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Induction of CD69 expression by cag PAI-positive Helicobacter pylori infection

World Journal of Gastroenterology 2011年第32期17卷 3691-3699页

作者： Naoki mori Chie Ishikawa Masachika Senba Department of Microbiology and Oncology Graduate School of Medicine University of the Ryukyus Nishihara Okinawa 903-0215 Japan Department of Internal Medicine Omoromachi Medical Center 1-3-1 Uenoya Naha Okinawa 900-0011 Japan Transdisciplinary Research Organization for Subtropics and Island Studies University of the Ryukyus Nishihara Okinawa 903-0213 Japan Department of Pathology Institute of Tropical Medicine Nagasaki University Nagasaki 852-8523 Japan

AIM: To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori ) infection. METHODS: The expression levels of CD69 in a T-cell line, Jurkat, primary human peripheral blood mononuclear cells (PBMCs), and CD4 + T cells, were assessed by immunohistochemistry, reverse transcription polymerase chain reaction, and flow cytometry. Activation of CD69 promoter was detected by reporter gene. Nuclear factor (NF)-κB activation in Jurkat cells infected with H. pylori was evaluated by electrophoretic mobility shift assay. The role of NF-κB signaling in H. pylori-induced CD69 expression was analyzed using inhibitors of NF-κB and dominant-negative mutants. The isogenic mutants with disrupted cag pathogenicity island (cag PAI) and virD4 were used to elucidate the role of cag PAI-encoding type Ⅳ secretion system and CagA in CD69 ***: CD69 staining was detected in mucosal lymphocytes and macrophages in specimens of pa- tients with H. pylori-positive gastritis. Although cag PAI- positive H. pylori and an isogenic mutant of virD4 induced CD69 expression, an isogenic mutant of cag-PAI failed to induce this in Jurkat cells. H. pylori also induced CD69 expression in PBMCs and CD4 + T cells. The activation of the CD69 promoter by H. pylori was mediated through NF-κB. Transfection of dominant-negative mutants of IκBs, IκB kinases, and NF-κB-inducing kinase inhibited H. pylori-induced CD69 activation. Inhibitors of NF-κB suppressed H. pylori-induced CD69 mRNA expression. CONCLUSION: The results suggest that H. pylori induces CD69 expression through the activation of NF-κB. cagPAI might be relevant in the induction of CD69 expression in T cells. CD69 in T cells may play a role in H. pylori-induced gastritis.

关键词： CD69 T cells Helicobacter pylori cag pathogenicity island Nuclear factor-κB

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Using orbital sensitivity analysis to pinpoint the role of orbital interactions in thermoelectric power factor

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npj Computational Materials 2023年第1期9卷 937-945页

作者： Wenhao Zhang Jean-François Halet Takao mori WPI Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceTsukubaJapan Graduate School of Pure and Applied Sciences University of TsukubaTsukubaJapan CNRS-Saint-Gobain-NIMS Laboratory for Innovative Key Materials and Structures(LINK)National Institute for Materials ScienceTsukubaJapan

The modification of the electronic band structure is of critical importance for thermoelectric materials whose heat to electricity power generation is related to carrier effective mass and alignment of semiconductor band *** approach to optimize the electronic band structure is by modification of orbital interactions through doping or *** the current ab-initio quantum chemical calculations can help us to investigate orbital components of electronic bands,they reveal little information on the relative tunability of electronic states and transport properties with respect to orbital *** this work,we present a method,based on a symmetry-adapted tight-binding model and sensitivity analysis,that can pinpoint the role of orbital interactions in determining electronic band structure and transport *** an application,a systematic theoretical analysis is used to show how the power factor of PbTe can/cannot be improved by playing with interatomic orbital *** orbital interaction sensitivity analysis introduced in this work can easily be applied to other compounds or properties.

