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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam sau man chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Spreadsheet quality assurance:a literature review

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Frontiers of Computer Science 2024年第2期18卷 61-82页

作者： Pak-Lok POON man Fai LAU Yuen Tak YU sau-Fun TANG School of Engineering and Technology Central Queensland UniversityMelbourne 3000Australia Department of Computing Technologies Swinburne University of TechnologyHawthorn 3122Australia Department of Computer Science City University of Hong KongHong Kong SAR 999077China The Royal Victorian Eye and Ear Hospital East Melbourne 3002Australia

Spreadsheets are very common for information processing to support decision making by both professional developers and non-technical end ***,business intelligence and artificial intelligence are increasingly popular in the industry nowadays,where spreadsheets have been used as,or integrated into,intelligent or expert systems in various application ***,it has been repeatedly reported that faults often exist in operational spreadsheets,which could severely compromise the quality of conclusions and decisions based on the *** a view to systematically examining this problem via survey of existing work,we have conducted a comprehensive literature review on the quality issues and related techniques of spreadsheets over a 35.5-year period(from January 1987 to June 2022)for target journals and a 10.5-year period(from January 2012 to June 2022)for target *** other findings,two major ones are:(a)Spreadsheet quality is best addressed throughout the whole spreadsheet life cycle,rather than just focusing on a few specific stages of the life cycle.(b)Relatively more studies focus on spreadsheet testing and debugging(related to fault detection and removal)when compared with spreadsheet specification,modeling,and design(related to development).As prevention is better than cure,more research should be performed on the early stages of the spreadsheet life *** by our comprehensive review,we have identified the major research gaps as well as highlighted key research directions for future work in the area.

关键词： decision support system end-user computing end-user programming Excel spreadsheet

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Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： Yu-Xin Zhu Zi-Ling Tang Lu Lu Zuo-Cheng Qiu Dabo Pan Yang Yu Hui-Hui Xiao man-sau Wong State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

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Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee sau man chan Leo C.H.Tsang Karl C.K.chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

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Expression, secretion and functional characterization of three laccases in E. coli

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Synthetic and Systems Biotechnology 2022年第1期7卷 474-480页

作者： Yating Mo Hou Ip Lao sau Wa Au Ieng Chon Li Jeremy Hu Hoi man Yuen Wai man Cheong Owen Lok In Lo Leo Chi U.Seak Pui Ching Middle School(Macao) Edificio Pui Ching7A Av.de Horta e CostaMacao SARChina Department of Physiology Development of NeuroscienceUniversity of CambridgeCambridgeCB23DYUnited Kingdom The Centre for Inflammation Research University of Edinburgh47 Little France CrescentEdinburghEH164TJUnited Kingdom

Endocrine Disrupting Chemicals(EDCs)are a group of molecules that can influence hormonal balance,causing disturbance of the reproductive system and other health *** the efforts to eliminate EDC in the environment,all current approaches are inefficient and *** previous research,studies revealed that laccase-producing microorganisms may be a potential candidate for EDC degradation,as laccases have been found to be able to degrade many kinds of EDCs effectively and ***,we created two recombinant laccases,each fused with secretion peptide,Novel Signal Peptide 4(NSP4),and expressed them in Escherichia coli(***,BL21),together with one laccase without secretion *** first optimized the culture condition of expressing these ***,we test the activity of the recombinant laccases of decolorizing of a synthetic dye,indigo ***,we confirmed the secreted can degrade one of the EDCs,β-estradiol,showing the potential of using the laccase secretion system to degrade toxic compounds.

关键词： Laccase Endocrine disrupting chemicals(EDCs)

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A joint computational-experimental study of intracranial aneurysms:Importance of the aspect ratio

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Journal of Hydrodynamics 2016年第3期28卷 462-472页

作者： Simon Sui-man LAI Abraham Yik-sau TANG Anderson Chun-On TSANG Gilberto Ka-Kit LEUNG Alfred Cheuk-Hang YU Kwok Wing CHOW Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Electrical and Computer Engineering University of Waterloo Ontario Canada

Rupture of a cerebral aneurysm （abnormal swelling of blood vessel in the brain） will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental study is conducted to assess the importance of the aspect ratio in the dynamics of blood flow. The aspect ratio is defined here to be the ratio of the height of the aneurysm to the linear dimension of the neck. Idealized models of such aneurysms located near a bifurcation point were investigated. Numerical simulations for hemodynamic properties like shear stress and flow rate were performed. The computational results were verified experimentally with specially fabricated phantoms, blood mimicking fluid and Doppler ultrasound imaging. Excellent agreements were obtained. Two features are highlighted, providing information in the intensely debated link between rupture risk and geometric factors. On increasing the aspect ratios, firstly, a jet impinging on the distal part of the neck can be observed, and secondly, a region of positive shear stress gradient can be found there. Furthermore, computational analyses for four patient-specific models were conducted to correlate with the results of idealized models and to provide further clinical insight.

