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Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal,healthy stomach

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World Journal of Gastroenterology 2009年第7期15卷 853-859页

作者： Katsunori Iijima Yasuhiko Abe Ryosuke Kikuchi Tomoyuki Koike Shuichi ohara Pentti Sipponen Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Pathology Helsinki University Central HospitalJorvi Hospital

AIM:To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa:*** with Helicobacter pylori(H pylori)gastritis or atrophic gastritis,who have a high risk of gastric cancer or peptic ulcer ***:Among 162 Japanese outpatients,pepsinogen-(Pg-)and(Pg)were measured using a conventional Japanese technique,and the European GastroPanel examination(Pg and Pg,gastrin-17 and H pylori antibodies).Gastroscopy with gastric biopsies was performed to classify the patients into those with healthy stomach mucosa,H pylori non-atrophic gastritis or atrophic ***:Pg-and Pg assays with the GastroPanel and the Japanese method showed a highly significant *** methodological reasons,however,serum Pg-,but not Pg,was twice as high with the GastroPanel test as with the Japanese *** biomarker assays revealed that 5%of subjects had advanced atrophic corpus gastritis which was also verified by endoscopic *** examination revealed an additional seven patients who had either advanced atrophic gastritis limited to the antrum or antrum-predominant H pylori *** compared to the endoscopic biopsy findings,the GastroPanel examination classified the patients into groups with "healthy" or "diseased" stomach mucosa with 94% accuracy,95% sensitivity and 93% specifi ***:Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy.

关键词： Gastric atrophy He/icobacter py/ori Serumgastrin-17 Serum pepsinogen

High-energy x-ray diffraction study on phase transition asymmetry of plastic crystal neopentylglycol

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Chinese Physics B 2022年第3期31卷 461-465页

作者： Zhe Zhang Yan-Na Chen Ji Qi Zhao Zhang Koji ohara Osami Sakata Zhi-Dong Zhang Bing Li Shenyang National Laboratory(SYNL)for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 10016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016 China Synchrotron X-ray Group Research Center for Advanced Measurement and CharacterizationNational Institute for Materials Science(NIMS)SayoJapan SPring-8 Diffraction and Scattering DivisionCenter for Synchrotron Radiation Research InstituteJapan Synchrotron Radiation Research InstituteSayoJapan

As a prototype material of colossal barocaloric effects, neopentylglycol is investigated by combining high-precision differential scanning calorimetric measurement and high-energy x-ray diffraction measurement. The diffraction data at constant temperatures indicate a first-order phase transition with thermal hysteresis as well as the phase transition asymmetry,specifically, the phase transition is completed faster at cooling than at heating. The analysis of resulting pair distribution function confirms the intermolecular disorder in the high-temperature phase. The phase transition asymmetry is quantitatively characterized by time-resolved x-ray diffraction, which is in agreement with the thermal measurement. Also, such an asymmetry is observed to be suppressed at high pressures.

关键词： colossal barocaloric effect plastic crystals phase transition asymmetry

Effects of Ethephon and Abscisic Acid Application on Ripening-Related Genes in ‘Kohi' Kiwifruit (Actinidia chinensis) on the Vine

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Horticultural Plant Journal 2017年第1期3卷 29-33页

作者： Kongsuwan Ampa Takanori Saito Katsuya Okawa Hitoshi ohara Satoru Kondo Graduate School of Horticulture Chiba University

The effects of ethephon and abscisic acid(ABA) application on ripening-related genes of pre-harvest ‘Kohi' kiwifruit(Actinidia chinensis) were studied to clarify the possibility of the fruit ripening on the vine. The fruits were treated on the vine at mature stage with 250 μL·L^(-1)ethephon or 100 μmol·L^(-1)ABA, and the expression levels of chlorophyll synthase(Ac CLS), chlorophyllase1(Ac CLH1), polygalacturonase(Ac PG), expansin(Ac EXP),β-amylase(Acβ-AM), sucrose synthase(Ac SUSY), MADS-box SEPALLATA4/RIPENING INHIBITOR-like(Ac SEP4/RIN) and FRUITFUL-like(Ac TDR4/FUL) genes were analyzed. The expression levels of Ac PG, Ac EXP, Acβ-AM, and Ac SUSY increased in the ethephon-treated fruit, but those of Ac CLH1 at 6and 9 days after treatment and Ac CLS decreased. Moreover, the expression levels of Ac SEP4/RIN and Ac TDR4/FUL, the latter of which is associated with ethylene biosynthesis, were higher in the ethephon-treated fruit. The expression level of each gene in ABA-treated fruit was not significantly different from that of the untreated control. The results suggest that ethephon application increases the expression levels of Ac PG,Ac EXP, Acβ-AM, Ac SUSY, Ac SEP4/RIN, and Ac TDR4/FUL in ‘Kohi' kiwifruit on the vine.

