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Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases

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World Journal of Gastroenterology 2017年第26期23卷 4796-4805页

作者： Dorota Cibor Danuta Owczarek saulius butenas Kinga Salapa Tomasz Mach Anetta Undas Department of Gastroenterology Hepatology and Infectious DiseasesJagiellonian University Medical College Department of Biochemistry College of MedicineUniversity of Vermont Department of Bioinformatics and Telemedicine Jagiellonian University Medical College Institute of Cardiology Jagiellonian University Medical College

AIM To evaluate the levels of von Willebrand factor(VWF) and metalloproteinase with thrombospondin type-1 motif, number 13(ADAMTS13) in inflammatory bowel disease(IBD) and correlate them with the disease *** Consecutive patients with IBD aged 18 years or older were enrolled in the study. Forty-seven patients with ulcerative colitis(UC), 38 with Crohn's disease(CD), and 50 healthy controls were included. The white blood cell count, haematocrit, platelet count, fibrinogen, partial activated thromboplastin time, C-reactive protein, albumin, VWF antigen level(VWF:Ag), VWF ristocetin cofactor activity(VWF:RCo), VWF collagen-binding activity(VWF:CB), and ADAMTS13 antigen level(ADAMTS13:Ag) and activity(ADAMTS13act) were measured. The following ratios were assessed: V W F : R C o/V W F : A g, V W F : C B/V W F : A g, V W F : A g/ADAMTS13 act, and ADAMTS13act/ADAMTS13:Ag. RESULTS Compared to controls, the odds ratio(OR) of an elevated VWF: Ag > 150% was 8.7(95%CI: 2.7-28.1) in the UC group and 16.2(95%CI: 4.8-54.0) in the CD group. VWF:CB was lower in UC patients, and active CD was associated with a higher VWF: RCo(+38%). The ORs of VWF:CB/VWF:Ag < 0.7(a marker of acquired von Willebrand syndrome) in the UC and CD groups were 11.9(95%CI: 4.4-32.4) and 13.3(95%CI: 4.6-38.1), respectively. Active UC was associated with lower ADAMTS13:Ag(-23%) and ADAMTS13act(-20%) compared to UC in remission. Patients with active CD had a 15% lower ADAMTS13 act than controls. The activity of UC, but not that of CD, was inversely correlated with ADAMTS13:Ag(r =-0.76) and ADAMTS13act(r =-0.81). CONCLUSION Complex VWF-ADAMTS13-mediated mechanisms disturb haemostasis in IBD. A reduced WVF:CB is a risk factor for bleeding, while a lower ADAMTS13 level combined with an elevated VWF:Ag could predispose one to thrombosis.

关键词： ADAMTS13 煽动性的肠疾病血栓获得的 von Willebrand 症候群 von Willebrand 因素

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Top-down control of bottom-up material synthesis@nanoscale

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Opto-Electronic Advances 2023年第4期6卷 1-2页

作者： saulius Juodkazis Optical Sciences Centre School of ScienceSwinburne University of TechnologyHawthornVic 3122Australia WRH Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaKanagawa 226-8503Japan

In a recently published paper in Opto-Electronic Advances,Mangirdas Malinauskas and his colleagues at Vilnius University report on a new high resolution inorganic material synthesis pathway using 3D laser printing and calcination.3D metamaterials(beyond what exist in nature)emerge from research in high-resolution 3D polymerisation/printing where proportions of inorganic parts of a composit can be widely *** adding a high temperature annealing(HTA)post-fabrication step of sintering/calcination in air/oxygen flow2−5 after the 3D polymerisation,a new glass and/or ceramic 3D structure with nanoscale features and large down-sizing can be produced6 as shown in Fig.1.