关键词： properties orbital symmetry

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Unfinished Revolution： A Paradox of Mourning Subjectivity in Su Manshu＇s The Lone Swan

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2015年第1期9卷 104-130页

作者： Makiko mori Department of Foreign Languages & Literatures Auburn University AL 36849 USA

Su Manshu＇s 苏曼殊（1884-1918） The Lone Swan （Duanhong lingyanji 断鸿零雁记, 1911, 1912） is best known for a sustained use of subjective voice and a thematic emphasis on tragic love. Critics have often credited the novella＇s intensely tragic narrative for spearheading a new kind of literary subjectivity that became a cornerstone of modern Chinese literature as heralded by the May Fourth critics in the late 1910s and the 1920s. However, very few have examined this new subjectivity as an effect of Su＇s critical engagement with a late Qing nationalist narrative. Su＇s novella was an appropriation of the anti-Manchu revolutionary narrative of a nation, which hinged on a paradoxical mode of envisaging a new China through a temporal return to the past and by means of a tragic sacrifice of the individual. Following a brief analysis of Su＇s early piece published in The People＇s Journal （Minbao 民报）, this article demonstrates how The Lone Swan elaborated on an excess of individual sacrifice, while developing the new, mourning subjectivity as a witness to the unfinished revolutionary enterprise of forging a powerful nation. Su＇s narrative of cultural devastation resonates with Lu Xun＇s （1881-1936） late Qing work, but, in the May Fourth period that immediately followed, this sense of despair would become an unequivocal obiect for overcoming.

关键词： Su Manshu anti-Manchu revolution mourning martyrdom literarymodernity

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Do predators prefer toxic animals?A case of chemical discrimination by an Asian snake that sequesters firefly toxins

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Current Zoology 2022年第6期68卷 627-634页

作者： Masaya FUKUDA Rinako UJIIE Takato INOUE Qin CHEN Chengquan CAO Li DING Naoki mori Akira mori Department of Zoology Graduate School of ScienceKyoto UniversityKyoto 606-8502Japan Department of Applied Life Science Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China College of Life Sciences Leshan Normal UniversityLeshanSichuan 614000China

Several Asian natricine snakes of the genus Rhabdophis feed on toads and sequester steroidal cardiac toxins known as bufadienolides(BDs)from them.A recent study revealed that species of the Rhabdophis nuchalis Group ingest lampyrine fireflies to sequester *** several species of fireflies are distributed in the habitat of the *** Group,only lampyrine fireflies,which have BDs,are included in the diet of these ***,we hypothesized that the *** Group chemically distinguishes fireflies that have BDs from those that do not have *** also predicted that the *** Group detects BDs as the chemical cue of toxin *** test these predictions,we conducted 3 behavioral experiments using Rhabdophis chiwen,which belongs to the *** *** the first experiment,*** showed a moderate tongue flicking response to cinobufagin,a compound of *** the other hand,the snake showed a higher response to the chemical stimuli of lampyrine fireflies(BD fireflies)than those of lucioline fireflies(non-BD fireflies).In the second experiment,in which we provided live BD and non-BD fireflies,the snake voluntarily consumed only the *** the third,a Y-maze experiment,the snake tended to select the chemical trail of BD fireflies more frequently than that of non-BD *** results demonstrated that *** discriminates BD fireflies from non-BD fireflies,but the prediction that BDs are involved in this discrimination was not fully *** identify the proximate mechanisms of the recognition of novel toxic prey in the *** Group,further investigation is necessary.

关键词： Bufadienolides chemical preference fireflies Rhabdophis toxin sequestration

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Autothermal reforming of biogas over a monolithic catalyst

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Journal of Natural Gas Chemistry 2010年第5期19卷 477-481页

作者： Sadao Araki Naoe Hino Takuma mori Susumu Hikazudani Hitachi Zosen Corporation Business & Product Development HeadquartersTechnical Research Institute