关键词： kiwifruit Actinidia chinensis ethephon ABA fruit ripening ethylene

Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

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World Journal of Gastroenterology 2008年第20期14卷 3212-3217页

作者： Ken Ariizumi Tomoyuki Koike Shuichi ohara Yoshifumi Inomata Yasuhiko Abe Katsunori Iijima Akira Imatani Tomoyoshi Oka Tooru Shimosegawa Division of Gastroenterology TohokuUniversity Graduate School of Medicine Sendai Miyagi9808574 Japan Division of Diabetes and Metabolic Diseases Tohoku University Graduate School of Medicine Sendai Miyagi 9808574 Japan

AIM： To investigate the incidence of reflux esophagitis （RE） and Hpylori infection in the diabetic patient. METHODS： The incidence of RE and Hpy/ori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS： The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls. The incidence of H pyiori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of Hpylori infection. CONCLUSION： No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pldori infection.

关键词： Diabetes mellitus Reflux esophagitis Helicobacter pylori

Effect of BNT162b2 mRNA COVID-19 vaccine on sperm morphokinetics and DNA integrity: A prospective observational study in Japan

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Asian pacific Journal of Reproduction 2023年第2期12卷 58-63页

作者： Yasuhiro ohara Shimpei Mizuta Hidehiko Matsubayashi Tomomoto Ishikawa Tsuyoshi Takiuchi Tadashi Kimura Department of Reproductive Medicine Reproduction Clinic Osaka4-20Ofuka-choKita-kuOsakaJapan Department of Obstetrics and Gynecology Graduate School of MedicineOsaka University2-15YamadaokaSuita CityOsakaJapan Department of Reproductive Medicine Reproduction Clinic Tokyo1-5-2Higashi-shinbashiMinato-kuTokyoJapan Department of Clinical Genomics Graduate School of MedicineOsaka University2-15YamadaokaSuita CityOsakaJapan

Objective:To assess whether the coronavirus disease 2019(COVID-19)mRNA vaccine affects sperm morphokinetics using a computer-assisted semen analyzer and other semen parameters using a sperm chromatin structure ***:Healthy male volunteers in two Japanese clinics between May 2021 and December 2021 were prospectively *** donated sperm twice,two days apart,in the following phases:before vaccination,2 weeks after the first vaccine dose,and 2,4,and 12 weeks after the second *** sperm parameters,sperm motility characteristics,and the percentage of DNA-damaged sperm were compared among the different ***:Ninety-six semen samples from ten volunteers,who were vaccinated with the BNT162b2 mRNA vaccine,were *** were no significant differences between any phases in basic semen findings and parameters of the sperm chromatin structure *** sperm motion characteristics,the average linear velocity,beat-cross frequency,and sperm motility index significantly decreased after the second vaccine dose(P=0.018,P=0.003,and P=0.027,respectively),with no significant differences between any two phases by post-hoc pairwise ***:After COVID-19 mRNA vaccination,while sperm motion characteristics might fluctuate,no apparent deterioration of basic sperm parameters or sperm DNA integrity was *** the adverse effects of COVID-19 on sperm,our findings suggest that there might be no reason to refrain from vaccination for healthy individuals.

