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Depth of invasion to the bladder wall as a prognostic factor and its association with circulating cell-free DNA levels in patients with muscle-invasive bladder cancer

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当代泌尿学（英文） 2023年第4期17卷 229-235页

作者： Yusuke lemura Makito Miyake Shinji Fukui Tomomi Fujii sayuri ohnishi Shunta Hori Yosuke Morizawa Yasushi Nakai Kazumasa Torimoto Nobumichi Tanaka Kiyohide Fujimoto Department of Urology Nara Medical UniversityKashiharaNaraJapan Department of Diagnostic Pathology Nara Medical UniversityKashiharaNaraJapan Department of Urology Nara Medical UniversityKashiharaNaraJapan Department of Prostate Brachytherapy Nara Medical UniversityKashiharaNaraJapan

Background:Radical cystectomy(RC)is the standard surgical treatment for patients with muscle-invasive bladder cancer,but the prognosis is not favorable,and new prognostic factors need to be *** investigated the potential of depth of invasion(DOI)as a prognostic factor in patients with muscle-invasive bladder cancer who underwent ***,we examined the asso-ciation between preoperative levels of circulating cell-free DNA and DOI.Materials and methods:We retrospectively reviewed patients who underwent RC between January 2007 and December 2017;those who received neoadjuvant chemotherapy were *** of invasion was measured using hematoxylin-eosin-stained RC specimens.Results:Of the 121 patients selected,41(33.9％)were eligible for *** median follow-up period was 14 months and mean DOI was 17 mm(range,2-75 mm).Long DOI(＞17 mm)was significantly associated with shorter progression-free survival(hazard ratio,14.5;95％confidence interval,3.9-53.97,p＜0.0001)and cancer-specific survival(hazard ratio,18.97;95％confidence interval,4.04-88.99,p=0.0002)compared with short *** analysis revealed that DOI was an independent risk factor for cancer-specific *** levels of circulating cell-free DNA were significantly higher in patients with a longer DOI than in those with short DOI(65 vs.20 ng/mL,respectively;p=0.028).Conclusions:Depth of invasion predicted with levels of circulating cell-free DNA and thus could be a useful prognostic factor.

关键词： Bladder cancer Cell-free DNA Depth of invasion

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Effectiveness of antibiotic prophylaxis for acute esophageal variceal bleeding in patients with band ligation: A large observational study

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World Journal of Gastroenterology 2024年第3期30卷 238-251页

作者： Chikamasa Ichita sayuri Shimizu Tadahiro Goto Uojima Haruki Naoya Itoh Masao Iwagami Akiko Sasaki Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan TXP Research TXP Medical Co.Ltd.Chiyoda-ku 101-0042TokyoJapan Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoBunkyo-ku 113-0033TokyoJapan Department of Genome Medical Sciences Project Research InstituteNational Center for Global Health and MedicineIchikawa 272-8516ChibaJapan Division of Infectious Diseases Aichi Cancer CenterNagoya 464-8681AichiJapan Department of Health Services Research Institute of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan

BACKGROUND Esophageal variceal bleeding is a severe complication associated with liver cirrhosis and typically necessitates endoscopic *** current standard treatment is endoscopic variceal ligation(EVL),and Western guidelines recom-mend antibiotic prophylaxis following ***,given the impro-vements in prognosis for variceal bleeding due to advancements in the management of bleeding and treatments of liver cirrhosis and the global concerns regarding the emergence of multidrug-resistant bacteria,there is a need to reassess the use of routine antibiotic prophylaxis after *** To evaluate the effectiveness of antibiotic prophylaxis in patients treated for *** We conducted a 13-year observational study using the Tokushukai medical database across 46 *** were divided into the prophylaxis group(received antibiotics on admission or the next day)and the non-prophylaxis group(did not receive antibiotics within one day of admission).The primary outcome was composed of 6-wk mortality,4-wk rebleeding,and 4-wk spontaneous bacterial peritonitis(SBP).The secondary outcomes were each individual result and in-hospital mortality.A logistic regression with inverse probability of treatment weighting was used.A subgroup analysis was conducted based on the Child-Pugh classification to determine its influence on the primary outcome measures,while sensitivity analyses for antibiotic type and duration were also *** Among 980 patients,790 were included(prophylaxis:232,non-prophylaxis:558).Most patients were males under the age of 65 years with a median Child-Pugh score of *** composite primary outcomes occurred in 11.2%of patients in the prophylaxis group and 9.5%in the non-prophylaxis *** significant differences in outcomes were observed between the groups(adjusted odds ratio,1.11;95%confidence interval,0.61-1.99;P=0.74).Individual outcomes such as 6-wk mortality,4-wk rebleeding,4-wk onset of SBP,and in-hospital mo

关键词： Esophageal varices Endoscopic hemostasis Antibiotic prophylaxis Liver cirrhosis Inverse probability of treatment weighting

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Starch Orodispersible Film Loaded with Melatonin for Human Supplementation

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Journal of Renewable Materials 2024年第7期12卷 1343-1354页