关键词： synthesis printing inorganic

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Green tea——a new perspective of glaucoma prevention

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 747-752页

作者： Kornelijus Gasiunas saulius Galgauskas Vilnius University Faculty of Medicine Vilnius 03101Lithuania Center of Eye Diseases Vilnius University Hospital Santaros KlinikosVilnius 08661Lithuania

AIM:To determine how green tea and catechins can affect intraocular pressure(IOP)***:Totally 43 young volunteers were included in the *** experiment was held between noon and 2 *** extracts—green tea and epigallocatechin gallate(EGCG,400 mg capsules)and placebo(400 mg capsules)were used in the *** were divided into three *** tea extract group(GT group)had 17 subjects,EGCG extract group 17 subjects,control(placebo)group 9 *** was measured with the Icare tonometer before and 30 min,1,1.5,2 h after the consumption of each extract and *** were analyzed using the IBM SPSS *** confidence level P<***:The most significant reduction of IOP from the beginning of the experiment was measured after 2 h in GT group(left 2.18±3.19 mm Hg,P=0.012;right 2.59±1.97 mm Hg,P<0.000)and after 1 h in EGCG extract group(left 2.41±2.98 mm Hg,P<0.004;right 1.94±1.98 mm Hg,P<0.001).In control group no significant changes were ***:People who have increased IOP or risk factors for glaucoma development,could benefit from drinking green tea or its concentrated extracts in moderate doses.

关键词： intraocular pressure glaucoma ocular hypertension tea catechin

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Plexiform neurofibroma of the cauda equina with follow-up of 10 years:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4519-4527页

作者： Zilvinas Chomanskis Raimondas Juskys saulius Cepkus Justyna Dulko Vaiva Hendrixson Osvaldas Ruksenas saulius Rocka Department of Neurology and Neurosurgery Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 03104Lithuania Anatomy Histology and Anthropology DepartmentVilnius UniversityFaculty of MedicineVilnius 03104Lithuania Department of Neurosurgery Republican Vilnius University HospitalVilnius 04130Lithuania Faculty of Medicine Vilnius UniversityVilnius 03104Lithuania Institute of Biomedicine Faculty of MedicineVilnius UniversityVilnius 03104Lithuania Institute of Biosciences Life Sciences CentreVilnius UniversityVilnius 10257Lithuania

BACKGROUND Plexiform neurofibromas are extremely rarely found in the region of cauda equina and can pose a significant challenge in the diagnostic and management *** our knowledge,only 7 cases of cauda equina neurofibromatosis(CENF)have been reported *** SUMMARY We describe a case of a 55-year-old man with a 10 years history of progressive lower extremities weakness and bladder *** presenting,patient was misdiagnosed with idiopathic *** spine MRI revealed a tortuous tumorous masses in the cauda equina region,extending through the Th12-L4 *** patient underwent Th12-L3 Laminectomy with *** the operation,the most enlarged electroneurographically silent nerve root was resected,anticipating inadequate decompression if nerve root was *** patient’s neurological condition improved post-operatively,but urinary retention became the major *** provide a follow-up period of 10 *** this time,the patient’s condition progressively worsened despite extensive *** consequent MRI scans showed progressive enlargement of cauda equina roots and increasing lumbar stenosis,predominantly affecting L3-L4 *** the follow-up 8 years after the operation,the patient complained of worsening lower extremities sensorimotor function and neurogenic *** MRI revealed lumbar spine stenosis at the level of L3-L4,requiring further *** patient underwent a second surgery involving L4-L5 Laminectomy with duraplasty and L2-L5 transpedicular *** post-operative period was *** follow-up 18 mo after the second surgery revealed substantial improvement in patient’s *** CENF should be kept in mind during the differential diagnostic work-up for *** with an extensive decompression,duraplasty and primary spinal fixation represents a rational approach to achieve a sustained symptomatic improvement and s

关键词： Cauda equina Plexiform neurofibroma Neurofibromatosis type I Spine Spinal tumor Case report

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Rabbit models of dry eye disease: comparative analysis

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1177-1185页

作者： Vytautas Baranauskas Julija Daukantaitė saulius Galgauskas Vilnius University Institute of Biochemistry Life Science CentreSauletekio av 7VilniusLT 10257Lithuania Vilnius University Faculty of Medicine M.K.Čiurlionio str.21VilniusLT 03101Lithuania

