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World Journal of Gastroenterology 2006年第15期12卷 2402-2405页

作者： Giovanni D De Palma Maria Rega Stefania Masone Marcello Persico saverio siciliano Pietro Addeo Giovanni Persico Centro di Eccellenza per 1'Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale e Tecnologie Avanzate Università degli Studi di Napoli Federico ⅡFacoltà di Medicina e ChirurgiaNapoliItaly

AIM： To accurately differentiate the adenomatous from the non-adenomatous polyps by colonoscopy. METHODS： All lesions detected by colonoscopy were first diagnosed using the conventional view followed by chromoendoscopy with magnification. The diagnosis at each step was recorded consecutively. All polyps were completely removed endoscopically for histological evaluation. The accuracy rate of each type of endoscopic diagnosis was evaluated, using histological findings as gold standard. RESULTS： A total of 240 lesions were identified, of which 158 （65.8%） were non-neoplastic and 82 （34.2%） were adenomatous. The overall diagnostic accuracy of conventional view, and chromoendoscopy with magnification was 76.3% （183/240） and 95.4% （229/240）, respectively （P〈 0.001） CONCLUSION： The combination of colonoscopy and magnified chromoendoscopy is the most reliable nonbiopsy method for distinguishing the non-neoplastic from the neoplastic lesions.

关键词： Colorectal polyps Colonoscopy Chromoendoscopy Magnifying endoscopy

In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy

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World Journal of Gastroenterology 2011年第5期17卷 677-680页

作者： Giovanni D De Palma Stefania Staibano saverio siciliano Francesco Maione Maria Siano Dario Esposito Giovanni Persico Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgerySection of Diagnostic and Therapeutic EndoscopyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly

Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was *** this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in *** study involved a patient presenting long-standing *** imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological *** mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination.

关键词： Colonoscopy Confocal laser endomicros-copy Chronic ulcerative colitis Dysplasia-associatedlesional mass Histology

Lower gastrointestinal bleeding secondary to a rectal leiomyoma

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World Journal of Gastroenterology 2009年第14期15卷 1769-1770页

作者： Giovanni D De Palma Maria Rega Stefania Masone saverio siciliano Marcello Persico Francesca Salvatori Francesco Maione Dario Esposito Antonio Bellino Giovanni Persico Department of Surgery and Advanced Technologies Center for Technical Innovation in Surgery University of Naples Federico II School of Medicine Via Pansini 5 Naples 80131 Italy

The occurrence of leiomyoma of the rectum is uncommon. Most of these lesions are clinically silent and are found incidentally during laparotomy or endoscopic procedures for unrelated conditions. Symptomatic leiomyomas of the rectum are encountered less frequently, with only sporadic reports in the literature. We describe a case of a leiomyoma of the rectum presenting as recurrent lower gastrointestinal hemorrhage and secondary anemia.

关键词： Rectal leiomyoma Gastrointestinal bleeding Endoscopy Endoscopic ultrasonography Immunohistochemistry

Contrast-free endoscopic stent insertion in malignant biliary obstruction

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World Journal of Gastroenterology 2007年第29期13卷 3973-3976页

作者： Giovanni D De Palma Giovanni Lombardi Maria Rega Immacolata Simeoli Stefania Masone saverio siciliano Francesco Maione Francesca Salvatori Antonio Balzano Giovanni Persico Department of General Surgery Oncologic Surgery and Advanced Technologies-Center for Technical Innovation in Surgery University of Naples Federico Ⅱ School of Medicine Naples Italy Division of Gastroenterology General Hospital A. Cardarelli Naples Italy

