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Effectiveness and adverse effects of hormonal therapy for prostate cancer： Japanese experience and perspective

Asian Journal of Andrology 2012年第3期14卷 451-457,I0007,I0008页

作者： Mikio Namiki satoru ueno Yasuhide Kitagawa Takashi Fukagai Hideyuki Akaza Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan Research Center for Advanced Science and Technology University of Tokyo Tokyo 153-8903 Japan

Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will improve hormonal therapy. On the other hand, there has been an increase in criticism of hormonal therapy, because hormonal therapy is supposed to induce adverse effects such as cardiovascular disease. In this review, we have introduced the Japanese experience of hormonal therapy, because we believe that there may be ethnic differences between Caucasians and Asian people in the efficacy and adverse effects of hormonal therapy. First, we showed that primary hormonal therapy can achieve long-term control of localized prostate cancer in some cases and that quality of life of patients receiving hormonal therapy is rather better than previously thought. Neoadjuvant and adjuvant hormonal therapy in cases undergoing radical prostatectomy or radiotherapy are very useful for high-risk or locally advanced prostate cancer. Further clinical trials are required to confirm the efficacy of neoadjuvant or adjuvant hormonal therapy. We showed that the death from cardiovascular dis- eases in Japanese patients receiving hormonal therapy was not higher than that in the general population. However; efforts should be made to decrease the adverse effects of hormonal therapy, because life-style change may increase the susceptibility to adverse effects by hormonal therapy even in Japan. Managements of endocrine and metabolic dysfunction, such as diabetes mellitus, are essential. New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed.

关键词： adverse effects androgen deprivation therapy hormonal therapy prostate cancer

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Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan

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Asian Journal of Andrology 2014年第6期16卷 833-837页

作者： Yasuhide Kitagawa Kazuaki Machioka Hiroshi Yaegashi Kazufumi Nakashima Mitsuo Ofud Kouji Izumi satoru ueno Yoshifumi Kadono Hiroyuki Konaka Atsushi Mizokami Mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan

To clarify the recent trends in prostate-specific antigen （PSA） distribution in men in Japan, we analyzed the PSA distributions of men undergoing PSA-based population screening. We summarized the annual individual data of PSA-based population screening in Kanazawa, Japan, from 2000 to 2011, and analyzed baseline serum PSA values of the participants at the first population screening. Serum PSA distributions were estimated in all participants and those excluding prostate cancer patients according to age. From 2000 to 2011, 19 620 men participated aged 54-69 years old in this screening program. Mean baseline serum PSA level of all participants at the first screening was 2.64 ng m1-1 in 2000, and gradually decreased to approximately 1.30 ng ml-I in 2006. That of participants excluding prostate cancer patients was 1.46 ng m1-1 in 2000, and there was no remarkable change during the study period. The 95t＂ percentiles in the participants excluding prostate cancer patients detected at the first population screening of men aged 54-59, 60-64, and 65-69 years old were 2.90, 3.60, and 4.50 ng m1-1, respectively. After the commencement of population screening, the proportion of prostate cancer patients with high serum PSA levels decreased. However, there were no changes in serum PSA levels in men without prostate cancer. Age-specific PSA reference level of men without prostate cancer in Japan was similar to that in China and Korea.

关键词： age-specific prostate-specific antigen reference range prostate cancer prostate-specific antigen-based population screening serum prostate-specific antigen distribution

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Z-shaped incision without epithelial resection in pterygium surgery

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1262-1266页

作者： satoru Kase Shinki Chin Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

AIM:To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic ***:This was a prospective *** pterygium surgery,all proliferative tissues were separated from the cornea and conjunctiva without resection of the *** unaffected conjunctiva was incised in a *** upper(or lower)conjunctival flap was sutured to the lower(or upper)normal conjunctiva on the limbal sclera,while the proliferative tissue was sutured to the upper conjunctiva(or lower)near the ***:Ten patients with pterygia were eligible for this *** patients with primary pterygia and 2 with recurrent pterygia were *** age of patients at surgery ranged from 47 to 90y(average:71.9y).Five patients each showed right and left-sided *** postoperative follow-up periods were from 8 to 78mo(average:25.0mo).The surgery was successfully conducted and wounds were favorably reconstructed in all *** proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles,and never showed re-growth after *** patients did not show *** pterygium was noted in 1 patient,but additional treatments were not ***:The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped *** scleral limbal wound can be covered with nonaffected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

关键词： pterygium surgery Z-shape non-resection

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Analysis software for upper atmospheric data developed by the IUGONET project and its application to polar science

