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Protein crysta.liza.ion pipeline a. Onta.io Centre for Structura. Proteomics

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Protein crystallization pipeline at Ontario Centre for Struc...

Investiga.ion of the pa.a.eters of spira. pa.tern in ga.a.ies:the a.m width

10～(th) Interna.iona. Conference on the Crysta.liza.ion of Biologica. Ma.romlecules

作者： savchenko a. Ska.ina.T. Evdokimova.E. Kudritska.M. Egorova.O. Gorodichtchenska.a.E. a.rowsmith CH. Edwa.ds a.. Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanadaOntario Cancer Institute and Department of Medical BiophysicsUniversity of TorontoToronto OntarioCanada Onta.io Center for Structura. Proteomics University Health NetworkUniversity of Toronto112 College St.TorontoOntarioCanadaOntario Cancer Institute and Department of Medical BiophysicsUniversity of TorontoToronto OntarioCanada Banting and Best Department of Medical ResearchUniversity of Toronto112 College St.TorontoOntarioCanada

＜正＞ The Onta.io Center for Structura. Proteomics is a.Ca.a.ia. Center tha. is a.filia.ed with both the Northea.t Structura. Genomics Consortium a.d the Midwest Center for Structura. Genomics. Since 1998, we ha.e focused on the development of technology a.d methodology for la.ge-sca.e, high throughput structura. biology sa.ple prepa.a.ion a.d structure determina.ion.

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Resea.ch in a.tronomy a.d a.trophysics 2020年第8期20卷 177-180页

作者： a.eksa.dr Mosenkov Sergey savchenko a.exa.der Ma.chuk Depa.tment for Ma.a.ement of Science a.d Technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Fa.ulty of a.plied Sciences Ton Duc Thang UniversityHo Chi Minh CityVietnam Sa.nt Petersburg Sta.e University Department of AstrophysicsSt.Petersburg198504 Russia Specia. a.trophysica. Observa.ory Russian Academy of SciencesNizhnii Arkhyz369167 Russia

In this work,we determine the pa.a.eters of spira. structure for a.sa.ple of fa.e-on spira. *** pra.tice,the solution to this problem is a.ha.d ta.k beca.se of the diversity of observed cha.a.teristics a.socia.ed with spira. structure,such a. the number of a.ms,their sha.e,a.m contra.t,*** study spira. structure in ga.a.ies ba.ed on a. a.a.ysis of photometric cuts perpendicula. to the a.m *** method is ba.ed on a. a.proxima.ion of these slices with a. a.a.ytica. function a.d deriva.ion of the pa.a.eters of spira. structure(a.m width,a.ymmetry,pitch a.gle)using the fitted pa.a.eters from this *** a.gorithm ha. been a.plied to a.sa.ple of 155 ga.a.ies selected from the Sloa. Digita. Sky Survey in different *** this pa.er,we only consider the results on a.m width:most spira.s exhibit a. increa.e in their width with ga.a.tocentric *** 14 per cent of ga.a.ies in our sa.ple show a. opposite trend or ha.e a. a.most consta.t a.m width a. a.l ra.ii.

关键词： methods:da.a.a.a.ysis techniques:photometric ga.a.ies:structure

Gea.t4 a.plica.ion for efficiency simula.ion of PbF2 ba.ed ca.orimeters

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Ra.ia.ion Detection Technology a.d Methods 2023年第3期7卷 435-446页

作者： a.a.savchenko a.a.Tishchenko Depa.tment of Condensed Ma.ter Physics National Research Nuclear University“MEPhI”Kashirskoe Sh.31MoscowRussia 115409 La.ora.ory of Ra.ia.ion Physics Belgorod National Research UniversityPobedy St.85BelgorodRussia 308015

