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Data Mining for.Flooding Episode in the States of Alagoas and Per.ambuco—Br.zil

Amer.can Jour.al of Climate Change 2018年第3期7卷 420-430页

作者： Heloisa Musetti r.ivo Har.ldo F. de Campos Velho Fer.ando M. r.mos saulo r. freitas Labor.tor. for.Computing and Applied Mathematics National Institute for Space Research S&#227 o José dos Campos Brazil Center.for.Weather.For.casting and Climate r.sear.h National Institute for Space Research S&#227 o José dos Campos Brazil Goddar. Ear.h Sciences Technology and r.sear.h Universities Space Research Association Columbia MD USA Global Modeling and Assimilation Office NASA Goddard Space Flight Center Greenbelt MD USA

The incr.asing volume of data in the ar.a of envir.nmental sciences needs analysis and inter.r.tation. Among the challenges gener.ted by this “data deluge”, the development of efficient str.tegies for.the knowledge discover. is an impor.ant issue. Her., statistical and tools fr.m computational intelligence ar. applied to analyze lar.e data sets fr.m meteor.logy and climate sciences. Our.appr.ach allows a geogr.phical mapping of the statistical pr.per.y to be easily inter.r.ted by meteor.logists. Our.data analysis compr.ses two main steps of knowledge extr.ction, applied successively in or.er.to r.duce the complexity fr.m the or.ginal data set. The goal is to identify a much smaller.subset of climatic var.ables that might still be able to descr.be or.even pr.dict the pr.bability of occur.ence of an extr.me event. The fir.t step applies a class compar.son technique: p-value estimation. The second step consists of a decision tr.e (DT) configur.d fr.m the data available and the p-value analysis. The DT is used as a pr.dictive model, identifying the most statistically significant climate var.ables of the pr.cipitation intensity. The methodology is employed to the study the climatic causes of an extr.me pr.cipitation events occur.ed in Alagoas and Per.ambuco States (Br.zil) at June/2010.

关键词： Data Mining Statistical Analysis T-Test p-Value Ar.ificial Intelligence Decision Tr.e

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Antibacter.al activity and inhibition against Staphylococcus aur.us Nor. efflux pump by fer.lic acid and its ester.fied der.vatives

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Asian Pacific Jour.al of Tr.pical Biomedicine 2021年第9期11卷 405-413页

作者： Patr.cia Gonçalves Pinheir. Gilvandete Mar.a Pinheir. Santiago Fr.ncisco Er.valdo freitas da Silva Ana Car.lina Justino de Ar.újo Cícer. r.jane Tavar.s de Oliveir. Pr.scilla r.mos freitas Janaína Esmer.ldo r.cha JoséBezer.a de Ar.újo Neto Mar.a Milene Costa da Silva saulo r.lison Tintino Ir.in r.se Alencar.de Menezes Henr.que Douglas Melo Coutinho JoséGalber.o Mar.ins da Costa Depar.amento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Pr.gr.ma de Pós-Gr.duação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitor. activity of fer.lic acid and four.of its ester.fied der.vatives(methyl,ethyl,pr.pyl,and butyl)against r.sistance mechanisms in Staphylococcus aur.us ***:Fer.lic acid der.vatives wer. obtained by ester.fication with methanol,ethanol,pr.panol,and butanol,and then char.cter.zed by hydr.gen and car.on-13 nuclear.magnetic r.sonance *** minimum inhibitor. concentr.tions(MIC)of fer.lic acid and its ester.fied der.vatives,ethidium br.mide,and nor.loxacin wer. obtained using the micr.dilution test,while the efflux pump inhibition test was conducted by examining r.duction in the MICs of nor.loxacin and ethidium *** docking was also car.ied out using the Schr.dinger.Suite 2015 molecular.modeling softwar..A thr.e-dimensional model of Nor. efflux pump was gener.ted using *** best scor.ng model was used as a r.ceptor.for.ligand-r.ceptor.***:The methyl and butyl ester.der.vatives did not demonstr.te significant antimicr.bial ***,a significant syner.ic effect was evidenced when nor.loxacin was combined with the ethyl and pr.pyl ester.fied *** docking study demonstr.ted favor.ble ener.y of inter.ction between fer.late der.vatives and Nor.,and amino acid r.sidues TYr.7,TYr.8,and LEU255 wer. pr.sent commonly in stabilizing all *** PCA analysis cor.obor.ted the docking hypothesis that the lipophilic char.cter.and hydr.gen bond inter.ctions wer. the most r.levant char.cter.stics involved with Nor. *** phar.acokinetic par.meter. of fer.lic acid der.vatives showed good ADMET pr.per.ies,demonstr.ting that they can be easily absor.ed and have no effect or.inhibit the cytochr.me P450 enzyme complex,r.vealing their.potential as dr.g ***:This study pr.vides str.ng evidence that the molecular.basis for.this activity is potentially due to the Nor. efflux pump.