AIM:To report ocular changes in rabbits after the implementation of three different induction methods to create dry eye(DE)conditions and provides evidence of DErelated disease ***:Experimental methods were divided into 3 *** first model used involved triple injection of complete Freund’s adjuvant,50µL each,also called the meibomian gland dysfunction(MGD)*** the second model,DE conditions were created by the resection of nictitating membranes(NM),Harderian glands(HG),and main lacrimal glands(LG),also called the LGR *** third model involved the topical administration of benzalkonium chloride(BAK)0.1%*** Schirmer test,ocular surface staining with fluorescein,and tear breakup time tests were implemented before and after *** euthanasia,the ocular tissues were ***,conjunctiva,and meibomian glands were treated with periodic acid–Schiff(PAS)staining and haematoxylin–eosin ***:The MGD model triggered inflammation of meibomian *** detected changes in the lipid layer of the tear *** bilateral resection of NM,HG,and LG reduced the watering layer of the tear *** topical administration of BAK of 0.1%solution impacted the mucosal layer of the tear ***:Different changes are observed with different DE syndrome *** composition of the tear film differ depending on which part of the eye is *** studies need to be done to confirm whether an increased thickness of the cornea has any impact on the DE disease.

关键词： ocular surface lid inflammation keratitis tear deficiency rabbits dry eye disease

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Laser polymerized photonic wire bonds approach 1 Tbit/s data rates

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Light(Science & Applications) 2020年第1期9卷 1338-1339页

作者： saulius Juodkazis Nanotechnology facility at Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) Swinburne University of TechnologyJohn st.Melbourne 3122 VICAustralia Tokyo Tech World Research Hub Initiative(WRHI) Tokyo Institute of TechnologyTokyo 152-8550Japan

Microelectronics has solved the challenge of packaging different functional elements with integrated chips(ICs)in modern computing and communication by wire *** was a trend guided by the requirements for faster,more portable and less expensive(smaller amount of materials)solutions,where wire bonding evolved to accommodate increasingly more complex 3D architectures of chips and printed circuit boards.

关键词： faster bonding portable

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Supracrustal suite of the Precambrian crystalline crust in the Ghor Province of Central Afghanistan

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Geoscience Frontiers 2017年第1期8卷 125-135页

作者： Gediminas Motuza saulius Sliaupa Department of Geology and Mineralogy Vilnius UniversityM.K.Ciurlionio 21/27 LT-03101 VilniusLithuania Nature Research Centre Akademijos 2LT-08412 VilniusLithuania

The Proterozoic pre-Ediacaran metamorphic basement of the southern Tajik （North Afghanistan） con- tinental block and the adjacent Band-e-Bayan zone is exposed in the Ghor Province of Central Afghanistan. It is predominantly composed of the EW-striking supracrustal succession consisting of interbedded felsic schists and gneisses （metapsammites）, amphibolites （metabasalts）, calcite and dolo- mite marbles, The metamorphic facies changes from greenschist in the Band-e-Bayan zone to amphib- olite facies in the Tajik block. The supracrustal rocks of the Band-e-Bayan zone and Tajik block possess common features suggesting that the former represents a tectonized part of the latter. The geochemical characteristics of metapsammites indicate derivation of the clastic material from a continental arc and, partly from a passive continental margin, whereas the composition of metabasalts suggests their possible formation in a continental rift basin. The tectonic setting of supracrustal unit could be interpreted as a back-arc type basin. We presume that the Tajik microcontinent split off the Gondwana supercontinent along an ancient rift zone during the late Paleozoic.

关键词： Afghanistan Tajik block Proterozoic rock units Continental arc Back-arc basin

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Beyond Lambertian light trapping for large-area silicon solar cells:fabrication methods

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Opto-Electronic Advances 2022年第9期5卷 14-25页

