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Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1)

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Journal of Behavioral and Brain Science 2020年第2期10卷 118-127页

作者： Richard Campbell Christine L.Petranovich savannah cheek Leslie Morrison Blaine Hart Department of Psychiatry and Behavioral Sciences University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Rehabilitation Medicine Children’s Hospital Colorado and the School of MedicineUniversity of Colorado DenverAuroraCOUSA University of New Mexico AlbuquerqueNMUSA Department of Neurology and Pediatrics University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Radiology University of New Mexico Health Sciences CenterAlbuquerqueNMUSA

Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated with increased risk for CCM1. Method: Fifty-four adults with previous genetic testing for the Common Hispanic Mutation completed a mail survey that included assessments of the above identified areas. Results: Self-reported depressive symptoms and quality of life did not differ between those with positive and negative genetic test results. The negative group expressed a more favorable attitude toward genetic testing (p p = 0.06). Using generalized linear regression, more subjective cognitive concerns were associated with poorer quality of life and more depressive symptoms (p p Conclusions: Subjective cognitive concerns and negative attitudes toward genetic testing may influence emotional well-being after genetic testing for the Common Hispanic Mutation. Additional research is needed that uses objective neuropsychological measures to understand the associations of subjective cognitive concerns, emotional well-being, and cognitive test performance in individuals with CCM1. There is also a need for research that focuses on protective factors and resiliency following genetic testing for CCM1 and the development of mental health interventions to preempt psychosocial difficulties.

关键词： Quality of Life Depression Genetic Testing Subjective Cognitive Concerns

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Examination of Homologies between COVID-19 Vaccines and Common Allergens:The Potential for T Cell-mediated Responses for Allergic Rhinitis and Asthma

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Infectious Diseases & Immunity 2022年第4期2卷 282-284页

作者： Micah Hartwell Benjamin H.Greiner savannah Nicks Oklahoma State University Center for Health Sciences Department of Psychiatry and Behavioral SciencesTulsaOklahomaUnited States Oklahoma State University Center for Health Sciences Office of Medical Student ResearchTulsaOklahomaUnited States University of Texas Medical Branch Department of Internal MedicineGalvestonTexasUnited States

As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens,dust mites,and molds,our objective was to assess the potential overlap between the COVID-19mRNA vaccines fromPfizer-BioNtech andModerna and known *** found 7 common allergens with potential for cross-reactivity with the Pfizer vaccine and 19 with theModerna vaccine,including common grasses,molds,and dust mites.T-cell mediated antigen cross-reactivity between viruses and allergens is a relatively new area of study in clinical immunology;a discipline that may be particularly useful regarding the SARS-CoV-2 virus and the allergic response in *** results suggest that vaccination with the Pfizer-BioNtech andModerna COVID-19 vaccinesmay contribute to T-cell cross-reactivity with allergens that impact allergic asthma and allergic *** research should assess the clinical implications of COVID-19 vaccination on the severity and symptomatology of the allergic disease,in addition to natural viral infection.

关键词： Rhinitis,allergic Allergy COVID-19 Cross-reactivity mRNA Vaccines

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哇！亲子英文玩出来

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作者：杨淑如 savannah

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作者： savannah Knoop.

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Cation engineering on lead iodide perovskites for stable and high-performance photovoltaic applications

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Journal of Energy Chemistry 2018年第4期27卷 1017-1039页

作者： Jue Gong Peijun Guo savannah E.Benjamin P.Gregory Van Patten Richard D.Schaller Tao Xu Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueLemontIL 60439USA Department of Chemistry Middle Tennessee State UniversityMurfreesboroTN 37132USA

