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Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju hasegawa Soichiro Yamada Koichi Imai Asuka Kaizaki-Mitsumoto satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular *** describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and *** hours after arrival,an electrocardiogram revealed a return to sinus *** patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,*** hospital day 15,he was transferred to a psychiatric *** other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the *** on admission contained 1.50 ng/mL of *** hospital day 2,neither were *** on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day *** The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

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In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

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Light(Advanced Manufacturing) 2022年第3期3卷 150-159页

作者： satoshi hasegawa Masatoshi Fujimoto Toshihisa Atsumi Yoshio Hayasaki Center for Optical Research and Education Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan Hamamatsu Photonics K.K. 5000 HirakuchiHamakita-kuHamamatsu 434-8601Japan

A line-shaped beam is useful for increasing the processing speed in laser grooving and *** laser grooving,depth control of the processed structure is important for performing precise *** this paper,in-process monitoring of the depth of a structure formed by femtosecond laser processing with a line-shaped beam using swept-source optical coherence tomography(SS-OCT)was *** the evaluation of the SS-OCT system,the depth resolution,measurement accuracy,and axial measurable range were 15.8μm,±2.5μm and 5.3 mm,*** laser grooving,the structural shape and the distribution of deposited debris were successfully *** measured depth agreed well with the depth obtained using a laser confocal *** proposed method will be effective for precise laser processing with feedback control of the laser parameters based on in-process monitoring of the processed structure.

关键词： Optical coherence tomography Computer-generated hologram Femtosecond laser processing In-process monitoring

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Body Characteristics of Professional Japanese Keirin Cyclists： Flexibility, Pelvic Tilt, and Muscle Strength

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Journal of Sports Science 2016年第6期4卷 341-345页

作者： Yuto Tashiro satoshi hasegawa Shu Nishiguchi Naoto Fukutani Daiki Adachi Takayuki Hotta Saori Morino Hidehiko Shirooka Yuma Nozaki Hinako Hirata Moe Yamaguchi Seishiro Tasaka Tomohumi Matsushita Keisuke Matsubara Tomoki Aoyama Human Health Sciences Graduate School of Medicine Kyoto University Kyoto 606-8501 Japan Research Fellow of the Japan Society for the Promotion of Science Tokyo 102-0083 Japan

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Effects of scallop shell extract on scopolamine-induced memory impairment and MK801-induced locomotor activity

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 643-647页

作者： Yasushi hasegawa Tatsuro Inoue satoshi Kawaminami Miho Fujita College of Environmental Technology Muroran Institute of Technology

Objective:To evaluate the neuroprotective effects of the organic components of scallop shells(scallop shell extract) on memory impairment and locomotor activity induced by scopolamine or 5-methyl-10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5,10-imine(MK801).Methods:Effect of the scallop shell extract on memory impairment and locomotor activity was investigated using the Y-maze test,the Morris water maze test,and the open field ***:Scallop shell extract significantly reduced scopolamine-induced short-term memory impairment and partially reduced scopolamine-induced spatial memory impairment in the Morris water maze *** shell extract suppressed scopolamine-induced elevation of acetylcholine esterase activity in the cerebral *** with scallop shell extract reversed the increase in locomotor activity induced by *** shell extract also suppressed the increase in locomotor activity induced by ***:Our results provide initial evidence that scallop shell extract reduces scopolamine-induced memory impairment and suppresses MK-801-induced hyperlocomotion.

关键词： Locomotor activity Memory impairment Scallop shell Schizophrenia

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PARTICLE-BASED TRANSPARENT FUSED VISUALIZATION APPLIED TO MEDICAL VOLUME DATA

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 104-114页

作者： KYOKO hasegawa SAORI OJIMA YOSHIYUKI SHIMOKUBO SUSUMU NAKATA KOZABURO HACHIMURA satoshi TANAKA College of Information Science and Engineering Ritsumeikan University Noji Higashi 1-1-1 KusatsuShiga525-8577Japan Graduate School of Science and Engineering Ritsumeikan University Noji Higashi 1-1-1 KusatsuShiga525-8577Japan

This paper proposes a method to create 3D fusion images,such as volume–volume,volume–surface,and surface–surface *** method is based on the particle-based rendering,which uses tiny particles as rendering *** method can create natural and comprehensible 3D fusion images simply by merging particles prepared for each element to be ***,the method does not require particle sorting along the line of sight to realize right depth *** apply our method to realize comprehensible visualization of medical volume data.

