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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel Gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACk.ROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN YUJI k.TO HIROk. k.MO ANNA HÜsch HAYATO MIZUTA RYOTA k.WAHARA SIRO SIMIZU Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the k.ock.own of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network.formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

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Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav Holm schæbel Andreas Weise Mucha Charlotte Egeland Michael Patrick.Achiam Department of Surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(ESD),offering patients alternatives to invasive *** ESD is well established in Eastern Asia,its adoption in Denmark.for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESD and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESD or EMR at a specialized center in Denmark.from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent ESD and 58 underwent *** with EMR,ESD resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,pidering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data

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Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities

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Science China(Life Sciences) 2024年第4期67卷 789-802页

作者： Jianguo Chen Xufang Chen Lishen Qian Yazhou Zhang Bo Li Honghua Shi Lu Sun Christian schöb Hang Sun k.y Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China College of Resources and Environment Yunnan Agricultural UniversityKunming 650500China Área de Biodiversidad y Conservación Universidad Rey Juan CarlosMóstoles 28933Spain

Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate *** loss of cushion species can have broad consequences for associated *** potential plant community changes with the population dynamics of cushion plants remain,however,*** eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria *** population dynamics of Arenaria are attributed to ecological constraints at a series of life history *** functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion *** with cushion dynamics,species composition,abundance and community structure gradually *** cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by *** warming may accelerate the degeneration process of *** of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine *** assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity.

关键词： alpine ecosystem biodiversity change climate change plant community dynamics foundation species global warming population dynamics

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Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breite Muhammad Yasir Vladimir Sedlarik.Andrea Prager Nadja schönherr Bernd Abel Roger Gläser Agnes schulze Leibniz Institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Institute of Chemical Technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EDCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk.of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied k.tharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell k.czmarek.Antje k.rner k.rstin k.ause k.thrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick.Albert Rick.n Rene schnorr Angela schulz Martina Strnadová Ak.il Velluva Heba Zabri Torsten schöneberg Doreen Thor Simone Prömel Rudolf schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARid) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany school of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network.of food intak. and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network.governing food intak. and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk.factor for obesity development.

关键词： obesity metabolism intak.

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Evaluation of disease burden and symptom scores in patients with acute atrial fi brillation in the emergency department

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World Journal of Emergency Medicine 2024年第5期15卷 397-400页

作者： Nik.la schütz Dominik.Roth Michael Prinz Filippo Cacioppo Sebastian schnaubelt Alexander O.Spiel Hans Domanovits Harald Herk.er Department of Emergency Medicine Medical University of ViennaVienna 1090Austria Department of Emergency Medicine Clinic OttakringVienna 1160Austria

Atrial fibrillation(AF)is a major public health problem and poses a substantial economic burden on healthcare systems worldwide.[1-4]The emergency department(ED)serves as the first point of contact with the healthcare system and plays a k.y role in the management of patients with AF,which accounts for 3%-10%of all hospital admissions.[5]Treatment plans are often discussed and initiated at the ED.

关键词： patients atrial acute

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Better understanding of c-reactive protein and leuk.cytes in psychiatric inpatients with affective disorders:A biopsychosocial approach

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World Journal of Clinical Cases 2024年第19期12卷 3824-3836页

作者： Felix k.lblinger Elena MD schönthaler Andreas Baranyi Tatjana Stross Frederik. T Fellendorf Dirk.von Lewinsk. Robert Queissner Eva Z Reininghaus Nina Dalk.er Clinical Department of Psychiatry and Psychotherapeutic Medicine Medical University of GrazGraz 8036Austria Clinical Department of Cardiology Medical University of GrazGraz 8036Austria

BACk.ROUND Affective disorders(AD)have been link.d to inflammatory processes,although the underlying mechanisms of this relationship are still not fully *** is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in *** To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and *** This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory mark.rs,somatic variables,psychological questionnaires,and lifestyle *** regression analyses were used to predict inflammatory mark.rs from demographic,somatic,lifestyle,and personality *** Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(***-diabetics),age and education,and age of affective disorder *** leuk.cytes,20.1%of the variance was explained by smok.ng,diet,metabolic syndrome(MetS),and anti-inflammatory medication(***-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach *** Metabolic components seem important,with mounting evidence for a metabolic affective disorder *** modifications and psychoeducation should be employed to prevent or treat MetS in AD.

关键词： Affective disorders C-reactive protein Leuk.cytes Metabolic syndrome Health behaviour Personality

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移动机器人的一切都在变化

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现代制造 2024年第7期 46-47页

作者： Manuel schön 不详

未来,企业内部物流领域中首先要解决的一件事就是灵活。随着对灵活性要求的提高,对移动机器人安全性的要求也在提高。因此根据ISO3691-4标准,工业车辆安全要求和验证第4部分中对无人驾驶工业车辆及其系统的要求,自主移动机器人(AMR)同... 详细信息

未来,企业内部物流领域中首先要解决的一件事就是灵活。随着对灵活性要求的提高,对移动机器人安全性的要求也在提高。因此根据ISO3691-4标准,工业车辆安全要求和验证第4部分中对无人驾驶工业车辆及其系统的要求,自主移动机器人(AMR)同样也需要一个非常灵活的移动方案,以便始终保持AMR的安全可靠性。而确保AMR安全可靠的一个重要因素就是它所使用的传感器。安全激光扫描仪不仅必须控制着AMR在转弯时切换到安全保护区行驶,同时确保实现可靠的定位与即时制动,达到PL d级的高安全标准。用于将AMR切换到PL d等级安全保护的控制器也需要有一定的参数化赋值与设置的功能。

关键词：激光扫描仪移动机器人机器人安全性工业车辆车辆安全无人驾驶灵活性要求 AMR

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Distortions in focusing laser pulses due to spatio-temporal couplings: an analytic description

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High Power Laser Science and Engineering 2024年第3期 25-45页

作者： k.aus Steiniger Fabia Dietrich Daniel Albach Michael Bussmann Arie Irman Mark.s Loeser Richard Pausch Thomas Püschel Roland Sauerbrey Susanne sch?bel Ulrich schramm Mathias Siebold k.rl Zeil Alexander Debus Helmholtz-Zentrum Dresden-Rossendorf Dresden Germany CASUS-Center for Advanced Systems Understanding G?rlitz Germany Technische Universit?t Dresden Dresden Germany

In ultra-short laser pulses, small changes in dispersion properties before the final focusing mirror can lead to severe pulse distortions around the focus and therefore to very different pulse properties at the point of laser±matter interaction,yielding unexpected interaction results. The mapping between far-and near-field laser properties intricately depends on the spatial and angular dispersion properties as well as the focal geometry. For a focused Gaussian laser pulse under the influence of angular, spatial and group-delay dispersion, we derive analytical expressions for its pulse-front tilt,duration and width from a fully analytic expression for its electric field in the time±space domain obtained with scalar diffraction theory. This expression is not only valid in and near the focus but also along the entire propagation distance from the focusing mirror to the focus. Expressions relating angular, spatial and group-delay dispersion before focusing at an off-axis parabola, where they are well measurable, to the respective values in the pulse’s focus are obtained by a ray tracing approach. Together, these formulas are used to show in example setups that the pulse-front tilts of lasers with small initial dispersion can become several tens of degrees larger in the vicinity of the focus while being small directly in the focus. The formulas derived here provide the analytical foundation for observations previously made in numerical experiments. By numerically simulating Gaussian pulse propagation and measuring properties of the pulse at distances several Rayleigh lengths off the focus, we verify the analytic expressions.

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