关键词： Computer-assisted semen analyzer COVID-19 vaccine Flow cytometry Male fertility Sperm chromatin structure assay

Common parameters of acupuncture for the treatment of hypertension used in animal models

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Journal of Traditional Chinese Medicine 2015年第3期35卷 343-348页

作者： Lu Shengfeng Cao Xin Hiroshi ohara Yuji Nakamura Hiroko Izumi-Nakaseko Kentaro Ando Liu Wanxin Atsushi Sugiyama Zhu Bingmei Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese Medicine Department of Pharmacology Faculty of MedicineToho University

Hypertension is associated with at least 7.6 million annual deaths *** pharmacotherapy may provide good control for blood pressure,it sometimes induces adverse ***,acupuncture has been used for the treatment of cardiovascular diseases,such as hypertension,coronary artery disease,and stroke,but its mechanisms of actions remain poorly *** efficacy of acupuncture depends on multiple constituent elements including acupoints,manipulation skills,and implementation programs,which are termed as acupuncture *** review summarized the previous information of experimental use of acupuncture on animals including species,hypertension models,acupoints selection,acupoint location,stimulation protocols,and evaluation of effectiveness to provide useful guidance for researchers when performing acupuncture in animal experiments.

关键词： Acupuncture Animals Cardiovascular diseases Hypertension Drug therapy Review

Identification of the layered morphology of the esophageal wall by optical coherence tomography

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World Journal of Gastroenterology 2009年第35期15卷 4402-4409页

作者： Satoshi Yokosawa Tomoyuki Koike Yasushi Kitagawa Waku Hatta Kaname Uno Yasuhiko Abe Katsunori Iijima Akira Imatani Shuichi ohara Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine1-1Seiryo-machiAoba-kuSendai Miyagi 980-8574Japan

AIM： To assess each layer of the optical coherence tomography （OCT） image of the esophageal wall with reference to the histological structure, METHODS： Resected specimens of fresh pig esophagus was used as a model for the esophageal wall. We injected cyanoacrylate adhesive into the specimens to create a marker, and scanned them using a miniature OCT probe. The localization of these markers was assessed in the OCT images. Then we compared the OCT-imaged morphology with the corresponding histological section, guided by the cyanoacrylate adhesive markers. We prepared a second set of experiments using nylon sutures as markers. RESULTS： The OCT image of the esophageal specimen has a clear five-layered morphology. First, it consisted of a relatively less reflective layer; second, a more reflective layer; third, a less reflective layer; fourth, a more reflective layer; and fifth, a less reflective layer. Comparing the OCT images with marked histological sections showed that the first layer corresponded to stratified squamous epithelium; the second to lamina propria; the third to muscularis mucosa; fourth, submucosa; and fifth, muscularis propria with deeper structures of the esophageal wa CONCLUSION： We demonstrated that the OCT image of the normal esophageal wall showed a five- layered morphology, which corresponds to histological esophageal wall components.

关键词： Optical coherence tomography Esophagus Muscularis mucosa Esophageal squamous cellcarcinoma Endoscopic ultrasonography

Brain activity following esophageal acid infusion using positron emission tomography

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World Journal of Gastroenterology 2010年第43期16卷 5481-5489页

作者： Shigeyuki Kobayashi Yasuhiko Abe Manabu Tashiro Tomoyuki Koike Katsunori Iijima Akira Imatani Shuichi ohara Satoshi Watanabe Shin Fukudo Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Division of Cyclotron Nuclear Medicine Cyclotron and Radioisotope Center Tohoku University Division of Behavioral Medicine Tohoku University Graduate School of Medicine

AIM: To investigate symptoms and brain activity following esophageal acid infusion. METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of ***: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/ posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms. CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

关键词： Esophageal acid infusion Brain imaging Positron emission tomography

Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer

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World Journal of Gastroenterology 2015年第10期21卷 3121-3126页

作者： Shinwa Tanaka Takashi Toyonaga Yoshiko ohara Tetsuya Yoshizaki Fumiaki Kawara Tsukasa Ishida Namiko Hoshi Yoshinori Morita Takeshi Azuma Department of Endoscopy Kobe University Division of Gastroenterology Department of Internal MedicineGraduate School of MedicineKobe University

Endoscopic submucosal dissection(ESD) is now widely accepted as a strategy to treat superficial esophageal *** rate of adverse events,such as perforation,has been decreasing with the improvement of devices and *** this paper,we report a case of esophageal cancer that had a diverticulum under cancerous *** diverticulum was not detected during preoperative examination,and led to perforation during the ESD *** case shows that,although rare,some diverticula can exist underneath the mucosal surface without obvious *** there is any sign of hidden diverticula during ESD,surgeons should proceed with caution or,depending on the case,the procedure should be discontinued to avoid adverse events.

关键词： Endoscopic submucosal dissection Eso-phageal cance