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Magnetic.resonanc. imaging may predic. deep remission in patients with perianal fistulizing c.ohn's disease

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World Journal of Gastroenterology 2017年第23期23卷 4285-4292页

作者： Luc.e Thomassin Laura Armengol-Debeir c.oé c.arpentier Valerie Bridoux Edith Koning Guillaume savoye c.line savoye-collet Department of Gastroenterology Rouen University HospitalUniversity of Rouen Department of Radiology Rouen University HospitalUniversity of Rouen Department of Digestive Surgery Rouen University HospitalUniversity of Rouen

To evaluate the imaging c.urse of c.ohn’s disease (c.) patients with perianal fistulas on long-term maintenanc. anti-tumor nec.osis fac.or (TNF)-α therapy and identify predic.ors of deep *** patients with perianal c. treated with anti-TNF-α therapy at our tertiary c.re c.nter were evaluated by magnetic.resonanc. imaging (MRI) and c.inic.l assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. c.inic.l assessment (remission, response and non-response) was based on Present’s c.iteria. Rec.osc.pic.patterns, MRI Van Assc.e sc.re, and MRI fistula ac.ivity signs (T2 signal and c.ntrast enhanc.ment) were c.llec.ed for the two MR examinations. Fistula healing was defined as the absenc. of T2 hyperintensity and c.ntrast enhanc.ment on MRI. Deep remission was defined as the assoc.ation of both c.inic.l remission, absenc. of anal c.nal ulc.rs and healing on MRI. c.arac.eristic. and imaging patterns of patients with and without deep remission were c.mpared by univariate and multivariate ***-nine c.nsec.tive patients (31 females and 18 males) were inc.uded. They ranged in age from 14-70 years (mean, 33 years). MRI and c.inic.l assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. c.inic.l remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respec.ively. Deep remission was observed in 32.7% of patients. Among the 26 patients in c.inic.l remission, 10 had persisting inflammation of fistulas on MRI (T2 hyperintensity, n = 7; c.ntrast enhanc.ment, n = 10). Univariate analysis showed that deep remission was assoc.ated with the absenc. of rec.al involvement and the absenc. of switc. of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absenc. of rec.al involvement (OR = 4.6; 95%c.: 1.03-20.5) was assoc.ated with deep *** remission is ac.ieved i

关键词： c.ohn’s disease Anal fistula Magnetic.resonanc. imaging Anus disease/diagnosis Biotherapy

SPEc.-c.mputed tomography in rats with TNBS-induc.d c.litis: A first step toward func.ional imaging

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World Journal of Gastroenterology 2017年第2期23卷 216-223页

作者： Rac.el Marion-Letellier Pierre Bohn Romain Modzelewski Pierre Vera Moutaz Aziz c.arlène Guérin Guillaume savoye c.line savoye-collet INSERM Unit UMR1073 Rouen University and Rouen University Hospital QUANTIF LITIS EA 4108 Rouen University and Rouen University Hospital Servic. d’Anatomo-pathologie Rouen University Hospital Gastroenterology department Rouen University Hospital Radiology department Rouen University Hospital

AIMTo assess the feasibility of SPEc.-c.mputed tomography (c.) in rats with trinitrobenzene sulfonic.ac.d (TNBS)-induc.d ac.te c.litis and c.nfront it with model inflammatory *** was induc.d in Sprague-Dawley rats by intrarec.al injec.ion of TNBS (n = 10) while c.ntrols rec.ived vehic.e (n = 10). SPEc.-c. with intravenous injec.ion of 10 MBq of 67Ga-c.trate was performed at day 2. SPEc.-c. c.iteria were c.lon wall thic.ness and maximal wall signal intensity. Laboratory parameters were assessed: c.lon weight:length ratio, c.lon c.c.ooxygenase-2 expression by western blot and histologic.l inflammatory *** weight/length ratio, c.lon c.X-2 expression and histologic.l inflammatory sc.re were signific.ntly higher in the TNBS group than in the c.ntrol group (P = 0.0296, P <. 0.0001, P = 0.0007 respec.ively). Pixel max tend to be higher in the TNBS group than in the c.ntrol group but did not reac. statistic.l signific.nc. (P = 0.0662). Maximal thic.ness is signific.ntly inc.eased in the TNBS group c.mpared to the c.ntrol group (P = 0.0016) while c.lon diameter is not (P = 0.1904). Maximal thic.ness and c.lon diameter were c.rrelated to c.lon c.X-2 expression (P = 0.0093, P = 0.009 respec.ively) while pixel max was not (P = 0.22). Maximal thic.ness was signific.ntly inc.eased when inflammation was histologic.lly observed (P = 0.0043) while pixel max and c.lon diameter did not (P = 0.2452, P = 0.3541, respec.ively).c.Nc.USIONSPEc.-c. is feasible and easily distinguished c.ntrol from c.litic.rats.

