This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate a...
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This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,dNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ***ever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever *** on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,didysimulans ***.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph *** new species are Amanita cornelii,***,Angustimassarina alni,***,***,***,***,Ascochyta italica,***,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,***,***,***,***,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,dacrymyces chiangraiensis,didysimulans italica,***,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,***,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,***nae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,***,***,Keissleriella cirsii,Lepiota cylindrocystidia,***,***,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,***tata,***,Panus subf
AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine ***: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanat...
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AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine ***: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. Effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(dSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BdF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase ***: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both dSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P d disease activity index(P drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever s
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