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Effects of Psychological Stress from a National License Examination on the Urine 8-Hydroxy-Deoxyguanosine Levels in Young Female Students, Taking into Account the Menstrual Cycle

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Open Journal of Preventive Medicine 2018年第2期8卷 21-31页

作者： Tadayuki Iida Yasuhiro Ito Hiroaki Ishikawa Miho Kanazashi Ryoji Teradaira Asami Tatsumi satoko Ezoe Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Mihara City Japan School of Health Sciences Fujita Health University Toyoake Japan Department of Nursing Hamamatsu University School of Medicine Hamamatsu Japan Health Service Center Izumo Shimane University Izumo Japan

Objective: Urine 8-hydroxy-deoxyguanosine (U8-OHdG) was a marker of oxidative stress-induced DNA damage;it was increased by psychological stress. Since the menstrual cycle may confound or modify the association between psychological stress and U8-OHdG. The aim of this study was to verify the effect of psychological stress from a national license examination on levels of U8-OHdG, which is a biomarker of oxidative stress. And the effects of women’s menstrual cycles, which should be considered in mental and physical assessments, on U8-OHdG, were evaluated. Methods: The subjects were 18 female university students at a medical university in whom Self-rating Depression Scale (SDS) scores, State-Trait Anxiety Inventory (STAI) scores, and U8-OHdG levels were measured in 3 phases of the menstrual cycle, the follicular phase, ovulatory phase, and luteal phase. The mean values were taken for the group during a time of classroom learning. The same measurements were also made one week before and the day after a national license examination and the measurements were compared among the three periods. Results and Conclusion: State anxiety and U8-OHdG levels were significantly higher in those with a week before the national license examination than in those with classroom lecture (State anxiety: p = 0.002, U8-OHdG levels: p = 0.007). The menstrual cycle did not show a significant correlation with U8-OHdG levels. This study demonstrated that levels of the oxidative stress biomarker U8-OHdG are not affected by changes in the menstrual cycle. It also showed that U8-OHdG levels increased with the psychological stress of a national license examination.

关键词： 8-OHdG Oxidative Stress Menstrual Cycles Psychological Stress

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热塑性氟橡胶

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橡胶参考资料 1986年第7期 9-17页

作者： Shoji kawachi 王启生

1.引言耐化学药品优良的氟橡胶也可作为热塑性弹性体。如图1所示,DAIEL~R热塑性氟橡胶类型是TP聚合物,在该聚合物中是将一个氟橡胶相(软段)与一个氟树脂相(硬段)结合在一起。这种产品作为热塑性橡胶有许多优点,然而它的应用温度不如交... 详细信息

1.引言耐化学药品优良的氟橡胶也可作为热塑性弹性体。如图1所示,DAIEL~R热塑性氟橡胶类型是TP聚合物,在该聚合物中是将一个氟橡胶相(软段)与一个氟树脂相(硬段)结合在一起。这种产品作为热塑性橡胶有许多优点,然而它的应用温度不如交联橡胶的应用温度高。为了避免损害化学稳定性和纯度,已试验了不填加补强材料并改善耐热性能的方法。认为辐射交联是改善这种热塑性橡胶热稳定性的最适宜的方法。按要求列出了该材料的大量性能图表,这些图表说明了热塑性氟橡胶的加工性能,物理性能和氟树脂的化学稳定性。

关键词：氟橡胶氟树脂扯断伸长率扯断强度硬段抗张强度热塑性塑料定伸强度

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Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C

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世界胃肠病学杂志：英文版 2007年第39期13卷 5180-5187页

作者： Atsushi Tanaka satoko Uegaki Hiroko Kurihara Kiyoshi Aida Masaki Mikami Ikuo Nagashima Junji Shiga Hajime Takikawa Department of Medicine Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605Japan Department of Pathology Teikyo University School of MedicineKagaItabashi-kuTokyo 173-8605 Japan Department of Surgery Teikyo University School of Medicine Kaga Itabashi-ku Tokyo 173-8605 Japan

