检索结果-南通市图书馆

Efficacy and Safety of Basal-Supported Prandial GLP-1 Receptor Agonist Therapy

Journal of Diabetes Mellitus 2017年第3期7卷 86-95页

作者： Taichi Nagahisa Mitsuhisa Tabata satoru yamada Diabetes Center Kitasato Institute Hospital Tokyo Japan

Aim: To assess the safety and efficacy of basal-supported prandial GLP-1 receptor agonist therapy (BPT)* in type 2 diabetes mellitus (T2DM). Methods: Patients with T2DM, who had previously received insulin injection therapy and who had had their treatment switched to BPT (liraglutide), were retrospectively recruited. The efficacy of BPT was assessed by determining changes in HbA1c, body weight and total daily insulin dose from baseline to 4 months after BPT initiation. Safety was assessed by comparing the frequency of hypoglycemic episodes at baseline and after 4 months. The Wilcoxon test was used to analyze changes in parameters throughout the study period. Results: Twenty-nine patients, previously treated with basal-supported oral therapy (BOT), basal-bolus insulin, or pre-mixed insulin, were recruited. When analyzed together, there was no change in HbA1c throughout the study period, but body weight decreased (baseline 68.8 ± 13.2 kg vs. month 4 67.3 ± 13.1 kg;p < 0.001). Total daily insulin dose decreased after 4 months (baseline 24.4 ± 15.5 U/day vs. month 4 14.7 ± 9.2 U/day;p < 0.001), and there was no change in the frequency of hypoglycemic episodes. Analysis was conducted within sub-groups based on previous treatment modality. In the BOT group, HbA1c decreased from baseline after 2 months and body weight did not change throughout the study period. In both the basal-bolus insulin group and the pre-mixed insulin group, HbA1c remained steady throughout and there was a decrease in body weight. No change in the frequency of hypoglycemia was observed in any of the sub-groups. Conclusion: BPT in T2DM was associated with weight loss without changes in glycemic control over 4 months, suggesting that it may be an effective and safe therapy.

关键词： Basal Insulin Combination Therapy GLP-1 Receptor agonists HbA1c Type 2 Diabetes Mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of glycemic variability between basal-bolus and premixed insulin therapy

引用

Journal of Diabetes Mellitus 2013年第2期3卷 45-51页

作者： satoru yamada Ryo Hirai Gaku Inoue Yoshifumi yamada Junichiro Irie Koichiro Atsuda Toshikazu Yamanouchi Center for Clinical Pharmacy and Clinical Sciences Kitasato University Tokyo Japan Department of Internal Medicine Keio University School of Medicine Tokyo Japan Department of Medicine Tokyo University School of Medicine Tokyo Japan Diabetes Center Kitasato Institute Hospital Tokyo Japan

Background: Several studies have shown that twice-daily injections of premixed insulin analogs (MIX) could achieve comparable HbA1c levels to basal-bolus (BB) therapy. However, HbA1c does not necessarily reflect short-term glycemic fluctuations that may contribute to the onset or progression of diabetic complications. Therefore, in this study, we compared MIX and BB therapies in terms of their effects on glycemic variability. Methods: We performed a crosssectional observational study of patients attending our outpatient clinics to compare the effects of two insulin regimens on glycemic variability. We recruited patients treated with MIX or BB with HbA1c 180 mg/dL (t > 180) was significantly shorter with BB therapy (88 ± 76 min) than with MIX therapy (145 ± 54 min;p < 0.05). After classification according to HbA1c levels, markers of glycemic variability were better in patients treated with BB than in those treated with MIX in better control group. Conclusion: These results suggest that BB therapy achieves better glucose profiles than MIX therapy in patients with type 2 diabetes, particularly after lunch.

关键词： Glycemic Variability Insulin Therapy Diabetes Continuous Glucose Monitoring

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Morphological Study of <i>Glochidion obovatum</i>under Heavy Browsing Pressure by Sika Deer

引用

American Journal of Plant Sciences 2014年第9期5卷 1345-1351页

作者： Shogo Takei Kazuhiro Yoshioka satoru yamada Hiroshi Hayakawa Jun Yokoyama Katsura Ito Shinichi Tebayashi Ryo Arakawa Tatsuya Fukuda Faculty of Agriculture Kochi University Kochi Japan Faculty of Science Yamagata University Yamagata Japan

To clarify the modification of physical defences of Glochidion obovatum Sieb. et Zucc., we compared the length of spine-like branches and frequency of lateral branches of G. obovatum between Kashima Island, which supports a high density of sika deer (Cervus nippon), and its neighbouring areas. The length of spine-like branches of G. obovatum in Kashima Island was not significantly longer than that of the neighbouring areas, but the frequency of lateral branches on the island was higher than that of the neighbouring areas. Since the branches of G. obovatum are heavily foraged by the sika deer, the shrub form of the species has evolved into the bonsai form, suggesting increased frequency of occurrence of lateral branches, which could develop as shoot-like branches. Thus, the observed features are facultative defence mechanisms of G. obovatum against heavy browsing in a small-sized island with very high density of sika deer.

