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Advances in laparoscopy for acute care surgery and trauma

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World Journal of Gastroenterology 2016年第2期22卷 668-680页

作者： Matteo Mandrioli Kenji Inaba Alice Piccinini Andrea Biscardi Massimo Sartelli Ferdinando Agresta Fausto Catena Roberto Cirocchi Elio Jovine Gregorio Tugnoli Salomone Di saverio Department of Emergency and General Surgery and Trauma Surgery Unit C.A.Pizzardi Maggiore Hospital Trauma Center40133 BolognaItaly Division of Trauma Surgery and Surgical Critical Care Department of SurgeryUniversity of Southern CaliforniaLos AngelesCA 90033United States Department of Surgery Macerata Hospital62100 MacerataItaly Department of Surgery Adria Hospital45011 AdriaRovigoItaly Department of Emergency and Trauma Surgery Maggiore Hospital43126 ParmaItaly Departement of Digestive Surgery and Liver Unit St.Maria Hospital05100 TerniPerugiaItaly

The greatest advantages of laparoscopy when compared to open surgery include the faster recovery times, shorter hospital stays, decreased postoperative pain, earlier return to work and resumption of normal daily activity as well as cosmetic benefits. Laparoscopy today is considered the gold standard of care in the treatment of cholecystitis and appendicitis worldwide. Laparoscopy has even been adopted in colorectal surgery with good results. The technological improvements in this surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its utilization in operations with fully intracorporeal anastomoses. Further progress in laparoscopy has included single-incision laparoscopic surgery and natural orifice trans-luminal endoscopic surgery. Nevertheless, laparoscopy for emergency surgery is still considered challenging and is usually not recommended due to the lack of adequate experience in this area. The technical difficulties of operating in the presence of diffuse peritonitis or large purulent collections and diffuse adhesions are also given as reasons. However, the potential advantages of laparoscopy, both in terms of diagnosis and therapy, are clear. Major advantages may be observed in cases with diffuse peritonitis secondary to perforated peptic ulcers,for example, where laparoscopy allows the confirmation of the diagnosis, the identification of the position of the ulcer and a laparoscopic repair with effective peritoneal washout. Laparoscopy has also revolutionized the approach to complicated diverticulitis even when intestinal perforation is present. Many other emergency conditions can be effectively managed laparoscopically, including trauma in select hemodynamically-stable patients. We have therefore reviewed the most recent scientific literature on advances in laparoscopy for acute care surgery and trauma in order to demonstrate the current indications and outcomes associated with a la

关键词： Laparoscopy Acute care surgery Singleincisionlaparoscopic surgery Natural orifice transluminalendoscopic surgery Trauma

The Effect of Bergamot-Derived Polyphenolic Fraction on LDL Small Dense Particles and Non Alcoholic Fatty Liver Disease in Patients with Metabolic Syndrome

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Advances in Biological Chemistry 2014年第2期4卷 129-137页

作者： Micaela Gliozzi Cristina Carresi Vincenzo Musolino Ernesto Palma Carolina Muscoli Cristiana Vitale Santo Gratteri Giuseppe Muscianisi Elzbieta Janda saverio Muscoli Francesco Romeo Salvatore Ragusa Rocco Mollace Ross Walker James Ehrlich Vincenzo Mollace Interregional Research Centre for Food Safety & Health University “Magna Graecia” of Catanzaro Catanzaro Italy San Raffaele IRCCS Rome Italy University of Rome “Tor Vergata” Rome Italy

The occurrence of Metabolic Syndrome (MS) represents an independent risk factor for developing cardiovascular disease states in patients suffering from type 2 diabetes mellitus. Moreover, both the size of LDL particles and liver dysfunction identified as non alcoholic fatty liver disease (NAFLD) represent important biomarkers for the development of cardiometabolic risk in patients with MS. Here we studied the effect of bergamot polyphenolic fraction (BPF) in patients with MS and NAFLD. 107 patients were enrolled at the San Raffaele IRCCS (Rome). All of them showed ultrasonografic evidences of NAFLD and at least three out of five previous identified criteria for the diagnosis of MS. Patients were divided into two groups: one receiving placebo and the second receiving BPF 650 mg twice a day for 120 consecutive days. In the group receiving BPF 650 mg twice a day, a significant reduction of fasting plasma glucose, serum LDL cholesterol and triglycerides alongside with an increase of HDL cholesterol was found. This effect was accompanied by significant reduction of both ultrasonographic and metabolic biomarkers of NAFLD. Moreover, a significant reduction of small dense LDL particles, as detected via proton NMR Spectroscopy, was found after BPF treatment. In conclusion, our data confirm the beneficial effect of bergamot-extract in patients with MS an effect highlighted by significant reduction of small dense LDL particles and by improvement of NAFLD biomarkers. This suggests a potential preventive role of bergamot derivatives in reducing cardiometabolic risk.

