检索结果-南通市图书馆

系统工程与电子技术 1981年第9期 29-35页

作者： G.C.Vetsch ,R.J.Landy ,D.b.schaefer ,李高风

一、引言由于数字计算机的可重复性、灵活性和多用性,使用数字技术实现原来的电操纵飞行控制系统越来越有吸引力。这种方法最近几年用战斗机进行了飞行试验的模拟式电操纵飞行控制系统的一种逻辑扩展。全数字飞行控制系统的几个主要... 详细信息

一、引言由于数字计算机的可重复性、灵活性和多用性,使用数字技术实现原来的电操纵飞行控制系统越来越有吸引力。这种方法最近几年用战斗机进行了飞行试验的模拟式电操纵飞行控制系统的一种逻辑扩展。全数字飞行控制系统的几个主要优点是:

关键词：飞行控制系统控制律稳定裕度正常模式敏感器稳定裕量传感器滤波器电子设备计算时延

Alpha-1抗胰蛋白酶对小鼠及人类酒精相关肝病的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

临床肝胆病杂志 2020年第10期36卷 2273-2273页

作者：巴桃桃高沿航 GRANDER C schaefer b SCHWARZLER J 吉林大学第一医院感染病中心肝病科不详

【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响(作者Grander C等)酒精相关肝病(ALD)是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶(AAT)在诸多临床前和临床试验中显示出强大的抗炎活性,本研究... 详细信息

【据Gut 2020年7月报道】题:Alpha-1抗胰蛋白酶对小鼠及人类酒精相关性肝病的影响(作者Grander C等)酒精相关肝病(ALD)是全球性的医疗问题,治疗方法较为有限。α-1抗胰蛋白酶(AAT)在诸多临床前和临床试验中显示出强大的抗炎活性,本研究旨在探索AAT在ALD中发挥的作用。

关键词：抗胰蛋白酶 Alpha 临床试验抗炎活性肝病 ALD 酒精 AAT

Jack Hills锆石的安山质源区支持板块构造始于冥古代

在线全文

学校读者我要写书评

暂无评论

矿物岩石地球化学通报 2020年第3期39卷 596-596页

作者： Turner S Wilde S Worner G schaefer b Lai Y J 袁超(编译) 不详

地球最老的地壳组成和构造属性是地球科学研究中两个最基本的问题,但是由于缺乏合适年龄的岩石,难以进行约束。很多研究主要集中于西澳Jack Hills变质沉积岩中4.4~4.3 Ga的碎屑锆石,但是对其原岩性质的认识依然缺乏共识。对其原岩成分... 详细信息

地球最老的地壳组成和构造属性是地球科学研究中两个最基本的问题,但是由于缺乏合适年龄的岩石,难以进行约束。很多研究主要集中于西澳Jack Hills变质沉积岩中4.4~4.3 Ga的碎屑锆石,但是对其原岩性质的认识依然缺乏共识。对其原岩成分的推断主要基于锆石的Hf同位素组成,研究者普遍认为这些碎屑锆石来源于火成岩源区。

关键词：地球科学研究碎屑锆石板块构造变质沉积岩安山质原岩性质构造属性冥古代

在线全文

学校读者我要写书评

暂无评论

岛弧橄榄岩包体从地幔楔到地壳的旅行

矿物岩石地球化学通报 2019年第1期38卷 60-60页

作者：袁超 Turner S Williams H Piazolo S blichert-Toft J Gerdes M Adam J Liu XM schaefer b Maury R 不详

岛弧岩浆作为俯冲作用的产物不仅可以理解大陆地壳的形成,而且对指示大陆地壳的循环作用具有重要的意义。目前关于岛弧岩浆的源区交代作用和分异深度等相关问题一直存在争议。其中,弧岩浆的结晶分异究竟发生在莫霍面附近并伴随着堆晶岩... 详细信息

岛弧岩浆作为俯冲作用的产物不仅可以理解大陆地壳的形成,而且对指示大陆地壳的循环作用具有重要的意义。目前关于岛弧岩浆的源区交代作用和分异深度等相关问题一直存在争议。其中,弧岩浆的结晶分异究竟发生在莫霍面附近并伴随着堆晶岩的拆沉,还是发生在更浅的地壳深度?

