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Clinical Evaluation of Moisturizers with Physiological Analysis of Stratum Corneum TARC and TSLP

Journal of Cosmetics, Dermatological Sciences and Applications 2014年第1期4卷 37-43页

作者： satoshi fukushima Eishin Morita Miki Tanioka Yoshiki Miyachi Yumi Murakami Hiroshi Matsunaka Hironobu Ihn Department of Dermatology and Plastic Surgery Faculty of Life Science Kumamoto University Kumamoto Japan Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan Shimane University Faculty of Medicine Shimane Japan TOKIWA Pharmaceutical Co. Ltd. Tokyo Japan

To verify the usefulness of moisturizers, a multi-center study was conducted on patients with atopic dermatitis who visited 3 university hospitals in Japan between November 2009 and March 2012. Thirty-seven patients with dry skin and stable symptoms who were receiving topical and oral treatments were given moisturizers for 8 weeks. The moisturizers contained components such as glycerin and seawater minerals in 3 forms: lotion, emulsion, and cream. The moisturizers were chosen by physicians based on the degree of dryness of the patients’ skin. In addition to observing the skin condition of the entire body, high-frequency conductance as a parameter of skin surface hydration and transepidermal water loss (TEWL) in the buccal region and the medial side of the forearm were measured, and those of the back were used for comparison. Furthermore, stratum corneum levels of thymic stromal lymphopoietin (TSLP) and thymus and activation-regulated chemokine (TARC), both of which were objective parameters for atopic dermatitis skin lesion severity, were analyzed using the tape stripping method. At the beginning of the study, TSLP showed a correlation with skin symptoms (dryness, itching) and high-frequency conductance, whereas TARC showed a correlation with skin symptoms (erythema, dryness, itching) and TEWL. In addition, a correlation was noted among TSLP, TARC, and itching. At the end of the study, erythema, dryness, itching, TEWL,TSLP, and TARC were significantly reduced, whereas high-frequency conductance was significantly increased. The moisturizers clearly improved the dry skin symptoms of these patients with atopic dermatitis and improved the physiology of their sensitive and damaged skin. These findings also support the involvement of cytokines/chemokines in the pathogenesis of atopic dermatitis lesions.

关键词： TSLP TARC Atopic Dermatitis Moisturizer Skin Physiology Dry Skin

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Evolution of Aerosols Near The Surface at AERU on The Southwestern Japan Coast in 2010-2015

Evolution of Aerosols Near The Surface at AERU on The Southw...

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第十八届中国科协年会——分12 大气雾霾及PM2.5控制先进技术研讨会

作者： satoshi fukushima Daizhou ZHANG Takashi SHIBATA Shuichiro KATAGIRI Tadahiro HAYASAKA Faculty of Environmental and Symbiotic Sciences Prefectural University of Kumamoto School of Environmental Studies Nagoya University Graduate School of Science Tohoku University

We observed the concentration and backscattering coefficients of aerosol particles at southwestern coast of Japan in 2011-2015. The constitution of particles in each of eight episodes, i.e. the portions of mineral dust, sea salt, sulfate and soot particles, was obtained with individual particle analysis by using an electron microscope. There was a close correlation(R2=0.76) between the BSCs and the volume concentrations of the particles when the relative humidity(RH) was lower than 0%, regardless of the difference in particle constitutions. In contrast, the BSCs normalized with aerosol concentrations differed largely even at similar concentrations of particles when the RH was larger than 70%. The BSCs of particles dominated by marine origin(sea salt) could be several times larger than those dominated by land origin(dust and soot) at 90% RH, as the latter might be slightly larger than the BSCs under the dry conditions. On the other hand, the difference of volume-size distributions of particles likely also made the BSCs largely different from each other under the humid conditions. These results indicate that the concentration of aerosol particle was the key parameter to determine the BSCs under dry conditions, while the BSCs under humid conditions were closely dependent on the content of deliquescent components and the size distributions of aerosol particles.