关键词： Particle-based rendering fused visualization stochastic particle generation.

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Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma

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Current Urology 2023年第1期17卷 52-57页

作者： Jun Teishima Daiki Murata Kazuma Yukihiro Yohei Sekino Shogo Inoue Tetsutaro Hayashi Koji Mita Yasuhisa hasegawa Masao Kato Mitsuru Kajiwara Masanobu Shigeta satoshi Maruyama Hiroyuki Moriyama Seiji Fujiwara Akio Matsubara Department of Urology Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan Department of Urology Hiroshima-City Asa Citizens HospitalHiroshimaJapan Department of Urology Fukuyama Medical CenterFukuyamaJapan Department of Urology Hiroshima General HospitalHatsukaichiJapan Department of Urology Hiroshima Prefectural HospitalHiroshimaJapan Department of Urology Kure Medical Center and Chugoku Cancer CenterKureJapan Department of Urology Miyoshi Central HospitalMiyoshiJapan Department of Urology Onomichi General HospitalOnomichiJapan Department of Urology Higashi-Hiroshima Medical Center Higashi-HiroshimaJapan

Objectives:This study aimed to clarify the significance of therapeutic timing on the effectiveness of nivolumab for treating metastatic renal cell *** and methods:Fifty-eight patients with metastatic renal cell carcinoma treated with nivolumab monotherapy were retrospectively *** who were treated with nivolumab as second-line therapy were included in the second-line group,while the others were included in the later-line *** clinicopathological characteristics,effects of nivolumab,and prognoses of these groups were ***:Twenty and thirty-eight patients were included in the second-line and later-line groups,*** were no significant differences in the distribution of International Metastatic Renal Cell Carcinoma Database Consotium risk and other clinicopathological characteristics between the 2 *** proportion of patients whose objective best response was progressive disease in the second-line group was significantly lower than that in the later-line group(15%vs.50%,p=0.0090).The 50%progression-free survival with nivolumab in the second-line group was significantly better than that in the later-line group(not reached and 5 months,p=0.0018).Multivariate analysis showed that the second-line setting was an independent predictive factor for better progression-free survival(p=0.0028,hazard ratio=0.108).The 50%overall survival after starting nivolumab in the second-line and later-line groups was not reached and 27.8 months,respectively(p=0.2652).Conclusions:The therapeutic efficacy of nivolumab as second-line therapy is expected to be better than that of later therapy.

关键词： Immune checkpoint inhibitor Metastatic renal cell carcinoma Nivolumab Prognostic factor Second-line treatment

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Quantitative evaluation of perceived depth of transparently-visualized medical 3D data presented with a multi-view 3D display

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 115-130页

作者： Yuichi Sakano Yurina Kitaura Kyoko hasegawa Roberto Lopez-Gulliver Liang Li Hiroshi Ando satoshi Tanaka Center for Information and Neural Networks(CiNet)National Institute of Information and Communications Technology and Osaka University 2B6CiNet1-4 Yamadaoka SuitaOsaka 565-0871Japan Graduate School of Frontier Biosciences Osaka University 1-4 YamadaokaSuitaOsaka565-0871Japan Graduate School of Information Science and Engineering Ritsumeikan University 1-1-1 Noji-higashi KusatsuShiga 525-8577Japan College of Information Science and Engineering Ritsumeikan University 1-1-1 Noji-higashi KusatsuShiga 525-8577Japan

