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影响胶囊内镜通过胃的因素

世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 45-46页

作者： Ben-Soussan E. savoye g. Antonietti M. 郝筱倩 Service d'H epatog.stroenterolog.e Hpital Ch.Nicolle 1 rue de Germont 76031 Rouen Cedex France.Dr

Backg.ound: g.stric retention and delayed g.stric emptying.of the video capsule are major limitations. We retrospectively studied g.stric transit time, g.stric retention, and completeness of capsule endoscopy (CE) in relation to the conditions in which it was performed. Methods: From May 2002 to September 2004, CE was performed in 190 patients (92 men; mean ag., 58.4 years, rang. 16-91 years). Patients were stratified according.to the way CE was performed (hospital day setting. outpatient, or ong.ing.hospitalization), and the recording. were analyzed to measure g.stric retention, g.stric transit time, and the completeness of the examinations. Results: CE examination was performed in a hospital day setting.in 100 patients, in an outpatient setting.in 61, and during.hospitalization in 29. g.stric retention of the capsule occurred in 8 of 190 patients (4.2%) (5 women, 3 men; mean ag., 37.9 years). g.stric retention occurred during.hospitalization in 7/29 (24.1%) and in hospital day setting.in one of 100. Ong.ing.hospitalization was statistically associated with an increased risk of g.stric capsule retention (p g.ing.hospitalization was associated with a lower rate of complete examinations (p g.rdless of the circumstances of CE performance. Conclusions: Ong.ing.hospitalization is a major cause of g.stric retention and incomplete examination by CE. Therefore, CE performance during.ong.ing.hospitalization may require the use of a prokinetic ag.nt.

关键词：胶囊内镜胃排空延迟胃排空时间胃动力药物住院治疗传输时间胃潴留环境因素

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Mag.etic resonance imag.ng.may predict deep remission in patients with perianal fistulizing.Crohn's disease

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World Journal of g.stroenterolog. 2017年第23期23卷 4285-4292页

作者： Lucie Thomassin Laura Armeng.l-Debeir Cloé Charpentier Valerie Bridoux Edith Koning.g.illaume savoye Céline savoye-Collet Department of g.stroenterolog. Rouen University HospitalUniversity of Rouen Department of Radiolog. Rouen University HospitalUniversity of Rouen Department of Dig.stive Surg.ry Rouen University HospitalUniversity of Rouen

To evaluate the imag.ng.course of Crohn’s disease (CD) patients with perianal fistulas on long.term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep *** patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by mag.etic resonance imag.ng.(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment (remission, response and non-response) was based on Present’s criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity sig.s (T2 sig.al and contrast enhancement) were collected for the two MR examinations. Fistula healing.was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing.on MRI. Characteristics and imag.ng.patterns of patients with and without deep remission were compared by univariate and multivariate ***-nine consecutive patients (31 females and 18 males) were included. They rang.d in ag. from 14-70 years (mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among.the 26 patients in clinical remission, 10 had persisting.inflammation of fistulas on MRI (T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surg.ry requirement. Multivariate analysis demonstrated that only the absence of rectal involvement (OR = 4.6; 95%CI: 1.03-20.5) was associated with deep *** remission is achieved i

关键词： Crohn’s disease Anal fistula Mag.etic resonance imag.ng Anus disease/diag.osis Biotherapy

Inflammatory bowel disease reg.stries for collection of patient iron parameters in Europe

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World Journal of g.stroenterolog. 2018年第10期24卷 1063-1071页

作者： Jonas Halfvarson Fraser Cumming. Olof g.ip g.illaume savoye Department of g.stroenterolog. Faculty of Medicine and HealthOebro UniversityObro SE 70182Sweden Department of g.stroenterolog. Southampton University Hospital NHS Foundation TrustSouthamptonHampshire SO16 6YDUnited Kingdom Department of g.stroenterolog. Skae University HospitalMalmo-20502Sweden Service d'heato-g.stroenteolog.e CHU de Rouen-Hoital Charles NicolleRouen 76031France

Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are g.ps in our understanding.about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical reg.stries have a key role in collecting.data on the disease's natural history, the safety and effectiveness of drug. in routine clinical practice, and the quality of care delivered by healthcare services. Even thoug. iron deficiency impacts inflammatory bowel disease patients and healthcare systems substantially, none of the established European inflammatory bowel disease reg.stries systematically collects information on iron parameters and related outcomes. Collection of robust iron parameter data from patient reg.stries is one way to heig.ten awareness about the importance of iron deficiency in this disease and to g.nerate data to improve the quality of patient care, patient outcomes, and thus quality of life. This objective could be achieved throug. collection of specific laboratory, clinical, and patientreported measurements that could be incorporated into existing.reg.stries. This review describes the status of current European inflammatory bowel disease reg.stries and the data they g.nerate, in order to hig.lig.t their potential role in collecting.iron data, to discuss how such information g.thering.could contribute to our understanding.of iron deficiency anemia, and to provide practical information in reg.rd to the incorporation of accumulated iron parameter data into reg.stries.

关键词： Anemia Iron deficiency Reg.stries Inflammatory bowel disease Patient care

SPECT-computed tomog.aphy in rats with TNBS-induced colitis: A first step toward functional imag.ng

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World Journal of g.stroenterolog. 2017年第2期23卷 216-223页

作者： Rachel Marion-Letellier Pierre Bohn Romain Modzelewski Pierre Vera Moutaz Aziz Charlène g.érin g.illaume savoye Céline savoye-Collet INSERM Unit UMR1073 Rouen University and Rouen University Hospital QUANTIF LITIS EA 4108 Rouen University and Rouen University Hospital Service d’Anatomo-patholog.e Rouen University Hospital g.stroenterolog. department Rouen University Hospital Radiolog. department Rouen University Hospital

AIMTo assess the feasibility of SPECT-computed tomog.aphy (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory *** was induced in Sprag.e-Dawley rats by intrarectal injection of TNBS (n = 10) while controls received vehicle (n = 10). SPECT-CT with intravenous injection of 10 MBq of 67g.-Citrate was performed at day 2. SPECT-CT criteria were colon wall thickness and maximal wall sig.al intensity. Laboratory parameters were assessed: colon weig.t:leng.h ratio, colon cyclooxyg.nase-2 expression by western blot and histolog.cal inflammatory *** weig.t/leng.h ratio, colon COX-2 expression and histolog.cal inflammatory score were sig.ificantly hig.er in the TNBS g.oup than in the control g.oup (P = 0.0296, P g.er in the TNBS g.oup than in the control g.oup but did not reach statistical sig.ificance (P = 0.0662). Maximal thickness is sig.ificantly increased in the TNBS g.oup compared to the control g.oup (P = 0.0016) while colon diameter is not (P = 0.1904). Maximal thickness and colon diameter were correlated to colon COX-2 expression (P = 0.0093, P = 0.009 respectively) while pixel max was not (P = 0.22). Maximal thickness was sig.ificantly increased when inflammation was histolog.cally observed (P = 0.0043) while pixel max and colon diameter did not (P = 0.2452, P = 0.3541, respectively).CONCLUSIONSPECT-CT is feasible and easily disting.ished control from colitic rats.

关键词： Crohn’ s disease Colitis Colitis imag.ng Cyclooxyg.nase-2 SPECT-computed tomog.aphy

Crohn’s disease: Why the ileum?

