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Current status of hepatitis E virus infection at a rhesus monkey farm in China

Current status of hepatitis E virus infection at a rhesus mo...

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第十五届中国实验动物科学年会

作者： Fengmei Yang Suqin Duan Yingqiu Guo Yanyan Li sayaka yoshizaki Naokazu Takeda Takaji Wakita Masamichi Muramatsu Yuan Zhao Zhanlong He Tian-Cheng Li Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical College Department of Virology II National Institute of Infectious Diseases Research Institute for Microbial Diseases Osaka University

Rhesus and several other species of monkeys are susceptible to genotypes of hepatitis E virus(HEV),and these species are thus commonly used as animal models for experimental HEV ***,information regarding HEV infection in monkeys in nature or at monkey farms is *** investigate the status of HEV infection in rhesus monkeys at farms,we collected 548 serum and 48 fecal samples from a rhesus monkey farm in China,and analyzed their levels of anti-HEV IgG antibodies and HEV *** enzyme-linked immunosorbent assay using genotype 3 HEV-like particles as antigen revealed anti-HEV IgG-positivity in 388(70.8%) *** antibody-positive rates in the 1-year-old and 2-year-old monkeys were signifificantly lower than those in monkeys > 3 years *** antibody-positive rate was greatly increased from 7.4% in the2-year-old monkeys to 100% in the 3-year-olds,suggesting that the latter received HEV infection at a high *** RNA was detected in one of 88 sera from 1-and 2-year-old monkeys and 10 of 48 fecal specimens from 3-year-old monkeys by reverse transcription-polymerase chain *** analyses revealed that the HEV strain RmKM15 was present in a serum sample that belonged to subtype 4 b in genotype 4,whereas 10 strains detected in the fecal specimens belonged to subtype 4 h,suggesting that two genetically difffferent strains were circulating at the ***,no signifificant clinical signs were observed in these *** studies are required to identify the source of infection and to evaluate the pathogenicity of HEV in rhesus monkeys.

关键词： Hepatitis E virus(HEV) Rhesus monkey ELISA Anti-HEV IgG

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