AIM: To elucidate risk factors contributing to the development of hepatocellular carcinoma (HCC) among patients with sustained viral response (SVR) after interferon (IFN) treatment and to examine whether HCV-RNA still remained in the liver of SVR patients who developed HCC. METHODS: Two-hundred and sixty-six patients, who achieved SVR, were enrolled in this study. We retrospectively reviewed clinical, viral and histological features of the patients, and examined whether the development of HCC depends on several clinical variables using Kaplan-Meier Method. RT-PCR was used to seek HCV-RNA in 3 out of 7 patients in whom liver tissue was available for molecular analysis. RESULTS: Among the enrolled 266 patients with SVR, HCC developed in 7 patients (7/266; 2.6%). We failed to detect HCV-RNA both in cancer and non-cancerous liver tissue in all three patients. The cumulative incidence for HCC was significantly different depending on hepatic fibrosis (F3-4) (P = 0.0028), hepatic steatosis (Grade 2-3) (P = 0.0002) and age (≥ 55) (P = 0.021) at the pre-interferon treatment. CONCLUSION: The current study demonstrated that age, hepatic fibrosis, and hepatic steatosis at pre- interferon treatment might be risk factors for developing HCC after SVR.

关键词：丙肝病毒慢性丙肝肝细胞癌干扰治疗

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Efficacy of volume navigation in assessment of extent of breast cancer

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中华乳腺病杂志（电子版） 2012年第5期6卷 36-38页

作者： satoko Suzuki Miki Mori Rena Shigenaga Kenya Suzuki Katsutoshi Enokido Terumasa Sawada Masanori Hirose Seigo Nakamura Department of Breast Surgical Oncology Showa University Department of Radiology Showa University

Objective Volume navigation (Vnav) combines real-time ultrasound (US) with previously acquired volume data from magnetic resonance imaging (MRI) data into a single display. The efficacy of Vnav for preoperative assessment of the extent of breast cancer lesions was evaluated in the present *** Twenty-nine breast cancer patients were evaluated using Vnav during second-look US or preoperative mapping. Retrospective chart review was performed. Correlation detection rates and pathological results were *** Vnav identified lesions that were initially detected on MRI in 23 of 29 patients (79.3%). Of the 23 patients who had US correlated lesions, pathological diagnoses of the corresponding lesions were as follows: benign (n=9) and malignant (n=14).Conclusion Vnav may be a useful technique for identification of the extent of breast cancer lesions.

关键词：摘要编辑部编辑工作读者

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A BELLOWS-DRIVEN MANIPULATOR USING A NEW MAGNETO-RHEOLOGICAL FLUID

A BELLOWS-DRIVEN MANIPULATOR USING A NEW MAGNETO-RHEOLOGICAL...

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第四届流体传动国际会议

作者： Kazuhiro Yoshida Jung-Ho Park Shinichi Yokota Masashi kawachi Kazuya Edamura Precision and Intelligence Laboratory Tokyo Institute of Technology 4259 Nagatsuta-cho Midori-ku Yokohama 226-8503 Japan NEOS Co. Ltd. 1-1 Ohoike-machi Kousei-cho Kouka-gun Shiga 520-3213 Japan New Technology Management Co. Ltd. 2-9-1-306 Higashi-Shinkoiwa Katsushika-Ku Tokyo 124-0023 Japan

A simple control valve using a magnetorheological (MR) fluid has been proposed and called the MR valve. The MR valve utilizes the apparent viscosity controllability of the MR fluid in the magnetic field and controls high-level fluid power without moving parts. However, conventional MR fluids have high baseviscosities to disperse heavy soft-iron particles and lose fluid power in pipelines. In this study, low base-viscosity MR fluids are newly developed using lightweight ferrite particles and applied to a bellows-driven manipulator. First, 4 MR fluids are fabricated with different compositions and the basic characteristics are experimentally investigated. The most suitable MR fluid is selected through theoretical evaluation to minimize the size of the three-port MR valve using a permanent magnet. Second, a fluid power source for the fabricated MR fluid is developed in consideration of the serious damage by the dispersed particles. Third, a bellows-driven manipulator is fabricated using the three-port MR valve and the static and dynamic characteristics are experimentally investigated.

