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Experience with hemoadsorption (CytoSorb~?) in the management of septic shock patients

World Journal of Critical Care Medicine 2020年第1期9卷 1-12页

作者： Yatin Mehta Chitra Mehta Ashish Kumar Joby Varghese George Aditi Gupta saurabh nanda Gourav Kochhar Arun Raizada Medanta The Medicity

BACKGROUND Cytokines and inflammatory mediators are the hallmarks of *** cytokine hemoadsorption devices are the newer clinical support system to overcome the cytokine storm during *** To retrospectively evaluate the clinical outcomes of patients admitted in intensive care unit with septic shock with different *** The laboratory parameters including biomarkers such as procalcitonin,serum lactate and C-reactive protein;and the hemodynamic parameters;mean arterial pressure,vasopressor doses,sepsis scores,cytokine levels and other vital parameters were *** evaluated these outcomes among survivors and *** Of 100 patients evaluated,40 patients *** treatment,the vasopressors dosage remarkably decreased though it was not statistically different;34.15%(P=0.0816)for epinephrine,20.5%for norepinephrine(P=0.3099)and 51%(P=0.0678)for *** the survivor group,a remarkable reduction of biomarkers levels;procalcitonin(65%,P=0.5859),C-reactive protein(27%,P=0.659),serum lactate(27%,P=0.0159)and bilirubin(43.11%;P=0.0565)were observed from baseline after CytoSorb^® therapy.A significant reduction in inflammatory markers;interleukin 6 and interleukin 10;(87%and 92%,P<0.0001)and in tumour necrosis factor(24%,P=0.0003)was also ***,28(28%)patients who were given CytoSorb^® therapy less than 48 h after onset of septic shock survived and the maximum duration of stay for 70%of these patients in intensive care unit was less than 15 *** CytoSorb^® is a safe and well tolerated rescue therapy option in patients with septic ***,early(preferably within<48 h after onset of septic shock)initiation could result in better clinical *** randomized trials are needed to define the potential benefits of this new treatment modality.

关键词： Hemoadsorption Sepsis Cytokines Clinical conditions Inflammation and extracorporeal

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A state-of-the-art review of solar passive building system for heating or cooling purpose

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Frontiers in Energy 2016年第3期10卷 347-354页

作者： Arun Kumar nanda C K PANIGRAHI Birla Institute of Technology Mesra Ranchiranchi 835215 India School of Electrical Engineering Kalinga Institute of Industrial Technology Bhubaneswar 751024 India

The major portion of energy in a building is consumed by heating, ventilating, and air-conditioning （HVAC）. The traditional heating and cooling systems contribute greatly to the emission of greenhouse gases, especially carbon dioxide. Four different ways, i.e., Trombe wall, solar chimney, unglazed transpired solar facade, and solar roof, are adopted for solar heating. Similarly, two major ways, i.e., evaporative cooling and building integrated evaporative cooling are adopted for cooling of the building. Therefore, an attempt has been made in this paper to compile the developments of solar heating and cooling technologies in a building.

关键词： HVAC heating cooling solar heating carbondioxide (CO2) emissions

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A Novel Optimizer in Deep Neural Network for Diabetic Retinopathy Classification

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Computer Systems Science & Engineering 2022年第12期43卷 1099-1110页

作者： Pranamita nanda N.Duraipandian Department of Computer Science and Engineering Velammal Institute of TechnologyChennai601204TamilnaduIndia Department of Computer Science and Engineering Saveetha Engineering CollegeChennai602105TamilnaduIndia

