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Clinical profile of patients with advanced age and inflammatoric dilated cardiomyopathy on endomyocardial biopsy

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Journal of Geriatric Cardiology 2015年第6期12卷 605-612页

作者： Marc-Alexander Ohlow Ting-Hui Chen andreas schmidt Joerg Saenger Bemward Lauer Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany

Background Endomyocardial biopsy （EMB） is an important tool when patients with inflammatoric cardiomyopathy （DCMi） are evaluated. We aimed to assess the clinical profile of elderly patients with DCMi on EMB. Methods Retrospective study of all consecutive patients hospitalized from January 2007 to December 2011 with clinical suspicion of DCMi undergoing EMB. Patients with evidence of DCMi on EMB （Group 1 〉 70 years, n = 85; Group 3 〈 70 years; n = 418） were compared to patients of the same age group without evi- dence of DCMi on EMB （Group 2 〉 70 years, n = 45; Group 4 〈 70 years; n = 147）. Results Among 24,275 patients treated at our institu- tion during the study period, 695 had clinical suspicion of DCMi and underwent EMB; 503 （2.1%） patients had DCMi on EMB. There were more male patients in Group 1, mean age was 74 ~ 2.8 years, mean ejection fraction was 38% q- 14%. On presentation, signs of hemody- namic compromise （NYHA functional class IIUIV, low cardiac output/index, and low cardiac power index） were more frequent in Group 1. EMB revealed viral genome in 78% of the patients, parvovirus B 19 （PVB） was frequently encountered in both age groups （Group 1： 69.4% vs. Group 2： 59.6%）; detection of more than one viral genome was more frequent in Group 1 （21.2% vs. 11.2%; P = 0.02） whereas the extent of immune response was significantly lower in individuals with advanced age. Conclusions In patients 〉 70 years with DCMi on EMB signs of hemodynamic compromise, detection of multiple viral genomes together with an overall lower extent of immune response were more frequently observed.

关键词： Advanced age Clinical profile Dilated cardiomyopathy Endomyocardial biopsy Inflammation factors

Predictors of long-term outcome in patients with biopsy proven inflammatory cardiomyopathy

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Journal of Geriatric Cardiology 2018年第5期15卷 363-371页

作者： Ohlow Marc-Alexander Michel Christoph Ting-Hui Chen schmidt andreas Saenger Joerg Lauer Bernward Brunelli Michele Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany Department of Cardiology Staedtisehes Klinikum Magdeburg Germany

Background The objective of this study was to identify prognostic indicators in patients with inflammatory cardiomyopathy （iCM） on endomyocardial biopsy （EMB）. Methods and results Between 2007 and 2011 all consecutive patients with diagnosed with iCM at EMB were retrospectively analyzed. The combined primary endpoint （EP）（1E°P） was cardiac death, aborted sudden cardiac death/appropriate implantable cardioverter defibrillator （ICD） shock, progressive heart failure requiring left venWicular assist device （LVAD） implantation and heart transplantation. 503 patients （mean age 58 ° 12 years, 73% male） were available for analysis. Genomes of cardiotrophic viruses were detected in 396 patients （79%） and immuno-histochemical signs of inflammation were present in 223 individuals （44%）. After 3.6 ° 2.4 years of follow-up, cardiac mortality was 3.0% （n = 14） and a total of 8.6% （n = 40） reached the primary endpoint. Independent predictors for the 1 °EP were： age 〉 50 years, presence and duration （〈 28 days） of symptomatic heart failure. A risk stratification approach based on the results of the multivariate analysis demonstrated that absence of signs and/or symptoms of congestive heart failure in younger （〈 50 years） patients with longer （〉 28 days） duration of disease appear to have an excellent prognosis with 100% survival and no events during follow-up The presence of all above mentioned independent risk factors results in an 1°EP occurrence of 35.9%. Conclusions Symptoms of heart fail- ure, short duration of disease, and older age are indicators of poor outcome in patients with iCM.

