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Drug-induced mucosal alterations observed during esophagogastroduodenoscopy

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World Journal of Gastroenterology 2024年第16期30卷 2220-2232页

作者： Masaya Iwamuro Seiji kawano Motoyuki Otsuka Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Several features of drug-induced mucosal alterations have been observed in the upper gastrointestinal tract,i.e.,the esophagus,stomach,and *** include pill-induced esophagitis,desquamative esophagitis,worsening of gastroesophageal reflux,chemotherapy-induced esophagitis,proton pump inhibitor-induced gastric mucosal changes,medication-induced gastric erosions and ulcers,pseudomelanosis of the stomach,olmesartan-related gastric mucosal inflammation,lanthanum deposition in the stomach,zinc acetate hydrate tabletinduced gastric ulcer,immune-related adverse event gastritis,olmesartan-associated sprue-like enteropathy,pseudomelanosis of the duodenum,and lanthanum deposition in the *** endoscopists,acquiring accurate knowledge regarding these diverse drug-induced mucosal alterations is crucial not only for the correct diagnosis of these lesions but also for differential diag-nosis of other *** minireview aims to provide essential information on druginduced mucosal alterations observed on esophagogastroduodenoscopy,along with representative endoscopic images.

关键词： Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Esophageal lesions Gastric lesions Duodenal lesions

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI kawano TATSUYA IWASAKI ICHRO ITONAGA YUTA KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI kawano TATSUYA IWASAKI ICHIRO ITONAGA YUTA KUBOTA HIROSHI TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Fine-tuning ROS homeostasis by ROD1 is a battleground between rice and Magnaporthe oryzae

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Molecular Plant 2021年第12期14卷 1979-1981页

作者： Yoji kawano CAS Center for Excellence in Molecular Plant Sciences Shanghai Center for Plant Stress BiologyChinese Academy of SciencesShanghai 201602China Kihara Institute for Biological Research Yokohama City UniversityYokohamaKanagawa 244-0813Japan Institute of Plant Science and Resources Okayama University2-20-1ChuoKurashikiOkayama 710-0046Japan

When plants recognize pathogens,reactive oxygen species(ROS)homeostasis is optimized to elicit immune *** also manipulate ROS homeostasis in host plants,which increases susceptibility to pathogens.A recent study found a novel regulation mechanism of ROS homeostasis through a rice susceptibility gene(ROD1)(Gao et al.,2021).The loss of function of ROD1 confers high resistance against three major rice pathogens but decreases yield,and an allele of ROD1 improves basal disease resistance without reducing *** current study sheds light on the fine-tuning of ROS ho-meostasis by ROD1 in rice and on how the Magnaporthe oryzae effector Avr-Piz-t highjacks on ROS homeostasis in rice.

关键词： homeostasis Magnaporthe susceptibility

Improving disease resistance to rice false smut without yield penalty by manipulating the expression of effector target

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Molecular Plant 2022年第12期15卷 1834-1837页

作者： Qiong Wang Yoji kawano School of Plant Protection Yangzhou UniversityYangzhou 225009China Institute of Plant Science and Resources Okayama UniversityOkayama 710-0046Japan Kihara Institute for Biological Research Yokohama City UniversityKanagawa 244-0813Japan

Rice grain production and quality are threatened by many devastating *** smut caused by Ustilaginoidea virens is emerging as a major fungal disease of rice,leading to a severe loss of *** invades only rice panicles at the late stage of booting and replaces grains with false smut balls containing mycotoxins,which endanger human and animal health(Sun et al.,2020).This successful colonization is accomplished through manipulating host immune responses by *** effectors.

关键词： false panicle resistance

Results obtained by geodetic instruments of SELENE (KAGUYA)

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2188-2193页

作者： kawano Nobuyuki VRAD/RSAT Team LALT Team Shanghai Astronomical Observatory

Japanese lunar explorer SELENE (KAGUYA) was equipped with 14 instruments for various measurements of the Moon. Three of these instruments took geodetic measurements of the Moon. These were two sub-satellites and a laser altimeter. The main results obtained by the instruments are: (1) precise orbit determination with an accuracy of ten meters by Doppler and same-beam VLBI; (2) the first precise gravity fields on the lunar far side by 4-way Doppler measurements; (3) the first topography in latitudes higher than 86 degrees; (4) a global map of the gravity anomaly by using the global topography and the global gravity fields; (5) a global map of the lunar crustal thickness and (6) an illumination rate map in the north and south polar regions.