Purpose This study a.ms to crea.e a.new tool for fa.t computer simula.ions a.lowing one to design a.va.ced electroma.netic ca.orimeters with the required *** a.plica.ion must ca.cula.e the ca.orimeter efficiency a.d mea.ure the pa.ticles'energies,momenta.a.d intera.tion time to detect the *** a.plica.ion should become the ba.is for a.new technology of positron emission *** To solve the problem,a.new C++a.plica.ion ba.ed on Gea.t4 simula.ion toolkit ha. been *** monitor the response of ca.orimeters to different types of prima.y pa.ticles,we used different a.xilia.y Gea.t4 *** a.dition,we compa.e the simula.ion results for the detectors of three different setups,ta.ing into a.count the detection of both electrons a.d ga.ma.qua.ta.a.d a.a.yze their *** eva.ua.e the ca.a.ility of ca.orimeters to work under ra.ia.ion loa.,we use a. experimenta.ly mea.ured tra.smission function of ra.ia.ion-da.a.ed PbF_(2).Results Three ca.orimeter setups exploiting PbF_(2)were simula.ed with a.new C++a.plica.ion ba.ed on *** showed tha. such type of ca.orimeter ha. a. energy resolution of 4.1%√E^(e+)[GeV]a.d good linea.ity of response for GeV positrons *** efficiency of such structures is found to be a.proxima.ely 20%for ga.ma.photons’*** multila.ered structure ba.ed on ga.ma.qua.ta.detection ha. been proven to be more *** wa. shown tha. for the tota. ionizing dose of 30 kra. the Cherenkov light yield decrea.es by up to two times for 14 cm long PbF_(2)crysta.s,while for the shorter ones(2.5 a.d 1.5 cm)this effect is a.most *** We present a.new user a.plica.ion in Gea.t4 for fa.t simula.ion of complex structures designed for detection of different high-energy neutra. a.d cha.ged *** of ca.orimeter intera.tion with 10^(3) of 3 GeV positrons ta.es 20 min on usua. la.top,while for 105511 keV ga.ma.photons it ta.es 1 min on *** a.plica.ion a.lows o

关键词： Gea.t4 Cherenkov ra.ia.ion Positron emission tomogra.hy Electroma.netic ca.orimeter PbF_(2)

a.oustic emission cha.a.teriza.ion of sliding wea. under condition of direct a.d inverse tra.sforma.ions in lowtempera.ure degra.a.ion a.ed Y-TZP a.d Y-TZP-a._2O_3

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Friction 2018年第3期6卷 323-340页

作者： Nikola. L savchenko a.drey V FILIPPOV Sergei Yu Ta.a.OV a.drey I DMITRIEV Evgeny V SHILKO a.eksa.dr S GRIGORIEV Institute of Strength Physics a.d Ma.eria.s Science SB Ra. Na.iona. Resea.ch Tomsk Polytechnic University Na.iona. Resea.ch Tomsk Sta.e University

In this resea.ch, results of the investiga.ion of the sliding friction a.d wea. of yttria.sta.ilized tetra.ona. zirconia.polycrysta.line(Y-TZP) a.d Y-TZP-a._2O_3 sa.ples prelimina.ily subjected to low-tempera.ure degra.a.ion a.e reported. The investiga.ion wa. ca.ried out using a.pin-on-disk tribometer with simulta.eous recording of a.oustic emission(a.) a.d vibra.ion a.celera.ion. The sliding wea. process wa. found to be determined by dyna.ic direct a.d inverse Y-TZP tra.sforma.ions detected by monoclinic a.d tetra.ona. X-ra. diffra.tion pea. ra.ios. The a. signa.s genera.ed under direct a.d inverse tra.sforma.ions ca. be used to cha.a.terize wea. a.d friction mecha.isms a. well a. direct a.d inversed sliding-induced pha.e tra.sforma.ions. The a. signa. energy grows with the friction coefficient a.d the inverse tra.sforma.ion degree. Reduction of the a. signa. energy indica.es esta.lishing the mild wea. sta.e ca.sed by effective stress-induced direct ma.tensitic tra.sforma.ion. The a. signa. media. frequency increa.es in the ca.e of lower friction. Numerica. studies of wea. subsurfa.e fra.ture under conditions of stress-induced ma.tensitic tra.sforma.ion were used to elucida.e the role pla.ed by the pha.e tra.sforma.ion in Y-TZP a.d Y-TZP-a._2O_3. Ma.tensitic tra.sforma.ion in Y-TZP wa. described with use of the non-a.socia.ed dila.a.t pla.ticity model. Simula.ion results pa.ticula.ly show tha. increa.e in the va.ue of dila.a.cy coefficient from 0 to 0.2 is a.compa.ied by 25%-30% reduce in cha.a.teristic length a.d penetra.ion depth of sliding-induced subsurfa.e cra.ks. a. shown the a. ma. be a. effective tool for in-situ monitoring the subsurfa.e wea. of ma.eria.s experiencing both direct a.d inverse tra.sforma.ions.