关键词： Deer Defence Frequency Herbivore Island Sika

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Length and Density of Prickles on <i>Zanthoxylum ailanthoides</i>(Rutaceae): A Comparison of Japanese Islands with Different Sika Deer Browsing Pressures

引用

American Journal of Plant Sciences 2014年第3期5卷 332-337页

作者： Shogo Takei Kazuhiro Yoshioka satoru yamada Hiroshi Hayakawa Jun Yokoyama Katsura Ito Shin-Ichi Tebayashi Ryo Arakawa Tatsuya Fukuda Faculty of Agriculture Kochi University Kochi Japan Faculty of Science Yamagata University Yamagata Ja-pan

To determine the effects of sika deer (Cervus nippon) browsing on the physical defences of the Japanese pricklyash “Zanthoxylum ailanthoides Sieb. et Zucc.” (Rutaceae), we compared the length and density of prickles on Japanese islands which were under different browsing pressures. We measured the length and density of prickles on the midribs, leaf rachis, and stems. We found that the prickles of Z. ailanthoides on Kashima island were not significantly longer or at higher densities than those in the neighbouring areas;the longest pickles at the highest densities were found on Akune island. The density of sika deer on Akune (ca. 520-600/km2) was higher than that on Kashima (ca. 38.5/km2), and consequently, Akune was under greater browsing pressure. Our results suggest that the increased length and density of prickles on Akune is a response by Z. ailanthoides to the high density of sika deer found on the island.

关键词： Deer Defence Density Herbivore Island Length Sika

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Z-shaped incision without epithelial resection in pterygium surgery

引用

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1262-1266页

作者： satoru Kase Shinki Chin Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

AIM:To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic ***:This was a prospective *** pterygium surgery,all proliferative tissues were separated from the cornea and conjunctiva without resection of the *** unaffected conjunctiva was incised in a *** upper(or lower)conjunctival flap was sutured to the lower(or upper)normal conjunctiva on the limbal sclera,while the proliferative tissue was sutured to the upper conjunctiva(or lower)near the ***:Ten patients with pterygia were eligible for this *** patients with primary pterygia and 2 with recurrent pterygia were *** age of patients at surgery ranged from 47 to 90y(average:71.9y).Five patients each showed right and left-sided *** postoperative follow-up periods were from 8 to 78mo(average:25.0mo).The surgery was successfully conducted and wounds were favorably reconstructed in all *** proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles,and never showed re-growth after *** patients did not show *** pterygium was noted in 1 patient,but additional treatments were not ***:The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped *** scleral limbal wound can be covered with nonaffected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

关键词： pterygium surgery Z-shape non-resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical reaction in a liquid–liquid phase‐separated multiple droplet:Synchronization of color change dynamics with droplet movement

引用

Droplet 2024年第1期3卷 103-112页

作者： Kenta Goto Kyoka Nakanishi Fumito Tani satoru Tokuda Department of Chemistry Graduate School of SciencesInstitute for Materials Chemistry and Engineering(IMCE)Kyushu UniversityFukuokaJapan Research Institute for Information Technology Kyushu UniversityKasugaJapan Mathematics for Advanced Materials-Open Innovation Laboratory AISTc/o Advanced Institute for Materials ResearchTohoku UniversitySendaiJapan

Liquid–liquid phase separation in a biotic cell system organizes complicated biochemical reactions and functions by forming membraneless compartments that allow a substrate to move across the phase *** the other hand,liquid–liquid phase separation in an abiotic system gives rise to an emulsion and/or multiple droplets that hardly undergo chemical *** have developed a method for the formation of phase‐separated multiple droplet in a ternary mixture with a 3D‐printed microchannel and demonstrated the occurrence of the iron(III)thiocyanate ligand exchange reaction in the multiple *** reaction proceeded differently in the outer‐and the inner‐droplet phases,giving a different iron(III)complex that was identified on the basis of its color ***,the color change was dynamic,enabling visualization of the interphase mass *** the same time,the color change dynamics synchronized with the multiple‐droplet movement.

