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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta c Marchiori cleber Rosito Pinto Kruel Marcio Fernandes chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BAcKGROUND Hepatocellular carcinoma(Hcc)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with Hcc being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with Hcc awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TAcE).However,the superiority of TAcE over TAE has not been consistently shown in the *** To compare the outcomes of TAcE and TAE in patients with Hcc awaiting *** All consecutive patients with Hcc awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TAcE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each Hcc nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TAcE group(only TAcE and TAcE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TAcE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TAcE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TAcE and TAE groups,respectively(P=0.145).Post-LT,Hcc recurred in 9(18.8%)and 4(13.8%)patients in the TAcE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

TNF-α release capacity is suppressed immediately after hemorrhage andresuscitation

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chinese Journal of Traumatology 2017年第4期20卷 207-211页

作者： Arian Bahrami Mohammad Jafarmadar heinz Redl Soheyl Bahrami Jian-Xin Jiang Ludwig Boltzmann Institute for Experimental and clinical Traumatology in AUVA Research center 1200 Vienna Austria State Key Laboratory of Trauma Burns and Combined Injury Institute of Surgery Research Doping Hospital Third Military Medical University Chongqing China

Purpose： It has been suggested that patients with traumatic insults are resuscitated into a state of an early systemic inflammatory response. We aimed to evaluate the influence of hemorrhagic shock and resuscitation （HSR） upon the inflammatory response capacity assessed by overall TNF-α secretion capacity of the host compared to its release from circulating leukocytes in peripheral circulation. Methods： Rats （8/group） subjected to HS （MAP of 30e35 mmHg for 90 min followed by resuscitation over 50 min） were challenged with Lipopolysaccharide （LPS）, 1 mg/kg intravenously at the end of resuscitation （HSR-LPS group） or 24 h later （HSR-LPS24 group）. control animals were injected with LPS without bleeding （LPS group）. Plasma TNF-α was measured at 90 min after the LPS challenge. In addition, whole blood （WB） was obtained either from healthy controls （cON） immediately after resuscitation （HSR）, or at 24 h post-shock （HSR 24）. WB was incubated with LPS （100 ng/mL） for 2 h at 37 c. TNF-α concentration and LPS binding capacity （LBc） was determined. Results： compared to LPS group, HSR followed by LPS challenge resulted in suppression of plasma TNF-a in HSR-LPS and HSR-LPS24 groups （1835 ± 478, 273 ± 77, 498 ± 200 pg/mL, respectively）. compared to cON the LPS-induced TNF-a release capacity of circulating leukocytes ex vivo was strongly declined both at the end of resuscitation （HSR） and 24 h later （HSR24）（1012 ± 259, 313 ± 154, 177 ± 63 ng TNF/mL, respectively）. The LBc in WB was similar between cON and HSR and only moderately enhanced in HSR24 （57 ± 6, 56 ± 6, 71 ± 5 %, respectively）. conclusion： Our data suggest that the overall inflammatory response capacity is decreased immediately after HSR, persisting up to 24 h, and is independent of LBc.

关键词： Injuries Endotoxins shock Immunosuppression

Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study

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cancer communications 2022年第10期42卷 1041-1045页

