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Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome

Asian Journal of Andrology 2006年第1期8卷 81-88页

作者： Anurag Mitra Rima Dada Rajeev kumar Narmada Prasad gupta Kiran Kucheria satish kumar gupta Gamete Antigen Laboratory National Institute of ImmunologyAruna Asaf Ali MargNew Delhi 110067India Department of Anatomy Department of Urology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

Aim： To study the occurrence of Y chromosome microdeletions in azoospermic patients with Klinefelter＇s syndrome （KFS）. Methods： Blood and semen samples were collected from azoospermic patients with KFS （n = 14） and a control group of men of proven fertility （n = 13）. Semen analysis was done according to World Health Organization （WHO） guidelines. Blood samples were processed for karyotyping, fluorescent in situ hybridization （FISH） and measurement of plasma follicle stimulating hormone （FSH） by radioimmunoassay. To determine Y chromosome microdeletions, polymerase chain reaction （PCR） of 16 sequence tagged sites （STS） and three genes （DFFRY, XKRY and RBM1 Y） was performed on isolated genomic DNA. Testicular fine needle aspiration cytology （FNAC） was done in selected cases. Results： Y chromosome microdeletions spanning the azoospermia factor （AZF）a and AZFb loci were found in four of the 14 azoospermic patients with KFS. Karyotype and FISH analysis revealed that, of the four cases showing Y chromosome microdeletion, three cases had a 47,XXY/46,XY chromosomal pattern and one case had a 46,XY/47,XXY/48,XXXY/48,XXYY chromosomal pattern. The testicular FNAC of one sample with Y chromosome microdeletion revealed Sertoli cell-only type of morphology. However, no Y chromosome microdeletions were observed in any of the 13 fertile men. All patients with KFS had elevated plasma FSH levels. Conclusion： Patients with KFS may harbor Y chromosome microdeletions and screening for these should be a part of their diagnostic work-up, particularly in those considering assisted reproductive techniques. （Asian JAndrol 2006 Jan; 8： 81-88）

关键词： azoospermia azoospermia factor follicle stimulating hormone Klinefelter's syndrome Y chromosome microdeletion

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla gupta Arvind kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

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Unraveling the intricacies of mammalian fertilization

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Asian Journal of Andrology 2014年第6期16卷 801-802页

作者： satish K gupta Reproductive Cell Biology Lab National Institute ofImmunology New Delhi 110067 India.

It is imperative to understand the molecular basis of various steps involved during fertilization. In the manuscript by Bianchi et al.1 a novel protein, Juno on egg membrane （oolemma） has been characterized that binds to sperm specific protein, Izumo-1. Monoclonal antibodies against Juno inhibited in vitro fertilization. Juno knock-out female mice failed to deliver litters on mating. It is rapidly shed from oolemma after fertilization, suggesting its role in preventing polyspermy. Taken together these studies will help in our understanding of sperm-egg recognition mechanisms and also facilitate development of new fertility treatment regimens and novel contraceptives.

关键词： @@

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Numerical investigation of the effect of transitory strand opening on mixing in a multistrand tundish

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 535-542页

作者： Sabin kumar Mishra Pradeep kumar Jha satish Chandra Sharma satish kumar Ajmani Department of Mechanical and Industrial Engineering Indian Institute of Technology RoorkeeRoorkee 247667UttarakhandIndia Steelmaking and Casting Research Group Tata SteelR&DBurma MinesJamshedpur 831007JharkhandIndia

In a multistrand,the outlet near the inlet produces short circuiting *** leads to the formation of dead zones inside the tundish,and consequently,the mean residence time *** the present study,numerical investigation of mixing inside a delta shaped tundish with sloping boundaries was carried out by solving the Navier-Stokes equation and employing the standard turbulence *** decrease the dead zone volume inside the tundish,the effect of closing the outlet near the inlet for a small amount of time and further opening it on the mixing behavior of the tundish was *** outlets near the inlet were closed for varying amount of time,and the transient analysis of fluid flow and the tracer dispersion study were carried out to find the mixing parameters of the tundish,namely,mean residence time and the ratio of mixed to dead volume of the *** optimum closure time of the near outlet has been found,which yields best mixing inside the *** numerical code was validated against the experimental observation by performing the tracer dispersion study inside a multistrand tundish and the reasonably good match between the experimental and numerical results in terms of residence time distribution （RTD） *** results obtained from the present study confirm the strong role of choosing the right time for opening and closing the outlets to get improved characteristics for the fluid flow and mixing behavior of the *** educational version of computational fluid dynamics （CFD） software PHOENICS was used to solve the governing equations and interpret the results in different forms.

