检索结果-南通市图书馆

Journal of Molecular Cell Biology 2023年第12期15卷 12-27页

作者： Raku Son Kenji Yamazawa Akiko Oguchi Mitsuo Suga Masaru Tamura Motoko Yanagita Yasuhiro Murakawa satoshi Kume RIKEN-IFOM Joint Laboratory for Cancer Genomics RIKEN Center for Integrative Medical SciencesYokohama 230-0045Japan Department of Nephrology Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan Advanced Manufacturing Support Team RIKEN Center for Advanced PhotonicsWako 351-0198Japan Multimodal Microstructure Analysis Unit RIKEN–JEOL Collaboration CenterKobe 650-0047Japan Technology and Development Team for Mouse Phenotype Analysis RIKEN BioResource Research CenterTsukuba 305-0074Japan Institute for the Advanced Study of Human Biology(ASHBi) Kyoto UniversityKyoto 606-8501Japan IFOM—The FIRC Institute of Molecular Oncology Milan 20139Italy Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobe 650-0047Japan Center for Health Science Innovation Osaka City UniversityOsaka 530-0011Japan Osaka Electro-Communication University Neyagawa 572-8530Japan

The living body is composed of innumerable fine and complex *** these structures have been studied in the past,a vast amount of information pertaining to them still remains *** attempting to observe these ultra-structures,the use of electron microscopy(EM)has become ***,conventional EM settings are limited to a narrow tissue area,which can bias ***,new trends in EM research have emerged,enabling coverage of far broader,nano-scale fields of view for two-dimensional wide areas and three-dimensional large ***,cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological *** together,these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology,which now arises as a new omics science termed‘morphomics’.

关键词： comprehensive morphological analysis next-generation electron microscopy 3D bioimaging imaging database deep learning

Biology and treatment of cervical adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2016年第2期28卷 254-262页

作者： satoshi Takeuchi Department of Obstetrics and Gynecology School of MedicineIwate Medical University

Uterine cervical adenocarcinoma （ADC） has been increasing in its prevalence world widely despite the decrease of squamous cell carcinoma （SCC）. It comprises nearly 20-25% of the all cervical malignancy in developed countries. The worse biological behavior had been reported in patients with intermediateand high risk factors after surgery, and in advanced stage over III, radiotherapy （RT） alone and concurrent chemo-radiotherapy （CCRT） with cisplatin was not always effective. As for chemotherapy （CT）, the iaduction CT has not established, as well. Further molecular targeted therapy （MTT） has been studied. The targets of oncogenic driver mutations were vascular endothelial growth factor （VEGF） in SCC, or tyrosine kinase （TK） of endothelial growth factor receptor 2 （EGFR2, Her2/neu）-Ras-MAPK-ERK pathway. Bevacizumab （Bey, anti-VEGF monoclonal antibody） is considered as one of key agent with paclitaxel and carboplatin in SCC, but not for ADC. This article focuses on up-to-date knowledge of biology and possible specific therapeutic directions to explore in the management of cervical ADC.

关键词： Cervical cancer adenocarcinoma (ADC) atypical glandular cell (AGC) gastric type adenocarcinoma (GAS)

Surgical outcome comparisons of multifocal IOLs of Lentis Comfort LS-313 MF15 and Tecnis Eyhance DIB00V

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第12期16卷 2004-2010页

作者： Kyohei Sugawara Ryosuke Ito Hiroshi Horiguchi Kei Mizobuchi satoshi Katagiri Hisato Gunji Tadashi Nakano Comparisons of multifocal IOLs of LS-313-MF15 and DIB00V Department of Ophthalmology the Jikei University School of MedicineTokyo 105-8461Japan

AIM:To compare the surgical outcomes of a multifocal intraocular lens(IOL;Lentis Comfort LS-313 MF15)with those of an enhanced monofocal IOL(Tecnis Eyhance DIB00V).METHODS:This retrospective study included patients who underwent cataract surgery with LS-313 MF15 or Eyhance IOL *** regarding patient demographics,surgical records,and ophthalmic examination before the cataract surgery and one and three months postoperatively were *** acuities,refractive values,defocus curves,contrast sensitivities and subjective symptoms were ***:Among the 71 eyes(47 patients)included in this study,32 eyes(20 patients)underwent LS-313 MF15 IOL implantation,and 39 eyes(27 patients)underwent Eyhance IOL *** significant differences were observed in age,axial length,or refractive error between the two groups ***,the distancecorrected and uncorrected distance visual acuities one month postoperatively did not differ between the groups,and both groups had sufficient visual acuities at the distances of 5,1 m,70,50,and 30 *** ophthalmic data,including subjective symptoms based on the 14-item Visual Function Index Questionnaire,monocular defocus curves,contrast sensitivities,and halo and glare,did not differ between the groups three months ***,both groups had good *** spherical equivalent one month postoperatively was significantly myopic in the LS-313 MF15 group compared with that in the Eyhance group(P=0.033);however,this difference was not observed three months postoperatively(P=0.471).CONCLUSION:Comparison of the surgical outcomes of LS-313 MF15 with those of Eyhance with different optical properties reveal that both IOLs show good postoperative outcomes,with no significant differences being noted between the two IOLs.

关键词： cataracts intermediate distances intraocular lens multifocal surgical outcomes

Advances in quantum dots for classical and non-classical light sources Invited Paper

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2008年第10期6卷 718-723页

作者： Yasuhiko Arakawa satoshi Iwamoto satoshi Kako Masahiro Nomura Denis Guimard Research Center for Advanced Science and Technology Institute for Nano Quantum Information ElectronicsThe University of Tokyo4-6-1 Meguro-ku153-8505 TokyoJapan

Recent advances in quantum dots （QDs） for classical and non-classical light sources are presented. We have established metal organic chemical vapor deposition （MOCVD） technology for InAs-based QD lasers at 1.3 μm and achieved ultralow threshold in QD lasers with photonic crystal （PhC） nanocavity. In addition, single photon emitters at 1.55 μm, GaN-based single photon sources operating at 200 K, and high-Q PhC nanocavity have been demonstrated.

