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Type 2 diabetes in children and adolescents:Exploring the disease heterogeneity and research gaps to optimum management

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World Journal of Clinical Pediatrics 2024年第2期13卷 80-99页

作者： Subhodip Pramanik Sunetra Mondal Rajan Palui sayantan Ray Department of Endocrinology Neotia Getwel Multi-specialty hospitalSiliguri 734010West BengalIndia Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia

Over the past 20 years,the incidence and prevalence of type 2 diabetes mellitus(T2DM)in children and adolescents have increased,particularly in racial and ethnic *** the rise in T2DM in children and adolescents,the pathophysiology and progression of disease in this population are not clearly ***-onset T2DM has a more adverse clinical course than is seen in those who develop T2DM in adulthood or those with ***,the available therapeutic options are more limited for children and adolescents with T2DM compared to adult patients,mostly due to the challenges of implementing clinical trials.A better understanding of the mechanisms underlying the development and aggressive disease phenotype of T2DM in youth is important to finding effective prevention and management *** review highlights the key evidence about T2DM in children and adolescents and its current burden and challenges both in clinical care and research activities.

关键词： Type 2 diabetes mellitus Children and adolescents Pathophysiology Heterogeneity Complications Treatment options Barriers

Unilateral neuropathic arthropathy of the shoulder secondary to syringomyelia: Diagnostic challenges

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World Journal of Clinical Cases 2015年第12期3卷 1017-1020页

作者： Partha Pratim Chakraborty Saumik Datta sayantan Ray Rana Bhattacharjee Subhankar Chowdhury Department of Endocrinology Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital

Neuropathic arthropathy of the shoulder is a rare disorder characterized by joint degeneration, and is associated with loss of sensory innervation. Syringomyelia is a disease in which fluid-containing cavities(syrinxes) form within the spinal cord. Here, we report a case of neuropathic arthropathy of the shoulder secondary to syringomyelia in a 40-year-old woman. X-rays of the left shoulder revealed damage to bone and joint architecture. Blood tests indicated vitamin D deficiency and secondary hyperparathyroidism. Magnetic resonance imaging of the cervical spine showed a large syrinx from the second cervical spine to the second dorsal spine. Although neuropathic arthropathy is uncommon, it should be considered in cases of unexplained pain, discomfort, or limited range of motion of the affected joint. Symptoms related to the affected joint may precede or overshadow neurological deficits. Appropriate radiological examinations and diagnoses are imperative to prevent misdiagnosis or undetected bone and joint disorders.

关键词： Neuropathic arthropathy Charcot shoulder Syringomyelia Magnetic resonance imaging Vitamin D deficiency

Liver abscess caused by Burkholderia pseudomallei in a young man: A case report and review of literature

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World Journal of Clinical Cases 2014年第10期2卷 604-607页

作者： Partha Pal sayantan Ray Avijit Moulick Subhasis Dey Anirban Jana Kokila Banerjee Department of General Medicine Calcutta National Medical College and Hospital Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Bankura Sammilani Medical College and Hospital Department of Microbiology Drs. Tribedi and Roy Diagnostic Laboratory

Pyogenic liver abscess is a common entity in Indian subcontinent and is mostly caused by gram negative bacteria. Melioidosis is not commonly seen in India and only a few cases are reported. It can give rise to multiple abscesses at different sites including liver. We report a case of isolated liver abscess caused by Burkholderia pseudomallei(B. pseudomallei) in a 29-yearold recently diagnosed diabetic, immunocompetent male. Diagnosis was made by imaging and culture of pus aspirated from the abscess and he was treated with percutaneous pigtail catheter drainage followed by antibiotics(meropenem and trimethoprim-sulphmethoxazole). Melioidosis is an emerging infection in India and has high mortality rate, so early diagnosis and promptmanagement is warranted which requires clinical vigilance and an intensive microbiological workup. Clinicians should be aware of isolated liver abscess caused by B. pseudomallei in appropriate clinical settings.