作者： Reynalda córdova Ana-Lucia Mayén Viktoria Knaze Elom Kouassivi Aglago casper Schalkwijk Karl-heinz Wagner Kim Overvad Anne Tjønneland cecilie Kyrø Verena Andrea Katzke charlotte Le cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-cornago Elisabete Weiderpass Mazda Jenab heinz Freisling Nutrition and Metabolism Branch International Agency for Research on Cancer(IARC-WHO)Lyon 69008France Department of Nutritional Sciences University of ViennaVienna 1090Austria Department of Internal Medicine Maastricht University Medical CentreMaastricht 6229the Netherlands Department of Public Health Aarhus UniversityAarhus 8000Denmark Danish cancer Society Research center Copenhagen 2100Denmark Division of cancer Epidemiology German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam-RehbrueckeNuthetal 14558Germany Institute of Nutritional Science University of PotsdamNuthetal 14558Germany cancer Risk Factors and Lifestyle Epidemiology Unit Institute for Cancer ResearchPrevention and Clinical Network(ISPRO)Florence 2-50139Italy Epidemiology and Prevention Unit Fondazione IRccS Istituto Nazionale dei Tumori di Milano Milan 20133Italy Department of clinical Medicine and Surgery University of Naples Federico IINaples 80138Italy Department of clinical and Biological Sciences University of TurinTurin 1012Italy Department of community Medicine UiT-the Arctic University of NorwayTromsø9037Norway Unit of Nutrition and cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelona 08908Spain Department of Epidemiology Harvard T.H.Chan School of Public HealthBoston 02115USA Department of Nutrition and Food Science Faculty of PharmacyUniversity of GranadaGranada 18071Spain Ministry of Health of the Basque Government Sub Directorate for Public Health and Addictions of GipuzkoaSan Sebastian 20013Spain Biodonostia Health Research Institute Epidemiology of Chronic and Communicable Diseases GroupSan Sebastián 2014Spain Spanish consortium for Research on Epidemiology and Public Health(cIBERESP) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Epidemiology Murcia Regional Health CouncilIMIB-ArrixacaM

Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed *** of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing *** production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].

关键词： dietary intake hence

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不锈钢在化工中的正确应用

化工装备技术 1985年第2期 29-32+10页

作者： c.M.Schillmoller ,heinz J.Althoff ,严培德

在化学过程工业中,几乎有60%的不锈钢设备故障是由于应力腐蚀开裂、局部点腐蚀或间隙腐蚀造成的。操作参数和环境因素,尤其是PH值、温度、氯化物浓度和氧浓度,对合金的性能有极大影响,因此了解不锈钢在这些变量条件下的使用范围,对于... 详细信息

在化学过程工业中,几乎有60%的不锈钢设备故障是由于应力腐蚀开裂、局部点腐蚀或间隙腐蚀造成的。操作参数和环境因素,尤其是PH值、温度、氯化物浓度和氧浓度,对合金的性能有极大影响,因此了解不锈钢在这些变量条件下的使用范围,对于防止其腐蚀是很重要的。文章着重述及了几种主要的不锈钢,同时也谈到了用于氯化物场合的一些其它合金——高钼镍合金。但限于篇幅,本文不可能

关键词：不锈钢设备点腐蚀氯化物应力腐蚀开裂点蚀卤化物缝隙腐蚀间隙腐蚀合金材料

高密度脂蛋白功能与心血管事件和死亡率的关系:一项系统综述和荟萃分析

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中华高血压杂志 2020年第5期28卷 494-494页

作者：刘青(译) 刘莉(校) Floridoabc MTS schroder H Grau M FitóM Lassale c 不详

该系统性综述和荟萃分析旨在综合评估高密度脂蛋白功能与心血管病风险、死亡率之间的关系。研究人员在Medline和Embase数据库上搜索符合纳入标准的观察性研究。用随机效应模型分别对致命性或非致命性心血管病和全因死亡率进行了风险估... 详细信息

该系统性综述和荟萃分析旨在综合评估高密度脂蛋白功能与心血管病风险、死亡率之间的关系。研究人员在Medline和Embase数据库上搜索符合纳入标准的观察性研究。用随机效应模型分别对致命性或非致命性心血管病和全因死亡率进行了风险估计。结果显示,在29篇论文中,研究高密度脂蛋白的胆固醇流出能力有20篇(13篇前瞻性和7篇横断面),研究其抗氧化能力10篇(7篇前瞻性和3篇横断面),研究其抗炎能力2篇(1篇前瞻性和1篇横断面)。在8项具有可比性的前瞻性研究中,胆固醇流出能力越强.

