检索结果-南通市图书馆

Pharmacology & Pharmacy 2015年第3期6卷 118-124页

作者： Rika Shimada Yasuaki Dohi Kazunori Kimura satoshi fujii Department of Critical Care Nursing Graduate School of Nursing Nagoya City University Nagoya Japan Department of Cardio-Renal Medicine and Hypertension Graduate School of Medicine Nagoya City University Nagoya Japan Pharmaceutical Department Nagoya City University Hospital Nagoya Japan Department of Laboratory Medicine Asahikawa Medical University Asahikawa Japan

A 32-Item Japanese Medication Adherence Scale had been developed as a tool for evaluating the medication-taking behavior of hypertensive patients and predicting therapeutic efficacy, and an Internet survey of 990 hypertensive patients throughout Japan was performed. As a result, factor 1 “Expectation of pharmacological efficacy” (9 items), factor 2 “Motivation to be self-controlled in taking medication” (6 items), and factor 3 “Negative feelings about taking medication” (4 items) were identified, comprising a total of 19 items. The scale was highly reliable. Because it proved capable of discriminating between the 2 groups with different medication-taking status and blood pressure, its validity had also been confirmed.

关键词： Drug Therapy Hypertension Measure Medication Adherence Scale

Novel crystal structure of Helicobacter pylori neutrophil-activating protein （HP-NAP）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel crystal structure of Helicobacter pylori neutrophil-ac...

新日本钢铁公司以计算机化为中心的自动化概况

亚洲晶体学联合大会

作者： Osamu Tsuruta Naoya Akao Hideshi Yokoyama satoshi fujii University of Shizuoka 52-1 YadaSuruga-kuShizuoka-shiShizuoka-ken422-8526Japan

＜正＞Background Helicobacter pylori is a pathogen associated with gastric diseases, including gastric ulcers and stomach cancers. Helicobacter pylori neutrophil-activating protein （HP-NAP） is a major 17 kDa antigen...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

钢铁 1985年第10期 77-78+58页

作者： Tadashi ATSUMI Takeyuki FUKUDA satoshi fujii 陈振宇新日本制铁·株新日本制铁·株新日本制铁·株

1.引言新日铁公司在近25年来致力于发展计算机应用,到目前为止已装设了约300台过程控制计算机。它们应用于生产线自动化,生产规划,生产调度,集成在线控制和试验室自动化等方面。此外在仪表和控制中微型计

关键词：计算机控制系统顺序控制仪表系统

Redox regulation of fertilisation and the spermatogenic process

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第3期13卷 420-423,511,512页

作者： Junichi fujii satoshi Tsunoda Department of Biochemistry and Molecular Biology Graduate School of Medical Science Yamagata University Yamagata 990-9585 Japan Respiratory and Cardiovascular Diseases Research Center Research institute for Advanced Molecular Epidemiology Yamagata University Yamagata 990-9585 Japan Global COE Program for Medical Sciences Japan Society for the Promotion of Science Tokyo Japan

Oxidative stress is one of the major causes of male infertility; it damages spermatogenic cells, the spermatogenic process and sperm function. Recent advances in redox biology have revealed the signalling role of reactive oxygen species （ROS） that are generated by cells. While highly reactive oxidants, such as the hydroxyl radical, exert largely deleterious effects, hydrogen peroxide can feasibly serve as a signal mediator because it is moderately reactive and membrane permeable and because it can oxidize only limited numbers of functional groups of biological molecules. The amino acid side chain most sensitive to oxidation is cysteine sulphydryl, which is commonly involved in the catalysis of some enzymes. Although the reactivity of cysteine sulphhydryl is not very high in ordinary proteins, some phosphatases possess a highly reactive sulphydryl group at their catalytic centre and are thereby oxidatively inactivated by transiently elevated hydrogen peroxide levels after extracellular stimuli and under certain environmental conditions. Peroxiredoxins, in turn, show moderate hydrogen peroxide-reducing activity, and their role in the modulation of ROS-mediated signal transduction in ordinary cells, mediated by protecting phosphatases from oxidative inactivation, has attracted much attention. Although knowledge of the signalling role of ROS in the male reproductive system is limited at present, its significance is becoming a focal issue. Here, we present a review of the emerging signalling role of hydrogen peroxide in testes.

