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自发性突发性耳聋危险因素分析

中国卫生统计 2007年第5期24卷 511-512页

作者：施海龙 Mieko Nakamura satoshi iwasaki Nobuo Aoki 王亚奇金鑫俞佳中国医科大学日本浜松医科大学110001 日本浜松医科大学

自发性突发性耳聋是一种突然发生的感觉神经性听力下降,经常发生在一侧且没有明显的诱因[1].因其发作剧烈且愈后不好而令人十分困扰.因此,从公共卫生学的角度上来说,这种听力疾患的预防非常重要.本研究旨在探索突发性耳聋的危险因素.

关键词：突发性耳聋危险因素自发性听力下降感觉神经性公共卫生学

Cochlear Implantation in Patients with Eosinophilic Otitis Media

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第1期4卷 32-37页

作者： Masahiro Takahashi Yasuhiro Arai Naoko Sakuma Daisuke Sano Goshi Nishimura Takahide Taguchi Nobuhiko Oridate satoshi iwasaki Shin-Ichi Usami Department of Otorhinolaryngology Head and Neck Surgery Yokohama City University School of Medicine Yokohama Japan Department of Otorhinolaryngology International University of Health and Welfare Mita Hospital Tokyo Japan Department of Otorhinolaryngology Shinshu University School of Medicine Nagano Japan

It is known that cochlear implantation for deaf patients with eosinophilic otitis media (EOM) is safe and can provide good speech perception. However, the best timing of implant surgery in patients with EOM is not yet known. The aim of this case report is to suggest the appropriate timing of the surgery in EOM patients with deaf. Cochlear implantation was indicated in two patients with EOM. One underwent cochlear implantation in the absence of any ear discharge. In the other case, implant surgery was delayed for three years due to persistent ear discharge. No complications related to implant device or skin flap were observed in either case. The speech recognition score after implantation was good in the first case and poor in the second case. Perioperative complications were manageable even in the patient with persistent ear discharge. However, the delay in implant surgery due to the persistent ear discharge resulted in a poor speech recognition score. Early implantation should be considered even in EOM patients with ear discharge, although the presence of active middle ear inflammation is regarded as one of the contraindications for implantation according to the current Japanese guidelines.

关键词： Eosinophilic Otitis Media Cochlear Implantation Speech Recognition

Efficacy of Daily Cone-Beam Computed Tomography as Part of a Rescan Protocol for Large Offset to Reduce the Inter-Fractional Motion of the Prostate

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第4期3卷 193-200页

作者： Shinsaku Yamaguchi Takayuki Ohguri Hajime Imada Katsuya Yahara Hiroyuki Narisada satoshi iwasaki Toshihiro Onoda Yuta Ezaki Eiji Hamada Yukunori Korogi Department of Radiology University of Occupational and Environmental Health Kitakyushu Japan Department of Cancer Therapy Center Tobata Kyoritsu Hospital Kitakyushu Japan

Purpose: To prospectively analyze the inter-fractional motion of the prostate in patients with prostate cancer treated with intensity-modulated radiation therapy (IMRT) using image-guided radiotherapy (IGRT) with daily cone-beam computed tomography (CBCT) as part of a rescan protocol for large offset, and to evaluate the efficacy of our protocol. Materials and Methods: Eligible patients were treated with the following protocol: 1) magnesium oxide and dimethylpolysiloxane were administered to ensure that patients had regular bowel movements;2) the patients were instructed to have an appropriately distended bladder during the planning CT and daily irradiation;3) the daily CBCT image was fused with the planning CT image using the prostate outline;and 4) if large offset was recognized, a rescan CBCT image was obtained after appropriate countermeasures, such as the discharge of gas and defecation, and re-registration was performed. Three shifts for the inter-fractional motion of the prostate were analyzed, in the fractions which needed the CBCT rescan;the displacement data after the final rescan were used. Results: Sixty-one patients were eligible, and a total of 2302 fractions were available for the analysis. Rescans of the CBCT for large offset were performed in 113 (5%) of the 2302 fractions. After the first rescan, the large offset was resolved in 106 (94%) of the 113 fractions. Excessive rectal gas was the reason for the large offset in 94 (83%) of the 113 fractions. The total mean and standard deviation of the inter-fractional motion of the prostate in the AP, LR, and SI directions were 1.1 ± 2.4, -0.1 ± 2.3, and 0.7 ± 3.0 mm, respectively. Conclusion: Large offset was recognized in 5% of all fractions. Daily CBCT with our rescan protocol could resolve the large offset, which was mainly caused by excessive rectal gas, and it may therefore be promising to reduce the inter-fractional motion of the prostate.