In severe cases, diabetic retinopathy can lead to blindness. For decades,automatic classification of diabetic retinopathy images has been a challenge. Medical image processing has benefited from advances in deep learning systems. Toenhance the accuracy of image classification driven by Convolutional Neural Network (CNN), balanced dataset is generated by data augmentation method followed by an optimized algorithm. Deep neural networks (DNN) are frequentlyoptimized using gradient (GD) based techniques. Vanishing gradient is the maindrawback of GD algorithms. In this paper, we suggest an innovative algorithm, tosolve the above problem, Hypergradient Descent learning rate based Quasi hyperbolic (HDQH) gradient descent to optimize the weights and biases. The algorithms only use first order gradients, which reduces computation time andstorage space requirements. The algorithms do not require more tuning of thelearning rates as the learning rate tunes itself by means of gradients. We presentempirical evaluation of our algorithm on two public retinal image datasets such asMessidor and DDR by using Resnet18 and Inception V3 architectures. The findings of the experiment show that the efficiency and accuracy of our algorithm outperforms the other cutting-edge algorithms. HDQHAdam shows the highestaccuracy of 97.5 on Resnet18 and 95.7 on Inception V3 models respectively.

关键词： CNN diabetic retinopathy data augmentation gradient descent deep learning optimization

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Biomineralized and chemically synthesized magnetic nanoparticles:A contrast

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Frontiers of Materials Science 2020年第4期14卷 387-401页

作者： Tanya nanda Ankita RATHORE Deepika SHARMA Present adress:School of Biological and Health Systems Engineering Ira A.Fulton Schools of EngineeringArizona State UniversityTempeAZ 85281USA Present address:Academy of Scientific and Innovative Research(AcSir) CSIR-National Institute of Science Communication and Information Resources(NISCAIR)New Delhi 110067India Institute of Nano Science and Technology Habitat CentreSector 64Mohali 160062India

Magnetic nanoparticles(MNPS)have widely been synthesized through chemical processes for biomedical applications over the past few ***,a new class of MNPs,known as bacterial magnetosomes,has been isolated from magnetotactic bacteria,a natural *** magnetosomes are magnetite or greigite nanocrystals which are biomineralized in the bacterial cell and provide magnet-like properties to *** to MNPs,bacterial magnetosomes are biocompatible,lower in toxicity,and can be easily cleared from the body due to the presence of a phospholipid bilayer around *** also do not demonstrate aggregation,which makes them highly *** this review,we have provided an in-depth comparative account of bacterial magnetosomes and chemically synthesized MNPs in terms of their synthesis,properties,and biomedical *** addition,we have also provided a contrast on how magnetosomes might have the potential to successfully substitute synthetic MNPs in therapeutic and imaging applications.

关键词： bacterial magnetosomes magnetic nanoparticles iron nanoparticles magnetotactic bacteria magnetosomes

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Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data

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World Journal of Diabetes 2014年第3期5卷 399-406页

作者： Jagriti Bhatia nanda Gamad saurabh Bharti Dharamvir Singh Arya Department of Pharmacology All India Institute of Medical Sciences

Canagliflozin(CFZ) is a member of new class of glucose lowering agents, sodium-glucose co-transporter(SGLT) inhibitors, which got approval by food and drug administration. It has insulin independent action by blocking the transporter protein SGLT2 in the kidneys, resulting in urinary glucose excretion and reduction in blood glucose levels. In clinical trials, CFZ significantly decreased HbA1c level when administered either as monotherapy or as combined therapy with other anti-diabetic drugs. Intriguingly, it showed additional benefits like weight reduction and lowering of blood pressure. The commonly observed side effects were urinary and genital infections. It has exhibited favorable pharmacokinetic and pharmacodynamic profiles even in patients with renal and hepatic damage. Hence, this review purports to outline CFZ as a newer beneficial drug for type 2 diabetes mellitus.

关键词： Type 2 diabetes mellitus Sodium-glucose co-transporter 2 Canagliflozin Clinical trial Safety profile

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Geochemistry of a paleosol horizon at the base of the Sausar Group,central India： Implications on atmospheric conditions at the Archeane Paleoproterozoic boundary

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Geoscience Frontiers 2016年第5期7卷 759-773页

作者： Sarada P.Mohanty Sangitsarita nanda Department of Applied Geology. Indian School of Mines Dhanbad 826004 India

