Science and Technology of China LHAASO Collaboration State Key Laboratory of Particle Detection and Electronics Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Research Center for Astronomical Computing Zhejiang Laboratory Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Yunnan University Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Department of Physics The Chinese University of Hong Kong Key Laboratory of Radio Astronomy and Technology National Astronomical Observatories Chinese Academy of Sciences School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Institute of High Energy Physics Institute of Frontier and Interdisciplinary Science Shandong University APC Université Paris Cité CNRS/IN2P3 CEA/IRFU Observatoire de Paris Department of Engineering Physics & Department of Astronomy Tsinghua University School of Physics and Microelectronics Chinese Academy of Sciences Zhengzhou University Yunnan Observatories Chinese Academy of Sciences China Center of Advanced Science and Technology College of Physics Sichuan University School of Physics Peking University Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and Technology University of Chinese Academy of Sciences Guangxi University Department of Physics Faculty of Science Mahidol University Moscow Institute

The ultra-high-energy（UHE） gamma-ray source 1LHAASO j0007+7303u is positionally associated with the composite SNR CTA1 that is located at high Galactic Latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PwN） and supernova remnant（SNR） at UHE. This paper conducted a dedicated data analysis of 1LHAASO j0007+7303u using the data collected from December 2019 to july 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the PwN of PSR j0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PwN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PwN is likely dominated by the advection process under the free-expansion phase assumption.

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LHAASO detection of very-high-energy γ-ray emission surrounding PSR j0248+6021

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Science China(Physics,Mechanics & Astronomy) 2025年

we report the detection of an extended very-high-energy(VHE) γ-ray source coincident with the location of middle-aged(62.4 kyr) pulsar PSR j0248+6021, by using the LHAASO-wCDA data of live 796 d and LHAASO-KM2A data of live 1216d. A significant excess of γ-ray induced showers is observed both by wCDA in energy bands of 1-25 Te V and KM2A in energy bands of >25 TeV with 7.3σ and 13.5σ, respectively. The best-fit position derived through wCDA data is R.A. = 42.06°± 0.12°and Dec. = 60.24°± 0.13°with an extension of 0.69°±0.15°and that of the KM2A data is R.A.= 42.29°± 0.13°and Dec. =60.38°± 0.07°with an extension of 0.37°±0.07°. No clear extended multiwavelength counterpart of this LHAASO source has been found from the radio band to the GeV band. The most plausible explanation of the VHE γ-ray emission is the inverse Compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo.

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Observation of the γ-ray emission from w43 with LHAASO

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Science China(Physics,Mechanics & Astronomy) 2025年

In this paper, we report the detection of the very-high-energy (VHE, 100 Ge V100 TeV) γ-ray emissions from the direction of the young star-forming region w43, observed by the Large High Altitude Air Shower Observation (LHAASO). The extended γ-ray source was detected with a significance of～16σby KM2A and～17σby wCDA, respectively. The angular extension of this γ-ray source is about 0.5 degrees, corresponding to a physical size of about 50pc. we discuss the origin of the γ-ray emission and possible cosmic ray acceleration in the w43 region using multi-wavelength data. Our findings suggest that w43 is likely another young star cluster capable of accelerating cosmic rays (CRs) to at least several hundred TeV.

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