关键词： Lidar humidity sea salt dust soot

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Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients

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Journal of Cosmetics, Dermatological Sciences and Applications 2016年第1期6卷 9-18页

作者： satoshi fukushima Keiichi Motoyama Yuki Tanida Taishi Higashi Yoichi Ishitsuka Yuki Kondo Tetsumi Irie Takumi Tanaka Hironobu Ihn Hidetoshi Arima Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan Graduate School of Pharmaceutical Sciences Kumamoto University Kumamoto Japan Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program” Kumamoto University Kumamoto Japan Daito Kasei Kogyo Co. Ltd. Osaka Japan

Atopic dermatitis is a skin disease characterized by inflammation, pruritus, and chronic or relapsing eczematous lesions. Recently, ampholytic polysaccharide sacran has attracted a particular focus of attention as a novel biomaterial. In the present study, we investigated the effect of sacran solution on atopic dermatitis in the clinical study. Almost all of the average scores for atopic dermatitis symptoms of each patient treated with sacran solutions were improved. In addition, the scores of sleep disorder and itching were also significantly ameliorated by the sacran treatment for 4 weeks, compared with those of initial states. In immatured dermal skin model stimulated with 2,4-dinitrofluorobenzene (DNFB), the sacran treatment markedly down-regulated inflammatory cytokine and chemokine mRNA levels such as MCP-1, TNF-α, IL-1β, and IL-6 mRNAs, compared with that of DNFB alone. Furthermore, a sacran solution significantly suppressed the mRNA expression of TNF-α and COX-2 in RAW264.7 cells, a murine macrophage-like cell line, stimulated with phorbol-12-myristate-13-acetate (PMA). In RBL-2H3 cells, a rat basophilic leukemia cell line, a sacran solution significantly lowered β-hexosaminidase release, indicating the suppression of allergic response. These results suggest that a sacran solution may have the potential to improve atopic dermatitis through the impairment of production of inflammatory cytokine and chemokine mRNA.

关键词： Sacran Polysaccharide Clinical Trial Atopic Dermatitis Skin Care

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Effect of equal-channel angular pressing on pitting corrosion resistance of anodized aluminum-copper alloy

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中国有色金属学会会刊：英文版 2009年第4期19卷 904-908页

作者： In-Joon SON Hiroaki NAKANO satoshi OUE Shigeo KOBAYASHI Hisaaki fukushima Zenji HORITA Department of Materials Process Engineering Graduate School of EngineeringKyushu University Department of Materials Science and Engineering Faculty of EngineeringKyushu University Department of Applied Chemistry and Biochemistry Faculty of EngineeringKyushu Sangyo University

The effect of equal-channel angular pressing(ECAP) on the pitting corrosion resistance of anodized Al-Cu alloy was investigated by electrochemical techniques in a solution containing 0.2 mol/L AlCl3 and also by surface *** was conducted for 20 min at 200 and 400 A/m2 in a solution containing 1.53 mol/L H2SO4 and 0.018 5 mol/L Al2(SO4)3·16H2O at 20 ℃.Anodized Al-Cu alloy was immediately dipped in boiling water for 20 min to seal the micro pores present in anodic oxide *** time required before initiating pitting corrosion of anodized Al-Cu alloy is longer with ECAP than without,indicating that ECAP process improves the pitting corrosion resistance of anodized Al-Cu *** phase precipitates such as Si,Al-Cu-Mg and Al-Cu-Si-Fe-Mn intermetallic compounds are present in Al-Cu alloy and the size of these precipitates is greatly decreased by application of ***-Cu-Mg intermetallic compounds are dissolved during anodization,whereas the precipitates composed of Si and Al-Cu-Si-Fe-Mn remain in anodic oxide films due to their more noble corrosion potential than ***-SEM and EPMA observation reveal that the pitting corrosion of anodized Al-Cu alloy occurs preferentially around Al-Cu-Si-Fe-Mn intermetallic compounds,since the anodic oxide films are absent at the boundary between the normal oxide films and these impurity *** improvement of pitting corrosion resistance of anodized Al-Cu alloy processed by ECAP appears to be attributed to a decrease in the size of precipitates,which act as origins of pitting corrosion.