关键词： QDs Advances in quantum dots for classical and non-classical light sources Invited Paper AIN InAs

Stand-Up Assistive Devices Allowing Patients to Perform Voluntary Movements within the Safety Movement Tolerance

在线全文

学校读者我要写书评

暂无评论

Journal of Artificial Intelligence and Technology 2022年第4期2卷 164-173页

作者： Daisuke Chugo satoshi Muramatsu Sho Yokota Jinhua She Hiroshi Hashimoto Kwansei Gakuin University Japan Tokai University Japan Tokyo University Japan Advanced Institute of Industrial Technology Japan

This paper proposes a novel standing assistance robot,which realizes voluntary movements of the patient within a safety motion *** the previous studies,conventional assistive robots did not require patients to use their own physical strength to stand,which led to decreased strength in the *** general assistive robots helped patients by using a fixed motion reference pathway in spite of their original intention,and as a result,these robots failed to use the physical strength of the ***,this study proposes a novel method for assisting the patient to stand up safely while using their physical abilities,by determining the range of movements that can be safely performed from the patient’s physical condition and allowing the patient to move freely within this *** standing motion is a set of different movements:inclining the trunk forward,lifting the trunk,and extending the *** this study,the range of movements in which the patient can safely stand in each movement is determined in terms of body stability and the muscle output that the patient can ***,this study proposes a robot control method that allows movements based on the patient’s free will if the patient’s posture is within the safety tolerance,and it corrects the movements when the patient’s posture is estimated to fall outside of *** proposed idea is implemented in our new prototype,and its effectiveness is verified by experimental results with elderly subjects who live in the nursing care house.

关键词： standing assistance assistive robot safety tolerance musculoskeletal simulation

Posture Maintenance Control of 2-Link Object By Nonprehensile Two-Cooperative-Arm Robot Without Compensating Friction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1397-1403页

作者： Changan Jiang satoshi Ueno Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan

In this paper, a method to posture maintenance control of 2-link object by nonprehensile two-cooperative-arm robot without compensating friction is proposed. In details, a mathematical model of the 2-link object is firstly built. Based on the model, stable regions for holding motion of nonprehensile two-cooperative-arm robot are obtained while the 2-link object is kept stable on the robot arms with static friction. Among the obtained stable regions, the robust pairs of orientation angles of the 2-link object are found. Under the robust orientation angles, a feedback control system is designed to control the arms to maintain the 2-link object's posture while it is being held or lifted up. Finally, experimental results are shown to verify the effectiveness of the proposed method.

关键词： Nursing care nonprehensile robot posture maintenance static friction two-cooperative-arm robot

A pH-dependent molecular switch for virion uncoating

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2014年第9期5卷 653-654页

作者： satoshi Koike Neurovirology Project Tokyo Metropolitan Institute of Medical Science 2-1-6 Kamikitazawa Setagaya-ku Tokyo 156-8506Japan

Enterovirus 71, belonging to human enterovirus speCies A in the genus Enterovirus of the family Picornaviridae, is one of the main causative agents of hand-foot-mouth disease. It can also cause severe neurological diseases such as acute encephalitis, polio-like paralysis, and neurogenic pulmonary edema, and it has become a serious public health concern especially in the Asia-Pacific region.

关键词： Capsid Protein EV71 Infection Lysosomal Compartment Neurogenic Pulmonary Edema Native Virion

Hepatic pseudolesions caused by alterations in intrahepatic hemodynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第46期27卷 7894-7908页

作者： satoshi Kobayashi Department of Quantum Medical Technology Kanazawa University Graduate School of Medical SciencesKanazawa 9200942IshikawaJapan

Hepatic pseudolesion may occur in contrast-enhanced computed tomography and magnetic resonance imaging due to the unique haemodynamic characteristics of the *** concept of hepatic arterial buffer response(HABR)has become mainstream for the understanding of the mechanism of the reciprocal effect between hepatic arterial and portal venous *** HABR is thought to be significantly related to the occurrence of the abnormal imaging findings on arterial phase of contrast enhanced images,such as hepatic arterial-portal vein shunt and transient hepatic attenuation difference,which mimic hypervascular tumor and may cause clinical *** inflow to the liver also cause hepatic pseudolesion,and some of the cases may show histopathologic change such as focal hyperplasia,focal fatty liver,and focal sparing of fatty liver,and called *** understand these phenomena might be valuable for interpreting the liver imaging findings.

关键词： Pseudolesion Focal sparing of fatty liver Computed tomography Hepatic blood flow Hepatic hemodynamics Hyperplastic change

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2016年第2期14卷 103-112页

作者： Yusei Kobori satoshi Mizuta Graduate School of Science and Technology Hirosaki University

Graphical representation of DNA sequences is one of the most popular techniques for alignment-free sequence comparison. Here, we propose a new method for the feature extraction of DNA sequences represented by binary images, by estimating the similarity between DNA sequences using the frequency histograms of local bitmap patterns of images. Our method shows linear time complexity for the length of DNA sequences, which is practical even when long sequences, such as whole genome sequences, are compared. We tested five distance measures for the estimation of sequence similarities, and found that the histogram intersection and Manhattan distance are the most appropriate ones for phylogenetic analyses.

关键词： Genome sequence Mitochondria Bitmap image Occurrence frequency Distance measure