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Experimental Study of Condensation Heat Transfer on Tube Bundles in Large Power Plant Condensers

Journal of Energy and Power Engineering 2014年第5期8卷 920-928页

作者： Koichi Inoue Issaku Fujita Kotaro Machii satoshi hiraoka Manabu Ishihara Faculty of Environmental Engineering The University of Kitakyushu Fukuoka 8080135 Japan Takasago Machinery Works Mitsubishi Heavy Industries Ltd. Hyogo 6768686 Japan

In order to clarify the effect of condensate inundation on steam condensation in a large tube bundle, condensation heat transfer and the condensate flow pattern in the tube bundle have been experimentally investigated. Test tube bundle consists of 36 cooling tubes, 12 condensate supply tubes and 24 un-cooled dummy tubes. Cooling test tubes are made of copper and have an outer diameter of 19.1 mm and condensing length of 150 mm, Steam flows horizontally through the test tube bundle at gap velocities 15-27 m/s at pressures of 8.8 kPa. In this study, experimental data about condensate flow pattern and condensation heat transfer in a tube bundle were collected for the optimization of tube arrangement in large power plant condensers.

关键词： Condensation inundation condenser tube bundle tube arrangement power station.

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Left hepatic trisectionectomy for perihilar cholangiocarcinoma with a right-sided round ligament:A case report

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World Journal of Gastrointestinal Surgery 2020年第2期12卷 68-76页

作者： Tomoyuki Ishida satoshi Nara Keiichi Akahoshi Takeshi Takamoto Yoji Kishi Minoru Esaki Nobuyoshi hiraoka Kazuaki Shimada Department of Hepatobiliary and Pancreatic Surgery National CancerCenter HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center HospitalTokyo 104-0045Japan

BACKGROUND A right-sided round ligament(RSRL)is a rare,congenital anomaly of the intrahepatic portal vein,with a reported frequency of 0.2%-1.2%.For patients with perihilar cholangiocarcinoma associated with an RSRL,an accurate understanding of the vascular and biliary anatomy is *** SUMMARY We report a 70-year-old male with perihilar cholangiocarcinoma associated with an *** percutaneous transhepatic embolization of the left and anterior portal branches,we conducted a left trisectionectomy of the liver with extrahepatic bile duct resection and *** postoperative course was uneventful,and R0 resection was *** the liver volume of each section was compared between 7 patients with an RSRL and 20 patients with normal portal vein anatomy,the posterior section in RSRL patients was significantly larger than that in patients with normal portal vein anatomy(median:457 mL vs 306 mL,P=0.031).In patients with perihilar cholangiocarcinoma associated with an RSRL,left trisectionectomy has several surgical advantages:(1)The posterior branch of the portal vein often ramifies independently,and the division of the portal vein is easily conducted;(2)A relatively large amount of remnant liver can be retained;and(3)The anatomy of the posterior branch of the Glissonian pedicle is similar to that in patients with normal *** In patients with an RSRL and perihilar cholangiocarcinoma that does not involve the posterior section,left trisectionectomy may be a favorable choice.

关键词： Right-sided round ligament Left-sided gallbladder Perihilar cholangiocarcinoma Case report

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Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

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World Journal of Hepatology 2017年第32期9卷 1227-1238页

作者： Yasuhito Iwao Hidenori Ojima Tatsushi Kobayashi Yoji Kishi satoshi Nara Minoru Esaki Kazuaki Shimada Nobuyoshi hiraoka Minoru Tanabe Yae Kanai Division of Molecular Pathology National Cancer Center Research Institute Hepatobiliary and Pancreatic Surgery Division National Cancer Center Hospital Hepatobiliary and Pancreatic Surgery Tokyo Medical and Dental University Department of Pathology Keio University School of Medicine Diagnostic Radiology Division National Cancer Center Hospital East