Perovskite solar cells （PSCs） based on methylammonium lead iodide （CH3NH3PbI3） have shown unprecedentedly outstanding performance in the recent years. Nevertheless, due to the weak interaction between polar CH3NH3＋（MA＋） and inorganic PbI3 sublattices, CH3NH3PbI3 dramatically suffers from poor moisture stability, thermal decomposition and device hysteresis. As such, strong electrostatic interactions between cations and anionic frameworks are desired for synergistic improvements of the abovementioned issues. While replacements of I with Br and/or CI evidently widen optical bandgaps of perovskite materials, compositional modifications can solely be applied on cation components in order to preserve the broad absorption of solar spectrum. Herein, we review the current successful practices in achieving efficient, stable and minimally hysteretic PSCs with lead iodide perovskite systems that employ photoactive cesium lead iodide （CsPbI3）, formamidinium lead iodide （HC（NH2）2PbI3, or FAPbI3）, MA1-x y-zFAxCsyRbzPbI3 mixed-cation settings as well as two-dimensional butylammonium （C4H9NH3＋, or BA＋）/MA＋, polymeric ammonium （PEI＋）/MA＋ co-cation layered structures. Fundamental aspects behind the stabilization of perovskite phases α-CsPbi3, α-FAPbI3, mixed-cation MA1-x-y-zFAxCsyRb2PbI3 and crystallographic alignment of （BA）2（MA）3Pb4I13 for effective light absorption and charge transport will be discussed. This review will contribute to the continuous development of photovoltaic technology based on PSCs.

关键词： Solar energy conversion Perovskite solar cells Power conversion efficiency Optical bandgaps Device hysteresis Metastabte phases

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The Butterfly Effect

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The World of Chinese 2021年第6期 70-72页

作者： savannah BILLMAN 不详

China in 1912:the most chaotic of times,the most hopeful of *** popular uprisings swept the country,the Qing dynasty collapsed and the Republic of China was established on January 1,*** of imperial rule,China was read... 详细信息

关键词： Butterfly chaotic Republic

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The complexities underlying age-related macular degeneration： could amyloid beta play an important role？

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Neural Regeneration Research 2017年第4期12卷 538-548页

作者： savannah A. Lynn Eloise Keeling Rosie Munday Gagandeep Gabha Helen Griffiths Andrew J.Lotery J.Arjuna Ratnayaka Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton United Kingdom Eye Unit University Southampton NHS Trust Southampton United Kingdom

e-related macular degeneration （AMD） causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as well as non-genetic/environmental risks are recognized, its complex aetiology makes it difficult to identify susceptibility, or indeed what type of AMD develops or how quickly it progresses in different individuals. Here we summarize the literature describing how the Alzheimer＇s-linked amyloid beta （Aβ） group of misfolding proteins accumulate in the retina. The discovery of this key driver of Alzheimer＇s disease in the senescent retina was unexpected and surprising, enabling an altogether different perspective of AMD. We argue that Aβ fundamentally differs from other substances which accumulate in the ageing retina, and discuss our latest findings from a mouse model in which physiological amounts of Aβ were subretinally-injected to recapitulate salient features of early AMD within a short period. Our discoveries as well as those of others suggest the pattern of Aβ accumulation and pathology in donor aged/AMD tissues are closely reproduced in mice, including late-stage AMD phenotypes, which makes them highly attractive to study dynamic aspects of Aβ-mediated retinopathy. Furthermore, we discuss our findings revealing how Aβ behaves at single-cell resolution, and consider the long-term implications for neuroretinal function. We propose Aβ as a key element in switching to a diseased retinal phenotype, which is now being used as a biomarker for latestage AMD.

关键词： amyloid beta (Aβ) retinal neurons retina mouse models age related macular degeneration(AMD)

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The Anatomy of the South Carolina U.S.A. Coastal Sea Breeze 2019-2020

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International Journal of Geosciences 2022年第7期13卷 576-592页

作者： Leonard J. Pietrafesa Shaowu Bao Paul T. Gayes Grant Mitchell savannah Burdette Brian Viner Stephen Noble Jian-Hua Qian David Werth School of Coastal & Marine Systems Science Burroughs & Chapin Center for Marine & Wetland Studies Coastal Carolina University Conway USA Department of Marine Earth Atmospheric Sciences North Carolina State University Raleigh USA savannah River National Laboratory Aiken USA