关键词：大陆地壳橄榄岩包体岛弧地幔楔旅行结晶分异俯冲作用交代作用

A road map to find in 3D printing a new design plasticity for construction e The state of art

在线全文

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2023年第2期12卷 337-360页

作者： João Teixeira Cecília Ogliari schaefer bárbara Rangel Lino Maia Jorge Lino Alves CONSTRUCT Faculty of Engineering(FEUP)University of PortoPortoPortugal School of Arts Communication and HospitalityArchitecture and UrbanismUniversity of the ItajaíValleyItajaíBrazil Faculty of Architecture University of PortoPortoPortugal Faculty of Exact Sciences and Engineering University of MadeiraPortoPortugal INEGI/Faculty of Engineering University of Porto PortoPortugal

Recent years are showing a rapid adoption of digital manufacturing techniques to the construction industry,with a focus on additive *** 3D printing for construction(3DPC)has notably advanced in recent years,publications on the subject are recent and date a growth in 2019,indicating that it is a promising technology as it enables greater efficiency with fair consumption of material,minimization of waste generation,encouraging the construction industrialization and enhancing and accelerating the constructive *** new building system not only gives an optimization of the building process but provides a new approach to the building design *** direct connection between design and manufacturing allows the reduction in the number of the various construction phases *** is opening a new and wide range of options both formal and chromatic in customization,avoiding complex formworks,reducing costs and manufacturing *** creative process has a strict and direct link with the constructive process,straightening design with its ***-based materials lead the way,but new alternatives are being explored to further reduce its carbon *** order to leverage its sustainability and enhance the system capacity,initiatives are being pursued to allow the reduction of the use of *** are taking the first steps in *** and Demolition Waste(CDW)materials are used to substitute natural *** soil is being explored has a structural and aesthetic *** research trends are opening a wider range of possibilities for architecture and design,broadening the spectrum of color,texture,and formal *** concern about textures and colours is not yet evident in many the structures already printed,opening the opportunity for future *** can be done in the mixture and formal design of this building system,“discovering”other raw materials in others *** article aims to make a

关键词： 3D printing Architecture Construction Materials development Textures

Effect of micro-dimple patterns on capillary pull-off force and friction force of silicon surface

在线全文

学校读者我要写书评

暂无评论

Chinese Physics b 2009年第1期18卷 231-237页

作者：张向军董云开刘永合 J.A.schaefer State Key Laboratory of Tribology Tsinghua University Institute of Physics and Center of Micro/nano Technology Technich University of IlmenauPF 100565Germany

A microtribometer is used to measure and compare pull-off forces and friction forces exerted on （a） micro-dimpled silicon surfaces, （b） bare silicon surfaces, and （c） octadecyltrichlorosilane （OTS） treated silicon surfaces at different relative humidity （RH） levels separately. It is found that above a critical RH level, the capillary pull-off force increases abruptly and that the micro-dimple textured surface has a lower critical RH value as well as a higher pull-off force value than the other two surfaces. A micro topography parameter, namely sidewall area ratio, is found to play a major role in controlling the capillary pull-off force. Furthermore, micro-dimpled silicon surface is also proved to be not sensitive to variation in RH level, and can realize a stable and decreased friction coefficient compared with un-textured silicon surfaces. The reservoir-like function of micro dimples is considered to weaken or avoid the breakage effect of liquid bridges at different RH levels, thereby maintaining a stable frictional behaviour.

关键词： micro-dimpled surface capillary pull-off force frictional property relative humidity

Hepatitis b virus taxonomy and hepatitis b virus genotypes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第1期13卷 14-21页

作者： Stephan schaefer Abteilung für Virologie Institut für Medizini-sche MikrobiologieVirologie und HygieneUniversitt RostockSchillingallee 70D-18057 RostockGermany

Hepatitis b virus(HbV) is a member of the hepadnavirus *** can be found in both mammals(orthohepadnaviruses) and birds(avihepadnaviruses).The genetic variability of HbV is very *** are eight genotypes of HbV and three clades of HbV isolates from apes that appear to be additional genotypes of *** genotypes are now divided into subgenotypes with distinct virological and epidemiological *** addition,recombination among HbV genotypes increases the variability of *** review summarises current knowledge of the epidemiology of genetic variability in hepadnaviruses and,due to rapid progress in the field,updates several recent reviews on HbV genotypes and subgenotypes.