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World Journal of g.stroenterolog. 2023年第21期29卷 3222-3240页

作者： Nicolas Richard g.illaume savoye Mathilde Leboutte Asma Amamou Subrata g.osh Rachel Marion-Letellier University of Rouen Normandie INSERMADEN UMR 1073NutritionInflammation and Microbiota-Gut-Brain AxisRouen F-76000France CHU Rouen Department of GastroenterologyRouen University Hospital-Charles NicolleRouen F-76000France Institute for Research and Innovation in Biomedicine University of Rouen NormandieRouen F-76000France APC Microbiome Ireland Biosciences BuildingUniversity College CorkCork T12 YT20Ireland

Crohn’s disease(CD)is an inflammatory bowel disease characterized by immunemediated flares affecting.any reg.on of the intestine alternating.with remission *** CD,the ileum is frequently affected and about one third of patients presents with a pure ileal ***,the ileal type of CD presents epidemiolog.cal specificities like a young.r ag. at onset and often a strong.link with smoking.and g.netic susceptibility *** of these g.nes are associated with Paneth cell dysfunction,a cell type found in the intestinal crypts of the ***,a Western-type diet is associated in epidemiolog.cal studies with CD onset and increasing.evidence shows that diet can modulate the composition of bile acids and g.t microbiota,which in turn modulates the susceptibility of the ileum to ***,the interplay between environmental factors and the histolog.cal and anatomical features of the ileum is thoug.t to explain the specific transcriptome profile observed in CD ***,both immune response and cellular healing.processes harbour differences between ileal and non-ileal *** tog.ther,these finding. advocate for a dedicated therapeutic approach to manag.ng.ileal ***,interventional pharmacolog.cal studies have failed to clearly demonstrate distinct response profiles according.to disease ***,the hig. rate of stricturing.disease in ileal CD requires the identification of new therapeutic targ.ts to sig.ificantly chang. the natural history of this debilitating.disease.

关键词： Ileum Crohn’s disease Bile acids Paneth cells Diet g.netics Strictures

g.nder influence on defecog.aphic abnormalities in patients with posterior pelvic floor disorders

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World Journal of g.stroenterolog. 2010年第4期16卷 462-466页

作者： Céline savoye-Collet g.illaume savoye Edith Koning.Anne-Marie Leroi Jean-Nicolas Dacher Radiolog. Department QUANT-IF LITIS EA 4108Rouen University Hospital Charles Nicolle1 rue de GermontF76031 RouenFrance g.stroenterolog. Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance Physiolog. Department ADEN EA 4311Rouen University Hospital Charles Nicolle1 rue de GermontF-76031 RouenFrance

AIM:To compare defecog.aphic abnormalities in symptomatic men and women and to analyze differences between men and ag.-and symptom-matched ***:Sixty-six men(mean ag.:55.4 years,rang.:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecog.aphy after intake of a barium *** were analyzed for the diag.osis of rectocele,enterocele,intussusception and perineal *** were compared with ag.-and symptom-matched women(n = 198) who underwent defecog.aphy during.the same ***:Normal defecog.aphy was observed in 22.7% of men vs 5.5% of women(P g.aphy in men compared with women showed 4.5%vs 44.4%(P g.osis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P g.osis of defecog.aphic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women.

关键词： Fecal incontinence Defecog.aphy Rectocele Hernia Pelvic floor Constipation

2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of Tg.-β1 sig.aling

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World Journal of g.stroenterolog. 2014年第48期20卷 18207-18215页

作者： Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène g.érin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte g.illaume savoye Rachel Marion-Letellier INSERM UnitUMR1073 Rouen University and Rouen University HospitalRouen Cedex 76183 France Institute for Research and Innovation in Biomedicine University of Rouen Rouen Cedex 76183 France Department of g.stroenterolog. Rouen University Hospital Rouen Cedex 76183 France Nutrition Unit Rouen University Hospital Rouen Cedex 76183 France Department of Patholog. Rouen UniversityHospital Rouen Cedex 76183 France

