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Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek Kumar Rai Anjali sing. saudan sing. Basant Kumar Dubey Raj Kishori Lal Arvind sing. Negi Nicholas Birse Prabodh Kumar Trivedi Christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using.rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using.Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using.this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

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Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

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World Journal of Gastroenterology 2012年第38期18卷 5351-5359页

作者： David Philippe Viral Brahmbhatt Francis Foata Yen saudan Patrick Serrant Stephanie Blum Jalil Benyacoub Karine Vidal Department of Nutrition and Health Nestlé Research CenterCH-1000 Lausanne Switzerland

AIM: To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB), bothin vitro and using.a mouse model of experimental colitis. METHODS: The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line. in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NFκB) activation, utilizing reporter cell lines. Following the in vitro assessment, the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using.a preclinical model of intestinal inflammation. Multiple outcomes including body weight, intestinal histology, colonic cytokine levels and anti-oxidative measures were ***: LWB reduced the LPS-mediated inductionof ROS production [+LPS vs 1% LWB + LPS, 1590 ± 188.5 relative luminescence units (RLU) vs 389 ± 5.9 RLU, P < 0.001]. LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5% LWB, 15% ± 7.8% vs 64% ± 5%, P < 0.001). In addition, LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB, 73% ± 6.9% vs 148% ± 28.3%, P < 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB, 10% ± 6.7% vs 35% ± 3.3%, P < 0.05). Furthermore, oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB, 5.39 ± 0.61 vs 3.66 ± 0.59, P = 0.0445) and histological scores (-LWB vs +LWB, 5.44 ± 0.32 vs 3.66 ± 0.59, P = 0.0087) in colitic mice. These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB, 570 ± 245 μg/L vs 89 ± 38 μg/L, P = 0.0106), keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB, 184 ± 49 μg/Lvs 75 ± 20 μg/L,P = 0.0244), IL-6 (-LWBvs +LWB, 318 ± 99 μg/L

关键词： Lacto-Wolfberry Colitis Nutrition Inflammation Wolfberry Inflammatory bowel disease Crohn's disease

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短期常压低氧步行训练对肥胖成年人运动能力和步态的影响

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中华高血压杂志 2018年第6期26卷 525-525页

作者：刘青叶鹏 Fernández Menéndez A saudan G Sperisen L Hans D Saubade M Millet GP Malatesta D

为了比较以个人喜好的步行速度（preferred walking speed,PWS）短期低氧与常氧训练对肥胖患者的能量、力学、效率和代谢风险标志物的影响,Fernández Menéndez等纳入肥胖患者23例,在缺氧[海拔3km,n=12;体质量指数（body mass index,BM... 详细信息

为了比较以个人喜好的步行速度（preferred walking speed,PWS）短期低氧与常氧训练对肥胖患者的能量、力学、效率和代谢风险标志物的影响,Fernández Menéndez等纳入肥胖患者23例,在缺氧[海拔3km,n=12;体质量指数（body mass index,BMI）（34.0±0.8）kg/m2]或常氧[海拔360m,n=11;BMI（32.9±0.8）kg/m2]情况下.

关键词：肥胖患者步行训练常压低氧运动能力成年人步态体质量指数步行速度

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