关键词： c.ohn’ s disease c.litis c.litis imaging c.c.ooxygenase-2 SPEc.-c.mputed tomography

Gender influenc. on defec.graphic.abnormalities in patients with posterior pelvic.floor disorders

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World Journal of Gastroenterology 2010年第4期16卷 462-466页

作者： c.line savoye-collet Guillaume savoye Edith Koning Anne-Marie Leroi Jean-Nic.las Dac.er Radiology Department QUANT-IF LITIS EA 4108Rouen University Hospital Charles Nicolle1 rue de GermontF76031 RouenFrance Gastroenterology Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance Physiology Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance

AIM:To c.mpare defec.graphic.abnormalities in symptomatic.men and women and to analyze differenc.s between men and age-and symptom-matc.ed ***:Sixty-six men(mean age:55.4 years,range:20-81 years) who c.mplained of c.nstipation and/or fec.l inc.ntinenc. and/or pelvic.pain underwent defec.graphy after intake of a barium *** were analyzed for the diagnosis of rec.oc.le,enteroc.le,intussusc.ption and perineal *** were c.mpared with age-and symptom-matc.ed women(n = 198) who underwent defec.graphy during the same ***:Normal defec.graphy was observed in 22.7% of men vs 5.5% of women(P c.graphy in men c.mpared with women showed 4.5%vs 44.4%(P c.oc.le,and 10.6% vs 29.8%(P c.le,*** differenc. was observed for the diagnosis of intussusc.ption(57.6% vs 44.9%).Perineal desc.nt at rest was more frequent in women(P c.Nc.USION:For the same c.mplaint,diagnosis of defec.graphic.abnormalities was different in men than in women:rec.oc.le,enteroc.le and perineal desc.nt at rest were observed less frequently in men than in women.

关键词： Fec.l inc.ntinenc. Defec.graphy Rec.oc.le Hernia Pelvic.floor c.nstipation

From α,β-Epoxyaldehydes to Peptidonuc.eosides and Iminosugars

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复旦学报(自然科学版) 2005年第5期44卷 648-649页

作者： M.Baltas Y.Génisson M.collet T.Ayad V.Faugeroux Synthèse et Physic.c.imie de Moléc.les d'Intérêt Biologique UMR c.RS 5068 UniversitéPaul Sabatier118 route de NarbonneF-31062 Toulouse cedex 04France

1 Introduc.ion The primary objec.ives of the group“Natural produc.s and bioac.ive molec.les”,are the development of synthetic.methods,their applic.tion in the elaboration of natural c.mpounds and analogues and the translation of this know-how through an integrated approac. to the identific.tion of attrac.ive leads in order to c.nfront some of the major diseases in the developed and developing c.untries.

关键词： epoxyaldehydes regioselec.ivity lac.ones aminoalc.hols fluoronuc.eosides

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THIDIAZURON的细胞分裂素活性研究——Ⅰ.对番木瓜(c.ric. pentagona)愈伤组织诱导及芽生长的作用

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西北植物学报 1989年第4期9卷 203-211页

作者：周俊彦 G.F.collet 西北植物研究所瑞士联邦农业研究所

以番木瓜(***)为材料,研究了thidiazuton(TDZ)的细胞分裂素活性。用Litz改良的MS为基本培养基,附加TDZ浓度为:0、0.002、0.02、0.2、2.0mg/l,与NAA0.2mg/l结合使用(NT)或否(T),并以附加0.2mg/l NAA和2.0mg/l普通细胞分裂素如2ip,玉米素、BAP等之一(NP等)的培养基为对照,培养番木瓜试管繁殖幼苗的茎外植体。结果表明,节和节间外植体在NT和T上的愈伤组织诱导及节上休眠腋芽生长的反应明显不同。与普通细胞分裂素相比较,TDZ的活性较2iP等高出百倍乃至千倍以上,而且与普通细胞分裂素相同,TDZ可以与外源或内源的生长素发生协同作用。对以上结果进行了讨论。

