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肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍

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中华高血压杂志 2016年第10期24卷 927-927页

作者：刘莉叶鹏 Karbach SH schnfelder t Brandao I Wilms E Hrmann N Jckel S schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S schüfer K Münzel t Reinhardt C Wenzel P

肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法：与常规饲养的小鼠（conventionally raised rats,CONV-R）比较,未受任何细菌影响的... 详细信息

肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法：与常规饲养的小鼠（conventionally raised rats,CONV-R）比较,未受任何细菌影响的无菌小鼠（GF）表现出较为严重的全身性辅助性t细胞1型滞后。

关键词：血管功能障碍肠道菌群血管紧张素Ⅱ 高血压辅助性t细胞1型免疫细胞功能无菌小鼠肠道微生物

Diagenetic history and porosity evolution of the Middle Permian clastic-carbonate mixed system,Indus Basin,Pakistan:Implications for reservoir development

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Energy Geoscience 2024年第4期5卷 156-173页

作者： Bilal Wadood Suleman Khan Michael Wagreich torsten Vennemann Hong Li Matee Ullah Katerina schöpfer Department of Geology University of SwabiAnbar-Swabi23561Pakistan State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069China Department of Geology University of ViennaViennaA-1090Austria Department of Geology University of PeshawarPeshawar25120Pakistan Institute of Earth Surface Dynamics University of LausanneLausanneCH-1015Switzerland Department of Lithospheric Research University of ViennaViennaA-1090Austria

this study deals with unraveling the diagenesis-induced porosity evolution in a mixed clastic-carbonate sequence of the Middle Permian Indus Basin,*** data sets including outcrop,petrography,cathodoluminescence,scanning electron microscopy(SEM),mineralogy,and geochemical isotopic compositions were integrated to establish a link between porosity evolution and *** spatial thickness and facies variations of the strata at outcrop scale are inherently controlled by the underlying bathymetry of the basin with deepening westward *** low values ofδ^(18)O of the target strata,relative to average values of the Permian carbonate,hints to diagenetic alteration in the *** data sets used in this study reveal modification of the strata in four environments,that is,i)early marine diagenesis indicated by micritization,pervasive dolomitization and isopachous fibrous cements,followed by ii)meteoric dissolution,and iii)shallow burial diagenetic processes including the precipitation of blocky cement,compaction of skeletal and non-skeletal allochems,and stylolites,and iv)a deep burial environment,characterized by pressure solution,and *** clastic intervals host subangular to subrounded quartz grains,floating textures,and almost complete absence of deleterious clay minerals,consequently resulting in the preservation of primary *** primary porosity of carbonate intervals is preserved in the form of intercrystalline and intracrystalline *** secondary porosity evolved through various diagenetic phases in the form of fractures and *** diagenetic solution mediated by organic matter in carbonates may have experienced both bacterial decomposition and thermochemical sulfate reduction,precipitating sulfides within the *** plug porosity/permeability analyses generally suggest high porosity in the siliciclastic unit,and carbonates with wackestone fabric while lower values were observed for the inner shelf pure

关键词： Reservoir Diagenesis Porosity Permian Indus Basin

DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN YUJI KAtO HIROKI KAMO ANNA HÜsch HAYAtO MIZUtA RYOtA KAWAHARA SIRO SIMIZU Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in Ht1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav Holm schæbel Andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam Department of Surgery and transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(ESD),offering patients alternatives to invasive *** ESD is well established in Eastern Asia,its adoption in Denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESD and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESD or EMR at a specialized center in Denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** the study included 130 patients(144 procedures):72 underwent ESD and 58 underwent *** with EMR,ESD resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,pter complication rates(28.7%vs.3.1%,ptimes(119.5 min vs.37.0 min,pthe ESD procedure time significantly decreased over time(p=0.01).the local recurrence rates were 14.5%for ESD and 23.8%for EMR(p=0.767).the one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESD and EMR are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data

Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities

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Science China(Life Sciences) 2024年第4期67卷 789-802页

作者： Jianguo Chen Xufang Chen Lishen Qian Yazhou Zhang Bo Li Honghua Shi Lu Sun Christian schöb Hang Sun Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China College of Resources and Environment Yunnan Agricultural UniversityKunming 650500China Área de Biodiversidad y Conservación Universidad Rey Juan CarlosMóstoles 28933Spain

Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate *** loss of cushion species can have broad consequences for associated *** potential plant community changes with the population dynamics of cushion plants remain,however,*** eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria *** population dynamics of Arenaria are attributed to ecological constraints at a series of life history *** functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion *** with cushion dynamics,species composition,abundance and community structure gradually *** cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by *** warming may accelerate the degeneration process of *** of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine *** assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity.