关键词： Intensity-Modulated Radiotherapy Prostate Cancer Daily Cone Beam Computed Tomography Inter-Fractional Motion

Mn-Cu系高阻尼合金的凝固组织控制及阻尼特性的改善(英文)

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物理学进展 2006年第3期26卷 323-331页

作者：殷福星岩崎智坂口琢哉长井寿日本物质材料研究机构丰田汽车公司第三材料研究部

Mn—Cu系阻尼合金兼有较高的阻尼特性和良好的力学性质，因而具有较大的实用前景。这类合金通常经过铸造，塑性加工和热处理来获得要求的性能和组织。加工后的Mn—Cu合金存在一个特定温度，在此温度以上合金的阻尼性能将会消失，因而影... 详细信息

Mn—Cu系阻尼合金兼有较高的阻尼特性和良好的力学性质，因而具有较大的实用前景。这类合金通常经过铸造，塑性加工和热处理来获得要求的性能和组织。加工后的Mn—Cu合金存在一个特定温度，在此温度以上合金的阻尼性能将会消失，因而影响了合金的在较高温度下的使用。该温度和合金的Mn含量有关，然而提高合金的Mn含量有会降低合金的加工性及力学性能。一般Mn-Cu合金的热处理都是利用400℃附近的时效来获得相分解后的局部高Mn组织。但是目前的时效处理后的Mn—Cu阻尼合金的最高使用温度只在80℃以下。为解决Mn—Cu阻尼合金使用温度的局限性，本研究选用凝固过程控制的方法在铸造组织中来获得较大幅度的Mn含量分布。从而在Mn-Cu合金得到较高的高阻尼特性温度。本工作利用铸型温度控制的方法，将M2052（Mn-20Cu-5Ni-2Fe）合金在250～0．1K／s冷却速度范围内控制凝固。随凝固冷却速度的降低在合金的铸态组织中观察到二次枝晶间距和晶粒尺寸的明显增大。同时还发现缓冷凝固的合金的成分比快冷凝固有较大的分布幅度。铸态下的合金阻尼性能评价也证实了凝固冷却速度对合金的凝固组织有很大的影响。尽管铸态组织的合金的高温阻尼性能并没有很大的改善，然而通过对铸态组织实施时效处理后发现缓冷凝固合金的高温阻尼性能有很大的改善。凝固冷却速度对时效处理后合金的阻尼性能有明显的影响。实验结果表明0．1K／s的冷却速度下缓慢凝固的合金在时效处理后高阻尼特性可持续高达120℃．

关键词： Mn-Cu系高阻尼合金阻尼行为凝固组织控制

Visualization of flashback in a premixed burner with swirling flow

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Science China(Technological Sciences) 2010年第1期53卷 40-45页

作者： satoshi TANIMURA Masaharu KOMIYAMA Kenichiro TAKEISHI Yuji iwasaki Kiyonobu NAKAYAMA Mitsubishi Heavy Industries Ltd.2-1-1ShinhamaArai-choTakasagoHyogo676-0871Japan Department of Mechanical Engineering Osaka University2-1YamadaokaSuitaOsaka565-0871Japan

In this study,the measurement object is a flame propagating in a premixed burner with swirling flow in order to investigate unsteady flame behavior in a gas turbine *** flashback,the flame propagating upstream was visualized with a high-speed ***,we established the technique to measure the instantaneous flow fields of unburned fuel-air mixture in a swirling premixed burner using particle image velocimetry(PIV).As a result,the characteristics of flame behavior propagating upstream were *** it was found that a low velocity region existed in the vicinity of the flame *** relationship between low velocity region and flame behavior was discussed in detail.