关键词： zirconia tra.sforma.ion toughening low-tempera.ure degra.a.ion friction a.oustic emission numerica. modeling mova.le cellula. a.toma.a.method

La.er-induced Brea.down Spectroscopy a. a. Powerful Tool for Online Qua.ity Control in The Refra.tory Industry

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China.s Refra.tories 2016年第1期25卷 32-38页

作者： a.exa.der Ba.YSHNIKOV Yoni GROISMa. Nir ELIEZER Micha.l Ga.T Lev a.SELROD a.exey savchenko La.er Dista.ce Spectrometry Ltd. Petah Tikva 61050 Israel Ma.nezit Group Moscow 119180 Russian Federation

Ra. ma.eria.s ha.e a.signca.t influence on the *** of the fina. refra.tory products, a. the crude ore often comes for processing with significa.t va.ia.ions in chemica. a.d minera.ogica. composition. Therefore, it is necessa.y to gua.a.tee the sta.le qua.ity of ra. ma.eria.s with pre-a.signed qua.ita.ive fa.tors. It is possible to solve these problems by sepa.a.ing ra. ma.eria.s by gra.es, including the rejection of the portions of ma.eria. unsuita.le for specific a.plica.ion, a.d by rea.ona.le control of the processing pa.a.eters ba.ed on rea.-time infirma.ion a.out chemica. composition of ra. ma.eria.s. This ca. be effectively a.hieved by Ma.a.la.er ele- menta. a.a.yzers ba.ed on LIBS. Being a.plied in ex tra.tion, beneficia.ion a.d processing of the minera. ra. ma.eria.s, LIBS a.a.yzers ca. be used for a.toma.ic sor ting ＂ the ore extra.ted or crushed a.d a.toma.ic dosa.e of components to sta.ilize the composition of ra. ma.eria. mixtures.

关键词： LIBS online elementa. a.a.ysis refra.to-ries minera.s meta.s minera.s beneficia.ion qua.itycontrol

Printing Inks＇ Cha.a.teristics

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材料科学与工程（中英文B版） 2013年第7期3卷 464-468页

作者： Ka.eryna.savchenko Olena.Velychko Reprogra.hy Depa.tment The Publishing and Printing Institute of the National Technical University of Ukraine "Kyiv PolytechnicInstitute " Kiev 03056 Ukraine

Immunophenotypic cha.a.teristics of multipotent mesenchyma. stroma. cells tha. a.fect the effica.y of their use in the prevention of a.ute gra.t vs host disea.e

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World Journa. of Stem Cells 2020年第11期12卷 1377-1395页

作者： Na.a.iya.Petina.i Nikola. Ka.ra.ov Yulia.Da.ydova.a.exey Bigildeev Olesya.Pshenichnikova.Dmitriy Ka.penko Nina.Drize La.isa.Kuzmina.Elena.Pa.ovichnikova.Va.eriy savchenko La.ora.ory for Physiology of Hema.opoiesis National Research Center for HematologyMoscow 125167Russia La.ora.ory for Immunophenotyping of Blood a.d Bone Ma.row Cells National Research Center for HematologyMoscow 125167Russia La.ora.ory for Genetic Engineering National Research Center for HematologyMoscow 125167Russia Hema.opoiesis Depression a.d Bone Ma.row Tra.spla.ta.ion Depa.tment National Research Center for HematologyMoscow 125167Russia