This study focused on measurement of the autothermal reforming of biogas over a Ni based monolithic catalyst. The effects of the steam/CH4 （S/C） ratio, O2/CH4 （O2/C） ratio and temperature were investigated. The CH4 conversions were higher under all examined temperatures than the equilibrium conversion calculated using the blank outlet temperature, because the catalyst layer was heated by the exothermic catalytic partial oxidation reaction. The CH 4conversion increased with increasing O2/C ratio. Moreover, the CH4 conversion was higher than the equilibrium conversion calculated using the blank outlet temperature for O2/C〉0.42 and reached about 100% at O2/C=0.55. However, the hydrogen concentration decreased for O2/C〉0.45 because hydrogen was combusted to steam in the presence of excess oxygen. On the other hand, the hydrogen and CO2 concentrations increased and the CO concentration decreased with increasing SIC ratio. As a result, it was found that the highest hydrogen concentrations and CH4 conversions were attained at the O2/C ratios of 0.45-0.55 and the SIC ratios of 1.5-2.5. Moreover, the H2/CO ratio could also be controlled in the range from about 2 to 3.5 to give at least 90% CH4 conversion, by regulating the O2/C or S/C ratios.

关键词： autothermal reforming biogas hydrogen production monolithic catalyst Ni based catalyst

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Supercontinuum Lightwave Sources for Photonic Networks

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光学学报 2003年第S1期23卷 733-734页

作者： Kunihiko mori NTT Network Innovation Laboratories NTT Corporation 1-1 Hikari-no-oka Yokosuka Kanagawa 239-0847 Japan

WDM optical sources based on supercontinuum (SC) generation are reviewed. The design of an SC lightwave source is described that uses a scaling rule among the parameters in an SC generating fiber and a seed optical pu... 详细信息

关键词： for in et on SC Supercontinuum Lightwave Sources for Photonic Networks WDM

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The responses of carbon-and nitrogen-acquiring enzymes to nitrogen and phosphorus additions in two plantations in southern China

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Journal of Forestry Research 2020年第4期31卷 1319-1324页

作者： Senhao Wang Taiki mori Jiangming Mo Wei Zhang Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems and Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou 510650GuangdongPeople’s Republic of China Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyotoJapan University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

In tropical plantations,nutrients such as nitrogen(N)or phosphorus(P)are often applied as management ***,the effects of such nutrient additions on topsoil C-and N-acquiring enzymes activities are *** this study,the impacts of fertilization onβ-1,4-glucosidase(BG),β-D-cellobiosidase(CBH),β-1,4-xylosidase(BX),β-1,4-N-acetyl-glucosaminidase(NAG),and leucine amino peptidase(LAP)enzymes activities from topsoil and litter layer of two tropical plantations(Acacia auriculiformis and Eucalyptus urophylla)were *** results showed that N addition had neutral impact on topsoil enzymes,while significantly elevating the activities of BG,CBH,BX,and NAG in the litter layer.P fertilization had no impacts except for an elevation of NAG in litter *** was no interactions found between N and P additions on these enzyme *** clearer impacts of N over P fertilization were unexpected because that the study site receives a high rate of atmospheric N deposition,and has low soil P *** impact of P fertilization on hydrolytic enzyme activities may be less important compared with that of N.

关键词： Tropical tree plantation Ecoenzymes Fertilization Forest management

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Enhancing of nominal characteristic trajectory following control for motion systems

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Journal of Systems Engineering and Electronics 2017年第6期28卷 1221-1235页

作者： Fitri Yakub Shamsul Sarip Andika Aji Wijaya Yasuchika mori Malaysia-Japan International Institute of Technology University of Technology MalaysiaKuala Lumpur 54100Malaysia Razak School of Engineering and Advanced Technology University of Technology MalaysiaKuala Lumpur54100Malaysia Department of Industrial Engineering University of Business and TechnologyJeddah 21361Saudi Arabia Graduate School of System Design Tokyo Metropolitan UniversityTokyo 191-0065Japan

The goal of this paper is to enhance a practical nominal characteristic trajectory following(NCTF) controller that is specifically designed for two-mass point-to-point positioning systems. A nominal characteristics trajectory contained in the NCTF controller acts as movement/motion reference and a compensator is utilized to force the object to detect and follow the reference/desired trajectory. The object must follow and track closely and should be as fast as possible. The NCTF controller is designed with two different intelligent based compensator approaches which are fuzzy logic and extended minimal resource allocation network. The proposed controller which is NCTF are compared with the conventional proportional integral compensator. Then the results of simulation are discussed for the positioning performances. The inertia variations due to the effect of the design parameters are also assessed to see the robustness of controllers. The results show that the NCTF control method designed from an intelligent based compensator has a better positioning performance in terms of percentage of overshoot, settling time, and steady state error than the classical based compensator.