关键词：铝铜合金抗点蚀挤压转角通道

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Vitreous hemorrhage and fibrovascular proliferation after laser-induced chorioretinal venous anastomosis

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 216-217页

作者： Tomoyasu Shiraya satoshi Kato Takashi Shigeeda Harumi fukushima Department of Ophthalmology University of Tokyo Graduate School of Medicine

·AIM:To describe a case in which vitrectomy was required for vitreous hemorrhage and fibrovascular proliferation after laser-induced chorioretinal venous anastomosis (LCVA) for non-ischemic central retinal vein occlusion (CRVO).·METHODS:Observational case report.·RESULTS:A 72-year-old man complained of central scotoma in the left eye,and was diagnosed as suffering from non-ischemic *** was performed in another *** favorable visual function was briefly maintained postoperatively,severe vitreous hemorrhage developed in his left eye,necessitating vitrectomy.·CONCLUSION:Considering that LCVA carries a risk of serious complications,we must apply this treatment with caution,especially in ethnic groups,such as the Japanese,in whom pigmentation reacts to photocoagulation excessively.·

关键词： vitreous hemorrhage fibrovascular proliferation laser-induced chorioretinal venous anastomosis non-ischemic central retinal vein occlusion

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Clinical significance of serum levels of vascular endothelial growth factor and its receptor in biliary disease and carcinoma

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World Journal of Gastroenterology 2005年第8期11卷 1167-1171页

作者： Munechika Enjoji Makoto Nakamuta Koji Yamaguchi satoshi Ohta Kazuhiro Kotoh Marie fukushima Masami Kuniyoshi Tomomi Yamada Masao Tanaka Hajime Nawata Department of Medicine and Bioregulatory Science Department of Surgery and Oncology Medical Information Science

AIM: To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (VEGFRl/Flt-1) (sVEGFR1) levels in biliary diseases. METHODS: We analyzed the serum levels of these proteins in patients with acute cholangitis (group 1), biliary malignancies (group 2), and primary biliary cirrhosis or primary sclerosing cholangitis (group 3), and in healthy donors (group 4). The influence of inflammation was also analyzed. Serum VEGF levels were expressed as VEGF per platelet (VEGF/PLT, pg/106) in order to exclude the influence of platelet counts. RESULTS: sVEGFRl levels were significantly higher in groups 1 and 2 than in the control group, but did not correlate with inflammatory markers. VEGF/PLT levels were generally higher in patients with active inflammation than in those with carcinoma. C-reactive protein strongly correlated with the levels of serum VEGF independently of platelet and leukocyte counts, even in cancer patients. In cancer patients, VEGF/PLT and sVEGFRl levels might be indicators for evaluating the effect of medical treatment or the disease progression. CONCLUSION: Serum VEGF and VEGFR1 might be useful markers for gauging the clinical effect of various treatments on patients.

关键词： VEGF VEGFRl Cholangiocarcinoma Cholangitis

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Congestion Control Algorithms for the Internet-A Secondary Publication

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Journal of Electronic Research and Application 2024年第2期8卷 33-48页

作者： satoshi Utsumi fukushima University FukushimaJapan

In the last five years,there has been a V-shaped recovery in the number of papers on congestion control algorithms on the *** this paper,congestion problems on the Internet are discussed,such as congestion collapse and bufferbloat from the perspective of the necessity of congestion control *** typical congestion control algorithms are introduced,and the research areas and methods of congestion control algorithms are *** research trends and future prospects of congestion control algorithms are also presented.