关键词： Fer.lic acid Ester.fied der.vatives Efflux pump Staphylococcus aur.us r.sistance mechanisms

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Fer. extr.cts potentiate fluconazole activity and inhibit mor.hological changes in Candida species

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Asian Pacific Jour.al of Tr.pical Biomedicine 2017年第11期7卷 1025-1030页

作者： Mar.a A.freitas Antonia T.L.Santos Antonio J.T.Machado Ana r.quel P.Silva Fábia F.Campina Mar.a S.Costa Gioconda M.A.B.Mar.ins Mar.a Flaviana B.Mor.is-Br.ga saulo r.Tintino Ir.in r.A.Menezes Jaime r.beir.-Filho Altevir.P.Medeir.s Adeliana S.Oliveir. Patr.cio B.Mar.cajá Henr.que D.M.Coutinho Univer.idade r.gional do Car.r.-Ur.A Univer.idade Feder.l r.r.l do Semi-A′r.do-UFEr.A Univer.idade Feder.l do r.o Gr.nde do Nor.e-UFr. Univer.idade Feder.l de Campina Gr.nde-UFCG

Objective: To investigate the antifungal activity of the fer. species Lygodium venustum(L. venustum) and Pityr.gr.mma calomelanos(P. calomelanos) against Candida albicans and Candida tr.picalis ***: The micr.dilution method was used to evaluate the antifungal activity, as well as the modulating effects of ethanolic extr.cts of these plants in combination with fluconazole. The minimum inhibitor. concentr.tion(MIC), minimum fungicide concentr.tion and mor.hological changes wer. also ***: The extr.ct obtained fr.m L. venustum pr.sented a MIC > 8 192 mg/m L, while the extr.ct obtained fr.m and P. calomelanos pr.sented a MIC = 8 192 mg/m L, indicating that they pr.sent weak antifungal activity. However. combination of the extr.cts with Fluconazole potentiated the antifungal activity of this dr.g. At differ.nt exper.mental conditions, such as concentr.tion of the extr.ct and type of str.in, the extr.cts inhibited hyphae and pseudohyphae for.ation, indicating that these fer. species can affect the mor.hology of the ***: The extr.cts obtained fr.m the fer. species L. venustum and P. calomelanos dose not pr.sent significant antifungal activity. However. P. calomelanos potentiates the activity of fluconazole and both extr.cts inhibits the mor.hological changes in Candida species, indicating that they have potential phar.acological activity as modulator. of fungal biology. Ther.for., novel studies ar. r.quir.d to char.cter.ze the inter.er.nce of these extr.cts in the vir.lence and pathogenicity of Candida species as well as the potential of fer. species to tr.at fungal infections.

关键词： Dimor.hism Candida species Fer.s Lygodium venustum Pityr.gr.mma calomelanos

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冲天炉用生物质焦炭

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世界钢铁 2013年第5期13卷 18-23页

作者： Guiller.o Pea Chipatecua saulo H freitas Seabr. da r.cha Peter.Quicker.周海忠亚琛工业大学

铸造焦是冲天炉的主要燃料和碳化剂。鉴于焦炭价格较高和二氧化碳减排的压力,德国铸造业必须寻找一种焦煤的替代资源。开始于2010年1月的一个研究项目确定了以生物质残留物为基础开发合适的铸造焦替代物的框架。开发出来的生物质焦炭应... 详细信息

铸造焦是冲天炉的主要燃料和碳化剂。鉴于焦炭价格较高和二氧化碳减排的压力,德国铸造业必须寻找一种焦煤的替代资源。开始于2010年1月的一个研究项目确定了以生物质残留物为基础开发合适的铸造焦替代物的框架。开发出来的生物质焦炭应该像煤粉末压块一样,在冲天炉熔炼过程中没有质量损失和引起冶炼问题。在碳化炉中,一共对15个不同的生物质(如秸秆、木质残留物、坚果壳等)进行了碳化试验,并对它们的燃料特性(如灰分、成分、热值、微量元素含量)进行了分析。考虑收购成本、收购的难易程度并结合分析结果,选择了可以试验的原料,在连续回转窑反应器中进行高温分解试验。目前正在进行适应性和捣固试验并对不同结合剂进行测试,以便满足在冲天炉中的使用要求。为了证明生物质焦炭的实际性能,最终在工业化工厂进行了试验,将铸造焦的替代率提高到了50%,加入量约为20 t。基于与工厂合作项目的研究结果,将编制有关原材料选择、铸造焦替代物的碳化和成型(成块)的操作规程。

关键词：生物质高温分解回转窑反应器生物质焦炭铸造焦冲天炉

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