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Recent advances in the surgical treatment of hepatocellular carcinoma

World Journal of Gastroenterology 2014年第39期20卷 14381-14392页

作者： Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase satoshi arakawa Rie Yoshida Masashi Isetani Department of Surgery Fujita Health University School of Medicine Banbuntane Houtokukai Hospital Nagoya 454-8509 Japan

Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.

关键词： Hepatocellular carcinoma Surgical treatment Hepatectomy Liver transplantation Laparoscopic hepatectomy Tumor thrombi Chemotherapy

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Surgery for pancreatic tumors in the midst of COVID-19 pandemic

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World Journal of Clinical Cases 2021年第18期9卷 4460-4466页

作者： Hiroyuki Kato Yukio Asano satoshi arakawa Masahiro Ito Norihiko Kawabe Masahiro Shimura Chihiro Hayashi Takayuki Ochi Hironobu Yasuoka Takahiko Higashiguchi Yuka Kondo Hidetoshi Nagata Akihiko Horiguchi Department of Gastroenterological Surgery Fujita Health University School of Medicine Bantane HospitalNagoya 454-8509Japan

The spread of the new coronavirus(COVID-19)infection in 2020 has had a significant impact on the treatment of cancer *** the COVID-19 pandemic,the biggest challenge for pancreatic surgeons is the difficulty in providing oncological *** this review article,from the standpoint of surgeons,we explain the concept of triaging of patients with pancreatic tumors under the COVID-19 pandemic,and the actual impact of COVID-19 on the treatment of patients with pancreatic *** most vital points in selecting the best therapeutic approach for patients with pancreatic tumors during this pandemic are(1)Oncologists need to tailor the treatment plan based on the COVID-19 phase,tumor malignant potential,and patients’comorbidities;and(2)Optimal treatment for pancreatic cancer should be planned according to the condition of each patient and tumor resectability based on national comprehensive cancer network resectability *** choose the best therapeutic approach for patients with pancreatic tumors during this pandemic,we need to tailor the treatment plan based on elective surgery acuity scale(ESAS).Newly established ESAS for pancreatic tumor and flowchart indicating the treatment strategy of pancreatic cancer,are feasible to overcome this situation.

关键词： COVID-19 Pancreatic ductal adenocarcinoma Surgical treatment Pancreatic tumor Pandemic National comprehensive cancer network resectability criteria

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Pure laparoscopic hepatectomy as repeat surgery and repeat hepatectomy

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World Journal of Gastroenterology 2015年第3期21卷 961-968页

作者： Masashi Isetani Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase satoshi arakawa Department of Surgery Fujita Health University School of MedicineBanbuntane Houtokukai HospitalAichiNagoya 454-8509Japan

AIM:To assess clinical outcomes of laparoscopic hepatectomy(LH) in patients with a history of upper abdominal surgery and repeat ***:This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal *** the 80 patients who underwent LH,22 had prior abdominal surgeries,including hepatectomy(n = 12),pancreatectomy(n = 3),cholecystectomy and common bile duct excision(n = 1),splenectomy(n = 1),total gastrectomy(n = 1),colectomy with the involvement of transverse colon(n = 3),and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen(n = 1).Clinical indicators including operating time,blood loss,hospital stay,and morbidity were compared among the ***:Eighteen of the 22 patients who had undergone previous surgery had severe adhesions in the area around the ***,there were no conversions to laparotomy in this *** the 58 patients without a history of upper abdominal surgery,the median operative time was 301 min and blood loss was 150 m *** patients with upper abdominal surgical history or repeat hepatectomy,the operative times were 351 and 301 min,and blood loss was 100 and 50 m L,*** median postoperative stay was 17,13 and 12 d for patients with no history of upper abdominal surgery,patients with a history,and patients with repeat hepatectomy,*** were five cases with complications in the group with no surgical history,compared to only one case in the group with a prior *** were no statistically significant differences in the perioperative results between the groups with and without upper abdominal surgical history,or with repeat ***:LH is feasible and safe in patients with a history of upper abdominal surgery or repeat hepatectomy.

