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Open Journal of Psychiatry 2015年第4期5卷 362-373页

作者： Eduardo Goncalves saul neves de jesus department of Psychiatry and Mental Health of Hospital Center of Algarve Faro Portugal department of Psychology of Faculty of Social and Human Sciences of University of Algarve Faro Portugal

The present study aimed to investigate the impact of chronic psychosocial stress and resilience, including at a biological level (immune and neuroendocrine function) in Portuguese citizens with psychic anomaly/mental disorder. The sample aggregated 69 participants. It has been used the following psychometric instruments: 21-item depression, anxiety and stress scales (DASS-21), in the Portuguese validated version;measuring state resilience (MSR), in the Portuguese validated version;the Portuguese scale of 23 questions on vulnerability to stress. Serum levels of cortisol, dehydroepiandrosterone sulfate, antibodies anti-viral capsid antigen of Epstein-Barr virus, triglycerides, high density lipoprotein-cholesterol and body mass index have been measured. It has been concluded that factors of vulnerability to stress and chronic stress, of social nature (lack of social support, adverse living conditions), correlate positively with depression, anxiety and stress, and, through alostatic load, are involved in a greater propensity for immune and neuroendocrine dysfunction in this population.

关键词： Vulnerability to Stress Stress Coping Resilience Alostatic Load Anxiety depression Cortisol dehydroepiandrosterone Epstein-Barr Virus Triglycerides High density Lipoprotein-Cholesterol Body Mass Index

Stress, Executive Function, Resilience and Quality of Life in Portuguese Subjects in Situations of Economic Insufficiency and Unemployment

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Open Journal of Psychiatry 2015年第4期5卷 350-361页

The aim of this study is the investigation of the impact of stress of Portuguese subjects in situations of economic insufficiency and unemployment on executive function and quality of life and the coping strategies and resilience skills used. The sample consists of 41 participants. The psychometric instruments used are validated for Portuguese population, measure (perceived) stress, coping, material deprivation, resilience and quality of life, defined by World Health Organization. Executive function has been evaluated through performances at Stroop and Berg tasks. It has been concluded that, in this population, resilience skills and active coping strategies are positively correlated with quality of life. Quality of life is negatively correlated with material deprivation. Active coping strategies are supported by adequate executive function, which neurobiological substrate is dorso-lateral prefrontal cortex. Not active coping strategies correlate negatively with cognitive flexibility, suggesting the presence of a deficit at infero-lateral prefrontal cortex.

关键词： Stress Economic Insufficiency Unemployment Coping Resilience Quality of Life Executive Function

High frequency heart rate variability evoked by repetitive transcranial magnetic stimulation over the medial prefrontal cortex: A preliminary investigation on brain processing of acute stressor-evoked cardiovascular reactivity

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Open Journal of Psychiatry 2013年第4期3卷 335-344页

作者： Eduardo Manuel Goncalves saul neves de jesus department of Psychiatry and Mental Health of Hospital of Faro FaroPortugal department of Psychology(Health Psychology) Faculty of Social SciencesUniversity of AlgarveFaroPortugal Research Center for Spatial and Organizational Dynamics of Algarve FaroPortugal

Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynaptically perigenual Anterior Cingulate Cortex (pACC, BA 33), insula, amigdala, hypothalamus and connected branches of the Autonomic Nervous System (ANS) involved in stressorevoked cardiovascular reactivity. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both, and, consequently, an increase in systolic/stroke volume, total vascular impedance/resistance and heart rate, a decrease of baroreflex sensitivity, i.e., an increase in blood pressure/arterial tension. Objectives and Aims: The present work aims, using TMS and accordingly to Gianaros modeling, based on functional neuroimaging studies and previous neuroanatomical data from animal models, to probe the connectivity of brain systems involved in stressor-evoked cardiovascular reactivity and to explore TMS potential as a tool for detection and stratification of individual differences concerning this reactivity and hemorreological risk factors correlated with the development of Coronary Heart Disease (CHD). Methods: Both subjects, a 52 years old male and a 40 years old female with previous increased Low Frequency (LF)/High Frequency (HF) Heart Rate Variability (HRV) ratios (respectively, 4.209/3.028) without decompensated cardiorespiratory symptoms, gave informed consent, and ethico-legal issues have been observed. Electroencephalographic (EEG) monitoring has been performed for safety purposes. Immediately after administration, over the mPFC, of 15 pulses of rTMS, during 60 second, with an inductive electrical current, at the stimulating coil, of 85.9 Ampère per μsecond and 66 Ampère per μsecond, respectively, for male and female subjects (a “figure-of-eight” coil and magnetic stimulator MagLite, Dantec/Medtronic, have been used), HRV spect

关键词： Repetitive Transcranial Magnetic Stimulation (rTMS) Medial Prefrontal Cortex (mPFC) Anterior Cingulate Cortex (ACC) Amigdala Autonomic Nervous System (ANS) Heart’s Conducting System Acute Sressor-Evoked Cardiovascular (Blood Pressure) Reactivity Heart Rate Variability (HRV)