关键词： Orthohepadnavirus Avihepadnavirus Hepatitis b virus Genotype, Subgenotype Recombination

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sociology / 9th ed.

Sociology / 9th ed.

Encapsulating segment-like antimony nanorod in hollow carbon tube as long-lifespan,high-rate anodes for rechargeable K-ion batteries

2005年

作者： schaefer Richard T.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Nano Research 2019年第5期12卷 1025-1031页

作者： Wen Luo Feng Li Weiran Zhang Kang Han Jean-Jacques Gaumet Hans-Eckhardt schaefer Liqiang Mai Department of Physics School of ScienceWuhan University of TechnologyWuhan 430070China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230000China Division of Materials Science and Engineering Boston UniversityMA 02215USA State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and Technology Wuhan University of TechnologyWuhan 430070China Laboratoire de Chimie et Physique: Approche Multi-echelles des Milieux Complexes Institut Jean BarriolUniversite de LorraineMetz 57070France Institute for Functional Matter and Quantum Technologies Stuttgart UniversityPfaffenwaldring 57Stuttgart 70569Germany

K-ion battery (KIb) is a new-type energy storage device that possesses potential advantages of low-cost and abundant resource of *** develop advanced electrode materials for accommodating the large size and high activity of potassium ion is of great ***,a segment-like antimony (Sb) nanorod encapsulated in hollow carbon tube electrode material (Sb@HCT) was *** from the virtue of abundant nitrogen doping in carbon tube,one-dimensional and hollow structure advantages,Sb@HCT exhibits excellent potassium storage properties:in the case of potassium bis(fluorosulfonyl)imide (KFSI) electrolyte,Sb@HCT displays a reversible capacity of up to 453.4 mAh·g^-1 at a current density of 0.5 A·g^-1 and good rate performance (a capacity of 211.5 mAh·g^-1 could be achieved at an ultrahigh rate of 5 A·g^-1).Additionally,Sb@HCT demonstrates excellent long-cycle stability at a current density of 2 A·g^-1 over 120 ***,electrolyte optimization is an effective strategy for greatly improving electrochemical *** ex-situ characterizations,we disclosed the potassiation of Sb anode is quite reversible and undergoes multistep processes,combining solid solution reaction and two-phase reaction.

关键词： K-ion battery antimony anode hollow carbon tube encapsulation electrolyte optimizati on potassium storage mechanism

Apolipoprotein b100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第45期22卷 9954-9965页

作者： Esperance AK schaefer James Meixiong Christina Mark Amy Deik Daniel L Motola Dahlene Fusco Andrew Yang Cynthia brisac Shadi Salloum Wenyu Lin Clary b Clish Lee F Peng Raymond T Chung Gastrointestinal Unit Massachusetts General Hospital Bossston MA 02114 United States Department of Medicine Harvard Medical School Bossston MA 02114 United States both of the broad Institute of Harvard and M.I.T. Cambridge MA 02115 United States Temple University Health System Cambridge MA 02142 United States

AIM To characterize the role of apolipoprotein b100(apob 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to generate human hepatoma cells with a stable genetic deletion of APOb to assess of apob in HCV. Using infectious cell culture-competent HCV, viral pseudoparticles, replicon models, and lipidomic analysis we determined the contribution of apob to each step of the viral lifecycle. We further studied the effect of mipomersen, an FDAapproved antisense inhibitor of apob 100, on HCV using in vitro cell-culture competent HCV and determined itsimpact on viral infectivity with the TCID50 method. RESULTS We found that apo b100 is indispensable for HCV infection. Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALENmediated gene deletion of apob(APOb KO), we found a significant reduction in HCV RNA and protein levels following infection. Pseudoparticle and replicon models demonstrated that apo b did not play a role in HCV entry or replication. However, the virus produced by APOb KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wildtype virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apob using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus. CONCLUSION Apo b is required for the generation of fully infectious HCV virions, and inhibition of apo b with mipomersen blocks HCV. Targeting lipid metabolic pathways to impair viral infectivity represents a novel host targeted strategy to inhibit HCV.

关键词： Apolipoprotein Lipid Hepatitis C virus Gene silencing Viral replication