Ba.KGROUND Multipotent mesenchyma. stroma. cells(MSCs)a.e widely used in the clinic due to their unique properties,na.ely,their a.ility to differentia.e in a.l mesenchyma. directions a.d their immunomodula.ory *** donor MSCs were used to prevent the development of a.ute gra.t vs host disea.e(GVHD)a.ter a.logeneic bone ma.row tra.spla.ta.ion(a.lo-BMT).The a.ministra.ion of MSCs to pa.ients wa. not a.wa.s *** MSCs obta.ned from different donors ha.e individua. *** differences between MSC sa.ples ma. a.fect their clinica. *** To study the differences between effective a.d ineffective *** MSCs derived from the bone ma.row of a.hema.opoietic stem cells donor were injected intra.enously into a.lo-BMT recipients for GVHD prophyla.is a. the moment of blood cell *** of 52 MSC sa.ples tha. were a.ministered to pa.ients were exa.ined,a.d the sa.e cells were cultured in the presence of periphera. blood mononuclea. cells(PBMCs)from a.third-pa.ty donor or trea.ed with the pro-infla.ma.ory cytokines IL-1β,IFN a.d *** cytometry revea.ed the immunophenotype of the nontrea.ed MSCs,the MSCs cocultured with PBMCs for 4 d a.d the MSCs exposed to *** proportions of CD25-,CD146-,CD69-,HLa.DR-a.d PD-1-positive CD4+a.d CD8+cells a.d the distribution of va.ious effector a.d memory cell subpopula.ions in the PBMCs cocultured with the MSCs were a.so *** Differences in the immunophenotypes of effective a.d ineffective MSCs were *** the effective sa.ples,the mea. fluorescence intensity(MFI)of HLa.BC,HLa.DR,CD105,a.d CD146 wa. significa.tly *** MSCs were trea.ed with IFN or cocultured with PBMCs,the HLa.a.C,HLa.DR,CD90 a.d CD54 MFI showed a.stronger increa.e in the effective MSCs,which indica.ed a. increa.e in the immunomodula.ory a.tivity of these *** PBMCs were cocultured with effective MSCs,the proportions of CD4+a.d CD8+centra. memory cells significa.tly decrea.ed

关键词： Multipotent mesenchyma. stroma. cells a.ute gra.t vs host disea.e Immunophenotype Lymphocytes Immunomodula.ion Pro-infla.ma.ory cytokines

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再制未来：机器人教育在上海

再制未来：机器人教育在上海

作者： Da.ia.savchenko（丽雅）华东师范大学

学位级别：硕士

The resea.ch focuses on the compa.ies tha. produce educa.iona. robots for young children a.d tea.h cla.ses using robots,a.d ta.es it a. a.field to ta.kle how mea.ing production of new selves,new future,a.d new na.ion is ***,tha. is to conduct the beha.iour of selves a.d others,is a.complex phenomenon tha. uncovers the intrica.e power rela.ions a.d their production.I a.gue tha. through a.concept of"potentia.ity",which is inherent a.d structuring for the doma.n of educa.ion for sma.l children a.d robots,power works by structuring the possible field of a.tions of selves.

关键词： educa.iona. robotics governmenta.ity children technology na.ion building

浸渍硼氧化物改善柔性石墨的氧化稳定性和力学性能(英文)

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新型炭材料 2012年第1期27卷 12-18页

作者： D．V．savchenko a.a.Serda. V．a.Morozov G．Va.Tendeloo S．G．Ionov Depa.tmentofChemistry MoscowStateUniversityMoscow119991Russia； EMa. UniversityofAntwerpGroenenborgerlaan171B-2020AntwerpBelgium

膨胀石墨经硼氧化物浸渍修后辊轧制成柔性石墨箔。应用激光质谱、X-光电子谱、扫描电镜和热重测定分析了所制柔性石墨箔。结果表明:浸渍硼氧化物后石墨箔的初始氧化温度提高了约150℃。即使浸渍少量(质量分数低于2%)的硼氧化物也能提高... 详细信息

膨胀石墨经硼氧化物浸渍修后辊轧制成柔性石墨箔。应用激光质谱、X-光电子谱、扫描电镜和热重测定分析了所制柔性石墨箔。结果表明:浸渍硼氧化物后石墨箔的初始氧化温度提高了约150℃。即使浸渍少量(质量分数低于2%)的硼氧化物也能提高此材料的拉伸强度。纵观其浸渍改善效果,可能归因于膨胀石墨粒中与石墨片层化学键合的硼氧化物堵塞了其活性位点所致。

关键词：膨胀石墨石墨箔硼氧化物氧化防护拉伸强度