Stress prevention by modulation of autonomic nervous system (heart rate variability): A preliminary study using transcranial direct current stimulation

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Open Journal of Psychiatry 2012年第2期2卷 113-122页

作者： Eduardo Manuel Gonçalves saul neves de jesus department of Psychiatry Mental Health of Hospital of FaroFaroPortugal department of Psychology(Health Psychology) Faculty of Social SciencesUniversity of AlgarveFaroPortugal CIEO—Research Center for Spatial and Organizational Dynamics University of AlgarveFaroPortugal

Introduction: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, technique for brain stimulation. Anodal stimulation causes neuronal depolarisation and long-term potentiation, while cathodal stimulation causes hyperpolarisation and long-term depression. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both. Associated with these reactions is a frequently reported increase in Low Frequency (LF) Heart Rate Variability (HRV), a decrease in High Frequency (HF) power, and/or an increase in the LF/HF ratio. Objectives and aims: The present work aims to explore the tDCS potential in the modulation of the Autonomic Nervous System (ANS), through indirect stimulation of Anterior Cingulate Cortex (ACC). Methods: Two subjects, a 39 year old female and a 49 year old male, gave informed consent. Saline soaked synthetic sponges involving two, thick, metalic (stainless steel) rectangles, with an area of 25 cm2 each have been used as electrodes, connected to Iomed Phoresor II Auto device. It has been delivered a 2 mA current, for 20 minutes, over the left Dorsolateral Prefrontal Cortex (DLPFC) (Anode). Spectrum analysis (cStress software) of HRV has been performed before and after tDCS administration. Results: The female/male subject results of LF power, HF power and LF/HF ratio, before tDCS administration, were, respectively: 50.1 nu/60 nu, 46.1 nu/21.7 nu and 1.087/2.771;and, after tDCS administration, respectively: 33.5 nu/52.7 nu, 47.6 nu/ 22.8 nu and 0.704/2.312. Conclusions: tDCS over the left DLPFC (left ACC) increased parasympathetic activity and decreased sympathetic activity, suggesting the importance of tDCS in the management of stress-related disorders.

关键词： Transcranial Direct Current Stimulation Left Dorsolateral Prefrontal Cortex Left Anterior Cingulate Cortex Autonomic Nervous System Heart Rate Variability Stress

Mental and Cardiovascular Health of Portuguese Subjects in a Situation of Economic Insufficiency

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Open Journal of Psychiatry 2015年第4期5卷 374-385页

作者： Eduardo Goncalves Emanuel Marco Moniz saul neves de jesus department of Psychiatry and Mental Health of Hospital Center of Algarve Faro Portugal department of Psychology of Faculty of Social and Human Sciences of University of Algarve Faro Portugal

Economic insufficiency causes stress and negative affects. Poverty is self-perpetuated, also due to a particular pattern of economic behaviors induced by negative affects and stress. Often, loneliness occurs together with economic insufficiency. For this study, it has been selected a sample of convenience. A positive correlation between anxiety/depression and negative affects is presented. Dispositional optimism and social support, factors which contribute to health, serve as buffers, in negative correlation, of the negative impact of negative affects, due to financial restraint, on health. Financial management is negatively correlated with the lack of cardiovascular health, and cardiovascular dysfunction correlates positively with loneliness, in this study. Positive affects correlate positively with resilience skills, which correlate negatively with depression. Within this context, psychobiological therapeutic interventions and psychotherapy, which also target psychological dysfunction related to economic behavior of persons in a situation of poverty, would be beneficial.

关键词： Poverty Stress Affects depression Heart Rate Variability Social Support Resilience Economic Behavior

Assessment of Stress Cognitive Control and Executive Function with Stress Control Rating Scale (ECOSTRESS) and Low Resolution Brain Electromagnetic Tomography (LORETA) (In Portuguese People in Situations of Unemployment and Economic Insufficiency)

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Open Journal of Psychiatry 2016年第2期6卷 158-164页

作者： Eduardo Gonçalves Marco Moniz saul neves jesus department of Psychiatry and Mental Health Hospital Center of Algarve Faro Portugal Research Center for Spatial and Organization Dynamics (CIEO) University of Algarve Faro Portugal

This article reviews the constructs of stress, appraisal, coping, according to a transactional perspective, and executive function, and presents a stress control rating scale (ECOSTRESS), which design is founded in these constructs. This psychometric tool is useful in the assessment of cognitive control of stress, correlated with the function of dorsolateral prefrontal cortex. It has been validated for its use in the assessment of Portuguese people in situations of stress related to unemployment and economic insufficiency. Also, within the context of the cognitive control of stress, it is highlighted the usefulness of low resolution brain electromagnetic tomography (LORETA).

