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World journal of Clinical Cases 2016年第10期4卷 351-355页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah sayyed j rizvi Bipin C Pal Manisha P Modi Priya S Shah Umesh T Varyani Pavan S Wakhare Saiprasad G Shinde Viajay A Ghodela Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and Clinical Transplantation Institute of Kidney Diseases and Research CenterDr.HL Trivedi Institute of Transplantation Sciences(IKDRC-ITS) Department of Urology and Transplantation IKDRC-ITS Department of Anesthesia IKDRC-ITS Department of Pathology Laboratory MedicineTransfusion Services and ImmunohematologyIKDRC-ITS

The combination of kidney paired donation(KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation(LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT.

关键词： Kidney failure Chronic Desensitization Immunologic Kidney transplantation Blood group incompatibility Living donors Tissue and organ procurement

International kidney paired donation transplantations to increase kidney transplant of O group and highly sensitized patient: First report from India

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World journal of Transplantation 2017年第1期7卷 64-69页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah sayyed j rizvi Bipin C Pal Priya S Shah Pavan S Wakhare Saiprasad G Shinde Vijay A Ghodela Umesh T Varyani Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and Clinical Transplantation Institute of Kidney Diseases and Research Center Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS) Department of Urology and transplantation IKDRC-ITS Department of Anesthesia IKDRC-ITS Department of Pathology Laboratory Medicine Transfusion Services and Immunohematology IKDRC-ITS

AIM To report the first international living related two way kidney paired donation(KPD) transplantation from India which occurred on 17 th February 2015 after legal per-mission from authorization committee. METHODS Donor recipient pairs were from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. The two donor recipient pairs had negative lymphocyte cross-matching, flow cross-matchand donor specific antibody in two way kidney exchange with the intended KPD donor. Local KPD options were fully explored for Indian patient prior to embarking on international KPD. RESULTS Both pairs underwent simultaneous uneventful kidney transplant surgeries and creatinine was 1 mg/d L on tacrolimus based immunosuppression at 11 mo follow up. The uniqueness of these transplantations was that they are first international KPD transplantations in our *** International KPD will increases quality and quantity of living donor kidney transplantation. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient. To the best of our knowledge this is first international KPD transplantation from India.

关键词： Kidney paired donation International kidney paired donation Living donor kidney transplantation

Six end-stage renal disease patients benefited from first non-simultaneous single center 6-way kidney exchange transplantation in India

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World journal of Nephrology 2016年第6期5卷 531-537页

作者： Vivek B Kute Himanshu V Patel Umesh T Varyani Pankaj R Shah Pranjal R Modi Veena R Shah sayyed j rizvi Bipin C Pal Priya S Shah Pavan S Wakhare Vijay A Ghodela Saiprasad G Shinde Varsha B Trivedi Minaxi H Patel Hargovind L Trivedi Department of Nephrology and Clinical Transplantation Institute of Kidney Diseases and Research Center Dr HL Trivedi Institute of Trans-plantation Sciences Department of Urology and Transplantation Dr HL Trivedi Institute of Trans-plantation Sciences Department of Anesthesia Dr HL Trivedi Institute of Transplantation Sciences Department of Pathology and laboratory medicine Dr HL Trivedi Institute of Transplantation Sciences

AIM To avoid desensitization protocols and ABO incompatible kidney transplantation(KT) due to high costs and increased risk of infections from intense *** We present institutional ethical review board- approved study of single center 6-way kidney exchange transplantation. The participants comprised ABO incompatibility(n = 1); positive cross-match and/or presence of donor specific antibody(n = 5). The average time required from registration in kidney paired donation(KPD) registry to find suitable donors was 45 d and time required to perform transplants after legal permission was 2 mo. RESULTS Graft and patient survival were 100%, and 100%, respectively. One patient had biopsy-proven acute borderline T cell rejection(Banff update 2013, type 3). Mean serum creatinine was 0.8 mg/dL at 9 mo followup. The waiting time in KPD was short as compared to deceased donor KT. CONCLUSION We report first non-simultaneous, single center, 6-way kidney exchange transplantation from India. Our experience will encourage other centers in India to undertake this practice.

关键词： Kidney transplantation/methods Kidney paired donation Living donors/supply and distribution Donor selection/methods

Past, present and future of kidney paired donation transplantation in India

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World journal of Transplantation 2017年第2期7卷 134-143页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah sayyed j rizvi Bipin C Pal Manisha P Modi Priya S Shah Umesh T Varyani Pavan S Wakhare Saiprasad G Shinde Vijay A Ghodela Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and Clinical Transplantation Institute of Kidney Diseases and Research CentreDr HL Trivedi Institute of Transplantation Sciences(IKDRC-ITS) Department of Urology and transplantation Department of Anaesthesia IKDRC-ITS Department of Pathology Laboratory MedicineTransfusion Services and Immunohematology

One third of healthy willing living kidney donors are rejected due to ABO blood group incompatibility and donor specific antibody. This increases pre-transplant dialysis duration leading to increased morbidity and mortality on the kidney transplantation waiting list. Over the last decade kidney paired donation is most rapidly increased source of living kidney donors. In a kidney transplantation program dominated by living donor kidney transplantation, kidney paired donation is a legal and valid alternative strategy to increase living donor kidney transplantation. This is more useful in countries with limited resources where ABO incompatible kidney transplantation or desensitization protocol is not feasible because of costs/infectious complications and deceased donor kidney transplantation is in initial stages. The matching allocation, ABO blood type imbalance, reciprocity, simultaneity, geography were the limitation for the expansion of kidney paired donation. Here we describe different successful ways to increase living donor kidney transplantation through kidney paired donation. Compatible pairs, domino chain, combination of kidney paired donation with desensitization or ABO incompatible transplantation, international kidney paired donation, nonsimultaneous, extended, altruistic donor chain and list exchange are different ways to expand the donor *** absence of national kidney paired donation program,a dedicated kidney paired donation team will increase access to living donor kidney transplantation in individual centres with team work. Use of social networking sites to expand donor pool, HLA based national kidney paired donation program will increase quality and quantity of kidney paired donation transplantation. Transplant centres should remove the barriers to a broader implementation of multicentre, national kidney paired donation program to further optimize potential of kidney paired donation to increase transplantation of O group and sensitized patients. T