关键词： Metabolic Syndrome Non Alcoholic Fatty Liver Disease Cardiometabolic Risk Bergamot Polyphenolic Fraction

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2015第54届米兰国际家具展

流行色 2015年第5期 126-145页

作者：王婷 Salone del Mobile.Milano Andrea Mariani Alessandro Russotti Carola Merello saverio Lombardi Vallauri

4月14日到19日，第54届米兰国际家具展在米兰Rho国际展览中心如期举行。作为世界范围内最重要的家居展会，米兰国际家具展吸引着来自全球的展商、设计师和业内人士踊跃参与。

关键词：国际家具展米兰国际展览中心世界范围业内人士 Rho 设计师

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在米兰体验自然的奇妙之旅

设计 2018年第12期31卷 152-155页

作者： Salone del Mobile.Milano Courtesy Salone del Mobile.Milan saverio Lombardi Vallauri Andrea Mariani

4月17日至25日,米兰国际家具展在米兰主教座堂广场前,人们可以零距离与大自然和谐共存,体验一个情感和感官都将得以充分触动的奇妙之旅,并反思当代生活中可持续发展的可能性。作为第57届米兰国际家具展的馆外展示项目,＂体验自然＂（La ... 详细信息

4月17日至25日,米兰国际家具展在米兰主教座堂广场前,人们可以零距离与大自然和谐共存,体验一个情感和感官都将得以充分触动的奇妙之旅,并反思当代生活中可持续发展的可能性。作为第57届米兰国际家具展的馆外展示项目,＂体验自然＂（La Natura dell’Abitare）与国际知名的设计事务所Carlo Ratti Associati（CRA）合作.

关键词：大自然米兰国际家具展可持续发展和谐共存 dell 零距离事务所

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Transumbilical laparoscopic-assisted appendectomy in children: Clinical and surgical outcomes

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World Journal of Gastrointestinal Endoscopy 2014年第4期6卷 101-104页

作者： Zampieri Nicola Scirè Gabriella Mantovani Alberto Camoglio Francesco saverio Pediatric Surgical Unit Department of Surgical SciencesUniversity of Verona

The aim of this paper is to present and describe tran-sumbilical laparoscopic-assisted appendectomy in chil-dren, focusing on its technical aspects and clinical andsurgical outcomes. The surgical charts of all patientsaged between 0 and 14 years treated with transumbili-cal laparoscopic-assisted appendectomy admitted tothe authors' institution from January 2009 to Septem-ber 2013 with a diagnosis of suspected appendicitis fol-lowing clinical, laboratory and ultrasound findings werereviewed. Operating time, intraoperative findings, needfor conversion or for additional trocars, and surgicacomplications were reported. During the study period,120 patients aged between 6 and 14 years(mean age:9.9 years), 73 females(61%) and 47 males(39%),were treated with transumbilical laparoscopic-assistedappendectomy. There were 37 cases of hyperemicappendicitis(subserosal and retrocecal), 74 cases ofphlegmonous appendicitis and 9 cases of perforatedgangrenous appendicitis. It was not possible to estab-lish a correlation between grade of appendicitis andmean operating time(P > 0.05). Eleven cases(9%)needed the use of one additional trocar, while 8 pa-tients(6%) required conversion to the standard laparo-scopic technique with the use of two additional trocars. No patient was converted to the open technique. Tran-sumbilical laparoscopic-assisted appendectomy is a safe technique in children and it could be used by surgeons who want to approach other minimally invasive tech-niques.

