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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 4-5页

作者： Henry C. R. satran d. Lind.ren B. T.d. Henry 杜媛(译) 马超(校) 不详 Minneapolis Heart Institute Found.tion 920 E 28th St Minneapolis MN 55407 United States

Context: Carbon monoxid.(CO) poisoning is a common cause of toxicological morbid.ty and.mortality. Myocard.al injury is a frequent consequence of mod.rate to severe CO poisoning. While the in- hospital mortality for these patients is low, the long- term outcome of myocard.al injury in this setting is unknown. Objective: To d.termine the association between myocard.al injury and.long- term mortality in patients following mod.rate to severe CO poisoning. d.sign, Setting, and.Participants: Prospective cohort stud. of 230 consecutive ad.lt patients treated.for mod.rate to severe CO poisoning with hyperbaric oxygen and.ad.itted.to the Hennepin County Med.cal Center, a regional center for treatment of CO poisoning, between January 1, 1994, and.January 1, 2002. Follow- up was through November 11, 2005. Main Outcome Measure: All- cause mortality. Results: Myocard.al injury(card.ac troponin I level ≥ 0.7 ng/mL or creatine kinase- MB level ≥ 5.0 ng/mL and.or d.agnostic electrocard.ogram changes) occurred.in 85(37% ) of 230 patients. At a med.an follow- up of 7.6 years(range: in- hospital only to 11.8 years), there were 54 d.aths(24% ). Twelve of those d.aths(5% ) occurred.in the hospital as a result of a combination of burn injury and.anoxic brain injury(n=8) or card.ac arrest and.anoxic brain injury(n=4). Among the 85 patients who sustained.myocard.al injury from CO poisoning, 32(38% ) eventually d.ed.compared.with 22(15% ) of 145 patients who d.d.not sustain myocard.al injury(ad.usted.hazard.ratio, 2.1; 95% confid.nce interval, 1.2- 3.7; P=.009). Conclusion: Myocard.al injury occurs frequently in patients hospitalized.for mod.rate to severe CO poisoning and.is a significant pred.ctor of mortality.

关键词：一氧化碳(CO)中毒重度CO中毒远期死亡率心肌损伤中毒后前瞻性队列研究高压氧治疗成年患者院内死亡率远期结果

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中度至重度一氧化碳中毒后的心肌损伤和长期死亡率

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 2-3页

作者： Henry C.R satran d.Lind.ren B T.d. Henry 江山 Minneapolis Heart Institute Found.tion 920 E 28th St Minneapolis MN 55407 United StatesDr.

Context: Carbon monoxid. (CO) poisoning is a common cause of toxicological morbid.ty and.mortality. Myocard.al injury is a frequent consequence of mod.rate to severe CO poisoning. While the in-hospital mortality for these patients is low, the long-term outcome of myocard.al injury in this setting is unknown. Objective: To d.termine the association between myocard.al injury and.long-term mortality in patients following mod.rate to severe CO poisoning. d.sign, Setting, and.Participants: Prospective cohort stud. of 230 consecutive ad.lt patients treated.for mod.rate to severe CO poisoning with hyperbaric oxygen and.ad.itted.to the Hennepin County Med.cal Center, a regional center for treatment of CO poisoning, between January 1, 1994, and.January 1, 2002. Follow-up was through November 11, 2005. Main Outcome Measure: All-cause mortality. Results: Myocard.al injury (card.ac troponin I level ≥ 0.7 ng/mL or creatine kinase-MB level ≥ 5.0 ng/mL and.or d.agnostic electrocard.ogram changes) occurred.in 85 (37% ) of 230 patients. At a med.an follow-up of 7.6 years (range: in-hospital only to 11.8 years), there were 54 d.aths (24% ). Twelve of those d.aths (5% ) occurred.in the hospital as a result of a combination of burn injury and.anoxic brain injury (n=8)or card.ac arrest and.anoxic brain injury (n=4). Among the 85 patients who sustained.myocard.al injury from CO poisoning, 32 (38% ) eventually d.ed.compared.with 22 (15% ) of 145 patients who d.d.not sustain myocard.al injury (ad.usted.hazard.ratio, 2.1; 95% confid.nce interval, 1.2- 3.7; P=.009). Conclusion: Myocard.al injury occurs frequently in patients hospitalized.for mod.rate to severe CO poisoning and.is a significant pred.ctor of mortality.

关键词：一氧化碳(CO)中毒重度CO中毒住院死亡率心肌损伤中度中毒后中毒患者心肌肌钙蛋白I 高压氧治疗脑缺氧损伤

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