关键词： hydrogen peroxide oxidative stress peroxiredoxin signal transduction

Polyarteritis nodosa clinically mimicking nonocclusive mesenteric ischemia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第23期19卷 3693-3698页

作者： Tsuyoshi Shirai Hiroshi fujii Shinichiro Saito Tomonori Ishii Hideyuki Yamaya Shigehito Miyagi satoshi Sekiguchi Naoki Kawagishi Masato Nose Hideo Harigae Department of Hematology and Rheumatology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Department of Histopathology Tohoku University Graduate School of MedicineSendai 980-8574 Japan

Here, we present the case of a 74-year-old Japanese man with segmental intestinal necrosis, which developed after treatment with pulsed methylprednisolone for mononeuritis multiplex. The patient was weakly positive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA). Computed tomography and surgical findings were compatible with nonocclusive mesenteric ischemia (NOMI). He underwent small intestinal resection by emergency surgery and an intestinal fistula was made. Pathologically, necrotizing vasculitis with fibrinoid necrosis was present in medium to small-sized arteries, which was equivalent to Arkin's classification Ⅱ-Ⅳ. Most of the arteries had fibrous intimal thickening, which was considered to obstruct the arteries and thus cause segmental intestinal necrosis. A diagnosis of polyarteritis nodosa (PAN) was made, and intravenous cyclophosphamide pulse therapy was added to the therapeutic regimen. This patient was successfully treated with these multidisciplinary therapies and his stoma was finally closed. This is a very rare and indicative case of PAN weakly positive for MPO-ANCA and clinically mimicking NOMI, which occurred even after treatment with pulsed methylprednisolone.

关键词： Anti-neutrophil cytoplasmic antibody Intestinal necrosis Myeloperoxidase Nonocclusive mesenteric ischemia Polyarteritis nodosa

Enhanced piezoelectric properties of (Ba_(0.3)Bi_(0.7))(Mg_(0.05)Fe_(0.6)Ti_(0.35))O_(3) piezoelectric ceramics with high Curie temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Dielectrics 2014年第1期4卷 81-86页

作者： Ichiro fujii Ryuta Mitsui Kouichi Nakashima satoshi Wada Interdisciplinary Graduate School of Medical and Engineering University of Yamanashi Kofu 400-8510Japan

(Ba_(0.3)Bi_(0.7))(Mg_(0.05)Fe_(0.6)Ti_(0.35))O_(3) ceramics were either doped with vanadium or sintered in calcined powder with the same *** to an undoped ceramic sintered without the calcined powder,both ceramics showed reduced leakage current densities(lower than 1×10^(-7) A/cm^(2))and absence of dielectric relaxation behaviors observed in frequency-and temperaturedependent dielectric *** Curie temperatures of both samples were higher than 460℃.The maximum field-induced strain over the applied field,S_(max)/E_(max),of 366 pm/V of the undoped ceramic sintered without the calcined powder increased to 455 and 799 pm/V for the V-doped ceramics and the ceramics sintered with the calcined powder,*** increase was related to a reduced concentration of bismuth vacancy-oxygen vacancy defect dipoles.

关键词： Piezoelectrics domain structure lead-free high Curie temperature dopant.

Glioblastoma without Remarkable Contrast Enhancement on Magnetic Resonance Imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2012年第6期3卷 439-445页

作者： satoshi Utsuki Hidehiro Oka Yoshiteru Miyajima Chihiro Kijima Yoshie Yasui Kiyotaka fujii Department of Neurosurgery Kitasato University School of Medicine Sagamihara Japan

This is the report of a histological and clinical investigation of 4 cases of glioblastoma, a rare tumor, in whom poor contrast enhancement of the tumor was visualized on magnetic resonance imaging (MRI). Among the 94 patients with first-occurrence glioblastoma treated between January 2000 and August 2011, 4 were enrolled in this retrospective study. There were 2 men and 2 women, ranging in age from 41 to 70 years (mean, 57 years). All the patients underwent tumor resection, postoperative irradiation, and chemotherapy. One died of local tumor recurrence after 36 months;the remaining three remain alive as of 25 to 72 months after the initial treatment. The histopathology was glioblastoma with nuclear pleomorphism and pseudopalisading necrosis in all cases. However, the typical vascular endothelial proliferation was not found in 3 cases. All glioblastomas were immunopositive for p53 and immunonegative for epidermal growth factor receptor (EGFR) and isocitrate dehydrogenase 1 (IDH1). These glioblastomas showing unclear contrast enhancement on MRI had similar clinical and pathological characteristics, but differed in characteristics from glioblastoma patients showing marked contrast enhancement of the tumor on MRI.