AIM To clarify the histological changes associated with liver atrophy after percutaneous transhepatic portalembolization(PTPE) in pigs and humans. METHODS As a preliminary study, we performed pathological examinations of liver specimens from five pigs that had undergone PTPE in a time-dependent model of liver atrophy. In specimens from embolized lobes(EMB) and nonembolized lobes(controls), we measured the portal vein to central vein distance(PV-CV), the area and number of hepatocytes per lobule, and apoptotic activity using the terminal deoxynucleotidyl transferase dU TP nickend labeling assay. Immunohistochemical reactivities were evaluated for light chain 3(LC3) and lysosomal-associated membrane protein 2(LAMP2) as autophagy markers and for glutamine synthetase and cytochrome P450 2 E1(CYP2 E1) as metabolic zonation markers. Samples from ten human livers taken 20-36 d after PTPE were similarly examined. RESULTS PV-CVs and lobule areas did not differ between EMB and controls at day 0, but were lower in EMB than in controls at weeks 2, 4, and 6(P ≤ 0.001). Hepatocyte numbers were not significantly reduced in EMB at day 0 and week 2 but were reduced at weeks 4 and 6(P ≤ 0.05). Apoptotic activity was higher in EMB than in controls at day 0 and week 4. LC3 and LAMP2 staining peaked in EMB at week 2, with no significant difference between EMB and controls at weeks 4 and 6. Glutamine synthetase and CYP2 E1 zonation in EMB at weeks 2, 4, and 6 were narrower than those in controls. Human results were consistent with those of porcine specimens. CONCLUSION The mechanism of liver atrophy after PTPE has two histological phases: Hepatocellular atrophy is likely caused by autophagy in the first 2 wk and apoptosis thereafter.

关键词： Liver atrophy Portal vein embolization Autophagy Apoptosis Zonation Lobule

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贝伐单抗联合放射方案的实验研究

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中华放射肿瘤学杂志 2010年第4期19卷 358-363页

作者：欧广飞坂坂聪曾丽华涩谷景子易俊林原田浩平冈真宽北京中国医学科学院肿瘤医院放疗科 100021 京都大学附属病院放射肿瘤与影像引导治疗科第四军医大学放射医学教研室

目的实时测定贝伐单抗和放射线作用人肺腺癌细胞系（NCI-H141）裸鼠移植瘤后活体乏氧调节蛋白（HIF-1α）水平变化,为优化贝伐单抗和放射线联合计划提供依据.方法用HIF-1α荧光蛋白报告质粒转染NCI-H441细胞连续测定肿瘤乏氧水平,并... 详细信息

目的实时测定贝伐单抗和放射线作用人肺腺癌细胞系（NCI-H141）裸鼠移植瘤后活体乏氧调节蛋白（HIF-1α）水平变化,为优化贝伐单抗和放射线联合计划提供依据.方法用HIF-1α荧光蛋白报告质粒转染NCI-H441细胞连续测定肿瘤乏氧水平,并观察贝伐单抗与放射线（122Scγ射线）早晚联合后HIF-1α水平变化、血管数量和渗透性、肿瘤反应、乏氧分子标记、凋亡率和肿瘤生长延迟的异同.结果单纯贝伐单抗作用后24 h肿瘤HIF-1α表达水平较对照组轻度下降（3.1×106：6.1×106;t=-1.73,P〉0.05）,功能血管密度升高（16.6：12.1;t=-1.40,P〉0.05）和血管渗透指标明显改善（2.9%：11.5%;t=6.80,P〈0.01）;随后HIF-1α表达水平迅速升高（7.4×106：20.4×106;t=2.36,P〈0.05）并维持至疗后8～10 d（第3天时高于对照组3～4倍）且总血管密度明显下降（37.4：15.9;t=5.36,P〈0.01）.贝伐单抗治疗72 h后联合放射线作用组比24 h后联合作用组肿瘤血管记数高（联合作用后第3天,9.33：3.17;t=-2.43,P〈0.05）、凋亡记数低（联合作用后第3天,23.33：43.83;t=2.54,P〈0.05）,生长延迟时间也明显缩短（10.5：23.0;t=2.67,P〈0.05）.结论贝伐单抗联合放射线作用后72 h贝伐单抗诱导的乏氧对血管和肿瘤细胞具有明显的放射抵抗作用,提示血管靶向药物联合放射作用可能存在时间增益窗口.

关键词：细胞系肺肿瘤肿瘤移植裸鼠贝伐单抗放射

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