作者： Fabio Tamanini Tatiane Zucchini de Souza Creusa sayuri Tahara Amaral Antônio JoséFelix Carvalho Eliane Trovatti Department of Health and Biological Sciences University of Araraquara(UNIARA)São Paulo14801-340Brazil Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloSão Paulo13563-120Brazil

An innovative pharmaceutical form for administering melatonin,based on starch orodispersibleﬁlm(ODF),was designed and *** composition of the ODF included starch as the polymer matrix,the active drug melatonin,and a ***,a natural hormone produced by the pineal gland in the brain,can be absorbed by passive diffusion across the mucous membrane,resulting in improved bioavailability when compared to conventional oral *** study shows a simple and efﬁcient method for preparing melatonin-loaded orodispersibleﬁlms with a physically stable and commercially viable matrix,suitable for use in the pharmaceutical ***ﬁlms were prepared by treating the starch with microwave irradiation,followed by plasticization with glycerol,melatonin loading and drying by solvent *** tests showed theﬁlms’robustness,with a modulus of approximately 97 MPa,indicating good handling *** uptake analysis showed fast water absorption,reaching about 150%within 2 min,indicating its fast oral disintegration *** tests in artiﬁcial saliva and dissolution studies indicated the release of the drug in min-utes,indicating the potential properties of theﬁlm for oral drug *** the best of our knowledge,there is no melatonin ODF based on starch described in the literature.

关键词： Starch orodispersibleﬁlm melatonin drug delivery

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Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators

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Asian Journal of Andrology 2023年第2期25卷 158-165页

作者： sayuri Takahashi Ichiro Takada Department of Urology The Institute of Medical ScienceThe University of TokyoShirokanedaiMinato-kuTokyo 108-8639Japan Department of Urology The Faculty of MedicineThe University of TokyoHongoBunkyo-kuTokyo 113-8655Japan

Prostate cancer is one of the most common diseases in men ***,radiation therapy,and hormonal therapy are effective treatments for early-stage prostate ***,the development of castration-resistant prostate cancer has increased the mortality rate of prostate *** develop novel drugs for castration-resistant prostate cancer,the molecular mechanisms of prostate cancer progression must be *** the signaling pathways regulating prostate cancer development,recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family(WNT)signaling pathways,mainly that involving WNT5A,in prostate cancer progression and metastasis;however,its role remains ***,chromatin remodelers such as the switch/sucrose nonfermentable(SWI/SNF)complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression ***,we review the roles of noncanonical WNT signaling pathways,chromatin remodelers,and epigenetic enzymes in the development and progression of prostate cancer.

关键词： chromatin remodeling histone-modifying enzymes prostate cancer WNT5A

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Clinical features of acute esophageal mucosal lesions and reflux esophagitis Los Angeles classification grade D: A retrospective study

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 408-419页

作者： Chikamasa Ichita Akiko Sasaki sayuri Shimizu Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236–0027KanagawaJapan

BACKGROUND Acute esophageal mucosal lesions(AEMLs)are an underrecognized and largely unexplored *** findings are similar,and a higher percentage of AEML could be misdiagnosed as reflux esophagitis Los Angeles classification grade D(RE-D).These diseases could have different pathologies and require different *** To compare AEML and RE-D to confirm that the two diseases are different from each other and to clarify the clinical features of *** We selected emergency endoscopic cases of upper gastrointestinal bleeding with circumferential esophageal mucosal injury and classified them into AEML and RE-D groups according to the mucosal injury’s shape on the oral *** examined patient background,blood sampling data,comorbidities at onset,endoscopic characteristics,and outcomes in each *** Among the emergency cases,the AEML and RE-D groups had 105(3.1%)and 48(1.4%)cases,*** variables exhibited significantly different results,indicating that these two diseases are *** clinical features of AEML consisted of more comorbidities[risk ratio(RR):3.10;95%confidence interval(CI):1.68–5.71;P<0.001]and less endoscopic hemostasis compared with RE-D(RR:0.25;95%CI:0.10–0.63;P<0.001).Mortality during hospitalization was higher in the AEML group(RR:3.43;95%CI:0.82–14.40;P=0.094),and stenosis developed only in the AEML *** AEML and RE-D were clearly distinct diseases with different clinical *** may be more common than assumed,and the potential for its presence should be taken into account in cases of upper gastrointestinal bleeding with comorbidities.

关键词： Acute esophageal mucosal lesion Comorbidities Esophageal reflux Black esophagus Acute necrotizing esophagitis

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Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1329-1339页

作者： Ryo Yamamoto sayuri Suzuki Koichiro Homma Shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 1608582Japan Division of Endocrinology Metabolism and NephrologyDepartment of Internal MedicineKeio University School of MedicineTokyo 1608582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 1608582Japan

BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after *** gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen species in various animal and clinical *** examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3%hydrogen *** To clarify the treatment effects and target cells of hydrogen gas for mesenteric *** Three rat groups underwent 60-min mesenteric artery occlusion(ischemia),60-min reperfusion following 60-min occlusion(reperfusion),or ischemiareperfusion with the same duration under continuous 3%hydrogen gas inhalation(hydrogen).The distal ileum was *** staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5(LGR5),a specific marker of intestinal stem cell,was conducted to evaluate the injury location and cell types protected by *** expressions of LGR5,olfactomedin 4(OLFM4),hairy and enhancer of split 1,Jagged 2,and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain *** oxidative stress was analyzed with immunostaining for 8-hydroxy-2'-deoxyguanosine(8-OHdG).Systemic oxidative stress was evaluated by plasma *** Ischemia damaged the epithelial layer at the tip of the villi,whereas reperfusion induced extensive apoptosis of the cells at the crypt base,which were identified as intestinal stem cells with double immunofluorescence *** mitigated such apoptosis at the crypt base,and the LGR5 expression of the tissues was higher in the hydrogen group than in the reperfusion ***4 was also relatively higher in the hydrogen group,whereas other measured RNAs were comparable between the groups.8-OHdG concentration was high in the reperfusion group,which was reduced by hydrogen,particularly at the crypt *** 8-OHdG concentrations were relatively higher in both reperfusion and

关键词： Hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5

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Pitfalls and promises of bile duct alternatives:A narrative review

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World Journal of Gastroenterology 2022年第39期28卷 5707-5722页

作者： Mitsuo Miyazawa Masayasu Aikawa Junpei Takashima Hirotoshi Kobayashi Shunsuke ohnishi Yoshito Ikada Department of Surgery Teikyo University Mizonokuch HospitalKanagawa 213-8507Japan Department of Surgery Saitama Medical University International Medical CenterSaitama 350-1298Japan Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan Department of Bioenvironmental Medicine Nara Medical UniversityNara 634-8521Japan

Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde *** chronic inflammation can cause liver dysfunction,liver abscess,and even bile duct *** research has been conducted for over 100 years to directly repair bile duct defects with alternatives,no bile duct substitute(BDS)has been *** narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near *** searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in *** independent reviewers reviewed studies on large animals with 8 or more *** types of BDSs prevail:Autologous tissue,non-bioabsorbable material,bioabsorbable material,and others(decellularized tissue,3D-printed structures,etc.).In most studies,BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile *** has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated.A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS.

关键词： Bile duct alternative Bile duct substitute Biliary regeneration Bile duct reconstruction Peribiliary gland Bioabsorbable polymer

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Extracellular matrix gene expression in human trabecular meshwork cells following mechanical fluid flow stimulation

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 388-393页

作者： Koichi Yoshida Motofumi Kawai Tsugiaki Utsunomiya Akihiro Ishibazawa Young-Seok Song Mariana sayuri BUdo Yoshikazu Tasaki Akitoshi Yoshida Department of Ophthalmology Asahikawa Medical UniversityAsahikawaHokkaido 078-8510Japan Department of Hospital Pharmacy&Pharmacology Asahikawa Medical UniversityAsahikawaHokkaido 078-8510Japan

AIM: To investigate changes in extracellular matrix(ECM) gene expression in human trabecular meshwork(HTM) cells in response to mechanical fluid flow ***: HTM cells were grown on a glass plate coated with 0.02% type Ⅰ collagen(COL) and exposed to shear stress(0, 0.2, 1.0 dyne/cm;) for 12 *** in genes related to the ECM were evaluated by real-time reverse transcriptase-polymerase chain *** of Smad2 protein was investigated by Western ***: After mechanical stimulation, COL type 4 alpha 2, COL type 6 alpha 1, and fibronectin-1 mRNA were significantly higher than the static control(P<0.05, <0.05, and <0.01, respectively).The metalloproteinase-2 and plasminogen activator inhibitor-1 mRNA were significantly higher than the static control(P<0.05 and <0.01, respectively), while the differences in the tissue inhibitors of metalloproteinases-2 mRNA were not *** phosphorylation of Smad2 levels was significantly higher compared to the static control ***: Changes in the expressions of genes associated ECM metabolism result in HTM cells after mechanical *** mechanical stimulation of the aqueous humor to the trabecular meshwork may promote ECM turnover and contribute to intraocular pressure homeostasis.

关键词： trabecular meshwork shear stress aqueous humor extracellular matrix glaucoma intraocular pressure

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Third-line therapies in patients with Kawasaki disease refractory to first-and second-line intravenous immunoglobulin therapy

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World Journal of Pediatrics 2022年第11期18卷 781-785页

作者： Takashi Furuta Hiroki Yasudo Seigo Okada Yuji ohnishi Akiko Kawakami-Miyake Yasuo Suzuki Shouichi Ohga Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi755-8505Japan Department of Pediatrics Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

Kawasaki disease(KD)is an acute febrile ilness characterized by systemic vasculitis affecting the small-and mediumsized arteries in children [1,2].One of the most critical complications of KD is the development of coronary artery lesions(CALs)approximately after 12 days of ilness,which may lead to myocardial infarction[3].High-dose intravenous immunoglobulin(IVIG)and oral administration of aspirin have been established as the first-line therapy for KD[4,5].

关键词： intravenous acute immunoglobulin

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Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

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Nano Research 2016年第5期9卷 1267-1275页

作者： Masato ohnishi Ken Suzuki Hideo Miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

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