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Urinary Oxalate Excretion Decreased in Androgen Receptor-Knockout Mice by Suppressing Oxalate Synthesis in the Liver

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Open Journal of Urology 2015年第8期5卷 123-132页

作者： Sayuri takahashi Seiji Aruga Yoko Yamamoto Takahiro Matsumoto Department of Urology the University of Tokyo Tokyo Japan Department of Urology Kyosai Hospital Tokyo Japan Department of Surgical Oncology the University of Tokyo Tokyo Japan Institute of Health Biosciences the University of Tokushima Graduate School Tokushima Japan

The incidence of calcium oxalate stone in men is higher than that in women. We evaluated the association between the androgen receptor (AR) and urinary oxalate excretion using Crefloxed male androgen receptor-knockout (ARKO) mice (ARL-/Y) and floxed mice (ARL+/Y) as control. Four-teen-week-old ARL-/Y and ARL+/Y mice were fed distilled water. Drinking water was then swapped for 0.5% ethylene glycol (EG). Urinary oxalate was measured on days 0, 14, and 28. Urinary calcium, inorganic phosphorus, citrate, uric acid, and ion-actibity products of calcium oxalate (APCaOx) in mouse, AP (CaOx)-indexMOUSE, were evaluated on days 0 and 15. On day 28, livers were harvested to measure mRNA expression of enzymes. Urinary oxalate excretion was significantly higher in ARL+/Y than in ARL-/Y mice 14 and 28 days after EG treatment (p L-/Y mice exhibited atrophic testes and low serum testosterone, both ARKO and control mice were orchiectomized and implanted DHT pellets (ARL-/Y-ORX-DHT, and ARL+/Y-ORX-DHT), and the same experiments as above were performed. EG loading for 14 and 28 days resulted in significantly higher excretion in ARL+/Y-ORX-DHT mice than ARL-/Y-ORX-DHT mice (p < 0.005). AP(CaOx)-indexMOUSE was significantly higher in ARL+/Y-ORX-DHT mice than in ARL-1/Y-ORX-DHT mice. mRNA expression levels of glycolate oxidase (GO) in liver were lower in ARKO mice than in control ones. AR modulates the excretion of oxalate in urine after EG treatment, which may be associated with increased oxalate synthesis by activated GO in the liver via the AR pathway.

关键词： Androgen Receptor Urinary Stone Oxalate

Remain Aggressive Behavior in Children with Temporal Lobe Epilepsy after Surgery

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Journal of Behavioral and Brain Science 2015年第3期5卷 81-87页

作者： sayuri Sukigara Eiji Nakagawa Masanori Ishikawa Kenji Sugai Masayuki Sasaki Takanobu Kaido Akio takahashi Taisuke Otsuki Department of Child Neurology National Center Hospital National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of Psychiatry NCNP Tokyo Japan Department of Neurosurgery NCNP Tokyo Japan

Behavioral problems have a high rate in patients with temporal lobe epilepsy but there have been few detailed reports about pediatric patients. We report two children with temporal lobe epilepsy who manifest behavior abnormality remaining after surgery. One child developed complex partial seizures at 10 years and 3 months of age caused by a left temporal ganglioglioma and manifested behavioral problems of lability, aggression, impulsivity and disinhibition. Seizures were relieved after temporal lobe resection at 10 years and 8 months of age but behavioral symptoms had been remained. The second child developed epilepsy at 3 years of age. He manifested similar behavioral problems at 7 years old. Seizures were relieved after temporal lobe resection at 13 years old but behavioral symptoms had been remained. Their courses suggested that aggressive behavior might be associated with not only temporal lesion but also other lesions such as frontal lobe or neural circuitry between both lobes. It is important to inform families of patients that behavioral disorders may not improve after epileptic surgery.

关键词： Temporal Lobe Epilepsy Behavioral Disorder Aggression Epileptic Surgery

Short-fetch high waves during the passage of 2019 Typhoon Faxai over Tokyo Bay

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Frontiers of Earth Science 2022年第1期16卷 206-219页

作者： Hiroshi TAKAGI Atsuhei takahashi School of Environment and Society Tokyo Institute of TechnologyTokyo 152-8550Japan

The risk of wind waves in a bay is often overlooked,owing to the belief that peninsulas and islands will inhibit high waves.However,during the passage of a tropical cyclone,a semi-enclosed bay is exposed to twodirectional waves:one generated inside the bay and the other propagated from the outer sea.Typhoon Faxai in 2019 resulted in the worst coastal disaster in Tokyo Bay in the last few decades.The authors conducted a post-disaster survey immediately after this typhoon.Numerical modeling was also performed to reveal the mechanisms of unusual high waves.No significant high-wave damage occurred on coasts facing the Pacific Ocean.By contrast,Fukuura-Yokohama,which faces Tokyo Bay,suffered overtopping waves that collapsed seawalls.To precisely reproduce multi-directional waves,the authors developed an extended parametric typhoon model,which was embedded in the JMA mesoscale meteorological model(JMA-MSM).The peak wave height was estimated to be 3.4 m off the coast of Fukuura,in which the contribution of the outer-sea waves was as low as 10%–20%.A fetchlimited wave developed over a short distance in the bay is considered the primary mechanism of the high wave.The maximum wave occurred on the left-hand side of the typhoon track in the bay,which appears to be contrary to the common understanding that it is safer within the semicircle of a storm than on the opposite side.Typhoon Faxai was a small typhoon;however,if the radius was tripled,it is estimated that the wave height would exceed 3 m over the entire bay and surpass 4 m off the coasts of Yokohama and Chiba.