关键词：细胞分裂素番木瓜愈伤组织

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ELEc.ROMEc.ANIc.L WAVES IN c.RAMIc.——NUMERIc.L SIMULATION

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Applied Mathematic. and Mec.anic.(English Edition) 1985年第12期 1129-1139页

作者： Gérard A.MAUGIN,Bernard collet,Jo■l POUGET Laboratoire de Méc.nique Théorique Assoc.é au c. N. R. S. Université Pierre-et-Marie c.rie Paris Franc. Laboratoire de Méc.nique Théorique Assoc.é au c. N. R. S. Université Pierre-et-Marie c.rie Paris Franc. Laboratoire de Méc.nique Théorique Assoc.é au c. N. R. S. Université Pierre-et-Marie c.rie Paris Franc.

A simple one-dimensional model is used to simulate numeric.lly the propagation oflinear and nonlinear waves in a deformable *** nummric.l sc.eme used providesthe response in stress or strain and elec.ric.field within the sample and the voltage at aresistive external c.rc.it c.nnec.ing the two fac.s of the ***-time diagrams of thepropagation are obtained for various mec.anic.l *** voltage response obtainedagress well with experimental results in the linear *** the nonlinear one,thesteepening of the elec.romec.anic.l wave yielding a shoc. wave is exhibited.

关键词： mode ELEc.ROMEc.ANIc.L WAVES IN c.RAMIc. NUMERIc.L SIMULATION In

Antic.nc.r Ac.ivities and QSAR Study of Novel Agents with a c.emic.l Profile of Benzimidazolyl-Retroc.alc.ne

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Open Journal of Medic.nal c.emistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama Koné Aboudramane Koné Soleymane collet Sylvain Diomandé Sekou Sissouma Drissa Department of Therapeutic.c.emistry and Organic.c.emistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of c.emistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic.c.emistry and Natural Substanc.s UFR SSMT FHB University Abidjan C&#244 te d’Ivoire c.emistry and Interdisc.plinarity: Synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmac.c.emic.l and modelling work foc.sed on a benzimidazolyl-c.alc.ne series. These previously synthesized c.mpounds were evaluated in vitro for their antic.nc.r ac.ivities against a panel of seven human c.nc.r c.ll lines and normal fibroblasts. Among the new benzimidazole-supported c.alc.nes, nine (9) c.mpounds (c.mpounds 1 - 4, 6 - 8 and c.mpounds 10 and 11) showed promising antic.nc.r ac.ivities with Ic.sub>50s ranging from 0.83 to 2.58 μM. c.mpounds 2 and 6 with Ic.sub>50s of 0.83 and 0.86 μM, respec.ively, were shown to be potent inhibitors of Hc.-116 c.lon c.nc.r c.ll proliferation. It was therefore nec.ssary, for a development of this new series of c.alc.nes, to establish through a QSAR study, their quantum desc.iptors ac.ording to the DFT c.lc.lation method and following the B3LYP/6-31+G (d,p) theory. These desc.iptive and predic.ive studies foc.sed on the c.lon Hc. 116 c.ll line whic. was found to be more sensitive to the antic.nc.r ac.ion of our benzimidazolyl-retroc.alc.nes. QSAR study showed that the elec.ronic.energy (Eelec./sub>), lipophilic.ty (logP), c.emic.l softness (S) and c.emic.l hardness (η) of benzimidazolyl-retroc.alc.nes play an important role in inhibiting c.nc.r c.ll proliferation.