关键词： alpine ecosystem biodiversity change climate change plant community dynamics foundation species global warming population dynamics

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breite Muhammad Yasir Vladimir Sedlarik Andrea Prager Nadja schönherr Bernd Abel Roger Gläser Agnes schulze Leibniz Institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Institute of Chemical technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EDCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(AtR-FtIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

Spatiotemporal drivers of Nature's contributions to people:A countylevel study

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Environmental Science and Ecotechnology 2024年第4期20卷 323-332页

作者： Wei Jiang Bojie Fu Zhongguo Shu Yihe Lv Guangyao Gao Xiaoming Feng Stefan schüler Xing Wu Cong Wang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesNo.18 Shuangqing Road100085BeijingChina Functional Agrobiodiversity Georg-August-Universit€at G€ottingenGrisebachstraße 637077G€ottingenGermany

Nature's contributions to people(NCP)encompass both the beneficial and detrimental effects of living nature on human quality of life,including regulatory,material,and non-material ***,vital NCPs have been deteriorating,accelerated by changes in both natural and anthropogenic drivers over recent *** the often inevitable trade-offs between NCPs due to their spatially and temporally uneven distributions,few studies have quantitatively assessed the impacts of different drivers on the spatial and temporal changes in multiple NCPs and their *** we evaluate the effects of precipitation,temperature,population,gross domestic product,vegetation restoration,and urban expansion on four key regulatory NCPs-habitat maintenance,climate regulation,water quantity regulation,and soil protection-in Nei Mongol at the county *** observe increasing trends in climate regulation and soil protection from 2000 to 2019,contrasted with declining trends in habitat maintenance and water quantity *** have identified the dominant positive and negative drivers influencing each NCP across individual counties,finding that natural drivers predominantly overpowered anthropogenic ***,we discover significant spatial disparities in the tradeoff or synergy relationships between NCPs across the *** findings illustrate how the impacts of various drivers on NCPs and their interrelationships can be quantitatively evaluated,offering significant potential for application in various spatial *** an understanding of trade-offs and scale effects,these insights are expected to support and inform policymaking at both county and provincial levels.

关键词： Potential regulating contributions Natural and anthropogenic drivers Path analysis trade-off or synergy relationship China

Lunar noise correlation,imaging and monitoring

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Earthquake Science 2010年第5期23卷 519-530页

作者： Christoph Sens-schnfelder Eric Larose Institute for Geophysics and Geology Universitt Leipzig Laboratoire de Géophysique Interne et tectonophysique CNRS and Université Joseph Fourier

Passive seismic techniques have revolutionarised seismology, leading for example to increased resolution in surface wave tomography, to the possibility to monitor changes in the propagation medium, and to many new processing strategies in seismic exploration. Here we review applications of the new techniques to a very particular dataset, namely data from the Apollo 17 lunar network. the special conditions of the lunar noise environment are investigated, illustrating the interplay between the properties of the noise and the ability to reconstruct Green＇s functions. With a dispersion analysis of reconstructed Rayleigh waves new information about the shallow shear velocity structure of the Moon are obtained. Passive image interferometry is used to study the effect of temperature changes in the subsurface on the seismic velocities providing direct observation of a dynamic process in the lunar environment. these applications highlight the potential of passive techniques for terrestrial and planetary seismology.

关键词： Moon monitoring passive image interferometry noise planetary seismology

Preparation of microparticles and nanoparticles using membrane-assisted dispersion,micromixing,and evaporation processes

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Particuology 2024年第1期84卷 30-44页

作者： Goran t.Vladisavljevic Chemical Engineering Department Loughborough UniversityLoughboroughLeicestershire LE113TUUnited Kingdom

Synthetic microporous membranes are increasingly used for energy-efficient and controlled production of micro-and nanoparticles and micro-and nanoemulsions with tuneable morphology and physico-chemical properties through various micromixing,emulsification,and evaporation *** emul-sification processes,the membrane pores are used for dispersed phase injection and size-controlled generation of droplets and droplet-templated *** micromixing processes,membrane is utilised as a micromixer for mixing two miscible liquids,usually solvent and antisolvent-rich solutions,which leads to the creation of supersaturation and subsequent nanoprecipitation or *** mem-brane evaporation processes,membrane is used to prevent phase dispersion while allowing efficient molecular diffusion of solvent and/or antisolvent vapour through gas-filled *** dispersion processes can be operated continuously by decoupling shear stress on the membrane surface from cross flow using tube insets,flow pulsations,swirling flow,membrane oscillations or membrane *** generation and solidification can be performed continuously in a single pass by connecting membrane module with a downstream *** dispersion processes can be used for pro-duction of nanoparticles such as nanovesicles(liposomes,micelles,ethosomes,and niosomes),nanogels,polymeric,lipid and metallic nanoparticles,and *** main advantages of membrane-assisted particle generation are in low energy consumption,controlled geometry and hydrodynamic conditions at the microscale level,flexible throughput due to modular and scalable design of membrane devices,and a wide choice of available microporous membranes with various wall porosities,wetta-bilities,pore sizes,and pore morphologies to suit different applications.

关键词： Nanoparticles Microparticles Nanoemulsions Microemulsions Microporous membrane Crystallisation Flash nanoprecipitation Emulsification Zero liquid discharge