关键词：荟萃分析胆固醇流出观察性研究高密度脂蛋白系统性综述心血管事件随机效应模型全因死亡率

内源性葡萄膜炎患者体内病毒B19DNA及细小病毒B19特异性抗体的患病率

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 51-52页

作者： heinz c. Plentz A. Bauer D. 王文军 Department of Ophthalmology St. Franziskus Hospital Muenster Hohenzollernring 54 48145 Muenster Germany

Background: Parvovirus B19 causes erythema infectiosum (fifth disease) in children. The virus has been associated with several autoimmune diseases and has been found in synovium or serum from patients with long-standing arthritis or other rheumatic diseases. We investigated serum and aqueous fluid samples of patients with endogenous uveitis. Methods: Sera of 70 consecutive uveitis patientswere investigated for IgG against structural proteinsVP1 and VP2 and non-structural protein NS1 by western blot technique. Viral DNA in serum was assessed by quantitative PcR. Simultaneous DNA analysis was also performed on aqueous fluid samples from 11 uveitis patients and 10 patients without uveitis during routine cataract extraction. Results: In 15 (21.4%; healthy population: 16 of 10,000) of the 70 serum samples (mean age 42.69 years, range 9-82 years; 48 women, 22 men), viral DNA was detected. IgG directed against structural protein VP1 or VP2 was found in 60 patients (85.7%; healthy population: 80%) and IgG against non-structural protein NS1 in 33 patients (47.1%; healthy population: 22%). In none of the patients was IgM antibody as a serological marker for acute parvovirus infection found. Patients with posterior uveitis (n=11) had detectable serum DNA in 54.5%(p=0.021). This group displayed the highest rate of deterioration of visual acuity (>2 Snellen lines), at 72.7%(all patients: 58.6%; p=0.219). In 2 of the 11 aqueous fluid samples, viral DNA was detected. Antibodies against parvovirus B19 were found in both samples, whereas viral DNA was absent in the serum. In the control group of 10 healthy cataract patients, 3 had detectable DNA in the aqueous humor; 1 of these 3 also had detectable levels of viral DNA in serum. conclusions: Prevalence of IgG antibodies against NS1 protein in serum samples and DNA in serum is increased in uveitis patients compared with the normal population, suggesting a persistent infection. The presence of DNA in aqueous humor samples shows, for t

关键词：葡萄膜炎色素膜炎葡萄膜疾病 B19DNA B19 患者细小病毒细小脱氧核糖核酸病毒特异性抗体内源性

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类肉瘤病患儿发生葡萄膜炎

世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 40-41页

作者： heinz c. Steuhl K.-P. Heiligenhaus A. 张少娟 Augenabteilung am St.-Franziskus-Hospital M¨unster Hohenzollernring 74 48145 Münster Germany Dr.

Background: Sarcoidosis is a rare cause of uveitis in childhood. Differentiation from other rheumatic diseases may be difficult. We report on five children with uveitis in childhood sarcoidosis and review the previous literature. Results: children were aged between seven month and 13 years at the time of diagnosis of uveitis. Four of the five patients had panuveitis, the fifth one had intermediate uveitis. In addition, three children had systemic diseasewith skin, joint and central nervous system involvement. The two children younger than 5 years showed the clinical triad of eye, joint and skin disease. Uveitic complications included corneal band keratopathy, cataract, posterior synechiae, macular scars and choroidal neovascularisation. Vision-limiting complications were found in six of nine eyes at the first visit. conclusion: In childhood sarcoidosis two clinical courses can be differentiated. Younger children aged up to five years express a clinical triad of arthritis, skin lesions and uveitis. In the older group of patients, the clinical course is more similar to that of adults. Rapid diagnosis and quiescence of disease are of particular importance to improve the long-term visual prognosis.

关键词：葡萄膜炎肉瘤病带状角膜变性虹膜后黏连脉络膜新生血管视力损害风湿性疾病成人患者中枢神经系统

蜱传脑炎病毒东北株E蛋白的核酸和氨基酸序列

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病毒学报 1997年第1期13卷 47-53页

作者：侯宗柳 Franz X heinz Micheal Ecker 白登云刘瑞璋俞永新云南省流行病防治研究所哈尔滨医科大学公共卫生学院中国药品生物制品检定所

从我国东北林区死者脑组织中，分离到蜱传脑炎病毒ＨＬＪ－１株，测定了它的Ｅ蛋白基因序列和推导的氨基酸序列，以及Ｅ蛋白抗原位点反应图谱。将该株与远东亚型Ｓｏｆｙｎ株和中欧亚型Ｎｅｕｄｅｒｆｌ株做了同源性比较，ＨＬＪ－１株... 详细信息