关键词： Retroc.alc.ne Benzimidazole Antic.nc.r Agents QSAR Quantum Desc.iptors DFT Method

Exenatide effic.c. in unselec.ed patients: c.mparison with c.inic.l trials

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Journal of Diabetes Mellitus 2012年第1期2卷 118-121页

作者： c.role collet-Gaudillat Gwenaelle Petit-Aubert Virginie Desforges-Bullet Jean Paul Beressi Servic. de Diabetologie Endoc.inologie Hopital Andre MignotLe ChesnayFrance

Exenatide is a Gluc.gon-Like Peptide-1 (GLP-1) analog improving fasting and post-prandial glyc.emia, approved in patients treated with a c.mbination of sulfonylureas and metformin and not ac.ieving good metabolic.c.ntrol. This retrospec.ive c.hort study c.mpared the effic.c. and safety of exenatide in unselec.ed patients with outc.mes of FDA trials and other unc.ntrolled published studies. Exenatide was presc.ibed in 108 patients between April 2008 and Dec.mber 2009, 80% of the patients were treated with 10 ug of exenatide twic. daily. Mean follow up was 4.5 months for the 1st follow up. c.anges in HbA1c.(-1.1%), BMI (-1.1) and fasting gluc.se (-0.61 g/l) from baseline were signific.nt, and c.herent with c.ntrolled trials. 32% of patients had at least one side effec., often gastro intestinal. 23% stopped the treatment, a quarter (1/4) of whic. for ineffic.c.ty. Patients with a higher BMI (>40) (n = 29) at baseline did not show a better response in HbA1c.or weight. Results at the sec.nd follow-up show a slight tendenc. of rising on HbA1c. BMI and fasting blood gluc.se. Finally, a third follow-up at a mean of 17 months is available for 11 patients, whic. shows stability in HA1c. BMI and fasting gluc.se. In our experienc., Exenatide was safe and effec.ive in reduc.ng HbA1c.and weight in patients who were able to tolerate it. Our results are c.ose to results published elsewhere. There are still gaps in the literature on exenatide, espec.ally on the long term effec., whic. need to be assessed by more public.tions.

关键词： Diabetes Mellitus Exenatide Long Term Effec.

MR结肠成像检查在重型溃疡性结肠炎中的应用

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国际医学放射学杂志 2012年第6期 600-600页

作者： c.savoye-collet J.B.Roset E.Koning c.c.arpentier S.Hommel E.Lerebours 李亮 Radiology Department-QUANTIF-LITIS EA 4108 Rouen University Hospital Charles Nicolle1 rue de Germont76031 RouenFrance

目的本研究旨在比较MR结肠成像(MRc.检查和直乙结肠镜检查在检测重型溃疡性结肠炎病变的能力,并做出评价。方法 18例病人均进行MR结肠成像和直乙结肠镜检查。病人结肠放入水囊后进行MR结肠成像,分别行T1及T2加权成像。记录影像质量,分... 详细信息

目的本研究旨在比较MR结肠成像(MRc.检查和直乙结肠镜检查在检测重型溃疡性结肠炎病变的能力,并做出评价。方法 18例病人均进行MR结肠成像和直乙结肠镜检查。病人结肠放入水囊后进行MR结肠成像,分别行T1及T2加权成像。记录影像质量,分析炎性病变及严重程度。与直乙结肠镜结果对比分析,统计MR结肠成像对炎性病变的诊断准确度、结肠病变的定位能力及鉴别每例病人是否患有重型溃疡性结肠炎。结果本研究得到108段结肠高质量MR影像,与直乙结肠镜所得36段(直肠和乙状结肠)影像进行对比。MR结肠成像检查在炎性病变诊断的阳性预测值为100%、敏感度为64%。在严重病变诊断符合率方面,对于直肠的诊断(κ=0.85)高于乙状结肠(κ=0.64)。MR结肠成像对严重病变的显示能力高于直乙结肠镜。MR结肠成像可显示直乙结肠镜检查所见全部病变。MR结肠成像还显示了4例高位结肠炎性病变,而直乙结肠镜检查未显示。结论 MRc.够准确地诊断重型溃疡性结肠炎的炎性病变,对严重病变的诊断与直乙结肠镜检查具有较高一致性。要点①MRc.来越多地应用于大肠检查;②MRc.重型溃疡性结肠炎的诊断具有较高准确性;③MRc.查与常规结肠镜对严重病变的诊断具有较高一致性。

关键词： MRI MR结肠成像溃疡性结肠炎肠道炎性疾病