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Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice:In vivo and in-silico study

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 312-322页

作者： Md Jamir Anwar sattam khulaif alenezi Faizul Azam Danish Mahmood Faisal Imam Khalid Saad Alharbi Department of Pharmacology and Toxicology Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmaceutical Chemistry&Pharmacognosy Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakahSaudi Arabia

Objective:To investigate the effect of Nigella sativa oil on cardiomyopathy and neurobehavioral changes induced by doxorubicin in ***:Swiss strain of albino female mice were divided into 6 groups of 5 animals in each:GroupⅠ(control group),groupⅡ(doxorubicin,10 mg/kg,i.v.),groupⅢ,Ⅳ,andⅤ(Nigella sativa oil;1.5,3,and 6 mL/kg,respectively),groupⅥ(Nigella sativa oil per se;6 mL/kg,p.o.).The duration of treatment was 15 d(10 days’pre-treatment and 5 days’post-treatment)and doxorubicin was administered on day 11th of the treatment *** Nigella sativa oil treatment,neurobehavioral tests,cardiac hypertrophy tests,and biochemical tests in serum and tissues were *** tests included assessment of anxiety-like behavior in the elevated plus maze,spontaneous alternation behavior in the cross maze,and depression-like behavior in modified forced swim *** tests included serum lactate dehydrogenase and creatinine kinase-MB,malondialdehyde and reduced glutathione in ***,molecular docking was used to estimate the affinity of the phytoconstituents of Nigella sativa oil with histone ***:Nigella sativa oil treatment significantly(P<0.001)restored doxorubicin-induced neurobehavioral changes,decreased lactate dehydrogenase and creatinine kinase-MB in the plasma,malondialdehyde contents in tissues,and increased reduced glutathione ***,no significant alteration was observed in Nigella sativa oil per se group as compared to the *** docking showed that Nigella sativa oil components had appreciable binding affinitiy with the protein cavities of HDAC1 and ***:The result shows that Nigella sativa oil exerts anxiolytic,antidepressant,and memory-enhancing effects in addition to cardioprotective effect against doxorubicin-induced cardiomyopathy in *** modulatory effect of Nigella sativa oil on oxidative stress could contribute to the cardioprotective effect and associated neuro

关键词： Nigella sativa oil Doxorubicin Cardiomyopathy Neurobehavioral changes Lactate dehydrogenase Creatinine kinase-MB Malondialdehyde Reduced glutathione Mice HDAC docking

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