AIM： To present a case series of MRCP-guided endoscopic biliary stent placement, performed entirely without contrast injection. METHODS： Contrast-free endoscopic biliary drainage was attempted in 20 patients with malignant obstruction, unsuitable for resection on the basis of tumor extent or medical illness. MRCP images were used to confirm the diagnosis of tumor, to exclude other biliary diseases and to demonstrate the stenoses as well as dilation of proximal liver segments. The procedure was carried out under conscious sedation. Patients were placed in the left lateral decubitus position. The endoscope was inserted, the papilla identified and cannulated by a papiUotome. A guide wire was inserted and guided deeply into the biliary tree, above the stenosis, by fluoroscopy. A papillotomy approximately 1 cm. long was performed and the papillotome was exchanged with a guiding-catheter. A 10 Fr＇ Amsterdam-type plastic stent, 7 to 15 cm long, was finally inserted over the guide wire/ guiding catheter by a pusher tube system. RESULTS： Successful stent insertion was achieved in all patients. There were no major complications. Successful drainage, with substantial reduction in bilirubin levels, was achieved in all patients. CONCLUSION： This new method of contrast-free endoscopic stenting in malignant biliary obstruction is a safe and effective method of palliation. However＇ a larger, randomized study comparing this new approach with the standard procedure is needed to confirm the findings of the present study.

关键词： Endoscopic retrograde cholangiopancreatography Biliary stenoses Biliary drainage Endoscopy Stents

Endoscopic approach to malignant strictures at the hepatic hilum

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World Journal of Gastroenterology 2007年第30期13卷 4042-4045页

作者： Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Francesca Salvatori saverio siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico Department of General Surgery Oncologic Surgery and Advanced Technologies Center for Technological Innovation in Surgery (ITC) University of Naples Federico Ⅱ School of Medicine Naples Italy

Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions （type Ⅱ lesions or higher）. The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented.

关键词： Malignant biliary stenoses Endoscopic retrograde cholangiopancreatography Endoscopic prostheses

Multimodal nonlinear microscopy: A powerful label-free method for supporting standard diagnostics on biological tissues

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 1-16页

作者： Riccardo Cicchi Francesco saverio Pavone National Institute of Optics National Research Council(INO-CNR)Largo E.Fermi6 50125 FlorenceItaly European Laboratory for Nonlinear Spectroscopy(LENS)University of Florence Sesto FiorentinoItaly Department of Physics University of Florence Sesto FiorentinoItaly International Center of Computational Neurophotonics(ICON)Florence Italy

The large use of nonlinear laser scanning microscopy in the past decade paved the way forpot ential clinical application of this imaging *** nonlinear microscopy techniquesoffer promising label-free solutions to improve diagnostic performances on *** particular,the combination of multiple nonlinear imaging techniques in the same microscope allows inte-grating_morphological with functional information in a morpho-functional *** provides a high-resolution label-free alternative to both histological and immunohis-tochemicai examination of tissues and is becoming increasingly popular among the ***,several technical improvements,including automatic scanning andimage analysis,are required before the technique represents a standard diagnostic *** thisreview paper,we highlight the capabilit ies of multimodal nonlinear microscopy for tissue inaging,by providing various examples on colon,arterial and skin *** comparison between images acquired using multimodal nonlinear microscopy and histology shows a good agreement bet ween the two *** results demonstrate that multimodal nonlinear microscopy is apowerful label-free alternative to standard histopathological methods and has the potential tofind a stable place in the clinical setting in the near future.

关键词： Non-linear microscopy tissue imaging.

A General Approach to L(h,k)-Label Interconnection Networks

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Journal of Computer Science & Technology 2008年第4期23卷 652-659页

作者： Tiziana Calamoneri saverio Caminiti Rossella Petreschi Department of Computer Science Sapienza University of Rome

Given two non-negative integers h and k, an L（h, k）-labeling of a graph G = （V, E） is a function from the set V to a set of colors, such that adjacent nodes take colors at distance at least h, and nodes at distance 2 take colors at distance at least k. The aim of the L（h, k）-labeling problem is to minimize the greatest used color. Since the decisional version of this problem is NP-complete, it is important to investigate particular classes of graphs for which the problem can be efficiently solved. It is well known that the most common interconnection topologies, such as Butterfly-like, Beneg, CCC, Trivalent Cayley networks, are all characterized by a similar structure： they have nodes organized as a matrix and connections are divided into layers. So we naturally introduce a new class of graphs, called （l × n）-multistage graphs, containing the most common interconnection topologies, on which we study the L（h, k）-labeling. A general algorithm for L（h, k）-labeling these graphs is presented, and from this method an efficient L（2, 1）-labeling for Butterfly and CCC networks is derived. Finally we describe a possible generalization of our approach.