关键词： Control valve Magneto-rheological (MR) fluid Actuator Manipulator Bellows

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Basal Cell Carcinoma Arising from a Follicular Hybrid Cyst

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Case Reports in Clinical Medicine 2015年第9期4卷 317-320页

作者： Takayuki Aizu Takahide Kaneko Noriko Takiyoshi satoko Minakawa Ayumi Korekawa Hajime Nakano Daisuke Sawamura Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan

Malignant tumors arising from follicular cysts are rare. Herein, we report of a 62-year-old Japanese woman with a slowly growing tumor, 22 × 20 mm in size, located on her nose for 2 years. Histopathological examination of the surgically excised tumor showed that the tumor cells were basaloid and formed peripheral palisading patterns. The tumor contained a cystic structure in its center, and the cyst wall was lined with stratified epithelium with or without keratohyalin granules. Based on these findings, a diagnosis of basal cell carcinoma arising from a follicular hybrid cyst was made. To our knowledge, this is the first case of basal cell carcinoma originating from a follicular hybrid cyst. A review of previous reports of basal cell carcinoma from a follicular cyst indicated that the majority of previous cysts were located on the face, and that the lesions had been present for a relatively long time. The present case showed typical clinical findings and followed a regular course. Malignant transformation may be a rare event, but it can occur in a follicular cyst, so cysts and suspected cysts, especially those found on the face and those persisting for relatively long time, should always be subjected to histological examination.

关键词： Epidermoid Cysts Trichilemmal Cyst Malignant Transformation

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Acute and Severe Hypercalcemia in a Near-Drowning Victim

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International Journal of Clinical Medicine 2013年第10期4卷 417-420页

作者： Tomoaki Takata Akihisa Nakaoka Kazuhiro Kato Takeaki Fukui satoko Maeta Chishio Munemura Yoshikazu Murawaki Department of Internal Medicine Sanin Rosai Hospital Yonago Japan Department of Internal Medicine Sanin Rosai Hospital Yonago Japan Department of Internal Medicine Sanin Rosai Hospital Yonago Japan Division of Medicine and Clinical Science Tottori Univer- sity School of Medicine Yonago Japan. Division of Medicine and Clinical Science Tottori Univer- sity School of Medicine Yonago Japan. Division of Medicine and Clinical Science Tottori University School of Medicine Yonago Japan Division of Medicine and Clinical Science Tottori University School of Medicine Yonago Japan.

An 80-year-old male was admitted to our hospital because of near-drowning in a hot spring. Besides hypoxia, serum calcium was extremely high at 15.5 mg/dL on admission. After the treatment with normal saline infusion, furosemide and calcitonin, the hypercalcemia was transient and didn’t recur during the course. The hot spring water contained much calcium, so his hypercalcemia was considered to be a result of calcium absorption mainly through the alveoli. In this case, we revealed that serum calcium rose within a short time after drowning, suggesting the necessity to measure the calcium concentration of the drowning fluid in a near-drowning victim.

关键词： Hypercalcemia Drowning Hot Spring

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3-D microstructuring inside photosensitive glass using femtosecond laser for biological applications

3-D microstructuring inside photosensitive glass using femto...

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CCAST“2002年全国强场激光物理”研讨会

作者： Koji Sugioka Masashi Masuda Katsumi Midorikawa Masako kawachi Kazuhiko Shihoyama Koichi Toyoda RIKEN The Institute of Physical and Chemical Research Hirosawa 2-1 Wako Saitama 351-0198 Japan Tokyo University of Science Yamazaki 2641 Noda Chiba 278-8510 Japan RIKEN The Institute of Physical and Chemical Research Hirosawa 2-1 Wako Saitama 351-0198 Japan Tokyo University of Science Yamazaki 2641 Noda Chiba 278-8510 Japan RIKEN The Institute of Physical and Chemical Research Hirosawa 2-1 WakoSaitama 351-0198 Japan HOYA Continuum Corporation Hikawacho 3-5-24 Toda Saitama 335-0027 Japan HOYA Continuum Corporation Hikawacho 3-5-24 Toda Saitama 335-0027 Japan Tokyo University of Science Yamazaki 2641 Noda Chiba 278-8510 Japan

