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Barrett's metaplasia:clinical implications

World Journal of Gastroenterology 2001年第4期7卷 563-565页

作者： sauidishaq bham ac.uk JanuszAJankowski Epithelial Laboratory Division of Medical SciencesUniversity of BirminghamEdgbastonB15 2 THUK This study is supported by the Cancer Research CampaignImperial Cancer Research Fund and Medical Research Council.Correspondence to:Dr.Janusz A Jankowski MD PhD FRCPEpithelial LaboratoryDivision of Medical SciencesUniversity of BirminghamEdgbastonB15 2THUK.j.jankowski

The incidence of Barretts metaplasia (BM) as well as Barrett' s adenocarcinoma (BA) has been increasing in western populations. The prognosis of BA is worse because individuals present at a late stage. Attempts have been made to intervene at early stage using surveillance programmes, although proof of efficacy of endoscopic surveillance is lacking, particularly outside the specialist centres. The management of BM needs to be evidencebased as there is a lack clarity about how best to treat this condition. The role of proton pump inhibitors and antireflux surgery to control reflux symptoms is *** adequate control of gastroesophageal reflux early in the disease alters the natural history of Barrett' s change once it has developed and or prevents it in patients with gastroesophageal reflux disease but with no Barrett' s change remains unanswered. There is much to be learned about BM. Thus there is great need for carefully designed large randomised controlled trials to address these issues in order to determine how best to manage patients with BM.

关键词： Barrett Esophagus Humans Incidence Mass Screening Metaplasia Prevalence Research Support, Non-U.S. Gov't

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