关键词： Chronic liver disease Laparoscopic hepatectomy Liv

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Case report of the fourth laparoscopic liver resection and review of repeat laparoscopic resection for recurrent hepatocellular carcinoma in cirrhotic liver

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Hepatoma Research 2016年第1期2卷 253-258页

作者： Zenichi Morise Masashi Isetani Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata satoshi arakawa Masahiro Ikeda Kenshiro Kamio Department of Surgery Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Surgery Fujita Health University Banbuntane Houtokukai HospitalNagoyaAichi 454-8509Japan

A 73-year-old woman with liver cirrhosis caused by hepatitis C virus(HCV)underwent treatment of three hepatocellular carcinomas(HCCs)in liver segment 4,following three previous laparoscopic liver resections(LLRs)over 73 ***-enhanced computed tomography showed three 0.5-1.2 cm HCCs deep within the portal territories of subsegments 4a and *** patient underwent laparoscopic resection of 4a and 4b,with the preservation of the portal branch to 4c,after minimal adhesiolysis around segment *** operation lasted 284 min,there was 50 mL of intra-operative bleeding and her recovery was *** was well,had experienced no recurrence and was HCV-negative,after taking oral anti-HCV therapy,21 months *** is associated with fewer adhesions after surgery and requires less adhesiolysis,because the laparoscope and forceps can be used in the small spaces between *** present patient underwent four LLRs over 6 years without severe deterioration of liver functional *** is a useful localized therapy,which can be performed repeatedly and may prolong the survival of patients with multicentric metachronous HCCs.

关键词： Laparoscopic liver resection,repeat liver resection hepatocellular carcinoma liver cirrhosis anatomical liver resection subsegmentectomy

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Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： Shinji Bono Ryotaro Nakai satoshi Konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

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Molecular biomarkers for vascular cognitive impairment and dementia:the current status and directions for the future

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Neural Regeneration Research 2024年第12期19卷 2579-2580页

作者： satoshi Hosoki Perminder SSachdev Centre for Healthy Brain Ageing Discipline of Psychiatry and Mental HealthSchool of Clinical MedicineFaculty of Medicine and HealthUniversity of New South WalesSydneyAustralia Department of Neurology National Cerebral and Cardiovascular CenterOsakaJapan

Dementia is a syndrome with various underlying pathologies acting independently or in concert to cause cognitive *** development of disease-specific treatments and targeted prevention strategies requires precise clinical sub-typing via etiology and pathophysiological ***,recent research advances in biomarkers,especially for Alzheimer's disease(AD)diagnosis,have improved diagnostic precision for dementia.

关键词： prevention diagnosis impairment

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Controllable multi-domain semantic artwork synthesis

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Computational Visual Media 2024年第2期10卷 355-373页

作者： Yuantian Huang satoshi Iizuka Edgar Simo-Serra Kazuhiro Fukui Department of Computer Science University of TsukubaTsukuba 305-8577Japan Department of Computer Science and Engineering Waseda UniversityTokyo 169-8050Japan

We present a novel framework for the multidomain synthesis of artworks from semantic *** of the main limitations of this challenging task is the lack of publicly available segmentation datasets for art *** address this problem,we propose a dataset called ArtSem that contains 40,000 images of artwork from four different domains,with their corresponding semantic label *** first extracted semantic maps from landscape photography and used a conditional generative adversarial network(GAN)-based approach for generating high-quality artwork from semantic maps without requiring paired training ***,we propose an artwork-synthesis model using domain-dependent variational encoders for high-quality multi-domain ***,the model was improved and complemented with a simple but effective normalization method based on jointly normalizing semantics and style,which we call spatially style-adaptive normalization(SSTAN).Compared to the previous methods,which only take semantic layout as the input,our model jointly learns style and semantic information representation,improving the generation quality of artistic *** results indicate that our model learned to separate the domains in the latent ***,we can perform fine-grained control of the synthesized artwork by identifying hyperplanes that separate the different ***,by combining the proposed dataset and approach,we generated user-controllable artworks of higher quality than that of existing approaches,as corroborated by quantitative metrics and a user study.

关键词： semantic artwork synthesis generative adversarial network(GAN) datasets non-photorealistic rendering

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Projected impacts of climate change and anthropogenic effects on habitat distribution of endangered Javan Hawk-Eagle in Indonesia

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Geography and Sustainability 2024年第2期5卷 241-250页

作者： Syartinilia Aryo Adhi Condro satoshi Tsuyuki Department of Landscape Architecture Faculty of AgricultureIPB University(Bogor Agricultural University)Bogor 16680Indonesia International Research Institute for Environment and Climate Change-IPB University Collaborative Research CentreBogor 16128Indonesia Rainforest Alliance DenpasarBali 80227Indonesia Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 113-8657Japan

