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Critical Role of Protein k.nase C (Pk.) in the Onset of Airway Hypersensitivity in Ova-Sensitized Guinea Pig Model of Asthma

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Open Journal of Respiratory Diseases 2014年第1期4卷 1-11页

作者： Rak.sh k.mar Mishra Ritu k.lshrestha Sunil k.mar Chhabra satish k. srivastav Surendra k.mar Bansal Department of Biochemistry and Molecular Biology The University of Texas Medical Branch Galveston USA Department of Biochemistry V.P. Chest Institute University of Delhi Delhi India Department of Cardiorespiratory Physiology V.P. Chest Institute University of Delhi Delhi India Department of Pathology V.P. Chest Institute University of Delhi Delhi India

Back.round and Objectives: Protein k.nase C (Pk.) activation plays an important role in activation of T-lymphocytes in asthma. Airway hypersensitivity is one of the main characteristic features of asthma, the mechanism of onset of which is not clearly understood. Therefore, the objective was to elucidate the role of Pk. in etiopathogenesis of airway hypersensitivity in asthma. Methods: Male guinea pigs (n = 30) were sensitized with ovalbumin and day of initial allergen-specific immune response determined by intradermal test, airway hypersensitivity, BALF cytology and lung histopathology. Total Pk. activity, Pk. isoenzymes and phosphoinositides were assessed in airway smooth muscles (ASM) and peripheral blood lymphocytes. Results: Intradermal test revealed that day 9 was the earliest time of allergen-specific response and onset of airway hypersensitivity to ovalbumin. It was associated with significant increase in total and differential (lymphocytes and eosinophils) BALF counts and grade I peribronchiolar chronic lymphocytic inflammation in lung. On day 14, grade II infiltration of lymphocytes and eosinophils with onset ofstructural remodelingofproximal and distal airways was seen. Total Pk. activity, expression of Pk.α, Pk.ε and phosphoinositides increased significantly in ASM and lymphocytes on day 9 and were maximum on day 14. There was no change in Pk.-τ expression. Conclusions: Activation of Pk., particularly Pk.α and Pk.ε, mediated signal transduction pathway plays a critical role in lymphocyte infiltration and onset of airway hypersensitivity, airway remodeling and asthma pathophysiology. The present study is the first one on the mechanism of the etiopathogenesis of the disease, which shows a direct evidence of the role of Pk. mediated pathway in the initiation and onset of airway hypersensitivity in ovalbumin sensitized guinea pig model.

关键词： Asthma Airway Hypersensitivity Protein k.nase C Airway Remodelling

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TiO<sub>2</sub>-Polysulfone Beads for Use in Photo Oxidation of Rhodamine B

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Soft Nanoscience Letters 2012年第4期2卷 67-70页

作者： Sanjay V. Ingale Pratap B. Wagh Arvind k. Tripathi Rohit srivastav srivastav Imejinary k. Singh Ramesh C. Bindal satish C. Gupta Applied Physics Division Bhabha Atomic Research Centre Mumbai India Chemistry Division Bhabha Atomic Research Centre Mumbai India Desalination Division Bhabha Atomic Research Centre Mumbai India

The nano sized TiO2 has been synthesized by sol gel process. The titaniumisopropaxide diluted in propanol hydrolyzed under acidic condition to form a gel. The solvent from gel pores has been extracted at ambient pressure resulting in nano sized TiO2 crystallites. The crystalline phase of TiO2 could be assigned to anatase structure. An average crystallite size is about 12 nm. The surface area of TiO2 found to be 235 m2/g. The TiO2 nanocrystallites thus produced were blended with polysulphone to form its beads for ease of operation. These beads of TiO2 were used as photo catalyst in conjunction with H2O2 oxidizer in presence of UV light (254 nm) for treating the 50 ppm Rhodamine B aqueous solution. The solution decolorized within 10 minutes resulting in disappearance of absorption peak.at around 600 nm in UV spectrometry. The organic entities degrade in about 60 minutes. The beads of nano sized TiO2 could be easily recovered from the treated effluent for further use.

关键词： Photo Oxidation Rhodamine B TiO2 Beads Polysulphone Nanocrystallite

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