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Advances in Polar Science 2013年第4期24卷 231-240页

作者： Yoshimasa Tanaka Atsuki Shinbori Tomoaki Hori Yukinobu Koyama Shuji Abe No-rio Umemura Yuka Sato Manabu Yagi satoru ueno Akiyo Yatagai Yasunobu Ogawa Yoshizumi Miyoshi National Institute of Polar Research 10-3 Midori-choTachikawaTokyo 190-8518Japan Research Institute for Sustainable Humanosphere GokashoUjiKyoto 611-0011Japan Solar-Terrestrial Environment Laboratory Nagoya UniversityFurou-choChikusaNagoyaAichi 464-8614Japan Data Analysis Center for Geomagnetism and Space Magnetism Graduate School of ScienceKyoto UniversityKi-tashirakawa-Oiwake ChoSakyo-kuKyoto 606-8502Japan International Center for Space Weather Science and Education Kyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan Planetary Plasma and Atmospheric Research Center Tohoku UniversityAramaki-aza-aobaAobaSendai 980-8578Japan Kwasan and Hida Observatories Graduate School of ScienceKyoto UniversityKurabashiraKamitakara-choTakayamaGifu 506-1314Japan

To comprehensively understand the Arctic and Antarctic upper atmosphere, it is often crucial to analyze various data that are obtained from many regions. Infrastructure that promotes such interdisciplinary studies on the upper atmosphere has been developed by a Japanese inter-university project called the Inter-university Upper atmosphere Global Observation Network （1UGONET）. The objective of this paper is to describe the infrastructure and tools developed by IUGONET. We focus on the data analysis software. It is written in Interactive Data Language （IDL） and is a plug-in for the THEMIS Data Analysis Software suite （TDAS）, which is a set of IDL libraries used to visualize and analyze satellite- and ground-based data. We present plots of upper atmospheric data provided by IUGONET as examples of applications, and verify the usefulness of the software in the study of polar science. We discuss IUGONET＇s new and unique developments, i.e., an executable file of TDAS that can run on the IDL Virtual Machine, IDL routines to retrieve metadata from the IUGONET database, and an archive of 3-D simulation data that uses the Common Data Format so that it can easily be used with TDAS.

关键词： data analysis software metadata database upper atmosphere ground-based observation polar science,interdisciplinary study IUGONET

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Chemical reaction in a liquid–liquid phase‐separated multiple droplet:Synchronization of color change dynamics with droplet movement

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Droplet 2024年第1期3卷 103-112页

作者： Kenta Goto Kyoka Nakanishi Fumito Tani satoru Tokuda Department of Chemistry Graduate School of SciencesInstitute for Materials Chemistry and Engineering(IMCE)Kyushu UniversityFukuokaJapan Research Institute for Information Technology Kyushu UniversityKasugaJapan Mathematics for Advanced Materials-Open Innovation Laboratory AISTc/o Advanced Institute for Materials ResearchTohoku UniversitySendaiJapan

Liquid–liquid phase separation in a biotic cell system organizes complicated biochemical reactions and functions by forming membraneless compartments that allow a substrate to move across the phase *** the other hand,liquid–liquid phase separation in an abiotic system gives rise to an emulsion and/or multiple droplets that hardly undergo chemical *** have developed a method for the formation of phase‐separated multiple droplet in a ternary mixture with a 3D‐printed microchannel and demonstrated the occurrence of the iron(III)thiocyanate ligand exchange reaction in the multiple *** reaction proceeded differently in the outer‐and the inner‐droplet phases,giving a different iron(III)complex that was identified on the basis of its color ***,the color change was dynamic,enabling visualization of the interphase mass *** the same time,the color change dynamics synchronized with the multiple‐droplet movement.

关键词： liquid phase separated

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Fluorescence‑Based Calibration Model for In‑Situ Measurement of Micro‑scaled Lubricant Thickness Distribution at Indentation Interface

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Nanomanufacturing and Metrology 2024年第2期7卷 76-88页

作者： Motoya Yoshikawa Saeko Fujii Shotaro Kadoya Tatsuya Sugihara Masaki Michihata satoru Takahashi Department of Precision Engineering The University of TokyoHongo 7‑3‑1BunkyoTokyo 113‑8656Japan Department of Mechanical Engineering Osaka UniversityYamadaoka 2‑1SuitaOsaka 565‑0871Japan

This study proposes a model for the measurement of microscale liquid film thickness distribution using fluorescence *** interfacial conditions between the tool and the workpiece in mechanical machining are important for understanding these phenomena and *** this study,indentation tests with transparent tools were used to observe interfaces;however,it was challenging to obtain the signal from a thin fluorescent liquid film on smooth and steeply inclined ***,fluorescence-based measurement,such as laser-induced fluorescence,was *** measure the absolute thickness of the thin fluorescent film,calibration of the measurement system is ***,a theoretical model was proposed considering the multiple reflections of excitation light and fluorescence at the inclined surface between the indenter and *** measuring the profile of the surface topography of the indented workpiece and comparing the results with those measured by a surface profiler,the validity of the proposed calibration method and the performance of this measurement system were *** measured surface profiles,including scratches of 2–4μm,were in good agreement,demonstrating the validity of the proposed method.