关键词： Living donor kidney transplantation Kidney paired donation Renal replacement therapy Developing country

Superconducting parameter determination for (Co0.5Zn0.5Fe2O4)x/Cu0.5Tl0.5-1223 composite

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journal of Advanced Ceramics 2016年第3期5卷 210-218页

作者： M.ME.BARAKAT N.AL-sayyed R.AWAD A.I.ABOU-ALY Physics Department Faculty of Science Alexandria University Alexandria Egypt Physics Department Faculty of Science Beirut Arab University Beirut Lebanon

The addition of magnetic Co0.5Zn0.5Fe2O4 nanoparticles to the superconducting Cu0.5Tl0.5-1223 phase has been used to investigate the electrical resistivity behavior of the composite above the superconducting transition temperature T c. This was studied according to the opening of spin gap and fluctuation conductivity. The results indicated that the pseudogap temperature (T*) and superconducting fluctuation temperature (T scf) change by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles. It was found that T* is related to hole carrier concentration P and it also depends on the antiferromagnetic fluctuation affected by magnetic nanoparticles. The excess-conductivity analysis showed four different fluctuation regions started from high temperature up to T c, and they were denoted by short wave (sw), two-dimensional (2D), three-dimensional (3D), and critical (cr) fluctuations. The crossover temperature between 3D and 2D (T 3D–2D) in the mean field region was decreased by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles, in accordance with the decrease in T scf with x. The coherence length at 0 K along c-axis ξ c(0), effective layer thickness of the 2D system d, and inter-layer coupling strength j were estimated as a function of Co0.5Zn0.5Fe2O4 nanoparticle addition. Moreover, the thermodynamics, lower and upper critical magnetic fields, as well as critical current density have been calculated from the Ginzburg number N G. It was found that the low concentration of Co0.5Zn0.5Fe2O4 nanoparticles up to x = 0.08 wt% improves the superconducting parameters of Cu0.5Tl0.5-1223 phase. On the contrary, these parameters were deteriorated for (Co0.5Zn0.5Fe2O4) x /Cu0.5Tl0.5-1223 composite with x > 0.08 wt%.

关键词： Co0.5Zn0.5Fe2O4 nanoparticles Cu0.5Tl0.5-1223 phase pseudogap temperature fluctuation conductivity

果糖催化合成四氢苯并[b]吡喃衍生物:动力学和机理研究(英文)

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催化学报 2015年第5期36卷 757-763页

作者： sayyedeh Shadfar Pourpanah sayyed Mostafa Habibi-Khorassani Mehdi Shahraki Department of Chemistry University of Sistan and Baluchestan

Fructose was used as an efficient catalyst for three-component condensation reactions of aryl aldehydes,malononitrile,and dimedone in a mixture of EtOH and H_2O as green *** advantages of this method are a short reaction time,high yields,low cost,easy accesses,and simple *** mechanism of the synthesis of a derivative of 4H-tetrahydrobenzo[b]pyran was clarified using spectroscopic kinetic *** activation energy(Ea=65.34 kj/mol)and related kinetic parameters(ΔG=69.14 kj/mol,ΔS=20.99 j/(mol·K),andΔH=62.89 kj/mol)were calculated,based on the effects of temperature,concentration,and *** first step in the proposed mechanism was identified as the rate-determining step(k1),based on the steady-state approximation.

关键词：吡喃衍生物动力学方法四氢苯并催化合成果糖机理绿色溶剂缩合反应

2023年journal of Diabetes第10期中文导读

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中华内分泌代谢杂志 2023年第11期39卷 990-993页

作者： j Diabetes编辑部不详

综述/Review Article 2型糖尿病患者的β细胞功能:能被保留或增强吗?Beta-cell function in type 2 diabetes(T2DM):can it be preserved or enhanced?Laure sayyed Kassem1,2,Aman Rajpal1,2,Margarita Barreiro1,3,and Faramarz Ismail-Beigi1,2,31Case Western Reserve University,2Cleveland VA Medical Center,and3University Hospitals of Cleveland【摘要】2型糖尿病(T2DM)是一种复杂的代谢紊乱,表现为高血糖、胰岛素抵抗和β细胞功能逐渐恶化。预防该疾病进展的一种方法是增强β细胞功能和胰岛素分泌。然而,此前大多数研究在患者使用降糖药物且没有足够的时间停药(洗脱期)的情况下检查了β细胞功能。在本文中,我们重点讨论了有洗脱期的研究。我们使用了β细胞功能和增强作为关键词进行了文献检索(2010年至2021年6月)。现有证据表明,β细胞功能可以增强。减重手术和极低热量饮食可改善许多个体的β细胞功能。此外,使用GLP-1受体激动剂进行长期治疗(3年或更长时间)也可以改善β细胞功能。需要进一步的研究来了解导致改善β细胞功能的机制,并确定可以增强T2DM患者β细胞功能的药物。

关键词：胰岛素分泌文献检索胰岛素抵抗受体激动剂