关键词： multistage interconnection network L(h k)-labeling channel assignment problem

Adolescent male genitalia dissatisfaction:a surgical perspective

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Asian Journal of Andrology 2022年第2期24卷 176-179页

作者： Nicola Zampieri Ilaria Dando Francesco saverio Camoglio Woman and Child Hospital Pediatric Surgical UnitUniversity of VeronaVerona 37100Italy Department of Neurosciences Biomedicine and Movement SciencesBiochemistry SectionUniversity of VeronaVerona 37100Italy

Genital dissatisfaction is well known in female and *** is known about male adolescents and their genital *** aim of this study was to investigate and report the role of surgery in male adolescents to improve the evaluation of their *** considered all patients treated for external genital pathology in the period of *** and exclusion criteria were *** underwent an evaluation test before and after *** the study period,137 patients were treated,and at the end of the study,98 cases were considered for *** most frequent pathologies were webbed penis and penile curvature.A postoperative score improvement was noted and patients with concealed penis and webbed penis showed a better postoperative *** was considered an important factor associated with a worse preoperative *** of the external genitalia is important in adolescents,and it is an understudied *** may be associated with a worse evaluation of one’s genital and should be clinically considered to avoid related social problems in ***,cosmetic genital surgery should be considered even in male adolescents.

关键词： adolescent esthetic genital dissatisfaction surgery

Endoscopic ultrasound-guided biliary drainage after failed endoscopic retrograde cholangiopancreatography: The road is open for almighty biliopancreatic endoscopists!

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2765-2768页

作者： Filippo Antonini Ilenia Merlini Salomone Di saverio Gastroenterology and Interventional Endoscopy UnitMazzoni Hospital AST Ascoli Piceno Ascoli Piceno 63100Italy Department of Surgery Madonna del Soccorso Hospital AST Ascoli PicenoSan Benedetto del Tronto 63074Italy

Commentary on the article written and published by Peng et al,investigating the role of endoscopic ultrasound(EUS)-guided biliary drainage for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiopan-creatography(ERCP).For 40 years endoscopic biliary drainage was synonymous with ERCP,and EUS was used mainly for diagnostic *** advent of therapeutic EUS has revolutionized the field,especially with the development of a novel device such as electrocautery-enhanced lumen-apposing metal *** biliopancreatic endoscopists with both skills in ERCP and in interven-tional EUS,would be ideally suited to ensure patients the best drainage technique according to each individual situation.

关键词： Cholestasis Drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound Endosonography Endoscopic retrograde cholangiopancreatogra-phy Interventional procedures Jaundice Malignant Biliary obstruction

Portomesenteric venous thrombosis:An early postoperative complication after laparoscopic biliopancreatic diversion

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World Journal of Gastroenterology 2015年第8期21卷 2546-2549页

作者： Manuela Cesaretti Hosam Elghadban Nicola Scopinaro Francesco saverio Papadia Department of Surgery San Martino Hospital University of Genoa

The number of bariatric operations,as well as the incidence of perioperative complications,has risen sharply in the past ten *** acute portal vein thrombosis is an infrequent and potentially severe postoperative complication that has not yet been reported after biliopancreatic diversion(BPD).Three cases are presented of portal vein thrombosis that occurred following BPD treatment for morbid obesity and type 2 *** thromboses were detectedby abdominal ultrasound and computed tomography with intravenous *** portomesenteric venous thromboses in all three cases presented as unexpected abdominal pain several days after discharge from the *** complications occurred despite adequate perioperative prophylaxis and progressed to bowel gangrene in the diabetic patients *** cases demonstrate the occurrence of this rare type of complication,which may be observed by physicians that do not routinely treat bariatric *** of this surgical complication will allow for early diagnosis and prompt initiation of adequate therapy.

关键词： Portal thrombosis Laproscopy Bariatric surgery Bil