关键词： Endomyocardial biopsy Inflammatory cardiomyopathy Outcome

通用的无线通信网络--利用WirelessHart实现无线通信网络的自我组织和自我修复

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流程工业 2010年第22期 26-27页

作者： Davis Mathews Garrett schmidt andreas Senger Phoenix Contact公司

目前还没有一种无线通信技术标准能够满足所有使用要求，同时，各种不同的无线通信技术在通信距离和与相关仪器设备的兼容性方面也有着很大的差异。若要做到“万能、通用”，则需要求多个不同的无线通信系统平行工作。基于这点，Wireles... 详细信息

目前还没有一种无线通信技术标准能够满足所有使用要求，同时，各种不同的无线通信技术在通信距离和与相关仪器设备的兼容性方面也有着很大的差异。若要做到“万能、通用”，则需要求多个不同的无线通信系统平行工作。基于这点，WirelessHart无线通信网络在流程工业领域中稳固地占据了一席之地。

关键词：无线通信网络自我修复通用无线通信技术组织利用无线通信系统仪器设备

黑格尔哲学中的费希特元素——A.施密特教授访谈

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伦理学术 2021年第2期 188-196页

作者： [德]A.施密特朱渝阳(整理) 不详

朱渝阳(以下简称“朱”):施密特教授您好!为纪念黑格尔诞辰250周年,我非常高兴能够采访您。您现在是德国耶拿大学德国观念论的教席教授。因此,对于您而言,德国观念论这一传统领域应具有特别的意义和重要性。您是通过费希特哲学而进入这... 详细信息

朱渝阳(以下简称“朱”):施密特教授您好!为纪念黑格尔诞辰250周年,我非常高兴能够采访您。您现在是德国耶拿大学德国观念论的教席教授。因此,对于您而言,德国观念论这一传统领域应具有特别的意义和重要性。您是通过费希特哲学而进入这一古老的研究领域。您时常感慨,费希特哲学今非昔比。当年您在慕尼黑读大学的时候,费希特哲学曾是众多大学生和年轻学者们竞相追捧的对象。慕尼黑大学的费希特课程远近闻名,常常是座无虚席。更值得一提的是,对课程参与者的要求甚高。学生不仅要提前选课占座,而且还要参加“道德测试”,以检查学生是否达到了学习费希特哲学的“道德要求”。作为经历者,您能为我们详细说一下当年这个“道德测试”是如何进行的?您是否通过了那次测试呢?

关键词：德国观念论黑格尔哲学费希特哲学慕尼黑大学大学生耶拿大学施密特教授访谈

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一座传授木材技术的木建筑

世界建筑 2018年第7期 116-119页

作者： Marcel Meili Markus Peter Zeno Vogel Thomas Kühne Marc Loeliger andreas schmidt Thomas Schnabel Urs Schnenberger Othmar Villiger Meili Peter Architekten

在瑞士的汝拉山脚下,有一座人口约5万的小城市——比尔（Biel/Bienne）,自19世纪起就一直拥有繁荣的工业和手表制造业。与这座城市的工业氛围相得益彰的,是充满实用精神的应用科学教育。所属于伯尔尼应用科学大学（Bern University of A... 详细信息

在瑞士的汝拉山脚下,有一座人口约5万的小城市——比尔（Biel/Bienne）,自19世纪起就一直拥有繁荣的工业和手表制造业。与这座城市的工业氛围相得益彰的,是充满实用精神的应用科学教育。所属于伯尔尼应用科学大学（Bern University of Applied Sciences）的比尔高等木材技术学校（Higher Technical School of Wood Biel,HTS）即坐落于这里。

关键词：技术学校木材木建筑应用科学科学教育小城市制造业工业

Degradation of the fungicide metalaxyl and its non-extractable residue formation in soil clay and silt fractions

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Pedosphere 2021年第4期31卷 549-559页

作者： Roschni KALATHOOR Jens BOTTERWECK andreas SCHÄFFER Burkhard schmidt Jan SCHWARZBAUER Institute of Geology and Geochemistry of Petroleum and Coal RWTH Aachen UniversityAachen 52062(Germany) Institute for Environmental Research RWTH Aachen UniversityAachen 52062(Germany) School of the Environment Nanjing UniversityNanjing 210023(China)

The proportion of organic matter and mineral composition are important factors determining the formation and type of non-extractable residues(NERs) of pesticides in soil. In this study, we investigated the enantioselectivity in degradation and NER formation of the chiral fungicide metalaxyl in soil particle size fractions(silt and clay). Microbial and extracellular enzyme activities during these processes were monitored in incubation of silt and clay samples isolated from sterilized and non-sterilized soil samples collected from a long-term agricultural field experimental site in Ultuna, Sweden. The temporal influence on the fate of the fungicide was noted by short-term(10-d) and long-term(92-d) incubations. Besides the acquisition of quantitative data with gas chromatography-mass spectrometry(GC/MS), stereoselective analyses were performed with chiral GC/MS. Quantitative results pointed to a higher metabolism rate of the pesticide through microbial activity than through extracellular enzyme activity. This was also confirmed by the enantioselective depletion of R-metalaxyl and the subsequent formation of R-metalaxyl acid in microbially active samples from non-sterilized soil. The silt fraction containing a high amount of organic matter exhibited a significant hydrolyzable proportion of metalaxyl NERs that was releasable under alkaline conditions. On the contrary, the clay fraction showed an enhanced affinity for covalently bound residues. Based on our results, we recommend differentiating between reversibly and irreversibly bound proportions of pesticides in persistence and environmental risk assessment because the reversible fraction contained potentially bioavailable amounts of residues that may be released under natural conditions.