＜正＞We show that femtosecond （fs） laser enables us to produce true three-dimensional （3D） microstructures inside a photosensitive glass （Foturan）, which has superior properties on transparency, hardness, chemical and thermal resistances, and biological compatibility. Exposure to the focused fs laser beam writes latent images inside the glass. Modified regions are developed by a post baking process and then preferentially etched away in dilute hydrofluoric （HF） acid. In general, an embedded microchannel fabricated by scanning focal beam perpendicularly to the direction of laser propagation becomes a cross section of an elliptical shape with a large aspect ratio according to the longitudinal beam profile. We demonstrate that the aspect ratio of channel can be improved merely by placing a slit before the focusing system.

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Evaluation of prognostic factors and scoring system in colonic perforation

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World Journal of Gastroenterology 2007年第23期13卷 3228-3231页

作者： Atsushi Horiuchi Yuji Watanabe Takashi Doi Kouichi Sato Syungo Yukumi Motohira Yoshida Yuji Yamamoto Hiroki Sugishita Kanji kawachi Department of Surgery 2 Ehime University School of Medicine

AIM: To study the significance of scoring systems assessing severity and prognostic factors in patients with colonic perforation. METHODS: A total of 26 patients (9 men, 17 women; mean age 72.7 ± 11.6 years) underwent emergency operation for colorectal perforation in our institution between 1993 and 2005. Several clinical factors were measured preoperatively and 24 h postoperatively. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Mannheim peritonitis index (MPI) and peritonitis index of Altona (PIA Ⅱ) scores were calculated preoperatively. RESULTS: Overall postoperative mortality rate was 23.1% (6 patients). Compared with survivors, non- survivors displayed low blood pressure, low serum protein and high serum creatinine preoperatively, and low blood pressure, low white blood cell count, low pH, low PaO2/FiO2, and high serum creatinine postoperatively. APACHE Ⅱ score was significantly lower in survivors than in non-survivors (10.4 ± 3.84 vs 19.3 ± 2.87, P = 0.00003). Non-survivors tended to display high MPI score and low PIA Ⅱ score, but no signif icant difference was identif ied. CONCLUSION: Pre- and postoperative blood pressure and serum creatinine level appear related to prognosis of colonic perforation. APACHE Ⅱ score is most associated with prognosis and scores ≥ 20 are associated with signif icantly increased mortality rate.

关键词：结肠穿孔刮伤系统预兆因子症状

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The Expression of Surfactant Proteins A and D in the Intestines and Pancreas of Murine Fetuses

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Open Journal of Pediatrics 2014年第1期4卷 12-20页

作者： Ryuta Saka Hiroomi Okuyama Kaoru Uchida Kumiko Nakahira Takashi Sasaki satoko Nose Masahiro Nakayama Masahiro Fukuzawa Itaru Yanagihara Department of Developmental Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Japan Department of Pediatric Surgery Hyogo College of Medicine Nishinomiya Japan Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Japan Pathology and Laboratory Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Japan

Purpose: Surfactant proteins exist in the digestive tract and may play an important role in the host defense. However, the expression of surfactant proteins in the premature digestive system remains unclear. The aim of this study was to investigate the expression of surfactant proteins in the intes-tines and pancreas of murine fetuses. Methods: Immunostaining for SP-A and SP-D was assessed in the small intestine and pancreas of ICR murine fetuses on days 15, 16, 17 and 18 of gestation (normal duration of pregnancy: 19 - 21 days). RT-PCR was performed to detect the expression of spa and spd mRNA in the small intestine and pancreas on day 16, 17 and 18 of gestation. Results: Immunoreactivity for SP-A and SP-D in the acinar cells of pancreas and intestinal mucosal surface were positive on day 16 of gestation onward. RT-PCR revealed that the expression of spa and spd mRNA was significant in the pancreas but weak in the small intestine. Conclusions: Our data revealed that surfactant proteins are present in the fetal intestines and pancreas and that a significant expression of spa and spd mRNA is detected in the fetal pancreas. Pancreas may be a possible organ involved in the synthesis and secretion of surfactant proteins into the intestinal lumen.

关键词： Surfactant Protein Fetus Intestine Pancreas

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