关键词： Stress Anxiety depression Mania Economic Insufficiency Executive Function Anterior Cingulate Cortex Dorsolateral Prefrontal Cortex Stress Control Rating Scale (ECOSTRESS) Low Resolution Brain Electromagnetic Tomography (LORETA) Neurofeedback

Sensitivity Analysis and Calibration of Hydrological Modeling of the Watershed Northeast Brazil

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Journal of Environmental Protection 2015年第8期6卷 837-850页

作者： Marinoé Gonzaga da Silva Antenor de Oliveira de Aguiar Netto Ramiro Joaquim de jesus neves Anderson Nascimento do Vasco Carina Almeida Gregório Guirado Faccioli Campus Sã o Cristóvã o Federal Institute of Sergipe S&#227 o Cristóvã o Brazil

Mathematical models of the quantity and quality of water in hydrographic basins enable simulation of a wide variety of processes, including the production of water and sediments, and the dynamics of point and nonpoint sources of pollution. These models have become increasingly complex, requiring large amounts of input data, which can increase the uncertainty of the results of simulations. For this reason, it is essential to perform calibration and validation procedures. The objective of this work was to conduct sensitivity analysis and calibration of a distributed hydrological model (SWAT) applied to the flows of water in the watershed of the Poxim River. Satisfactory performance of the model was indicated by the values obtained for the Nash-Sutcliffe efficiency coefficient (0.77), the percent bias (5.05), the root mean square error (0.48), and the ratio of the RMSE to the standard deviation of the observations (RSR) (0.49). The set of parameters identified here could be used for the simulation and evaluation of other scenarios.

关键词： Sensitivity Analysis Calibration Hydrological Model Watershed

Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A_(1) and A_(2) Adenosine-Receptor Antagonists in Rats

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Pharmacology & Pharmacy 2013年第3期4卷 303-311页

作者： Ilhuicamina Daniel Limon-Perez de Leon Maria del Carmen Parra-Cid Alejandro Munoz-Zurita saul Alejandro Merino-Contreras Sara Montiel-Smith Socorro Meza-Reyes Gerardo Ramirez-Meja jesus Sandoval-Ramirez Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de PueblaPueblaMexico Instituto Nacional de Rehabili-tacion Unidad de Ingenieria de TejidosTerapia Celular y Medicina RegenerativaMexico DFMexico.

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

关键词： Xantines Adenosine Receptors Antagonists Turning Behavior Anti-Parkinsonian Drugs

Case Report: Clinical and Diagnostic Aspects of Mayer-Rokitansky-Kuster-Hauser Syndrome

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Health 2019年第10期11卷 1367-1372页

作者： Lucas Ferreira de Paula Filho Guilherme Carolino neves Laís Figueira Bandoli Lucas Caraline de Almeida Coelho Nathália de Souza Ferreira Feital Renan Vieira Murad Ana Luísa Conceiç o de jesus Diana Aristótelis de Sá Larissa Bianca Cunha de Sá Jonathan Mwambire Alberto Krayyem Arbex IPEMED Medical School/AFYA Educational Postgraduation in Endocrinology Rio de Janeiro Brazil UNIFESO Medical School Teresópolis Brazil department of Pediatrics Medical School University of So Paulo (USP) So Paulo Brazil Medical Clinic in Endocrinology and Diabetology Schleswig-Flensburg Germany.

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a rare disease characterized by total or partial vagina agenesis, karyotype 46, XX with normal secondary sexual characters. Still, it is the second leading cause of primary amenorrhea. The absence of obvious signs and symptoms often causes the syndrome to be diagnosed only after puberty. The case presented here highlights exactly this difficulty of early diagnosis, which meets the objective of the study, and is precisely to provide reliable material that facilitates the diagnosis and management of patients with MRKH syndrome.

关键词： Mayer-Rokitansky-Kuster-Hauser Syndrome Primary Amenorrhea Gonadal Dysgenesis

Analysis of Key Features of Non-Linear Behavior Using Recurrence Plots. Case Study: Urban Pollution at Mexico City

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Journal of Environmental Protection 2012年第9期3卷 1147-1160页

作者： Marco A. Aceves-Fernandez jesus Carlos Pedraza-Ortega Artemio Sotomayor-Olmedo Juan M. Ramos-Arreguín Jose Emilio Vargas-Soto saul Tovar-Arriaga Campus Juriquilla Universidad Autonoma de Queretaro Santiago de Querétaro México

The use of Recurrence plots have been extensively used in various fields. In this work, Recurrence Plots (RPs) investigates the changes in the non-linear behaviour of urban air pollution using large datasets of raw data (hourly). This analysis has not been used before to extract information from large datasets for this type non-linear problem. Two different approaches have been used to tackle this problem. The first approach is to show results according to monitoring network. The second approach is to show the results by particle type. This analysis shows the feasibility of using Recurrence Analysis for pollution monitoring and control.

关键词： Recurrence Plot Air Quality Air Pollution Modelling Atmospheric Pollution Recurrence Quantification Analysis