从我国东北林区死者脑组织中，分离到蜱传脑炎病毒ＨＬＪ－１株，测定了它的Ｅ蛋白基因序列和推导的氨基酸序列，以及Ｅ蛋白抗原位点反应图谱。将该株与远东亚型Ｓｏｆｙｎ株和中欧亚型Ｎｅｕｄｅｒｆｌ株做了同源性比较，ＨＬＪ－１株与Ｓｏｆｙｎ株Ｅ蛋白基因的核苷酸及氨基酸的同源性分别为９４．３％和９８．８％；与Ｎｅｕｄｏｅｒｆｌ的核苷酸和氨基酸的同源性分别为８３．７％和９６％，在Ｅ蛋白的核苷酸序列中，ＨＬＪ－１和Ｓｏｆｙｎ株之间存在着８５个碱基的变异和６个氨基酸的改变，变化的氨基酸分别是Ｓｅｒ－４３８→Ｇｌｙ，Ａｒｇ－４５１→Ｌｙｓ，Ａｌａ－６１２→Ｖａｌ，Ｍｅｔ－６３８→Ｉｌｅ，Ａｓｎ－６４６→Ｔｈｒ，Ｖａｌ－６８２→Ａｌａ。从Ｅ蛋白的模型得知，变异的氨基酸位于Ｅ蛋白的保守区域，故对抗原性影响不大。另Ｅ蛋白位点总图谱显示，ＨＬＪ－１与Ｓｏｆｙｎ株在Ｃ位点的反应存在差异，这可能是由于培养液低ｐＨ引起ＨＬＪ－１的空间结构改变所致。本文首次从基因水平证实了从东北林区分离的蜱传脑炎病毒属于远东型蜱传脑炎病毒。

关键词：蜱传脑炎病毒 E蛋白核酸序列氨基酸序列

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深海六放海绵大骨针的结构与特性(英文)

动物学报 2007年第3期53卷 557-569页

作者：王晓红李锦和乔莉 heinz c.ScHR DER carsten EcKERT Klaus KROPF 王毅民冯庆玲 Werner E. G. MLLER 国家地质实验测试中心中国科学院海洋所清华大学材料系 Institutfr Physiologische chemie Abteilung Angewandte Molekularbiologie Universitat Duesbergweg 6 D-55099 Mainz Germany

在海绵动物(多孔动物)中,六放海绵和寻常海绵为硅质骨骼。生活在深海(1000m)中的六放海绵是最古老的海绵动物,其中间单根海绵和春氏单根海绵有长达3m的骨针,是地球上最长的生物硅结构。利用电子显微技术观测,这些直径达8mm的巨大根须骨... 详细信息

在海绵动物(多孔动物)中,六放海绵和寻常海绵为硅质骨骼。生活在深海(1000m)中的六放海绵是最古老的海绵动物,其中间单根海绵和春氏单根海绵有长达3m的骨针,是地球上最长的生物硅结构。利用电子显微技术观测,这些直径达8mm的巨大根须骨针具有同心层状结构,其横截面显示明显的构造分界:中间为含有轴丝的轴管,外围是一50 -150μm厚的轴筒,最外面为层状区(300 -500层,每层厚度3 -5μm)。生物化学研究显示其主要的蛋白质为35kD大分子,另外,还检测到23 -24kD多肽,可能是硅蛋白相关蛋白。依据现有的红血球凝聚活性,从骨针提取物中也检测到了凝集素。由电子探针获得其化学成分主要为Si , K和Na。此外,骨针的光传输实验表明,该巨大根须骨针用作光纤可传输600nm至1 400nm范围的光,而滤掉小于600nm的光(类似高通滤波器)和大于1 400nm的红外光(类似低通滤波器)。另外,从六放海绵的空囊泡沫海绵中分离出一个基因并确证了其推导的编码蛋白序列,该蛋白编码一个光裂合酶相关蛋白,蛋白相似性比较结果显示属于光裂合酶相关蛋白中多细胞动物隐色素一类。基于以上数据给出了六放海绵硅质骨针形成的示意图。另外,由单根海绵骨针可作为波导传输光/电和/或化学信号,推断在海绵动物中有类似神经系统的网络系统。

关键词：海绵中间单根海绵春氏单根海绵骨针生物硅形成光导硅蛋白相关蛋白纳米生物技术