A paleosol horizon is described from the contact of the Sausar Group（w2400 Ma） and its basement（Tirodi Gneiss; 〉2500 Ma） in Central India. Physical evidence of pedogenesis is marked by the development of stress corrosion cracks, soil peds, corestone weathering and nodular rocks. XRD and SEM-EDX data indicate the presence of siderite, ankerite, uraninite, chlorite, alumino-silicate minerals, ilmenite,rutile and magnetite, in addition to quartz, feldspar and mica. The chemical index of alteration, the plagioclase index of alteration, and the chemical index of weathering show an increasing trend from parent rock to the paleosol and indicate a moderate trend of weathering. The A-CN-K plot indicates loss of feldspars, enrichment in Al2O3 and formation of illite. Different major element ratios indicate baseloss through hydrolysis, clay formation, leaching of some elements, and more precipitation with good surface drainage. The paleosol is depleted in HREE in comparison to the parent rock indicating high fluid-rock interaction during weathering. The paleosol samples show flat Ce and Eu anomalies, low SREE, and high（La/Yb）N, indicative of a reducing environment of formation. Reducing condition can also be inferred from the concentration of elements such as V, Co, Cu, Pb, and Zn in the paleosol profile. Although enriched in Fe and Mg, the overall geochemical patterns of the paleosol indicate oxygen deficient conditions in the atmosphere and development by weathering and leaching processes associated with high precipitation and good surface drainage at the time of development of this paleosol during the Archeane Paleoproterozoic transition.

关键词： Paleosol Anoxic weathering Great oxidation event Paleoproterozoic Sausar Group

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Hexagonal yttrium manganite:A review on synthesis methods,physical properties and applications

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Journal of Rare Earths 2023年第1期41卷 19-31页

作者： Bhagyashree Munisha Bindhybasinee Mishra Jyotirmayee nanda Centre for Nanoscience and Nanotechnology ITERS‘O’A(Deemed to be)UniversityKhandagiriBhubaneswar751030OdishaIndia Department of Physics ITERS‘O’A(Deemed to be)UniversityKhandagiriBhubaneswar751030OdishaIndia

Hexagonal rare-earth manganites have attracted considerable interest due to their complex multiferroic properties,and they possess a spontaneous electric polarization and may be utilized in various technological applications ranging from solar cells to non-volatile memories and light *** narrow bandgap of hexagonal rare-earth manganite-based compounds can perform remarkable optical anisotropy properties,which make these very efficient photovoltaic materials in parallel with the widely used TiO_(2)-based *** enlargement of the traditional field of hexagonal rare-earth manganite photocatalysis also arose in the last *** article imparts an extensive review of the rational synthesis,optical properties,structural characterization,and applications of hexagonal rare-earth *** properties of hexagonal rare-earth perovskite manganite are also emphasized,and a range of unique applications in photocatalysis and photovoltaics are ***,we wind up this review with some linear perspectives and future research in this area.

关键词： Yttrium manganite Multiferroic Optical analysis Photocatalysis Photovoltaics Rare earths

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Microsponges for dermatological applications:Perspectives and challenges

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 273-291页

作者： Sheefali Mahant Sunil Kumar Sanju nanda Rekha Rao Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak 124001India Department of Pharmaceutical Sciences Guru Jambheshwar University of Science and TechnologyHisar 125001India

Dermatological disorders have a huge psychosocial impact, causing significant impairment of patient’s life. Topical therapy plays a pivotal role in management of such *** topical delivery systems result in overmedication/undermedication, leading to adverse effects and reduction in therapeutic efficacy. Consequently, researchers have been striving towards the development of alternative delivery systems for dermatological applications. In the last decade, microsponges emerged as an attractive option for topical delivery. Their characteristic particle size offers enhanced benefits, making them superior to the contemporary microcarriers. The present review furnishes a comprehensive account of state of the art, important factors affecting the performance and mechanism of drug release from topically applied microsponges, along with characterization techniques. Further, a list of marketed products and their applications for common dermatological disorders has been presented. All in all, this paper is an attempt to lay a bibliographic foundation for researchers working in this field and foster further investigations in this arena.