关键词： liquid phase separated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluorescence‑Based Calibration Model for In‑Situ Measurement of Micro‑scaled Lubricant Thickness Distribution at Indentation Interface

引用

Nanomanufacturing and Metrology 2024年第2期7卷 76-88页

作者： Motoya Yoshikawa Saeko Fujii Shotaro Kadoya Tatsuya Sugihara Masaki Michihata satoru Takahashi Department of Precision Engineering The University of TokyoHongo 7‑3‑1BunkyoTokyo 113‑8656Japan Department of Mechanical Engineering Osaka UniversityYamadaoka 2‑1SuitaOsaka 565‑0871Japan

This study proposes a model for the measurement of microscale liquid film thickness distribution using fluorescence *** interfacial conditions between the tool and the workpiece in mechanical machining are important for understanding these phenomena and *** this study,indentation tests with transparent tools were used to observe interfaces;however,it was challenging to obtain the signal from a thin fluorescent liquid film on smooth and steeply inclined ***,fluorescence-based measurement,such as laser-induced fluorescence,was *** measure the absolute thickness of the thin fluorescent film,calibration of the measurement system is ***,a theoretical model was proposed considering the multiple reflections of excitation light and fluorescence at the inclined surface between the indenter and *** measuring the profile of the surface topography of the indented workpiece and comparing the results with those measured by a surface profiler,the validity of the proposed calibration method and the performance of this measurement system were *** measured surface profiles,including scratches of 2–4μm,were in good agreement,demonstrating the validity of the proposed method.

关键词： Laser-induced fluorescence(LIF) Thickness distribution In-situ measurement Lubricant Mechanical machining

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma

引用

Cancer Innovation 2024年第2期3卷 80-95页

作者： satoru Sasagawa Jun Kumai Toru Wakamatsu Yoshihiro Yui Molecular Biology Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Sarcoma Treatment Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Department of Musculoskeletal Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the *** deacetylase(HDAC)inhibitors(HDACis)are arising as potent molecular targeted drugs,as HDACi treatment disrupts the SS oncoprotein complex,which includes HDACs,in addition to general HDACi *** provide further molecular evidence for the advantages of HDACi treatment and its limitations due to drug resistance induced by the microenvironment in SS cells,we examined cellular responses to HDACi treatment in combination with two-dimensional(2D)and 3D culture ***:Using several SS cell lines,biochemical and cell biological assays were performed with romidepsin,an HDAC1/2 selective ***38 was concomitantly used as an ameliorant drug with romidepsin ***,apoptosis induction,and MHC class I polypeptide-related sequence A/B(MICA/B)induction were monitored to evaluate the drug *** addition to the conventional 2D culture condition,spheroid culture was adopted to evaluate the influence of cell-mass microenvironment on ***:By monitoring the cellular behavior with romidepsin and/or SN38 in SS cells,we observed that responsiveness is diverse in each cell *** the apoptotic inducible cells,co-treatment with SN38 enhanced cell *** nonapoptotic inducible cells,cytostasis and MICA/B induction were observed,and SN38 improved MICA/B induction *** a novel efficacy of SN38,we revealed TWIST1 suppression in SS *** the spheroid(3D)condition,romidepsin efficacy was severely restricted in TWIST1-positive *** demonstrated that TWIST1 downregulation restored romidepsin efficacy even in spheroid form,and concomitant SN38 treatment along with romidepsin reproduced the ***:The current study demonstrated the benefits and concerns of using HDACi for SS treatment in 2D and

关键词： HDAC inhibitor MICA/B SN38 spheroid synovial sarcoma TWIST1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction and performance test of charged particle detector array for MATE

引用

Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of in-bore balloting and control of jump variability

引用

Defence Technology（防务技术） 2019年第5期15卷 721-734页

作者： satoru Shoji Wakayama-dai ShimamotoOsakaJapan21-104

The variability of projectile jump is the long-term issue to improve weapon *** we have many simulation codes to predict ***,these codes cannot explain explicitly how the variability of jump *** aims of this paper are,(1)to give fundamental explanations for the variability of Jump,and (2)to offer design factors to make the variability of Jump *** model presented here was formulated in accordance with the transition of the system in reverse way commencing from the target impact stage to the chambering *** of the simulation are generic 120mm smooth bore and long rod system which are extremely simplified to the vibration of tube,the spring effect by sabot,and the free-ends beam of *** calculations clarified that high Jump-variability is generated only when the last rebound is on the muzzle *** particular state of rebound is achieved by many combinations of *** map named JV-Chart is proposed to show the high Jumpvariability zone.

关键词： Jump variability Coupled vibration In-bore balloting Cantilever tube

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：