关键词： Typhoon Faxai Tokyo Bay high waves short fetch overtopping wave hindcasting parametric typhoon JMA-MSM storm surge

Theoretical Study on Direction of Vibrational Transition Dipole Moment of XH Stretching Vibration in HXD

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Chinese Journal of Chemical Physics 2020年第1期33卷 13-22页

作者： Kaito takahashi Institute of Atomic and Molecular Sciences Academia SinicaTaipei 10617

Experimental vibrational spectra of heavy light XH stretching vibrations of simple molecules have been analyzed using the local mode model.In addition,the bond dipole approach,which assumes that the transition dipole moment(TDM)of the XH stretching mode is aligned along the XH bond,has helped analyze experimental spectra.We performed theoretical calculations of the XH stretching vibrations of HOD,HND^−,HCD,HSD,HPD^−,and HSiD using local mode model and multi-dimensional normal modes.We found that consistent with previous notions,a localized 1D picture to treat the XH stretching vibration is valid even for analyzing the TDM tilt angle.In addition,while the TDM of the OH stretching fundamental transition tilted away from the OH bond in the direction away from the OD bond,that for the XH stretching fundamental of HSD,HND^−,HPD^−,HCD,and HSiD tilted away from the OH bond but toward the OD bond.This shows that bond dipole approximation may not be a good approximation for the present systems and that the heavy atom X can affect the transition dipole moment direction.The variation of the dipole moment was analyzed using the atoms-in-molecule method.

关键词： Heavy light stretching vibration Transition dipole moment Vibrational mode coupling Quantum chemistry

Slip Flow on Graphene:Current Status and Perspective

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Journal of Thermal Science 2022年第4期31卷 1115-1134页

作者： CHEN Kuan-Ting LI Qin-Yi takahashi Koji Department ofAeronautics and Astronautics Kyushu UniversityFukuoka 819-0395Japan International Institute for Carbon-Neutral Energy Research(WPI-I2CNER) Kyushu UniversityFukuoka 819-0395Japan

Fast fluid transport on graphene has attracted a growing body of research due to a wide range of potential applications including thermal management,water desalination,energy harvesting,and lab-on-a-chip.Here,we critically review the theoretical,simulational,and experimental progress regarding the fluid slippage on graphene.Based on the summary of the past studies,we give perspectives on future research directions towards complete understanding and practical applications of slip flow on graphene.

关键词： slip flow graphene nanochannel simulation experiment

Preface of the Special Issue: Queueing Systems and Engineering Applications

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Journal of Systems Science and Systems Engineering 2019年第2期28卷 129-131页

作者： Wuyi Yue Yutaka takahashi Department of Intelligence and Informatics Konan University Kobe 658-8501 Japan Graduate School of Informatics Kyoto University Kyoto 606-8501 Japan

This volume of the Journal of Systems Science and Systems Engineering is devoted to the extended versions of papers selected and presented at the 12th International Conference on Queueing Theory and Network Applicatio... 详细信息

关键词： Systems 12th Applications

Urban climate in the Tokyo metropolitan area in Japan

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Journal of Environmental Sciences 2017年第9期29卷 54-62页

作者： Jun Matsumoto Fumiaki Fujibe Hideo takahashi Research Center for Climatology Department of Geography Tokyo Metropolitan University Department of Coupled Ocean-Atmosphere-Land Processes Research JAMSTEC

Long-term climate changes related with urbanization in Tokyo, Japan, and recent temperature and heavy rainfall distribution in the Tokyo metropolitan area are reviewed. A relatively high temperature increase in annual mean temperature at the rate of 3.0°C/century was detected in Tokyo for the period 1901–2015. Some observational evidence showed the existence of both thermal and mechanical effects of urbanization on recent heavy rainfall occurrences, and modeling studies also support precipitation enhancement. Urban influences were recognized in other climatological elements, such as number of fog days, relative humidity, and wind circulation.

关键词： Heat island Cool island Heavy rainfall Fog Humidity Sea breeze

Challenges for beyond 5G:ultra-densification of radio access network

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通信学报 2020年第11期41卷 1-11页

作者： Fumiyuki Adachi Ryo takahashi Hidenori Matsuo Research Organization of Electrical Communication Tohoku UniversitySendai 980-8577Japan

Ultra-densification of radio access network(RAN)is a key to efficiently support the exponentially growing mobile data traffic in 5 G era.Furthermore,extremely high frequency band like mm Wave band was utilized to solve the bandwidth shortage problem.However,untra-dense reusing the same radio resource produced severe interference.And the mm Wave link was very harsh due to frequent blockage by obstacles.Therefore a new RAN architecture needed to be introduced to realize ultra-reliable communications in such a severe radio propagation environment.An architecture of distributed MIMO based RAN was presented.Then,enhanced interference coordination(e IC)was described.Finally,the effectiveness of distributed MIMO based RAN with e IC by computer simulation was showed.

关键词： 5G advanced systems distributed MIMO radio access network interference coordination cooperative signal transmission

Placenta Previa Accreta and Previous Cesarean Section：Some Clarifications

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Chinese Medical Journal 2018年第12期131卷 1504-1505页

作者： Shigeki Matsubara Hironori takahashi Department of Obstetrics and Gynecology Jichi Medical University Tochigi Japan

To the Editor： Placenta accreta （accreta, increta, or percreta） is challenging： effort to reduce its incidence is of paramount importance. We already know well that cesarean section （CS） increases the risk ofacc... 详细信息

关键词： DELIVERY