关键词： two-mass rotary system intelligent approach classi cal method mechanical vibration nominal characteristic trajectory following

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Ru complex and N,P-containing polymers confined within mesoporous hollow carbon spheres for hydrogenation of CO_(2)to formate

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Nano Research 2023年第4期16卷 4515-4523页

作者： Guoxiang Yang Yasutaka Kuwahara Kohsuke mori Catherine Louis Hiromi Yamashita Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute for Open and Transdisciplinary Research Initiatives(OTRI) Osaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Unit of Elements Strategy Initiative for Catalysts&Batteries(ESICB) Kyoto UniversityKatsuraKyoto 615-8520Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan Sorbonne Université CNRSLaboratoire de Réactivitéde SurfaceLRSF-75005 ParisFrance

The development of reliable catalysts with both excellent activity and recyclability for carbon dioxide(CO_(2))hydrogenation is ***,a ternary hybrid heterogeneous catalyst,involving mononuclear Ru complex,N,P-containing porous organic polymers(POPs),and mesoporous hollow carbon spheres(Ru^(3+)-POPs@MHCS)is reported for CO_(2)hydrogenation to *** on comprehensive structural analyses,we demonstrated that Ru^(3+)-POPs were successfully immobilized within *** optimized Ru^(3+)-0.5POPs@MHCS catalyst,which was obtained with about 5 wt.%Ru^(3+)and 0.5 mmol POPs polymers confined into 0.3 g MHCS,exhibited high catalytic activity for CO_(2)hydrogenation to formate(turnover number(TON)>1,200 for 24 h under mild reaction conditions(4.0 MPa,120℃))and improved durability,compared to Ru^(3+)catalysts without POPs polymers(Ru^(3+)-MHCS)and unencapsulated MHCS(Ru^(3+)-0.5POPs)*** improved catalytic performance is attributed to the high surface area and large pore volume of MHCS which favors dispersion and stabilization of Ru^(3+)-***,the MHCS and POPs showed high CO_(2)adsorption ***^(3+)-POPs encapsulated into MHCS reduces the activation energy barrier for CO_(2)hydrogenation to formate.

关键词： heterogeneous catalysis porous organic polymers(POPs) mesoporous hollow carbon spheres CO_(2)hydrogenation formate synthesis

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Microstructure analysis and thermoelectric properties of iron doped CuGaTe_(2)

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Journal of Materiomics 2018年第3期4卷 221-227页

作者： Fahim Ahmed Naohito Tsujii Takao mori International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Namiki 1-1Tsukuba 305-0044Japan Graduate School of Pure and Applied Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8577Japan

Chalcopyrite related compounds have attracted much attention in recent years due to their promising thermoelectric *** this research we report Fe doping in chalcopyrite-type CuGaTe_(2)and its influence on structural and thermal transport *** synthesized polycrystalline samples with composition CuGa_(1-x)Fe_(x)Te_(2)with x=0.0 to 0.05 by spark plasma sintering *** structural analysis powder X-ray diffraction and electron probe micro analysis were *** of Fe in CuGaTe_(2)was found to be very small,and other phases like FeTe_(2)and CuTe were *** conductivity showed a significant decrease with the addition of Fe up to x=0.02,which started to increase for x≥*** the other hand,the addition of Fe caused slight increase in the power factor from 1.3mW/K^(2)m for x=0.0 to 1.6 mW/K^(2)m for x=0.02 at T=770 *** a result,ZT peak value of 0.92 is recorded for x=0.02 at 870 K,which corresponds to an enhancement of 60%from that of non-doped CuGaTe_(2).This work demonstrates that thermoelectric properties of compositematerials can be greatly improved by controlling its microstructure.

关键词： Thermoelectric CuGaTe_(2) Microstructure Seebeck coefficient Thermal conductivity Composite material

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