关键词： Enhancement Effect Glioblastoma EGFR IDH1 p53 Secondary Glioblastoma

Outcome of Vision Impairment and Diabetes Insipidus in Suprasellar Region Germinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2011年第2期2卷 82-85页

作者： satoshi Utsuki Hidehiro Oka Yoshiteru Miyajima Chihiro Kijima Kiyotaka fujii Shinichi Kan 不详

Aim: Many cases of suprasellar region germinoma occurs in diabetes insipidus (DI), but a patient initially may come to the hospital for the chief complaint of visual impairment. The aim of this study is to determine the etiology of initial symptom presentation and the outcomes of visual impairment and DI in suprasellar region germinoma. Methods: We investigated eleven cases of single lesion suprasellar germinomas that were diagnosed and treated in our hospital. For each, a magnetic resonance imaging (MRI) was performed. Results: At the hospital visit, decreased visual acuity was found in 5/11 cases, while DI was found in all cases. The decreased visual acuity was improved in 4/5 cases by treatment, but DI improved in only 2/11 cases. In 10 cases, DI occurred earlier than visual impairment. As the initial symptom, visual impairment occurred earlier than DI in only one case and did not improve by treatment. In this case, a pituitary stalk of the normal thickness could be identified by MRI, and the optic nerve was swollen. In ten cases except this case, no significant enlargement of optic nerve was detected, and a swollen pituitary stalk was confirmed. Conclusions: In suprasellar germinomas, it is rare, but the optic nerve can significantly swell at onset, while the pituitary stalk may be intact. In such cases, visual impairment occurs earlier than DI, and visual impairment may not be improved.

关键词： Diabetes Insipidus Neurohypophyseal Germinoma Optic Nerve Germinoma Visual Function

Recent Advanced neurosurgical procedure using integrated system of intraoperative MRI and neuronavigation with multimodal neuroradiological images

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advanced neurosurgical procedure using integrated sys...

Preoperative Prediction of Whether Intraoperative Fluorescence of Protoporphyrin IX Can Be Achieved by 5-Aminolevulinic Acid Administration

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Toshihiko Wakabayashi Masazumi fujii Yasukazu Kajita Astushi Natsume satoshi Maezawa Jun Yoshida Department of Neurosurgery Nagoya University Graduate School of Medicine

＜正＞Recent promotion of collaboration between medical science and engineering brings significant advancement in the development of image diagnostic technology and surgical assist system. Using high-resolution micros...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2012年第2期3卷 132-135页

作者： satoshi Utsuki Hidehiro Oka Chihiro Kijima Madoka Inukai Kiyotaka fujii Masahiro Ishizuka Kiwamu Takahashi Katsushi Inoue Department of Neurosurgery Kitasato University School of Medicine Sagamihara Japan SBI ALApromo Co. Ltd. Tokyo Japan

Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection, using 5-aminolevulinic acid (5-ALA), is among the most valuable tools for determining tumor removal area. However, PPIX fluorescence is not necessarily achieved during an operation visually even when 5-ALA is used, and we do not know until tumor exposure to the excitation light of the ultraviolet region whether PPIX fluorescence has been achieved. When a particular biopsy and frozen section diagnosis is made, the reason for lack of PPIX fluorescence in the tissue cannot be judged. We do not know whether the tumor fails to fluoresce or no fluorescence is seen because it is not the main body of the tumor. We investigated whether the presence or absence of tumor fluorescence could be predicted by examining urinary porphyrin before surgery, at the time of intraoperative fluorescence diagnosis using 5-ALA. The urine of brain tumor patients 2 hours after 5-ALA administration was irradiated with a 405 ± 1 nm laser light. The patients were divided into a fluorescent urine group and negative fluorescent urine group. Red fluorescence was observed in response to the 405 ± 1 nm laser beam for all tumors in the fluorescent urine group. Clear red fluorescence was not observed even with 405 ± 1 nm laser beam irradiation in any tumors in the negative fluorescent urine group. Preoperative prediction of the intraoperative fluorescence of PPIX can be achieved by observation of urine 2 hours after 5-ALA administration with exposure to a 405 ± 1 nm laser light.

关键词： 5-Aminolevulinic Acid Intraoperative Fluorescence Coproporphyrin Protoporphyrin IX Urinary Porphyrin