Transparent visualization is used in many fields because it can visualize not only the frontal object but also other important objects behind *** in many situations,it would be very important for the 3D structures of the visualized transparent images to be perceived as they are simulated,little is known quantitatively as to how such transparent 3D structures are *** address this question,in the present study,we conducted a psychophysical experiment in which the observers reported the perceived depth magnitude of a transparent object in medical images,presented with a multiview 3D *** the visualization,we employed a stochastic point-based rendering(SPBR)method,which was developed recently as a technique for efficient *** depth of the transparent object was smaller than the simulated *** found,however,that such depth underestimation can be alleviated to some extent by(1)applying luminance gradient inherent in the SPBR method,(2)employing high opacities,and(3)introducing binocular disparity and motion parallax produced by a multi-view 3D display.

关键词： Transparent visualization automultiscopic 3D image psychophysics.

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Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

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World Journal of Gastroenterology 2017年第13期23卷 2414-2423页

作者： Hiroki Sato Nao Nakajima Kazuya Takahashi Go hasegawa Ken-ichi Mizuno Satoru Hashimoto satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai Division of Gastroenterology and Hepatology Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital Division of Cellular and Molecular Pathology Department of Cellular FunctionNiigata University Graduate School of Medical and Dental Sciences

AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue *** In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo *** Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs.

关键词：嗜曙红的食道炎嗜曙红的食道的肌炎 Peroral 内视镜的肌切开术手提钻食管 Achalasia Peroral 食道的肌肉活体检视

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Female Preponderance in the Discordant Association between Retinopathy and Nephropathy in Patients with Type 2 Diabetes Mellitus

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International Journal of Clinical Medicine 2011年第1期2卷 13-17页

作者： Satsuki Kawasaki Shinobu Satoh Osamu hasegawa satoshi Morita satoshi Kato Yasuo Terauchi 不详

Aim: To elucidate clinical features in patients with type 2 diabetes with advanced retinopathy but without nephropathy. Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes mellitus. Diabetic reti-nopathy was graded according to the International Clinical Classification of Diabetic Retinopathy as no diabetic reti-nopathy, mild or moderate non-proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy. Diabetic nephropathy was classified into four stages of severity according to the Guideline Committee of the Japan Diabetes Society. Each patient was examined for retinopathy grade and nephropathy stage. Clinical features of patients with proliferative diabetic retinopathy were compared with regard to the four grades of diabetic nephropathy. Results: Fifty-two patients with type 2 diabetes (3.9% of the whole series of 1324 patients with type 2 diabetes and 25.7% of patients with proliferative diabetic retinopathy) had proliferative diabetic retinopathy without the presence of nephropathy. Multiple statistical analysis using a proportional odds model revealed that pa-tients with proliferative diabetic retinopathy without nephropathy had a significantly lower systolic blood pressure (p < 0.001) than those who did and were preponderantly female (p < 0.05). Conclusions: A possible susceptibility of dia-betic females to proliferative advanced retinopathy without nephropathy encourages further studies on the role of hor-mones and blood coagulation in the pathogensis of proliferative diabetic retinopathy.

关键词： Discordance Female Gender preponderance Hormone Nephropathy Pathogenesis Proliferative Retinopathy Risk factor Type 2 diabetes

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SYNERGISTIC EXTRACTION OF EUROPIUM（Ⅲ） WITH 2-THENOYLTRIFLUOROACETONE AND A LEWIS BASE AND THE APPLICATION TO PREPARATION OF BINUCLEAR COMPLEXES

SYNERGISTIC EXTRACTION OF EUROPIUM（Ⅲ） WITH 2-THENOYLTRIFL...

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International Solvent Extraction Conference 2005

作者： Yuko hasegawa satoshi Kumaki Koichiro Tanaka Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan

In the extraction of lanthanoids(III) with 2-thenoyltrifluoroacetone (Htta) and a Schiff base complexed copper(II), the distribution ratio of europium(III) has been measured as a function of pH, Htta

关键词： Synergistic extraction Schiff base Cu(saltn) lanthanoids(III) stability constants binuclear complexes

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