关键词： TCP Congestion control algorithm Congestion Internet

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Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese

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World Journal of Hepatology 2019年第6期11卷 531-541页

作者： Shinya Nishida Koichi Hamada Noriyuki Nishino Daizo fukushima Ryota Koyanagi Yoshinori Horikawa Yoshiki Shiwa satoshi Saitoh Department of Gastroenterology Shin-Yurigaoka General HospitalKawasaki 215-0026Japan Department of Gastroenterology Southern-Tohoku General HospitalKoriyama 963-8563Japan Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical UniversityFukushima 960-1295Japan Department of Hepatology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Hepatic encephalopathy(HE)is a complication of liver cirrhosis and can result in neuropsychological and neuromuscular dysfunctions in ***,an antibiotic,has been reported to decrease the occurrence of overt HE and also improve cognitive function in studies from Europe and the United States of *** is not enough evidence of the relationship between the long-term use of rifaximin and its clinical effects in the *** To determine the clinical effects of long-term rifaximin therapy in decompensated liver cirrhosis patients,with overt HE or *** In this single-center retrospective observational cohort study,we reviewed the data of 38 patients who had taken rifaximin at the dose of 1200 mg/d for more than 24 *** primary outcome measured was the efficacy of long-term rifaximin use,and secondary outcome measured was the safety of its long-term use as determined by its influence on portosystemic shunts as well as Escherichia coli-related ***,we compared the prognosis between the rifaximin group and control cases,matched for hepatic elasticity assessed by magnetic resonance ela-stography,age,and Child-Pugh *** Of the 38 patients included in the study,12(31.6%)had overt HE,27(71.1%)had complications of esophageal varices,and 9(23.7%)had hepatocellular carcinoma(HCC).The control group was matched for age,Child-Pugh classification,liver stiffness,and presence of *** median of serum ammonia level before treatment was 104μg/dL(59-297),and 2 wk after treatment,it significantly decreased to 85μg/dL(34-153)(P=0.002).A significantly low value of 80.5μg/dL(44-150)was maintained 24 wk after *** long-term use of rifaximin did not cause a decline in liver *** occurred in 2 patients,who improved with the administration of probiotics,and there were no cases of aborted rifaximin therapy owing to adverse *** patients with Child C,the survival was short,but there

关键词： Hepatic encephalopathy Rifaximin Hepatic cirrhosis Spontaneous portosystemic shunt Magnetic resonance elastography Child-Pugh classification

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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

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World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM： To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs. METHODS： The right lateral lobe of pigs, i.e. the 25% of the liver, was transplanted orthotopically. The pigs were divided into two groups： graft without portocaval shunt （n = 11） and graft with portocaval shunt （n = 11）. Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated. RESULTS： In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h afcer transplantation. In the group with portocaval shunt, eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 ml./min/100 g liver tissue, respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 ml./ min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively （P〈0.01）. As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed afl：er reperfusion, but these findings were not recognized in the group with portocaval shunt. CONCLUSION： These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词： Hyperperfusion syndrome Liver regeneration Portocaval shunt Postoperative liver dysfunction Sinusoidal microcirculatory injury Small-for-size liver transplantation

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激光诱导脉络膜视网膜静脉吻合术后玻璃体出血及纤维血管增生1例(英文)

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国际眼科杂志 2011年第5期11卷 765-766页

作者： Tomoyasu Shiraya satoshi Kato Takashi Shigeeda Harumi fukushima 东京大学医学研究生院眼科

目的:报告1例非缺血性中央视网膜静脉阻塞的患者实施激光诱导脉络膜视网膜静脉吻合术后出现玻璃体出血及纤维血管增生而进行玻璃体切割术。方法:病例报告。结果:患者,男,72岁,主诉左眼中央有一暗点,诊断为非缺血性中央视网膜静脉阻塞。... 详细信息

目的:报告1例非缺血性中央视网膜静脉阻塞的患者实施激光诱导脉络膜视网膜静脉吻合术后出现玻璃体出血及纤维血管增生而进行玻璃体切割术。方法:病例报告。结果:患者,男,72岁,主诉左眼中央有一暗点,诊断为非缺血性中央视网膜静脉阻塞。在其他医院实施激光诱导脉络膜视网膜静脉吻合术。术后患者左眼视力短暂恢复,但并发严重的玻璃体出血,遂来我院实施玻璃体切割术。结论:激光诱导脉络膜视网膜静脉吻合术有发生严重并发症的危险,要求临床医师慎重选择,特别是对于某些种族(比如日本),因为色素沉着可引起光凝过度反应。

关键词：膜静脉吻合术非缺血性中央视网膜静脉阻塞

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