Changing climate will jeopardize biodiversity,particularly the geographic distribution of endemic *** such species is the Javan Hawk-Eagle(JHE,Nisaetus bartelsi),a charismatic raptor found only on Java Island,***,it is crucial to develop an appropriate conservation strategy to preserve the *** niche modeling is considered a valuable tool for designing conservation plans for the *** provide an ecological niche modeling approach and transfer its model to future climate scenarios for the *** utilize various machine learning algorithms under sustainability and business-as-usual(BAU)scenarios for ***,we investigate the conservation vulnerability of the JHE,capturing multifaceted pressures on the species from climate dissimilarities and human disturbance *** study reveals that the ensemble model performs exceptionally well,with temperature emerging as the most critical factor affecting the JHE *** finding indicates that climate change will have a significant impact on the JHE *** results suggest that the JHE distribution will likely decrease by 28.41%and 40.16%from the current JHE distribution under sustainability and BAU scenarios,***,our study reveals high-potential refugia for future JHE,covering 7,596 km^(2)(61%)under the sustainability scenario and only 4,403 km^(2)(35%)under the BAU ***,effective management and planning,including habitat restoration,refugia preservation,habitat connectivity,and local community inclusivity,should be well-managed to achieve JHE conservation targets.

关键词： Climate change Ecological niche Ensemble model Refugia Javan Hawk-Eagle

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Enhancing Offensive Language Detection with Data Augmentation and Knowledge Distillation

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Research 2024年第2期6卷 29-40页

作者： Jiawen Deng Zhuang Chen Hao Sun Zhexin Zhang Jincenzi Wu satoshi Nakagawa Fuji Ren Minlie Huang The CoAl group DCSTInstitute for Artificial InteligenceState Key Lab of Intelligent Technology and SystemsBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China Graduate School of Information Science&Technology The University of Tokyo.Tokyo 1138654Japan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengduSichuan611731China

Offensive language detection has received important attention and plays a crucial role in promoting healthy communication on social platforms,as well as promoting the safe deployment of large language *** data is the basis for developing detectors;however,the available offense-related dataset in Chinese is severely limited in terms of data scale and coverage when compared to English *** significantly affects the accuracy of Chinese offensive language detectors in practical applications,especially when dealing with hard cases or out-of-domain *** alleviate the limitations posed by available datasets,we introduce AugCOLD(Augmented Chinese Offensive Language Dataset),a large-scale unsupervised dataset containing 1 million samples gathered by data crawling and model ***,we employ a multiteacher distillation framework to enhance detection performance with unsupervised *** is,we build multiple teachers with publicly accessible datasets and use them to assign soft labels to *** soft labels serve as a bridge for knowledge to be distilled from both AugCOLD and multiteacher to the student network,i.e.,the final offensive *** conduct experiments on multiple public test sets and our well-designed hard tests,demonstrating that our proposal can effectively improve the generalization and robustness of the offensive language detector.

关键词： COLD dealing limitations

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Determinants of Tobacco Cultivation and the Associated Impacts of Adoption in Hurungwe District, Zimbabwe

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Agricultural Sciences 2024年第4期15卷 505-531页

作者： Spencer Sibanda satoshi Tsuyuki Department of Information and Computer Sciences Graduate School of Science and Engineering Saitama University Saitama Japan Department of Global Agricultural Sciences Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan

Tobacco is an essential cash crop in Zimbabwe and a strategic livelihood option for hundreds of thousands of rural households. However, the crop is linked to negative environmental, economic, and social impacts. The existing studies on tobacco cultivation in Zimbabwe present contradictory findings on the determinants and impacts of adoption, leaving unanswered questions about the crop’s sustainability impact in the country. This article investigates the determinants of smallholder farmers’ decisions to grow tobacco and the associated impacts of adoption. Random and purposive sampling were used to select 273 household surveys, including tobacco and non-tobacco smallholder farmers, and 56 expert interviews to answer the research questions. We employed regression models alongside expert interviews and document analysis to identify the determinants influencing the decision-making process of smallholder farmers in Zimbabwe regarding tobacco cultivation. Additionally, our investigation aimed to elucidate the perceived impacts associated with the adoption of this agricultural practice. The regression analysis indicated that the farmer’s age, education level, farming experience, family size, household income, and perceived high farm profitability are significant drivers of tobacco adoption. We also discovered divergent and convergent perceptions of the critical impacts of tobacco cultivation. The study highlights the need for proactive multi-stakeholder collaboration and sustainable financial arrangements to address the negative impacts of tobacco production. As the primary stakeholder responsible for regulating and promoting agricultural activities, the Zimbabwean government should provide meaningful financial support, increase access to credit, and ensure better market facilities for alternative crops to reduce the over-dependence on tobacco.

关键词： Tobacco Cultivation Determinants of Adoption Sustainability Impacts Economic Livelihood Stakeholder Perceptions

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