作者： Jovan Maksimovic Jingwen Hu Soon Hock Ng Tomas Katkus Gediminas Seniutinas Tatiana Pinedo Rivera Michael Stuiber Yoshiaki Nishijima Sajeev John saulius Juodkazis Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyHawthorn Vic 3122Australia Melbourne Centre for Nanofabrication ANFF Victoria151 Wellington Rd.Clayton Vic 3168 Australia Department of Electrical and Computer Engineering Graduate School of EngineeringYokohama National University79-5 TokiwadaiHodogaya-kuYokohama 240-8501Japan Institute of Advanced Sciences Yokohama National University79-5 TokiwadaiHodogaya-kuYokohama 240-8501Japan Department of Physics University of Toronto60 St.George StreetTorontoONM5S 1A7Canada World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

Light trapping photonic crystal(PhC)patterns on the surface of Si solar cells provides a novel opportunity to approach the theoretical efficiency limit of 32.3%,for light-to-electrical power conversion with a single junction *** is beyond the efficiency limit implied by the Lambertian limit of ray trapping~29%.The interference and slow light effects are harnessed for collecting light even at the long wavelengths near the Si *** compare two different methods for surface patterning,that can be extended to large area surface patterning:1)laser direct write and 2)step-&-repeat 5×reduction projection *** area throughput limitations of these methods are compared with the established elec-tron beam lithography(EBL)route,which is conventionally utilised but much slower than the presented ***-tral characterisation of the PhC light trapping is compared for samples fabricated by different *** of Si etched via laser patterned mask was~7%at visible wavelengths and was comparable with Si patterned via EBL made *** later pattern showed a stronger absorbance than the Lambertian limit6.

关键词： silicon solar cells laser ablation light trapping Lambertian limit

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Husserlian Phenomenology and Derridean Deconstruction: Their Fundamental Methodological Commitments

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Frontiers of Philosophy in China 2020年第3期15卷 451-471页

作者： saulius Geniusas Department of Philosophy The Chinese University of Hong KongShatinNew TerritoriesHong KongChina

This paper reinterprets the relation between Derridian deconstruction and Husserlian phenomenology on the basis of their respective methodological *** to the proposed view,epoche,reduction,and eidetic variation are the fundamental methodological principles of Husserlian *** paper interprets Derrida's reading of Husserl as presenting a type of semiological reductionism,which is marked by the absorption of the fundamental phenomenological principles within a semiological *** of meaning as a sign that refers to other signs,Derrida contends that neither epoche,nor reduction,nor eidetic variation can be carried through successfully;their validity is thereby indefinitely *** paper also addresses the relationship between indication and expression,the Principle of all Principles,the living present,and their alleged deconstruction in Derrida's writings.I conclude with some suggestions concerning how,apart from deconstructing phenomenology,one could also phenomenologize *** to my suggestion,this would require problematizing evidence that underlies the central claims and commitments of deconstruction.

关键词： Husserl Derrida phenomenology deconstruction (post-)structuralism methodology

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Review of Fresnel incoherent correlation holography with linear and non-linear correlations

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Chinese Optics Letters 2021年第2期19卷 1-6页

作者： Vijayakumar Anand Tomas Katkus Soon Hock Ng saulius Juodkazis Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyHawthornVIC 3122Australia Melbourne Centre for Nanofabrication ANFFClaytonVIC 3168Australia Tokyo Tech World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

Fresnel incoherent correlation holography(FINCH)is a well-established incoherent imaging *** FINCH,three selfinterference holograms are recorded with calculated phase differences between the two interfering,differently modulated object waves and projected into a complex *** object is reconstructed without the twin image and bias terms by a numerical Fresnel back propagation of the complex hologram.A modified approach to implement FINCH by a single camera shot by pre-calibrating the system involving recording of the point spread function library and reconstruction by a nonlinear cross correlation has been introduced *** expression of the imaging characteristics from the modulation functions in original FINCH and the modified approach by pre-calibration in spatial and polarization multiplexing schemes are *** study reveals that a reconstructing function completely independent of the function of the phase mask is required for the faithful expression of the characteristics of the modulating function in image *** the polarization multiplexing method by non-linear cross correlation,a partial expression was observed,while in the spatial multiplexing method by non-linear cross correlation,the imaging characteristics converged towards a uniform behavior.

关键词： digital holographic imaging Fresnel incoherent correlation holography holographic techniques imaging systems incoherent holography and speckle noise

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