关键词： Appendectomy Children Minimally invasive surgery Transumbilical Procedure

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2018国际厨房家具展探索“未来厨房”

设计 2018年第12期31卷 156-159页

作者： Salone del Mobile.Milano Chris Courtesy Salone del Mobile.Milano saverio Lombardi Vallauri

4月底,在米兰国际家具展举办的同期,第7届国际厨房家具展FTK（Technology For the Kitchen）也在米兰国际展览中心如火如荼地进行着。Aloys Dornbracht（Dornbracht）、Ar？elik（Beko、Grundig）、Asko Appliances、Aton、Barazza、Ber... 详细信息

关键词：国际家具展厨房 Electrolux 国际展览中心 Bora 米兰

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Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation

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World Journal of Gastroenterology 2015年第13期21卷 3912-3920页

作者： Stefano Gitto Luca saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone Department of Medical and Surgical Sciences University of Bologna and Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’Orsola Malpighi40138 BolognaItaly Department of Gastroenterology Azienda Ospedaliero-Universitaria and University of Modena and Reggio Emilia41124 ModenaItaly Department of Hepatology and Gastroenterology Niguarda Hospital20162 MilanItaly Hepatobiliopancreatic and General Surgery Unit Regina Elena Institute00186 RomeItaly Department of General Surgery and Transplantation Niguarda Hospital20162 MilanItaly

AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic ***: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders"(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

关键词： Hepatitis C Liver transplantation Hepatitis C viru

为 Budd-Chiari 症候群的 caval 自体移植片由于劣等的静脉 cava 阻塞

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World Journal of Hepatology 2013年第5期5卷 292-295页

作者： Andrea Mancuso Luigi Martinelli Luciano De Carlis Antonio Gaetano Rampoldi Giovanni Magenta Aldo Cannata Luca saverio Belli Epatologia e Gastroenterologia Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Cardiochirurgia Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Chirurgia Generale e dei Trapianti Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Radiologia Interventistica Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly Cardiologia 3 Ospedale Niguarda Cà GrandaPiazza Ospedale Maggiore 320162 MilanoItaly

Transjugular intrahepatic portosystemic shunt (TIPS) is the standard treatment of Budd-Chiari syndrome (BCS) non responsive to medical therapy. However, patients with inferior vena cava (IVC) obstruction proximal to the atrium do not benefit from TIPS and a surgical approach is mandatory. We report the case of BCS due to intrapericardial IVC obstruction. We describe a novel surgical approach using a fresh caval homograft. An attempt to balloon dilatation of the IVC obstruction was complicated by right atrial disruption with tamponade and ventricular fibrillation. Lately, the patient successfully underwent a reconstruction of the cavo-atrial continuity by the interposition of a fresh caval homograft, a novel surgical approach never described before for BCS. Further follow-up revealed progressive reduction and resolution of ascites, and overall clinical improvement. IVC obstruction near to the atrium can be surgically approached with a new technique consisting in inferior vena cava resection and replacement with a caval homograft.

关键词： Budd-Chiari syndrome Inferior vena cava Occlusion Surgery Liver transplantation

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一英里观景塔

现代装饰 2016年第6期 124-127页

作者： Carlo Ratti Giovanni de Niederhusern Emma Greer saverio Panata Alberto Bottero Gary di Silvio Andrea Galli Pietro Leoni Monica Lve Schlaich Bergermann 白骐鸣 Carlo Ratti Associati Joerg Schlaich Mike Schlaich Boris Reyher柏林办公室 Atmos设计工作室

该方案命名为＂一英里观景塔（The Mile）,这个一英里高的垂直公园与观景平台,是由Carlo Ratti Associati与德国工程师Schlaich Bergerman以及英国设计工作室Atmos联合设计。该方案的灵感来自于设计师的愿望,＂一英里＂不仅是人类永恒... 详细信息

该方案命名为＂一英里观景塔（The Mile）,这个一英里高的垂直公园与观景平台,是由Carlo Ratti Associati与德国工程师Schlaich Bergerman以及英国设计工作室Atmos联合设计。该方案的灵感来自于设计师的愿望,＂一英里＂不仅是人类永恒的追求垂直海拔高度,它还解决了我们人类需要从不同的角度去看世界。

关键词：观景塔设计工作室观景平台联合设计海拔高度工程师设计师垂直

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