关键词： chiral fungicide enantioselectivity metalaxyl enantiomer non-extractable pesticide residues organo-mineral complex pesticide degradation extracellular enzymes soil particle size fractions

Charcoal kiln sites, associated landscape attributes and historic forest conditions:DTM-based investigations in Hesse(Germany)

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Forest Ecosystems 2016年第3期3卷 174-189页

作者： Marcus schmidt andreas M?lder Egbert Sch?nfelder Falko Engel Werner Fortmann-Valtink Northwest German Forest Research Institute Department A (Forest Growth) Kellerwald-Edersee National Park

Background： An examination of the distribution of ancient charcoal kiln sites in the forest landscape seems to be worthwhile, since general trends in the selection of suitable kiln site locations in the past might become obvious. In this way forest landscape elements with a more intense usage by charcoal burning can be identified. By doing this, we can expect to gain information on the former condition and tree species composition of woodland. Investigations on the spatial distribution of charcoal kiln sites in relation to landscape attributes are sparse, however, probably due to the high on-site mapping effort. The outstanding suitability of LiDAR-derived digital terrain models （DTMs） for the detection of charcoal kiln sites has been recently proved. Hence, DTM-based surveys of charcoal kiln sites represent a promising attempt to fill this research gap. Methods： Based on DTM-based surveys, we analyzed the spatial distribution of charcoal kiln sites in two forest landscapes in the German federal state of Hesse： Reinhardswald and Kellerwald-Edersee National Park. In doing so, we considered the landscape attibutes ＂tree species composition＂, ＂water supply status＂, ＂nutrient supply status＂, ＂soil complex classes＂, ＂altitude＂, ＂exposition＂, and ＂inclination＂. Results： We found that charcoal kiln sites were established preferably on hillside locations that provided optimal growing and regeneration conditions for European beech （Fagus sylvatico） due to their acidic brown soils and sufficient water supply. These results are in line with instructions for the selection of appropriate kiln site locations, found in literature from the 18th to the 19th century. Conclusions： We conclude that there were well-stocked, beech-dominated deciduous forest stands in northern Hesse before 1800, particularly at poorly accessible hillside locations. These large stocks of beech wood were utilized by the governments of the different Hessian territories through the establishment of ironworks

关键词： Airborne laser scanning Charcoal production Cultural remains Digital terrain model Fagus sylvatica Forest history Historical ecology Landscape history Industrial history Metallurgy

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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： Jon Christiansen Anne-Katrin Guttsches Ulrike Schara-schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner Stenzel andreas Roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany Humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of Eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDR12 MMD3 Muscle inflammation Muscle MRI

Monitoring concept for structural integration of PZT-fiber arrays in metal sheets:a numerical and experimental study

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International Journal of Smart and Nano Materials 2018年第1期9卷 56-67,I0003页

作者： Welf-Guntram Drossel andreas Schubert Matthias Putz Hans-Joachim Koriath Volker Wittstock Sebastian Hensel Alexander Pierer Benedikt Müller Marek schmidt Fraunhofer Institute for Machine Tools and Forming Technology ChemnitzGermany Professorship for Adaptronics and Lightweight Design Chemnitz University of TechnologyChemnitzGermany Professorship Micromanufacturing Technology Chemnitz University of TechnologyChemnitzGermany Professorship for Machine Tools and Forming Technology Chemnitz University of TechnologyChemnitzGermany

The technique joining by forming allows the structural integration of piezoceramic fibers into locally microstructured metal sheets without any elastic interlayers.A high-volume production of the joining partners causes in statistical deviations from the nominal dimensions.A numerical simulation on geometric process sensitivity shows that the deviations have a high significant influence on the resulting fiber stresses after the joining by forming operation and demonstrate the necessity of a monitoring *** this basis,the electromechanical behavior of piezoceramic array transducers is investigated experimentally before,during and after the joining *** piezoceramic array transducer consists of an arrangement of five electrical interconnected piezoceramic *** findings show that the impedance spectrum depends on the fiber stresses and can be used for in-process monitoring during the joining *** on the impedance values the preload state of the interconnected piezoceramic fibers can be specifically controlled and a fiber overload.

关键词： Impedance spectroscopy joining by forming process monitoring function integration sensitivity