关键词： intracranial aneurysms aspect ratio Doppler ultrasound

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Metabolic syndrome and benign prostatic hyperplasia:An update

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Asian Journal of Urology 2017年第3期4卷 164-173页

作者： Ho-Yin Ngai Kar-Kei Steffi Yuen Chi-man Ng Cheung-Hing Cheng sau-Kwan Peggy Chu Division of Urology Department of SurgeryQueen Elizabeth HospitalHong KongChina Division of Urology Department of SurgeryTuen Mun HospitalHong KongChina

Metabolic syndrome(MetS)is a cluster of metabolic abnormalities related to central adiposity and insulin *** importance is increasingly recognized as it associates with increased risks of metabolic and cardiovascular *** metabolic aberrations of MetS may lead to development of benign prostatic hyperplasia(BPH)and lower urinary tract symptoms(LUTS)in men.A 26.5%-55.6% prevalence of MetS in men with LUTS was reported in worldwide *** the exact biological pathway is not clear yet,insulin resistance,increased visceral adiposity,sex hormone alterations and cellular inflammatory reactions played significant roles in the related pathophysiological *** should recognize the cardiovascular and metabolic impacts of MetS in men with LUTS,early risk factors optimization and use of appropriate medical therapy may possibly alter or slower the progression of LUTS/BPH,and potentially avoid unnecessary morbidities and mortalities from cardiovascular and metabolic diseases for those men.

关键词： Inflammation Insulin resistance Lower urinary tract symptoms Metabolic syndromeX Prostatic hyperplasia

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Trabecular bone deterioration at the greater trochanter ol mice with unilateral obstructive nephropathy

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Asian Journal of Andrology 2013年第4期15卷 564-566,I0011,I0012页

作者： Sa-Sa Gu Yan Zhang Xi Chen Teng-Yue Diao Yoseph Gebru man-sau Wong Center tor Systems Biomedical Sciences University ot Shanghai tor Science and I echnology Shanghai 200093 China School ot Medical Instrument and Food Engineering University of Shanghai for Science and Technology Shanghai 200093 China and Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong SAR China

Our previous study showed the early molecular responses of bone in response to obstructive nephropathy in a unilateral ureteral obstruction （UUO） mouse model. Here, we addressed the changes in trabecular bone properties at greater trochanter, the proximal and the distal metaphysis of femur in UUO mice. The male mice were subjected to UUO （n= 10） or sham operation （n= 10）. All mice were killed on day 7 after the surgical operation. The micro-computed tomography （micro-CT） analysis for different femoral trabecular bone sites demonstrated pathological alterations of trabecular bone mass and micro-networks at greater trochanter as shown by decreases in bone mineral density/bone volume （P〈O.05） and trabecular number （P〈O.05） and increases in trabecular separation （P〈O.01） and bone surface/bone volume （P〈O.05） in UUO mice. The present study demonstrates that UUO-induced unilateral obstructivenephropathy has markedly detrimental effects on the trabecular trochanter of the femur.

关键词： bone femur micro-computed tomography (micro-CT) trochanter unilateral ureteral obstruction (UUO)

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“主之谓”之“之”的韵律属性、功能及语体特征

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韵律语法研究 2020年第2期 162-184页

作者：陈远秀香港中文大学中国语言及文学系

本文首先讨论上古汉语"主之谓"结构里"之"的性质,论证"之"不是句法功能词,而是韵律占位词;然后提出"之"具有的不同韵律功能,包括整饬节律、加重韵律分量及调整语调;借此进一步分析它能够为"主之谓"带来正式语体属性的原因。

关键词：之主之谓韵律占位词语调正式语体

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肾素抑制剂阿利吉仑对低钙喂饲小鼠松质骨的作用

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中国药理学通报 2014年第10期30卷 1477-1478页

作者：张方怡 Gebru Yoseph 黄文秀张岩上海理工大学系统生物医学研究中心上海200093 香港理工大学应用生物及化学科技学系

低钙饮食导致骨吸收增强,可诱发骨量的流失[1],严重的则可导致骨质疏松。近年来有研究发现,肾素-血管紧张素系统（ RAS ）存在于骨组织并参与骨代谢疾病的发病过程[2-3]。由于骨组织RAS的活性升高,其活性肽血管紧张素II（AngII）的生成... 详细信息

低钙饮食导致骨吸收增强,可诱发骨量的流失[1],严重的则可导致骨质疏松。近年来有研究发现,肾素-血管紧张素系统（ RAS ）存在于骨组织并参与骨代谢疾病的发病过程[2-3]。由于骨组织RAS的活性升高,其活性肽血管紧张素II（AngII）的生成增加,AngⅡ作为RAS的最重要的活性物质[4]通过调控骨代谢致骨量流失[5]。阿利吉仑（ Aliskiren）是一种新研制的可口服的具有直接抑制肾素活性的新型长效降压药物[6]。阿利吉仑通过抑制RAS首步肾素的活性,可以有效抑制血管紧张素原向血管紧张素I的转化[7],继而有效减少 RAS活性肽 AngII的生成[8]。本实验以肾素抑制剂阿利吉仑为研究对象,探讨其对低钙饮食小鼠松质骨的作用。

关键词：阿利吉仑肾素-血管紧张素系统肾素抑制剂松质骨低钙饮食骨损伤

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