关键词： gas turbine lean premixed combustion flashback particle image velocimetry

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第10期15卷 1267-1272页

作者： Takayuki Kogure Yoshiyuki Ueno satoshi Sekiguchi Kazuyuki Ishida Takehiko Igarashi Yuta Wakui Takao iwasaki Tooru Shimosegawa Division of Gastroenterology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku University Sendai 980-8574Japan Department of Pathology Tohoku University HospitalSendai 980-8574Japan Division of Gastroenterology Osaki Citizen Hospital Furukawa 989-6183Japan

A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral *** diagnostics showed the typical findings of liver cell adenoma(LCA).Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed *** tumor was found to contain fat on magnetic resonance imaging.A benign fat containing liver tumor was ***,radiological findings altered,which caused us to suspect that a welldifferentiated hepatocellular carcinoma(HCC)containing fat was becoming *** hepatectomy was performed and the pathological findings showed the typical findings of *** case was an extremely rare LCA,which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

关键词：肝细胞腺瘤调查结果高分化放射性肝癌改建电脑断层扫描周期分析

Investigation of <i>β</i>-Cryptoxanthin Fatty Acid Ester Compositions in Citrus Fruits Cultivated in Japan

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Food and Nutrition Sciences 2013年第9期4卷 98-104页

作者： Yusuke Wada Atsuki Matsubara Takato Uchikata Yugo iwasaki satoshi Morimoto Katsuta Kan Tetsuya Ookura Eiichiro Fukusaki Takeshi Bamba Department of Biotechnology Graduate School of Engineering Osaka University Osaka Japan Food Function Division National Food Research Institute National Agricultural and Food Research Organization Tsukuba Japan. Food Research Center Ehime Institute of Industrial Technology Matsuyama Japan Graduate School of Bioagricultural Sciences Nagoya University Nagoya Japan Omishima Fruits Processing Co. Ltd. Imabari Japan

In this study, a catalog of β-cryptoxanthin (βCX) and its fatty acid esters (βCXFAs) in citrus fruits were constructed. The peel and pulp of citrus fruits from nine Japanese cultivars and one foreign cultivar were surveyed by supercritical fluid chromatography/triple quadrupole mass spectrometry (SFC/QqQMS). In each citrus sample, the major components were βCX and its laurate ester, myristate ester, palmitate ester, and oleate ester. However, the composition ratio of βCXFA varied with the citrus breed and between the pulp and the peel of the fruit in most cultivars. The SFC/QqQMS system could be used to obtain new information about βCXs and carry out further discussion on the feature and tendency of each citrus variety.

关键词： β-Cryptoxanthin Fatty Acid Ester Supercritical Fluid Chromatography

Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature

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Open Journal of Obstetrics and Gynecology 2014年第10期4卷 617-620页

作者： Motoki Matsuura Masato Tamate Masahiro Suzuki Tasuku Mariya Sakura Takada Yuta Tabuchi Mizue Teramoto Seiro Satohisa Ryoichi Tanaka Masahiro iwasaki Kaori Fukunaka Noriyoshi Fukunaka satoshi Tanaka Tsuyoshi Saito Department of Obstetrics and Gynecology Hakodate Goryoukaku Hospital Hakodate Japan Department of Obstetrics and Gynecology Sapporo Medical University Sapporo Japan

Primary adenocarcinomas of the uterine cervix account for 5% - 15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received.

关键词： Metastatic Adenocarcinoma Cervical Cancer Colorectal Carcinoma