关键词： continuous casting billets tundish flow simulation mean residence time dead volume computational fluid dynamics (CFD)

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Are environment-related technologies key to unlock the path towards sustainable development:An econometric analysis

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Geoscience Frontiers 2024年第4期15卷 437-448页

作者： Amar Rao satish kumar School of Management BML Munjal UniversityGurugramHaryanaIndia Indian Institute of Management Nagpur India

The objective of this study is to investigate the correlation between energy intensity and environmentrelated technology in industrialized *** utilizing panel data from 23 countries over a span of 32 years(1990-2021),this research aims to contribute to the comprehension of the role of green innovation in sustainable *** study employs the Stochastic Impacts by Regression on Population,Affluence,and Technology model while controlling for variables including population growth,gross domestic product in purchasing power parity,Information and Communication Technology capital deepening,renewable energy consumption,and green innovation represented by research and development expenditure on environment-related *** results of the analysis,employing panel unit root tests,cross-sectional dependence tests,and a Method of Moments quantile regression,reveal that green innovation has a positive influence on diminishing energy intensity,with a more substantial impact at higher ***,ICT capital deepening is determined to have a positive and noteworthy effect on reducing energy *** findings of this study offer valuable insights for policymakers in their endeavours to accomplish sustainable development goals.

关键词： Technology Sustainable development Energy intensity Quantile regression

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Effect of cooling media on bead geometry,microstructure,and mechanical properties of wire arc additive manufactured IN718 alloy

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Advances in Manufacturing 2024年第1期12卷 124-149页

作者： Parveen kumar satish kumar Sharma Ratnesh kumar Raj Singh Department of Mechanical Engineering Thapar Institute of Engineering and TechnologyPatialaPunjab147004India

This work aims to present and explore thermal management techniques for the wire arc additive manufacturing(WAAM)of IN718 *** heat can be mitigated via air or water *** this study,the material was deposited under four different heat-input conditions with air or water *** air cooling,the layer is deposited in a normal atmospheric air environment,whereas with water cooling,the material is deposited inside a water tank by varying the water *** validate the air and water cooling thermal management techniques,IN718 single-pass and multilayer linear walls were deposited using the bidirectional gas metal arc welding based WAAM setup under four different heat input *** the deposition of single layers,the temperature profiles were recorded,and the geometric and microstructural features were *** multilayer wall structures,the mechanical properties(hardness,tensile strength,and elongation)were determined and assessed using the corresponding microstructural features explored through scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),and electron backscatter diffraction(EBSD)*** microstructure observed through SEM analysis in the building direction was found to be nonhomogenous compared with that in the deposition ***,water cooling was found to govern bead characteristics,such as wall width and *** grain size and anisotropy of the mechanical properties also decreased in the water-cooled ***,water cooling is an economical and efficient method to mitigate excessive heat accumulation in WAAM-deposited IN718.

关键词： Air cooling Water cooling IN718 Bead characteristics Microstructure Electron backscatter diffraction(EBSD)

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Acrosome reaction： relevance of zona pellucida glycoproteins

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Asian Journal of Andrology 2011年第1期13卷 97-105页

作者： satish K gupta Beena Bhandari Reproductive Cell Biology Laboratory National Institute of Immunology New Delhi-110 067 India

During mammalian fertilisation, the zona pellucida （ZP） matrix surrounding the oocyte is responsible for the binding of the spermatozoa to the oocyte and induction of the acrosome reaction （AR） in the ZP-bound spermatozoon. The AR is crucial for the penetration of the ZP matrix by spermatozoa. The ZP matrix in mice is composed of three glycoproteins designated ZP1, ZP2 and ZP3, whereas in humans, it is composed of four （ZP1, ZP2, ZP3 and ZP4）. ZP3 acts as the putative primary sperm receptor and is responsible for AR induction in mice, whereas in humans （in addition to ZP3）, ZP1 and ZP4 also induce the AR. The ability of ZP3 to induce the AR resides in its C-terminal fragment. O-linked glycans are critical for the murine ZP3-mediated AR. However, N-linked glycans of human ZP1, ZP3 and ZP4 have important roles in the induction of the AR. Studies with pharmacological inhibitors showed that the ZP3-induced AR involves the activation of the Gi-coupled receptor pathway, whereas ZP1- and ZP4-mediated ARs are independent of this pathway. The ZP3-induced AR involves the activation of T-type voltage-operated calcium channels （VOCCs）, whereas ZP1- and ZP4-induced ARs involve both T- and L-type VOCCs. To conclude, in mice, ZP3 is primarily responsible for the binding of capacitated spermatozoa to the ZP matrix and induction of the AR, whereas in humans （in addition to ZP3）, ZP1 and ZP4 also participate in these stages of fertilisation.