关键词： SELENE gravity field lunar far side topography gravity anomaly crustal thickness illumination rate

Proposal of Japanese Vocabulary Difficulty Level Dictionaries for Automated Essay Scoring Support System Using Rubric

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Journal of the Operations Research Society of China 2020年第4期8卷 601-617页

作者： Megumi Yamamoto Nobuo Umemura Hiroyuki kawano School of Contemporary International Studies Nagoya University of Foreign StudiesIwasaki-choNisshin 470-0197Japan School of Media and Design Nagoya University of Arts and SciencesNagoya 470-0196Japan Faculty of Science and Engineering Nanzan UniversityNagoya 466-8673Japan

We are developing a Moodle plug-in,which is an AES(automated essay scoring)support system for the basic education of university *** system evaluates essays based on rubric,which has five evaluation viewpoints“Contents,Structure,Evidence,Style,and Skill”.Vocabulary level is one of the scoring items of *** is calculated using Japanese Language Learners’Dictionaries constructed by Sunakawa et *** this does not fully cover the words used in the student-level essays,we found that there is a problem with the accuracy of the vocabulary level *** this paper,we propose to construct comprehensive Japanese vocabulary difficulty level dictionaries using Japanese Wikipedia as the *** apply Latent Dirichlet Allocation(LDA)to the Wikipedia corpus and find the word appearance probability as one of the indexes of word *** use the TF-IDF value instead of the LDA value of the words,which rarely *** a result,we constructed highly comprehensive Japanese vocabulary difficulty level *** confirmed that the vocabulary level can be scored for all words in the test dataset by using the constructed dictionaries.

关键词： Automated essay scoring Vocabulary level Dictionary Wikipedia Corpus LDA Rubric

Shielding effect on tritium water monitoring system based on CaF2 flow-cell detector

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Nuclear Science and Techniques 2014年第A1期25卷 20-22页

作者： Takao kawano Hidemichi Ohashi Yohsei Hamada Erdenetog Jamsranjav National Institute for Fusion Science Oroshi-cho 322-6 Toki-city Gifu 509-5292 Japan ATOX Co. Ltd. 2-3-4 Shintomi Chuo-ku Tokyo 104-0041 Japan

A monitoring system based on a CaF2 flow-cell detector was previously developed for measuring the tritium concentration in water. The flow-cell detector was fabricated using a granular CaF2(Eu) solid scintillator. In the present study, the effect of lead shielding on the measurement sensitivity was investigated. First, measurements were carried out both on tritium water and tritium-free water without the use of shielding. Counts were accumulated for either 600 or 10 000 s and the detection limits without shielding were calculated. Second, the effect of shielding was evaluated using background radiation. Lead blocks with a thickness of 5 cm were used as shielding materials. Full shielding around the entire measurement system reduced the background count by 53.8%. Approximating this to a background reduction of 2 times, the detection limit with full shielding was then calculated. It was concluded that 5-cm-thick lead shielding reduced the detection limit for tritium by at least 35%. © 2014, Science Press. All rights reserved.

关键词：屏蔽计算监测系统细胞检测氟化钙氚水测量灵敏度检测极限背景辐射

MICROSCOPIC ANALYSIS OF POLYCRYSTALLINE MATERIAL AT HIGH TEMPERATURE

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 350-354页

作者： S.Imatani R.Kawakami Y.kawano Kyoto University Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 Japan

The microscopic analyses of polycrystalline material at high temperature were carried out. The crystal plasticity model proposed by Asaro and Needleman was applied to a polycrystal model in the finite element simulation and the crystal slip system was randomly provided for each crystal. The grain boundary sliding, which was characteristic at high temperature, was also taken into account. It was shown that the inhomo-geneous deformation develops over the polycrystal and that the strain concentration appears around the triple point of crystal grain boundary.

关键词： crystal plasticity finite element method grain boundary inho-mogeneity