关键词： Liver abscess Diabetes Burkholderia pseudomallei Emerging infection India

Poncet's disease: An unusual presentation of tuberculosis in a diabetic lady

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World Journal of Clinical Cases 2015年第4期3卷 385-388页

作者： Partha Pratim Chakraborty sayantan Ray Chitra Selvan Rana Bhattacharjee Sanjay Kumar Mandal Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Medical College and Hospital

Authors describe a 53-year-old woman who presentedto their diabetes clinic with a three week history of multiple painful and swollen joints. She had been diagnosed with type 2 diabetes 5 years back. On examination, both knee joints and left ankle were swollen. A soft tissue swelling appeared over the medial end of the left clavicle few days later. Rheumatoid arthritis, collagen vascular diseases and other common causes of polyarthritis were ruled out by appropriate investigations. Non steroidal anti-inflammatory drugs failed to give satisfactory pain relief and the arthritis persisted. Conventional cultures of synovial fluid samples including cultures for tuberculosis were negative. Computed tomography showed a space occupying lesion involving the left sternoclavicular joint. Fine needle aspiration from the lesion was performed and acidfast bacilli were demonstrated in the smear using ZiehlNeelsen stain. The explanation of her arthritis was therefore tuberculous arthritis in left sternoclavicular joint and reactive arthritis in the rest of the joints. A diagnosis of Poncet's disease was considered in her case. We treated her with standard anti-tuberculosis drugs and the arthritis resolved within a few days. She remained symptom-free at her 2 years' follow-up.

关键词： Poncet’s disease Diabetes Tuberculous arthritis Reactive arthritis Acid-fast bacilli

Exact Solution of Second Grade Fluid in a Rotating Frame through Porous Media Using Hodograph Transformation Method

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Journal of Applied Mathematics and Physics 2015年第11期3卷 1443-1453页

作者： sayantan Sil Manoj Kumar Department of Physics S.S.L.N.T. Mahila College Dhanbad India Post Graduate Department of Physics Ranchi College Ranchi India

In this paper exact solution for a homogenous incompressible, second grade fluid in a rotating frame through porous media has been provided using hodograph-Legendre transformation method. Results are summarised in the... 详细信息

关键词： Non-Newtonian Fluid Rotating Frame Hodograph Transformation Porous Media Exact Solution

Optimization of Electrical Parameters for Production of Carbon Nanotubes

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Journal of Minerals and Materials Characterization and Engineering 2012年第10期11卷 961-964页

作者： sayantan Chattopadhyay Kalyan Kumar Singh Department of Mechanical Engineering & Mining Machinery Engineering Indian School of Mines (ISM) Dhanbad India

For more than two decades, there had been extensive research on the production of carbon nanotubes (CNT) and opti- mization of its manufacture for the industrial applications. It is believed that they are the strong enough but most flexi- ble materials known to mankind. They have potential to take part in new nanofabricated materials. It is known that, carbon nanotubes could behave as the ultimate one-dimensional material with remarkable mechanical properties. More- over, carbon nanotubes exhibit strong electrical and thermal conducting properties. In the process of optimizing the production in line with the industrial application, the researchers have found a new material to act as an anode i.e. coal, which is inexpensive as compared to graphite. There are various methods such as arc discharge, laser ablation, chemical vapour deposition (CVD), template-directed synthesis and the use of the growth of CNTs in the presence of catalyst particles. The production of carbon nanotubes in large quantities is possible with inexpensive coal as the starting carbon source by the arc discharge technique. It is found that a large amount of carbon nanotubes of good quality can be ob- tained in the cathode deposits in which carbon nanotubes are present in nest-like bundles. This paper primarily concen- trates on the optimising such parameters related to the mass production of the product. It has been shown through Sim- plex process that based on the cost of the SWNT obtained by the arc discharge technique, the voltage and the current should lie in the range of 30 - 42 V and 49 - 66 A respectively. Any combination above the given values will lead to a power consumption cost beyond the final product cost, in turn leading to infeasibility of the process.

关键词： Coal Carbon Nanotubes SWCNT Simplex Optimization

Non-alcoholic fatty liver disease in type 2 diabetes:Emerging evidence of benefit of peroxisome proliferator-activated receptors agonists and incretin-based therapies

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World Journal of Methodology 2024年第2期14卷 38-50页

作者： Subhodip Pramanik Partha Pal sayantan Ray Department of Endocrinology Neotia Getwel Multispecialty HospitalSiliguri 734010West BengalIndia Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Endocrinology All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia

Nonalcoholic fatty liver disease(NAFLD)is a global epidemic,affecting more than half of the people living with type 2 diabetes(T2D).The relationship between NAFLD and T2D is bidirectional and the presence of one perpetuates the other,which significantly increases the hepatic as well as extrahepatic *** recently,there was no approved pharmacological treatment for NAFLD/nonalcoholic steatohepatitits(NASH).However,there is evidence that drugs used for diabetes may have beneficial effects on *** sensitizers acting through peroxisome proliferator-activated receptor(PPAR)modulation act on multiple levels of NAFLD ***(PPARγ agonist)and saroglitazar(PPARα/γagonist)are particularly beneficial and recommended by several authoritative bodies for treating NAFLD in T2D,although data on biopsyproven NASH are lacking with the *** data on elafibanor(PPARα/δ agonist)and Lanifibranor(pan PPAR agonist)are *** the other hand,incretin therapies based on glucagon-like peptide-1(GLP-1)receptor agonists(GLP-1RA)and dual-and triple-hormone receptor co-agonists reported impressive weight loss and may have anti-inflammatory and antifibrotic ***-1 RAs have shown beneficial effects on NAFLD/NASH and more studies on potential direct effects on liver function by dual-and triple-agonists are ***,the long-term safety of these therapies in NAFLD needs to be *** efforts among healthcare providers such as primary care doctors,hepatologists,and endocrinologists are warranted for selecting patients for the best possible management of NAFLD in T2D.

关键词： Non-alcoholic fatty liver disease Type 2 diabetes Evidence PPAR agonists Incretin-based therapies

Neural Network Approach to Response of Buildings Due to Earthquake Excitation

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International Journal of Geosciences 2012年第3期3卷 630-639页

作者： sayantan Chakraborty Prashant Kumar Swapan Kumar Chakraborty Department of Applied Mathematics B. I. T. Mesra Ranchi 835215 Jharkhand India Department of Civil Engineering B.E.S.U. Shibpur Howrah West Bengal India

The present article investigates the physical phenomena associated with the wave passage effect into a building considering the ground floor as the soft floor with the conformity of the up-to-date scenario of the construction of high rise buildings, due to shear excitation of the base. The aim of the study is to analyse the post-earthquake situation of the building in respect to its health. With this vision, the ensuing problem on two-dimensional building models, non-incorporating soil-structure interaction, is being tackled by both analytical and neural network approaches. Computational results from both ends (of the approaches) show that the wave energy does not always propagate from the ground into the building, but for lower frequency range it sails to the building without any disturbances. However, for higher frequency range, the computational results show that the building experiences large “torsional” deformations, as a result the building may collapse. Finally, both the approaches maintain a good agreement among themselves. The present investigation may lead to a long way in contributing to better and more rational, simplified design criteria.

关键词： Neural Network Anisotropic Building Soft Ground Floor

Induced defense response in red mango fruit against Colletotrichum gloeosporioides

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Horticulture Research 2021年第1期8卷 212-222页

作者： Pradeep Kumar Sudheeran Noa Sela Mira Carmeli-Weissberg Rinat Ovadia sayantan Panda Oleg Feygenberg Dalia Maurer Michal Oren-Shamir Asaph Aharoni Noam Alkan Department of Postharvest Science of Fresh Produce Agricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel Department of Plant Pathology and Weed Research AROVolcani CenterRishon LeZion 7505101Israel Department of Fruit Tree Sciences Agricultural Research OrganizationVolcani CenterPO Box 6Bet-Dagan 7505101Israel Department of Ornamental Plants and Agricultural Biotechnology AROVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel

Mango fruit exposed to sunlight develops red skin and are more resistant to biotic and abiotic *** we show that harvested red mango fruit that was exposed to sunlight at the orchard is more resistant than green fruit to Colletotrichum *** analysis showed high amounts of antifungal compounds,as glycosylated flavonols,glycosylated anthocyanins,and mangiferin in red *** mango skin,correlated with higher antioxidant and lower ***,also the green side of red mango fruit that has low levels of flavonoids was resistant,indicated induced *** of red and green fruit inoculated on their red and green sides with *** were ***,in red fruit skin,2,187 genes were upregulated in response to *** the green side of red mango,upregulation of 22 transcription factors and 33 signaling-related transcripts indicated induced *** RNA-Seq analysis suggests that resistance of the whole red fruit involved upregulation of ethylene,brassinosteroid,and phenylpropanoid *** conclude,red fruit resistance to fungal pathogen was related to both flavonoid toxicity and primed resistance of fruit that was exposed to light at the orchard.

关键词： gloeosporioides resistance fruit