The study presented herein is the analysis of Sodar based instrument measurements of air temperature, dew point, and vertical wind speed and direction, recorded at two South Carolina sites, Waties Island in North Myrtle Beach and in Sumter, and at three atmospheric ground stations. Two of the ground stations are National Weather Service stations near the Sodars and one is a Coastal Carolina University Sea-Econet, as a part of the National Oceanic & Atmospheric Administration, MESO program, weather-sensor site on the Coastal Carolina University campus in Conway South Carolina. Objectives of this study are to establish specific values of winds, land and sea temperatures, precipitation and dew points associated with the changes induced by passages of the Sea Breeze Front, and to examine differences in the station-to-station incarnation of the Sea Breeze circulation. Variability from station to station in the nature and timing of Sea Breeze Front passage is found to be a function of relative proximity to the coast with Sea Breeze Front passage occurring earliest at the North Myrtle Beach site (the station at the coast), then at Sumter (~100 km inland) and finally Aiken at >100 km inland. Satellite based estimates of the percentages of onshore penetration distances from the coast are depicted. Wind vectors and air temperatures associated with onsets and passages of the Sea Breeze display robust wind fields directed onshore perpendicular to the coastline. Kinematical descriptors of the Sea Breeze wind particle motions are presented and display coherent stable elliptical motions during the late summer to early fall but are absent during the winter.

关键词： Sea Breeze Sea-Land Temperature Differences Wind Sticks

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Microglial process convergence on axonal segments in health and disease

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Neuroimmunology and Neuroinflammation 2020年第1期7卷 23-39页

作者： savannah D.Benusa Audrey D.Lafrenaye Department of Anatomy and Neurobiology Virginia Commonwealth UniversityRichmondVA 23298USA

Microglia dynamically interact with neurons influencing the development, structure, and function of neuronal networks. Recent studies suggest microglia may also influence neuronal activity by physically interacting with axonal domains responsible for action potential initiation and propagation. However, the nature of these microglial process interactions is not well understood. Microglial-axonal contacts are present early in development and persist through adulthood, implicating microglial interactions in the regulation of axonal integrity in both the developing and mature central nervous system. Moreover, changes in microglial-axonal contact have been described in disease states such as multiple sclerosis (MS) and traumatic brain injury (TBI). Depending on the disease state, there are increased associations with specific axonal segments. In MS, there is enhanced contact with the axon initial segment and node of Ranvier, while, in TBI, microglia alter interactions with axons at the site of injury, as well as at the axon initial segment. In this article, we review the interactions of microglial processes with axonal segments, analyzing their associations with various axonal domains and how these interactions may differ between MS and TBI. Furthermore, we discuss potential functional consequences and molecular mechanisms of these interactions and how these may differ among various types of microglial-axonal interactions.

关键词： Microglia multiple sclerosis traumatic brain injury microglia-axonal interactions

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Feasibility study of minimally trained medical students using the Rural Obstetrical Ultrasound Triage Exam(ROUTE)in rural Panama

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World Journal of Emergency Medicine 2018年第3期9卷 216-222页

作者： Annasha Vyas Katherine Moran Joshua Livingston savannah Gonzales Marlene Torres Ali Duffens Carina Mireles Romo Gnevieve Mazza Briana Livingston Shadi Lahham John Christian Fox School of Medicine University of California IrvineIrvineCA 92697USA Department of Obstetrics and Gynecology University of California IrvineOrangeCA 92868USA Department of Emergency Medicine University of California IrvineOrangeCA 92868USA

BACKGROUND:Maternal and infant mortality rates reported in rural Panama are greater than those in urban *** del Toro is a region of Panama inhabited by indigenous people at greater risk for pregnancy-related complications and deaths due to geographic isolation and limited access to health *** ultrasound training programs have recently been implemented in low-resource settings to increase access to diagnostic *** goal of this study is to determine the feasibility of teaching firstyear medical students the Rural Obstetrical Ultrasound Triage Exam(ROUTE)to help identify pathology in pregnant women of the Bocas del Toro region of ***:Eight first-year medical students completed ROUTE training *** training,the students were compared to professional sonographers to evaluate their accuracy in performing the *** then performed the ROUTE in mobile clinics within Bocas del *** enrolled women pregnant in their 2nd or 3rd trimesters and measured biparietal diameter,head circumference,amniotic fluid index,fetal lie and placental *** abnormal measurement would be further analyzed by the lead physician for a potential hospital ***:A total of 60 women were enrolled in the *** women were detected as having a possible high-risk pregnancy and thus referred to a hospital for further ***:Based on our data,first-year medical students with additional training can use the ROUTE to identify complications in pregnancy using ultrasound in rural *** studies are required to determine the optimal amount of training required for proficiency.

关键词： Point of care ultrasound Ultrasound education Rural Panama Obstetrics ultrasound

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