关键词： Laser-induced fluorescence(LIF) Thickness distribution In-situ measurement Lubricant Mechanical machining

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Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma

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Cancer Innovation 2024年第2期3卷 80-95页

作者： satoru Sasagawa Jun Kumai Toru Wakamatsu Yoshihiro Yui Molecular Biology Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Sarcoma Treatment Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Department of Musculoskeletal Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the *** deacetylase(HDAC)inhibitors(HDACis)are arising as potent molecular targeted drugs,as HDACi treatment disrupts the SS oncoprotein complex,which includes HDACs,in addition to general HDACi *** provide further molecular evidence for the advantages of HDACi treatment and its limitations due to drug resistance induced by the microenvironment in SS cells,we examined cellular responses to HDACi treatment in combination with two-dimensional(2D)and 3D culture ***:Using several SS cell lines,biochemical and cell biological assays were performed with romidepsin,an HDAC1/2 selective ***38 was concomitantly used as an ameliorant drug with romidepsin ***,apoptosis induction,and MHC class I polypeptide-related sequence A/B(MICA/B)induction were monitored to evaluate the drug *** addition to the conventional 2D culture condition,spheroid culture was adopted to evaluate the influence of cell-mass microenvironment on ***:By monitoring the cellular behavior with romidepsin and/or SN38 in SS cells,we observed that responsiveness is diverse in each cell *** the apoptotic inducible cells,co-treatment with SN38 enhanced cell *** nonapoptotic inducible cells,cytostasis and MICA/B induction were observed,and SN38 improved MICA/B induction *** a novel efficacy of SN38,we revealed TWIST1 suppression in SS *** the spheroid(3D)condition,romidepsin efficacy was severely restricted in TWIST1-positive *** demonstrated that TWIST1 downregulation restored romidepsin efficacy even in spheroid form,and concomitant SN38 treatment along with romidepsin reproduced the ***:The current study demonstrated the benefits and concerns of using HDACi for SS treatment in 2D and

关键词： HDAC inhibitor MICA/B SN38 spheroid synovial sarcoma TWIST1

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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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Analysis of in-bore balloting and control of jump variability

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Defence Technology（防务技术） 2019年第5期15卷 721-734页

作者： satoru Shoji Wakayama-dai ShimamotoOsakaJapan21-104

The variability of projectile jump is the long-term issue to improve weapon *** we have many simulation codes to predict ***,these codes cannot explain explicitly how the variability of jump *** aims of this paper are,(1)to give fundamental explanations for the variability of Jump,and (2)to offer design factors to make the variability of Jump *** model presented here was formulated in accordance with the transition of the system in reverse way commencing from the target impact stage to the chambering *** of the simulation are generic 120mm smooth bore and long rod system which are extremely simplified to the vibration of tube,the spring effect by sabot,and the free-ends beam of *** calculations clarified that high Jump-variability is generated only when the last rebound is on the muzzle *** particular state of rebound is achieved by many combinations of *** map named JV-Chart is proposed to show the high Jumpvariability zone.

关键词： Jump variability Coupled vibration In-bore balloting Cantilever tube

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Sustainable meat consumption in China

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Journal of Integrative Agriculture 2015年第6期14卷 1023-1032页

作者： satoru Shimokawa Division of Social Science Hong Kong University of Science and Technology

Sustainable meat consumption is critical to achieve a sustainable food system because meat products are among the most energy-intensive, ecologically burdensome, and ethically concerned foods. This paper focuses on the case of China and discusses the difficulties and possibilities to achieve sustainable meat consumption in China by reviewing previous empirical studies and descriptive statistics, particularly considering consumers＇ dietary transitions in quantity and quality following China＇s rapid economic growth. Given China＇s sheer size of population and meat demand, the sustainable meat consumption in China is also a relevant topic in the global food system.

关键词： sustainable capita concerned income sector reviewing descriptive livestock empirical dietary

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