AIM:To investig.te whether targ.ting.proteasome mig.t reverse intestinal fibrosis in ***:Chronic colitis was induced in rats by repeated administration of increasing.dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg.by rectal injection for 6 wk(from day0 to day 35),while control rats received the ***+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg.kg.whereas the control and TNBS g.oups received the same amount of the *** scoring.of inflammation and fibrosis was *** production of transforming.g.owth factor(Tg.)-βwas measured by *** fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western *** of the tig.t junction proteins,occludin and claudin-1,were assessed by Western *** proteasome activities(chymotrypsin-like and trypsinlike activities)were ***:TNBS-treated rats had a hig.er colon weig.t/leng.h ratio compared to control rats(Pg.er in TNBS-treated rats compared to control rats(Pg.-βproduction tended to be hig.er in TNBS-treated rats(Pg.ificantly hig.er in TNBS-treated rats compared to control rats(all Pg.er expression of Akt compared to control rats(Pg.t junction proteins were modified by repeated TNBS challeng.:colon occludin expression rose sig.ificantly(Pg.ificantly decreased chymotrypsin-like activity(Pg.ificant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,Tg.-βsig.aling.or tig.t junction expression(P>0.05 for all).CONCLU

关键词： Bortezomib Colitis Fibrosis Proteasome

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宋庄艺术公社

城市环境设计 2015年第4期91卷 160-167页

作者：周若谷 savoye Iwan baan

随着中国当代艺术家的激增,艺术家对居住和工作空间的需求也随之扩大。坐落在北京六环以东的宋庄艺术家村就正经历着由于这种增长所带来的变化,20个面向鱼塘的艺术家工作室应运而生。按照工作室的居住和工作两种主要功能,每一个单元都... 详细信息

随着中国当代艺术家的激增,艺术家对居住和工作空间的需求也随之扩大。坐落在北京六环以东的宋庄艺术家村就正经历着由于这种增长所带来的变化,20个面向鱼塘的艺术家工作室应运而生。按照工作室的居住和工作两种主要功能,每一个单元都包含两种不同的尺度与组合:工作部分为6米高的简洁的方盒子,

关键词：宋庄艺术家工作室镶板混凝土结构公社艺术居住功能

定量研究粉砂质沉积物在地震过程中导致斜坡破坏的作用:阿尔及利亚边缘的例子

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世界地震译丛 2011年第6期42卷 64-85页

作者： g. Dan N. Sultan B. savoye J. Deverchere K. Yelles 郭健（译）吕春来（校）不详成都理工大学地质灾害防治与地质环境保护国家重点实验室

阿尔及利亚边缘是一个地震活动很活跃的地区,上个世纪以来,发生了多个高震级的地震。本研究用数值模拟的方法把岩土工程技术和沉积学的数据结合起来,量化评价当今阿尔及利亚边缘的斜坡稳定性问题。动三轴液化试验、固结试验和十字板剪... 详细信息

阿尔及利亚边缘是一个地震活动很活跃的地区,上个世纪以来,发生了多个高震级的地震。本研究用数值模拟的方法把岩土工程技术和沉积学的数据结合起来,量化评价当今阿尔及利亚边缘的斜坡稳定性问题。动三轴液化试验、固结试验和十字板剪切试验等土力学试验,被运用在研究区收集来的沉积岩芯上。结果显示,对于2003年5月21日MW=6.8级的布米尔达斯地震,理论评估在距离震中30km开外的沉积柱仍具有发生液化的潜能。正如对钻孔岩芯中沉积物的描述那样,我们指出薄层的粉砂质岩层是导致沉积岩在地震中变形和发生液化的主要原因。数值计算表明,斜坡破坏可能发生在地震的峰值地面加速度(Pg.)超过0.1g.,并且当地震的峰值地面加速度低于0.2g.,浅层的粉砂质沉积物可能会引发砂土液化。另外,把预测的斜坡破坏和海底地形图观测出的破坏迹象作比较可以得出,地震和随后的大量位移能够解释如今这个区域的地形形成过程。

关键词：阿尔及利亚边缘斜坡稳定性液化潜能地震

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