关键词： Skin Polymers Drug release Dermatology Safety aspects Stability

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Financial burden of seeking diabetes mellitus care in India:Evidence from a Nationally Representative Sample Survey

Health Care Science

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Health Care Science 2023年第5期2卷 291-305页

作者： Mehak nanda Rajesh Sharma University School of Management and Entrepreneurship Delhi Technological UniversityDelhiIndia Department of Humanities and Social Sciences National Institute of Technology KurukshetraKurukshetraHaryanaIndia

Background:Diabetes mellitus(DM)is a major public health concern in India,and entails a severe burden in terms of disability,death,and economic *** study examined the out-of-pocket health expenditure(OOPE)and financial burden associated with DM care in ***:The study used data from the latest round of the National Sample Survey on health,which covered 555,115 individuals from 113,823 households in *** the present study,data of 1216 individuals who sought inpatient treatment and 6527 individuals who sought outpatient care for DM were ***:In India,10.04 per 1000 persons reported having DM during the last 15 days before the survey date,varying from 6.94/1000 in rural areas to 17.45/1000 in urban *** 38%of Indian households with diabetic members experienced catastrophic health expenditure(at the 10%threshold)and approximately 10%of DM-affected households were pushed below the poverty line because of OOPE,irrespective of the type of care sought.48.5%of households used distressed sources to finance the inpatient costs of *** constituted one of the largest proportion of total health expenditure,regardless of the type of care sought or type of healthcare facility *** average monthly OOPE was over 4.5-fold and 2.5-fold higher for households who sought inpatient and outpatient care,respectively,from private health facilities,compared with those treated at public ***,the financial burden was more severe for households residing in rural areas,those in lower economic quintiles,those belonging to marginalised social groups,and those using private health ***:The burden of DM and its associated financial ramifications necessitate policy measures,such as prioritising health promotion and disease prevention strategies,strengthening public healthcare facilities,improved regulation of private healthcare providers,and bringing outpatient services under the purview of health insurance,to manage th

关键词： out-of-pocket health expenditure distressed financing catastrophic health expenditure diabetes mellitus

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Empirical mode decomposition of near-infrared spectroscopy signals for predicting oil content in palm fruits

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Information Processing in Agriculture 2023年第3期10卷 289-300页

作者： Inna Novianty Ringga Gilang Baskoro Muhammad Iqbal Nurulhaq Muhammad Achirul nanda Computer Engineering Study Program College of Vocational StudiesIPB UniversityBogor 16680Indonesia Informatics Management Study Program College of Vocational StudiesIPB UniversityBogor 16680Indonesia Technology and Plantation Production Management Study Program College of Vocational StudiesIPB UniversityBogor 16680Indonesia Department of Agricultural and Biosystem Engineering Faculty of Agro-Industrial TechnologyUniversitas PadjadjaranJatinangor 45363Indonesia

Oil content estimation in palm fruits is a precious property that significantly impacts oil palm production,starting from the upstream and *** content can be used to monitor the progress of the oil palm fresh fruit bunch(FFB)and be applied to identify product *** on the near-infrared(NIR)signals,this study proposes an empirical mode decomposition(EMD)technique to decompose signals and predict the oil content of palm ***,350 palm fruits with Tenera varieties(Elaeis guineensis ***),at various ages of maturity,were harvested from the Cikabayan Oil Palm Plantation(IPB University,Indonesia).Second,each sample was sent directly to the laboratory for NIR signal measurements and oil content ***,the EMD analysis and arti-ficial neural network(ANN)were employed to correlate the NIR signals and oil ***,a robust EMD-ANN model is generated by optimizing the lowest possible *** on performance evaluation,the proposed technique can predict oil content with a coefficient of determination(R2)of 0.933±0.015 and a root mean squared error(RMSE)of 1.446±*** results demonstrate that the model has a good predictive capacity and has the potential to predict the oil content of palm fruits directly,without neither solvents nor reagents,which makes it environmentally ***,the proposed technique has a promising potential to be applied in the oil palm *** like this will lead to the effective and efficient management of oil palm production.

关键词： Artificial neural network Empirical mode decomposition Oil palm Oil content prediction

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