关键词： acrosome reaction fertilisation oocyte signalling pathways spermatozoa zona pellucida glycoproteins

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Optimal integration of DGs into radial distribution network in the presence of plug-in electric vehicles to minimize daily active power losses and to improve the voltage profile of the system using bioinspired optimization algorithms

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Protection and Control of Modern Power Systems 2020年第1期5卷 21-35页

作者： satish kumar Injeti Vinod kumar Thunuguntla Department of Electrical Engineering National Institute of Technology WarangalTelengana State 506004India

Purpose:The increase in plug-in electric vehicles(PEVs)is likely to see a noteworthy impact on the distribution system due to high electric power consumption during charging and uncertainty in charging *** address this problem,the present work mainly focuses on optimal integration of distributed generators(DG)into radial distribution systems in the presence of PEV loads with their charging behavior under daily load pattern including load models by considering the daily(24 h)power loss and voltage improvement of the system as objectives for better system ***/methodology/approach:To achieve the desired outcomes,an efficient weighted factor multi-objective function is *** Swarm Optimization(PSO)and Butterfly Optimization(BO)algorithms are selected and implemented to minimize the objectives of the system.A repetitive backward-forward sweep-based load flow has been introduced to calculate the daily power loss and bus voltages of the radial distribution *** simulations are carried out using MATLAB ***:The simulation outcomes reveal that the proposed approach definitely improved the system performance in all *** PSO and BO,BO is comparatively successful in achieving the desired ***/value:The main contribution of this paper is the formulation of the multi-objective function that can address daily active power loss and voltage deviation under 24-h load pattern including grouping of residential,industrial and commercial *** of repetitive backward-forward sweep-based load flow and the modeling of PEV load with two different charging scenarios.

关键词： Plug-in electric vehicles(PEVs) Distributed generators(DGs) Repetitive distribution power flow Particle swarm optimization algorithm(PSO) Butterfly optimization(BO) Daily active power loss

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A Hybrid Offline-Online Approach to Adaptive Downlink Resource Allocation Over LTE

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 766-777页

作者： satish kumar Rajesh Devaraj Arnab Sarkar IEEE the Department of Computer Science and Engineering IIT Guwahati

Radio resource management mechanisms in current and future wireless networks is expected to face an enormous challenge due to the ever increasing demand for bandwidth and latency sensitive applications on mobile devices. This is because an optimal resource allocation scheme which attempts to multiplex the available bandwidth in order to maximize Quality of service(QoS), will pose an exponential computational burden at eNodeB. In order to minimize such computational overhead, this work proposes a hybrid offline-online resource allocation strategy which effectively allocates all the available resources among flows such that their QoS requirements are satisfied. The flows are firstly classified into priority buckets based on real-time criticality factors. During the offline phase, the scheduler attempts to maintain the system load within a pre-specified safe threshold value by selecting an appropriate number of buckets. This offline selection procedure makes use of supervisory control theory of discrete event systems to synthesize an offline scheduler. Next, we have devised an online resource allocation strategy which runs on top of the offline policy and attempts to minimize the impact of the inherent variability in wireless networks. Simulation results show that the proposed scheduling framework is able to provide satisfactory QoS to all end users in most practical scenarios.

关键词： Discrete event systems (DES) hybrid scheduling long term evolution (LTE) quality of service (QoS) radio resource management supervisory control

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Active Learning Query Strategies for Classification,Regression,and Clustering:A Survey

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Journal of Computer Science & Technology 2020年第4期35卷 913-945页

作者： Punit kumar Atul gupta Indian Institute of Information Technology Design and ManufacturingJabalpurMadhya Pradesh 482005India

Generally,data is available abundantly in unlabeled form,and its annotation requires some *** labeling,as well as learning cost,can be minimized by learning with the minimum labeled data *** learning(AL),learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or *** active learner uses an instance selection strategy for selecting those critical query instances,which reduce the generalization error as fast as *** process results in a refined training dataset,which helps in minimizing the overall *** key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid *** survey reviews AL query strategies for classification,regression,and clustering under the pool-based AL *** query strategies under classification are further divided into:informative-based,representative-based,informative-and representative-based,and ***,more advanced query strategies based on reinforcement learning and deep learning,along with query strategies under the realistic environment setting,are *** a rigorous mathematical analysis of AL strategies,this work presents a comparative analysis of these ***,implementation guide,applications,and challenges of AL are discussed.

关键词： active learning active learning query strategy active classification active regression active clustering deep active learning

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